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Olander Medica Development AB","award":["83433"],"award-info":[{"award-number":["83433"]}]},{"DOI":"10.13039\/501100003252","name":"Lund University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurointensive care is moving toward more automated patient management. This study aimed to evaluate a novel external ventricular drainage (EVD) system, the VGuard\u00ae system, as a tool for intracranial pressure (ICP) monitoring and automating ventricular drainage of cerebrospinal fluid (CSF), focusing on its safety and potential to reduce complications associated with manual EVD management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective, randomized clinical study was conducted in the Department of Neurosurgery at Sk\u00e5ne University Hospital, Lund, Sweden. Patients (aged\u2009&gt;\u200918\u00a0years) with different acute brain pathologies requiring an EVD were enrolled and randomized (1:1) to receive the VGuard\u00ae system or a manual EVD. Both systems employed a ventricular probe for simultaneous intraventricular and intraparenchymal ICP monitoring. Measurement accuracy was determined by comparing the median of absolute difference in ICP, using the Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test. To further investigate the accuracy of ICP measuring, a post\u00a0hoc Spearman correlation test was applied. In addition, as part of a post\u00a0hoc analysis, we evaluated patient outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 30 patients were included in the study. The VGuard\u00ae system demonstrated significantly better accuracy in ICP measurements compared with the manual EVD; median absolute difference: 1.07 versus 2.88,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; median Spearman correlation coefficients: 0.81 versus 0.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05. There were no statistically significant differences in patient outcomes [mortality, Glasgow Outcome Scale-Extended (GOSE), modified Rankin Scale (mRS), median time with the EVD, and length of intensive care unit (ICU) stay], or adverse events (AE). No serious adverse events were noted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first study to evaluate the VGuard\u00ae system, showing results of increased accuracy in measured ICP compared with the manual EVD. The VGuard\u00ae system offers an automated EVD solution, representing a step toward increased neurointensive care automation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12028-026-02477-4","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:03:40Z","timestamp":1774307020000},"page":"368-381","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a Novel Automated Cerebral Ventricular Drainage System for Intracranial Pressure Monitoring and Cerebrospinal Fluid Drainage in Neurocritical Care Patients: A Prospective, Randomized Clinical Study"],"prefix":"10.1007","volume":"45","author":[{"given":"Josefine Maria","family":"\u00d6hman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-5626","authenticated-orcid":false,"given":"Niklas","family":"Marklund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cederberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"issue":"9","key":"2477_CR1","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.3390\/jcm8091422","volume":"8","author":"CYC Chau","year":"2019","unstructured":"Chau CYC, Craven CL, Rubiano AM, Adams H, Tulu S, Czosnyka M, et\u00a0al. 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The study was approved by The Swedish Ethical Review Authority (EPM) (Dnr 2021-04061) and the Swedish Medical Council (CIV-SE-21-06-036906). The study was monitored by Clinical Studies Sweden and registered at\n                      \n                      (NCT05177692) (2021\/12\/14). An application was approved by the Scanian Healthcare Agency responsible for individual patient extraction (Samr\u00e5d KVB, dossier no. 355-21). The enrollment of participants in the study was solely based on exclusion and inclusion criteria. The participant\u2019s autonomy was highly valued, and when patients were providing consent, either by themselves or via next-of-kin, it was greatly emphasized that participation was voluntary. It was also emphasized that consent for participation in the study could be withdrawn without any consequences.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"NCT05177692; ClinicalTrials.gov (registered 14 December 2021)\n                      \n                      .","order":3,"name":"Ethics","label":"Trial Registration","group":{"name":"EthicsHeading","label":"Declarations"}}]}}