{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:14:07Z","timestamp":1790723647444,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Funds of China","doi-asserted-by":"crossref","award":["81870913"],"award-info":[{"award-number":["81870913"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Research and Development Program for the Thirteenth Five-year Plan of the Ministry of Science and Technology of the People\u2019s Republic of China","award":["2016YFC1307301-DR"],"award-info":[{"award-number":["2016YFC1307301-DR"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Neurovascular coupling (NVC) refers to the process of aligning cerebral blood flow with neuronal metabolic demand. This study explores the potential of contralateral NVC\u2014linking neural electrical activity on the stroke side with cerebral blood flow velocity (CBFV) on the contralesional side\u2014as a marker of physiological function of the brain. Our aim was to examine the association between contralateral NVC and neurological outcomes in patients with ischemic stroke following endovascular thrombectomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We concurrently recorded the CBFVs of the middle cerebral arteries and electroencephalographic (EEG) signals of patients after endovascular thrombectomy. We employed phase-amplitude cross-frequency coupling to quantify the contralateral coupling between EEG activity on the stroke side and CBFV on the contralesional side. Key neurological outcomes were measured, including changes in National Institute of Health Stroke Scale (NIHSS) scores, infarct volume progression over 7\u00a0days, and modified Rankin Scale scores at 90\u00a0days.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 52 study participants were enrolled in our study (mean age 61.5\u2009\u00b1\u200910.4\u00a0years; 90.4% male; median preprocedural NIHSS score 14 [interquartile range 10\u201317]). We successfully computed contralateral NVC in 48 study participants. A significant association emerged between contralateral coupling and improvements in NIHSS scores over 7\u00a0days (theta band, <jats:italic>P<\/jats:italic>\u2009=\u20090.030) and in infarct volume progression (delta band, <jats:italic>P<\/jats:italic>\u2009=\u20090.001; theta band, <jats:italic>P<\/jats:italic>\u2009=\u20090.013). Stronger contralateral NVC in the delta and theta bands correlated with better outcomes at 90\u00a0days (adjusted odds ratio for delta 7.53 [95% confidence interval 1.13\u201350.30], <jats:italic>P<\/jats:italic>\u2009=\u20090.037; adjusted odds ratio for theta 6.36 [95% confidence interval 1.09\u201337.01], <jats:italic>P<\/jats:italic>\u2009=\u20090.039).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>A better contralateral coupling between stroke-side EEG and contralesional CBFV is associated with favorable neurological outcomes, suggesting that contralateral NVC analysis may aid in assessing brain function after recanalization. Replication with a deeper understanding of the mechanisms is needed before clinical translation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s12028-024-02178-w","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T17:57:00Z","timestamp":1736272620000},"page":"996-1006","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Contralateral Neurovascular Coupling in Patients with Ischemic Stroke After Endovascular Thrombectomy"],"prefix":"10.1007","volume":"42","author":[{"given":"Zhe","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafiul","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Sadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixuan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changgeng","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2943-055X","authenticated-orcid":false,"given":"Liping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"2178_CR1","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","volume":"387","author":"M Goyal","year":"2016","unstructured":"Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: A meta-analysis of individual patient data from five randomised trials. Lancet. 2016;387:1723\u201331. https:\/\/doi.org\/10.1016\/S0140-6736(16)00163-X.","journal-title":"Lancet"},{"key":"2178_CR2","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1056\/NEJMoa1713973","volume":"378","author":"GW Albers","year":"2018","unstructured":"Albers GW, Marks MP, Kemp S, et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med. 2018;378:708\u201318. https:\/\/doi.org\/10.1056\/NEJMoa1713973.","journal-title":"N Engl J Med"},{"key":"2178_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1706442","volume":"378","author":"RG Nogueira","year":"2018","unstructured":"Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018;378:11\u201321. https:\/\/doi.org\/10.1056\/NEJMoa1706442.","journal-title":"N Engl J Med"},{"key":"2178_CR4","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1056\/NEJMoa1804355","volume":"379","author":"G Thomalla","year":"2018","unstructured":"Thomalla G, Simonsen CZ, Boutitie F, et al. MRI-guided thrombolysis for stroke with unknown time of onset. N Engl J Med. 2018;379:611\u201322. https:\/\/doi.org\/10.1056\/NEJMoa1804355.","journal-title":"N Engl J Med"},{"key":"2178_CR5","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1056\/NEJMoa2213379","volume":"388","author":"X Huo","year":"2023","unstructured":"Huo X, Ma G, Tong X, et al. Trial of endovascular therapy for acute ischemic stroke with large infarct. N Engl J Med. 2023;388:1272\u201383. https:\/\/doi.org\/10.1056\/NEJMoa2213379.","journal-title":"N Engl J Med"},{"key":"2178_CR6","doi-asserted-by":"publisher","first-page":"e790","DOI":"10.1212\/WNL.0000000000013210","volume":"98","author":"FC Ng","year":"2022","unstructured":"Ng FC, Churilov L, Yassi N, et al. Prevalence and significance of impaired microvascular tissue reperfusion despite macrovascular angiographic reperfusion (no-reflow). Neurology. 2022;98:e790\u2013801. https:\/\/doi.org\/10.1212\/WNL.0000000000013210.","journal-title":"Neurology"},{"key":"2178_CR7","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1161\/STROKEAHA.123.044240","volume":"54","author":"CP Sperring","year":"2023","unstructured":"Sperring CP, Savage WM, Argenziano MG, et al. No-reflow post-recanalization in acute ischemic stroke: mechanisms, measurements, and molecular markers. Stroke. 2023;54:2472\u201380. https:\/\/doi.org\/10.1161\/STROKEAHA.123.044240.","journal-title":"Stroke"},{"key":"2178_CR8","doi-asserted-by":"publisher","first-page":"73","DOI":"10.7554\/eLife.14315","volume":"24","author":"AR Nippert","year":"2018","unstructured":"Nippert AR, Biesecker KR, Newman EA. Mechanisms mediating functional hyperemia in the brain. Neuroscientist. 2018;24:73\u201383. https:\/\/doi.org\/10.7554\/eLife.14315.","journal-title":"Neuroscientist"},{"key":"2178_CR9","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1177\/0271678X15617954","volume":"36","author":"AA Phillips","year":"2016","unstructured":"Phillips AA, Chan FH, Zheng MMZ, Krassioukov AV, Ainslie PN. Neurovascular coupling in humans: Physiology, methodological advances and clinical implications. J Cereb Blood Flow Metab. 2016;36:647\u201364. https:\/\/doi.org\/10.1177\/0271678X15617954.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2178_CR10","doi-asserted-by":"publisher","first-page":"634A","DOI":"10.3389\/fneur.2021.720770","volume":"12","author":"LC Beishon","year":"2021","unstructured":"Beishon LC, Minhas JS. Cerebral autoregulation and neurovascular coupling in acute and chronic stroke. Front Neurol. 2021;12:634A. https:\/\/doi.org\/10.3389\/fneur.2021.720770.","journal-title":"Front Neurol"},{"key":"2178_CR11","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3389\/fneur.2019.00194","volume":"10","author":"X Liu","year":"2019","unstructured":"Liu X, Pu Y, Wu D, Zhang Z, Hu X, Liu L. Cross-frequency coupling between cerebral blood flow velocity and EEG in ischemic stroke patients with large vessel occlusion. Front Neurol. 2019;10:194. https:\/\/doi.org\/10.3389\/fneur.2019.00194.","journal-title":"Front Neurol"},{"key":"2178_CR12","doi-asserted-by":"publisher","first-page":"26006","DOI":"10.3389\/fneur.2019.00194","volume":"17","author":"D Wu","year":"2020","unstructured":"Wu D, Liu X, Gadhoumi K, et al. Causal relationship between neuronal activity and cerebral hemodynamics in patients with ischemic stroke. J Neural Eng. 2020;17:26006. https:\/\/doi.org\/10.3389\/fneur.2019.00194.","journal-title":"J Neural Eng"},{"key":"2178_CR13","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1161\/STR.0b013e318284056a","volume":"44","author":"EC Jauch","year":"2013","unstructured":"Jauch EC, Saver JL, Adams HP, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke. 2013;44:870\u2013947. https:\/\/doi.org\/10.1161\/STR.0b013e318284056a.","journal-title":"Stroke"},{"key":"2178_CR14","doi-asserted-by":"publisher","first-page":"e46","DOI":"10.1161\/STR.0000000000000158","volume":"49","author":"WJ Powers","year":"2018","unstructured":"Powers WJ, Rabinstein AA, Ackerson T, et al. 2018 guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke. 2018;49:e46\u2013110. https:\/\/doi.org\/10.1161\/STR.0000000000000158.","journal-title":"Stroke"},{"key":"2178_CR15","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1016\/j.jtcvs.2017.04.091","volume":"154","author":"D Hori","year":"2017","unstructured":"Hori D, Nomura Y, Ono M, et al. Optimal blood pressure during cardiopulmonary bypass defined by cerebral autoregulation monitoring. J Thorac Cardiovasc Surg. 2017;154:1590-1598.e2. https:\/\/doi.org\/10.1016\/j.jtcvs.2017.04.091.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2178_CR16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1148\/radiology.207.1.9530305","volume":"207","author":"MJ Krabbe-Hartkamp","year":"1998","unstructured":"Krabbe-Hartkamp MJ, van der Grond J, de Leeuw FE, et al. Circle of Willis: Morphologic variation on three-dimensional time-of-flight MR angiograms. Radiology. 1998;207:103\u201311. https:\/\/doi.org\/10.1148\/radiology.207.1.9530305.","journal-title":"Radiology"},{"key":"2178_CR17","doi-asserted-by":"publisher","first-page":"3222","DOI":"10.1161\/STROKEAHA.121.037869","volume":"53","author":"SM Uniken Venema","year":"2022","unstructured":"Uniken Venema SM, Dankbaar JW, van der Lugt A, Dippel DWJ, van der Worp HB. Cerebral collateral circulation in the era of reperfusion therapies for acute ischemic stroke. Stroke. 2022;53:3222\u201334. https:\/\/doi.org\/10.1161\/STROKEAHA.121.037869.","journal-title":"Stroke"},{"key":"2178_CR18","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1161\/STROKEAHA.115.011788","volume":"47","author":"OA Berkhemer","year":"2016","unstructured":"Berkhemer OA, Jansen IGH, Beumer D, et al. Collateral status on baseline computed tomographic angiography and intra-arterial treatment effect in patients with proximal anterior circulation stroke. Stroke. 2016;47:768\u201376. https:\/\/doi.org\/10.1161\/STROKEAHA.115.011788.","journal-title":"Stroke"},{"key":"2178_CR19","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.1161\/STROKEAHA.120.032935","volume":"52","author":"E Venema","year":"2021","unstructured":"Venema E, Roozenbeek B, Mulder MJHL, et al. Prediction of outcome and endovascular treatment benefit: validation and update of the MR PREDICTS decision tool. Stroke. 2021;52:2764\u201372. https:\/\/doi.org\/10.1161\/STROKEAHA.120.032935.","journal-title":"Stroke"},{"key":"2178_CR20","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1161\/STROKEAHA.121.034471","volume":"53","author":"DS Liebeskind","year":"2022","unstructured":"Liebeskind DS, Saber H, Xiang B, et al. Collateral circulation in thrombectomy for stroke after 6 to 24 hours in the DAWN trial. Stroke. 2022;53:742\u20138. https:\/\/doi.org\/10.1161\/STROKEAHA.121.034471.","journal-title":"Stroke"},{"key":"2178_CR21","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1161\/STROKEAHA.118.023407","volume":"50","author":"A de Havenon","year":"2019","unstructured":"de Havenon A, Mlynash M, Kim-Tenser MA, et al. Results from DEFUSE 3: good collaterals are associated with reduced ischemic core growth but not neurologic outcome. Stroke. 2019;50:632\u20138. https:\/\/doi.org\/10.1161\/STROKEAHA.118.023407.","journal-title":"Stroke"},{"key":"2178_CR22","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1002\/ana.20976","volume":"60","author":"GW Albers","year":"2006","unstructured":"Albers GW, Thijs VN, Wechsler L, et al. Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol. 2006;60:508\u201317. https:\/\/doi.org\/10.1002\/ana.20976.","journal-title":"Ann Neurol"},{"key":"2178_CR23","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1177\/0271678X17721666","volume":"38","author":"TS Engedal","year":"2018","unstructured":"Engedal TS, Hjort N, Hougaard KD, et al. Transit time homogenization in ischemic stroke\u2014a novel biomarker of penumbral microvascular failure? J Cereb Blood Flow Metab. 2018;38:2006\u201320. https:\/\/doi.org\/10.1177\/0271678X17721666.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2178_CR24","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s12028-010-9414-6","volume":"16","author":"B Foreman","year":"2012","unstructured":"Foreman B, Claassen J. Quantitative EEG for the detection of brain ischemia. Crit Care. 2012;16:216. https:\/\/doi.org\/10.1007\/s12028-010-9414-6.","journal-title":"Crit Care"},{"key":"2178_CR25","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1002\/ana.21130","volume":"58","author":"T van Seeters","year":"2016","unstructured":"van Seeters T, Biessels GJ, Kappelle LJ, van der Graaf Y, Velthuis BK. Determinants of leptomeningeal collateral flow in stroke patients with a middle cerebral artery occlusion. Neuroradiology. 2016;58:969\u201377. https:\/\/doi.org\/10.1002\/ana.21130.","journal-title":"Neuroradiology"},{"key":"2178_CR26","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1038\/jcbfm.2014.7","volume":"57","author":"T van Seeters","year":"2015","unstructured":"van Seeters T, Hendrikse J, Biessels GJ, et al. Completeness of the circle of Willis and risk of ischemic stroke in patients without cerebrovascular disease. Neuroradiology. 2015;57:1247\u201351. https:\/\/doi.org\/10.1038\/jcbfm.2014.7.","journal-title":"Neuroradiology"}],"container-title":["Neurocritical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-024-02178-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12028-024-02178-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-024-02178-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T15:28:00Z","timestamp":1749050880000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12028-024-02178-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["2178"],"URL":"https:\/\/doi.org\/10.1007\/s12028-024-02178-w","relation":{},"ISSN":["1541-6933","1556-0961"],"issn-type":[{"value":"1541-6933","type":"print"},{"value":"1556-0961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]},"assertion":[{"value":"23 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study adhered to ethical guidelines and indicated ethical approvals and use of informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval\/Informed Consent"}}]}}