{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:32:27Z","timestamp":1789083147528,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"crossref","award":["2019010"],"award-info":[{"award-number":["2019010"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005366","name":"University of Oslo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Optic nerve sheath diameter (ONSD) is a promising noninvasive parameter for intracranial pressure (ICP) assessment. However, in the setting of aneurysmal subarachnoid hemorrhage (aSAH), several previous studies have reported no association between ultrasonically measured ONSD and ICP. In this study, we evaluate ONSD in patients with aSAH using a novel method of automated real-time ultrasonographic measurements and explore whether factors such as having undergone surgery affects its association to ICP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We prospectively included adult patients with aSAH undergoing invasive ICP monitoring. ONSD was obtained using a prototype ultrasound machine with software for real-time automated measurements at the bedside. Correlation between ONSD and ICP was explored, and the ability of ONSD to discriminate dichotomized ICP was evaluated. Abovementioned analyses were performed for the whole cohort and repeated for subgroups by whether the basal cisterns had been surgically entered before ultrasound examination.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Twenty-six ultrasound examinations were performed in 20 patients. There was a positive correlation between ONSD and ICP (<jats:italic>R<\/jats:italic>\u2009=\u20090.43; <jats:italic>p<\/jats:italic>\u2009=\u20090.03). In the subgroup where the basal cisterns had not been surgically\u00a0entered before ultrasound examination, there was a stronger correlation (<jats:italic>R<\/jats:italic>\u2009=\u20090.55; <jats:italic>p<\/jats:italic>\u2009=\u20090.01), whereas no correlation was seen in the subgroup where the basal cisterns had been\u00a0surgically entered (<jats:italic>R<\/jats:italic>\u2009=\u2009\u2212\u20090.16; <jats:italic>p<\/jats:italic>\u2009=\u20090.70). ONSD displayed an ability to discriminate ICP dichotomized at\u2009\u2265\u200915\u00a0mm Hg (area under the curve [AUC]\u2009=\u20090.84, 95% confidence interval [CI] 0.65\u20130.96). Subgroup analysis revealed a perfect discriminatory ability (AUC\u2009=\u20091, 95% CI 0.81\u20131) where the basal cisterns had not been surgically entered and no discriminatory ability (AUC\u2009=\u20090.47, 95% CI 0.16\u20130.84) where the basal cisterns had been surgically entered before ultrasound examination.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Automatically measured ONSD correlated well with ICP\u00a0and displayed a perfect discriminatory ability in patients with aSAH in whom the basal cisterns had not been entered surgically before ultrasound examination, and may be a clinically valuable noninvasive marker of ICP in these patients. Caution should be exercised in using ONSD in patients in whom the basal cisterns have been entered surgically before ONSD measurements, as no association was observed in this subgroup.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s12028-024-02194-w","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T17:58:15Z","timestamp":1736272695000},"page":"1043-1053","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Real-Time Automated Measurements of Optic Nerve Sheath Diameter for Noninvasive Assessment of Intracranial Pressure in Aneurysmal Subarachnoid Hemorrhage"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0382-0713","authenticated-orcid":false,"given":"Dag Ferner","family":"Netteland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Aarhus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Else Charlotte","family":"Sandset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Sorteberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llewellyn","family":"Padayachy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirik","family":"Helseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reidar","family":"Brekken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"issue":"2","key":"2194_CR1","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3171\/jns.1973.39.2.0226","volume":"39","author":"H Nornes","year":"1973","unstructured":"Nornes H. The role of intracranial pressure in the arrest of hemorrhage in patients with ruptured intracranial aneurysm. J Neurosurg. 1973;39(2):226\u201334.","journal-title":"J Neurosurg"},{"issue":"6","key":"2194_CR2","doi-asserted-by":"publisher","first-page":"784","DOI":"10.3171\/jns.1982.56.6.0784","volume":"56","author":"B Voldby","year":"1982","unstructured":"Voldby B, Enevoldsen EM. Intracranial pressure changes following aneurysm rupture: part 3: recurrent hemorrhage. J Neurosurg. 1982;56(6):784\u20139.","journal-title":"J Neurosurg"},{"issue":"1","key":"2194_CR3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s12028-023-01752-y","volume":"39","author":"A Addis","year":"2023","unstructured":"Addis A, Baggiani M, Citerio G. Intracranial pressure monitoring and management in aneurysmal subarachnoid hemorrhage. 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Nisonic AS did not otherwise contribute to the design or execution of the study. LP is a medical advisor to Nisonic AS. ECS is employed by the Norwegian Air Ambulance Foundation. The remaining authors reported no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"In accordance with the Helsinki Declaration, proxy consent was obtained for unconscious patients at the time of inclusion. If the patient regained ability to give informed consent, this was obtained from the patient at a later stage. The study was approved by the Regional Committee for Medical and Health Research Ethics South East Norway (2018\/136).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval\/Informed Consent"}}]}}