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I.A. reports consulting fees from Neurelis and Graviton unrelated to the submitted work and medicolegal consulting. D.F.H. reports personal fees from Neurotrope, Neurelis, and medicolegal outside of the submitted work. W.C.Z. is an associate editor for the journal\n                      Neurocritical Care\n                      . All other authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Johns Hopkins Institutional Review Board. Written informed consent was obtained from all participants or their legally authorized representatives as part of the MISTIE III clinical trial.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}