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This study aimed to explore the application of quantitative analysis of CEUS diagnosing increased ICP in patients with severe brain injury after surgery, and to provide a novel idea for the non-invasive evaluation of ICP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational study included 34 patients with craniocerebral injuries admitted to the intensive care unit from May 2022 to December 2023. Patients were divided into a normal cranial pressure group (&lt;\u200920\u00a0mm Hg) and an intracranial hypertension group (\u2265\u200920\u00a0mm Hg) on the basis of the invasive ICP monitoring values. All patients underwent CEUS examination within 24\u00a0h postoperatively. Time-intensity curves of the central retinal artery and short posterior ciliary artery were generated using CEUS quantitative analysis software. Quantitative parameters were obtained, and the difference was calculated. The diagnostic accuracy of each parameter was assessed by computing the area under the receiver operating characteristic curve (AUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 15 patients (44%) had intracranial hypertension. The arrival time difference (\u0394AT) and peak time difference (\u0394TP) were significantly higher in the intracranial hypertension group than in the normal cranial pressure group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.010, respectively). The peak intensity difference (\u0394PkI) was significantly lower in the intracranial hypertension group than in the normal cranial pressure group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.025). The diagnostic accuracy of \u0394AT for identifying intracranial hypertension was excellent, with an AUC of 0.944 [95% confidence interval (CI) 0.874\u20131.014], which yielded an optimal cutoff value of 0.86\u00a0s with 93.3% sensitivity (95% CI 0.849\u20131.017) and 84.2% specificity (95% CI 0.719\u20130.964). The AUC of \u0394AT was significantly higher than that of \u0394TP and \u0394PkI (AUC 0.761 and 0.721, respectively; both\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The CEUS quantitative analysis parameter, \u0394AT, is a promising parameter for evaluating postoperative ICP elevation in patients with severe brain injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12028-026-02447-w","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:42:40Z","timestamp":1770752560000},"page":"142-150","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Intracranial Pressure in Patients with Severe Brain Injury Using Contrast-Enhanced Ultrasound: A Pilot Study with Preliminary Findings"],"prefix":"10.1007","volume":"45","author":[{"given":"Xixi","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caibao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-9167","authenticated-orcid":false,"given":"Bin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"issue":"4","key":"2447_CR1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1055\/s-0037-1598654","volume":"21","author":"C Perin","year":"2017","unstructured":"Perin C, Meroni R, Rega V, et al. 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It does not involve financial disclosure and conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"This study was approved by the Medical Ethics Committee of Zhejiang Hospital (approval no. 2021-139K). All patients\u2019 families were informed about the trial before enrollment, and they signed an informed consent form.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Ethics"}}]}}