{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:08:48Z","timestamp":1793210928737,"version":"4.5.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["82202421"],"award-info":[{"award-number":["82202421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Research Fund of the Hunan Medical Association","award":["HNA 202101028"],"award-info":[{"award-number":["HNA 202101028"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The objective of this study was to evaluate the relationship between the N20-P25 amplitude of short-latency somatosensory evoked potentials (SSEPs) and neurologic outcomes in patients in a coma state.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively enrolled neurocritical patients who were older than 18\u00a0years; were admitted to the Department of Critical Medicine, Xiangya Hospital, Central South University, from January 2017 to January 2021 for 1\u20133\u00a0days; had a Glasgow Coma Scale score \u2264\u20098; had a body temperature \u2265\u200935\u00a0\u00b0C; and had SSEP records. Good outcome was defined as Cerebral Performance Category scores 1\u20133 at 1\u00a0year. The specificity and sensitivity of different SSEP patterns and amplitudes were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 457 patients were included in this study. The N20-P25 amplitude can be used for predicting awakening for traumatic brain injury (TBI) (area under the curve [AUC] 0.70,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0077), aneurysmal subarachnoid hemorrhage (SAH) (AUC 0.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), intracerebral hemorrhage (ICH) (AUC 0.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), and cardiac arrest (CA) (AUC 0.72,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0077). An N20-P25 amplitude &gt;\u20091.6\u00a0\u03bcV predicted awakening in CA, with a sensitivity of 100% (95% confidence interval [CI] 81.6\u2013100%) and specificity of 46.7% (95% CI 30.9\u201360.9%). In SAH, an N20-P25 amplitude &gt;\u20090.74\u00a0\u03bcV predicted the sensitivity and specificity of awakening were 100% (95% CI 93.8\u2013100%) and 16% (95% CI 8.3\u201328.5%), respectively. In TBI, an N20-P25 amplitude &gt;\u20091.20\u00a0\u03bcV predicted awakening with a sensitivity of 100% (95% CI 86.2\u2013100%) and a specificity of 34.2% (95% CI 21.2\u201350.1%). An N20-P25 amplitude &gt;\u20090.65\u00a0\u03bcV predicted the sensitivity and specificity of awakening in ICH were 100% (95% CI 91.0\u2013100%) and 14.3% (95% CI 5.7\u201331.5%), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>N20-P25 amplitude can predict awakening in patients in a coma state at 1\u00a0year. Different diseases have different cutoff values for predicting awakening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12028-025-02335-9","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T20:14:21Z","timestamp":1754943261000},"page":"902-910","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["N20-P25 Amplitude can Predict Awakening from Coma"],"prefix":"10.1007","volume":"43","author":[{"given":"Li","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-han","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-lin","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-yi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-lin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-guang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"2335_CR1","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s12028-019-00903-4","volume":"32","author":"B Lachance","year":"2020","unstructured":"Lachance B, Wang Z, Badjatia N, Jia X. 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