{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:16:47Z","timestamp":1793121407721,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"DOI":"10.1007\/s12028-026-02623-y","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T18:24:06Z","timestamp":1785954246000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Albumin-Anchored Thromboinflammatory Ratios Provide Modest Incremental Prognostic Value Beyond Clinical Severity Scores in Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-9810","authenticated-orcid":false,"given":"Omer","family":"Aykanat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0776-9421","authenticated-orcid":false,"given":"Aykut","family":"Sezer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8844-0020","authenticated-orcid":false,"given":"Yucel","family":"Duzenli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9913-4913","authenticated-orcid":false,"given":"Lokman","family":"Bayrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"issue":"4","key":"2623_CR1","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1161\/strokeaha.124.048950","volume":"56","author":"L Gu","year":"2025","unstructured":"Gu L, Zhou J, Zhang L, Li C, Bao K, Du F, et al. Global, regional, and national burden of subarachnoid hemorrhage: trends from 1990 to 2021 and 20-year forecasts. Stroke. 2025;56(4):887\u201397. https:\/\/doi.org\/10.1161\/strokeaha.124.048950.","journal-title":"Stroke"},{"issue":"10355","key":"2623_CR2","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/s0140-6736(22)00938-2","volume":"400","author":"J Claassen","year":"2022","unstructured":"Claassen J, Park S. Spontaneous subarachnoid haemorrhage. Lancet. 2022;400(10355):846\u201362. https:\/\/doi.org\/10.1016\/s0140-6736(22)00938-2.","journal-title":"Lancet"},{"key":"2623_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0323453","author":"DP Patra","year":"2025","unstructured":"Patra DP, Li W, Yang H, Rui F, Ruan X, Xiong J, et al. Systematic analysis of the global, regional, and national burden of subarachnoid hemorrhage from 1990 to 2021. PLoS ONE. 2025. https:\/\/doi.org\/10.1371\/journal.pone.0323453.","journal-title":"PLoS ONE"},{"key":"2623_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031015","author":"DL Alsbrook","year":"2023","unstructured":"Alsbrook DL, Di Napoli M, Bhatia K, Desai M, Hinduja A, Rubinos CA, et al. Pathophysiology of early brain injury and its association with delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a review of current literature. J Clin Med. 2023. https:\/\/doi.org\/10.3390\/jcm12031015.","journal-title":"J Clin Med"},{"issue":"5","key":"2623_CR5","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1161\/strokeaha.122.040072","volume":"54","author":"DC Lauzier","year":"2023","unstructured":"Lauzier DC, Jayaraman K, Yuan JY, Diwan D, Vellimana AK, Osbun JW, et al. Early brain injury after subarachnoid hemorrhage: incidence and mechanisms. Stroke. 2023;54(5):1426\u201340. https:\/\/doi.org\/10.1161\/strokeaha.122.040072.","journal-title":"Stroke"},{"issue":"2","key":"2623_CR6","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s12028-017-0471-y","volume":"28","author":"J Savarraj","year":"2017","unstructured":"Savarraj J, Parsha K, Hergenroeder G, Ahn S, Chang TR, Kim DH, et al. Early brain injury associated with systemic inflammation after subarachnoid hemorrhage. Neurocrit Care. 2017;28(2):203\u201311. https:\/\/doi.org\/10.1007\/s12028-017-0471-y.","journal-title":"Neurocrit Care"},{"key":"2623_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02264-2","author":"P Lassar\u00e9n","year":"2021","unstructured":"Lassar\u00e9n P, Lindblad C, Frostell A, Carpenter KLH, Guilfoyle MR, Hutchinson PJA, et al. Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury. J Neuroinflammation. 2021. https:\/\/doi.org\/10.1186\/s12974-021-02264-2.","journal-title":"J Neuroinflammation"},{"issue":"6","key":"2623_CR8","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1093\/neuros\/nyab354","volume":"89","author":"JR Geraghty","year":"2021","unstructured":"Geraghty JR, Lung TJ, Hirsch Y, Katz EA, Cheng T, Saini NS, et al. Systemic immune-inflammation index predicts delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2021;89(6):1071\u20139. https:\/\/doi.org\/10.1093\/neuros\/nyab354.","journal-title":"Neurosurgery"},{"key":"2623_CR9","doi-asserted-by":"publisher","DOI":"10.3171\/2018.1.Jns172925","author":"AP Wessell","year":"2018","unstructured":"Wessell AP, Kole MJ, Cannarsa G, Oliver J, Jindal G, Miller T, et al. A sustained systemic inflammatory response syndrome is associated with shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage. J Neurosurgery. 2018. https:\/\/doi.org\/10.3171\/2018.1.Jns172925.","journal-title":"J Neurosurgery"},{"key":"2623_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1014501","author":"L Wang","year":"2022","unstructured":"Wang L, Zhang Q, Zhang G, Zhang W, Chen W, Hou F, et al. Risk factors and predictive models of poor prognosis and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage complicated with hydrocephalus. Frontiers Neurol. 2022. https:\/\/doi.org\/10.3389\/fneur.2022.1014501.","journal-title":"Frontiers Neurol"},{"issue":"6","key":"2623_CR11","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.hest.2025.08.005","volume":"6","author":"F Wang","year":"2025","unstructured":"Wang F, Zhang X, Gao T, Jiang M, Chen Z, Luo X, et al. The role of D-dimer in intracerebral haemorrhage outcomes. Brain Hemorrhages. 2025;6(6):269\u201376. https:\/\/doi.org\/10.1016\/j.hest.2025.08.005.","journal-title":"Brain Hemorrhages"},{"key":"2623_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.01114","author":"Z Zhou","year":"2018","unstructured":"Zhou Z, Liang Y, Zhang X, Xu J, Kang K, Qu H, et al. Plasma D-dimer concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis. Frontiers Neurol. 2018. https:\/\/doi.org\/10.3389\/fneur.2018.01114.","journal-title":"Frontiers Neurol"},{"key":"2623_CR13","doi-asserted-by":"publisher","DOI":"10.3171\/2021.12.Focus21512","author":"F Fang","year":"2022","unstructured":"Fang F, Wang P, Yao W, Wang X, Zhang Y, Chong W, et al. Association between D-dimer levels and long-term mortality in patients with aneurysmal subarachnoid hemorrhage. Neurosurg Focus. 2022. https:\/\/doi.org\/10.3171\/2021.12.Focus21512.","journal-title":"Neurosurg Focus"},{"key":"2623_CR14","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.221158","author":"Q-x Chen","year":"2017","unstructured":"Chen Q-x, Liu J-h, Li X-k, Chen Z-b, Cai Q, Wang L, et al. D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective study. Neural Regen Res. 2017. https:\/\/doi.org\/10.4103\/1673-5374.221158.","journal-title":"Neural Regen Res"},{"issue":"4","key":"2623_CR15","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1159\/000540163","volume":"87","author":"X Shang","year":"2024","unstructured":"Shang X, Li X. D-dimer and the short-term prognosis of patients with subarachnoid hemorrhage: a meta-analysis. Eur Neurol. 2024;87(4):188\u2013202. https:\/\/doi.org\/10.1159\/000540163.","journal-title":"Eur Neurol"},{"key":"2623_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12121700","author":"W Wu","year":"2022","unstructured":"Wu W, Liu X, Zhu Q, Chen X, Sheng B, Zhang J, et al. The D-dimer\/albumin ratio is a prognostic marker for aneurysmal subarachnoid hemorrhage. Brain Sci. 2022. https:\/\/doi.org\/10.3390\/brainsci12121700.","journal-title":"Brain Sci"},{"issue":"2","key":"2623_CR17","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s12028-016-0259-5","volume":"25","author":"R Behrouz","year":"2016","unstructured":"Behrouz R, Godoy DA, Topel CH, Birnbaum LA, Caron J-L, Grandhi R, et al. Early hypoalbuminemia is an independent predictor of mortality in aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2016;25(2):230\u20136. https:\/\/doi.org\/10.1007\/s12028-016-0259-5.","journal-title":"Neurocrit Care"},{"key":"2623_CR18","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jcrc.2017.06.002","volume":"41","author":"M Di Napoli","year":"2017","unstructured":"Di Napoli M, Behrouz R, Topel CH, Misra V, Pomero F, Giraudo A, et al. Hypoalbuminemia, systemic inflammatory response syndrome, and functional outcome in intracerebral hemorrhage. J Crit Care. 2017;41:247\u201353. https:\/\/doi.org\/10.1016\/j.jcrc.2017.06.002.","journal-title":"J Crit Care"},{"issue":"5","key":"2623_CR19","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s00415-017-8451-x","volume":"264","author":"A Morotti","year":"2017","unstructured":"Morotti A, Marini S, Lena UK, Crawford K, Schwab K, Kourkoulis C, et al. Significance of admission hypoalbuminemia in acute intracerebral hemorrhage. J Neurol. 2017;264(5):905\u201311. https:\/\/doi.org\/10.1007\/s00415-017-8451-x.","journal-title":"J Neurol"},{"key":"2623_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.719226","author":"F Shang","year":"2021","unstructured":"Shang F, Zhao H, Cheng W, Qi M, Wang N, Qu X. Predictive value of the serum albumin level on admission in patients with spontaneous subarachnoid hemorrhage. Frontiers Surgery. 2021. https:\/\/doi.org\/10.3389\/fsurg.2021.719226.","journal-title":"Frontiers Surgery"},{"key":"2623_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7100333","author":"JE Park","year":"2018","unstructured":"Park JE, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, et al. The C-reactive protein\/albumin ratio as a predictor of mortality in critically ill patients. J Clin Med. 2018. https:\/\/doi.org\/10.3390\/jcm7100333.","journal-title":"J Clin Med"},{"key":"2623_CR22","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9957563","author":"J Wang","year":"2021","unstructured":"Wang J, Zhao K, Mao X, Zhang Y, Shao J, Fan W, et al. Relationship between CRP albumin ratio and the mortality in critically ill patients with AKI: a retrospective observational study. BioMed Res Int. 2021. https:\/\/doi.org\/10.1155\/2021\/9957563.","journal-title":"BioMed Res Int"},{"key":"2623_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2020.106051","author":"R Wang","year":"2020","unstructured":"Wang R, He M, Ou X, Xie X, Kang Y. CRP Albumin ratio is positively associated with poor outcome in patients with traumatic brain injury. Clinical Neurol Neurosurgery. 2020. https:\/\/doi.org\/10.1016\/j.clineuro.2020.106051.","journal-title":"Clinical Neurol Neurosurgery"},{"issue":"6","key":"2623_CR24","doi-asserted-by":"publisher","first-page":"736","DOI":"10.3340\/jkns.2025.0061","volume":"68","author":"Z Huang","year":"2025","unstructured":"Huang Z, Ge H, Sun Y. Association between neutrophil-to-albumin ratio and 28-day all-cause mortality in patients with traumatic brain injury\u202f: a retrospective analysis of the MIMIC-IV database. J Korean Neurosurg Soc. 2025;68(6):736\u201348. https:\/\/doi.org\/10.3340\/jkns.2025.0061.","journal-title":"J Korean Neurosurg Soc"},{"issue":"10069","key":"2623_CR25","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/s0140-6736(16)30668-7","volume":"389","author":"RL Macdonald","year":"2017","unstructured":"Macdonald RL, Schweizer TA. Spontaneous subarachnoid haemorrhage. Lancet. 2017;389(10069):655\u201366. https:\/\/doi.org\/10.1016\/s0140-6736(16)30668-7.","journal-title":"Lancet"},{"key":"2623_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1705544","author":"H Lu","year":"2025","unstructured":"Lu H, Wang C, Yang M, Lin Y, Jiang W. Admission monocyte-to-albumin ratio predicts 3-month functional outcomes after acute ischemic stroke: a retrospective cohort study. Frontiers Neurol. 2025. https:\/\/doi.org\/10.3389\/fneur.2025.1705544.","journal-title":"Frontiers Neurol"},{"issue":"3","key":"2623_CR27","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1161\/01.STR.0000258355.23810.c6","volume":"38","author":"JL Banks","year":"2007","unstructured":"Banks JL, Marotta CA. Outcomes validity and reliability of the modified Rankin Scale: implications for stroke clinical trials. Stroke. 2007;38(3):1091\u20136. https:\/\/doi.org\/10.1161\/01.STR.0000258355.23810.c6.","journal-title":"Stroke"}],"container-title":["Neurocritical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-026-02623-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12028-026-02623-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-026-02623-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T18:24:08Z","timestamp":1785954248000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12028-026-02623-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":27,"alternative-id":["2623"],"URL":"https:\/\/doi.org\/10.1007\/s12028-026-02623-y","relation":{},"ISSN":["1541-6933","1556-0961"],"issn-type":[{"value":"1541-6933","type":"print"},{"value":"1556-0961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"assertion":[{"value":"2 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflicts of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the ethical principles of the Declaration of Helsinki. The study protocol was reviewed and approved by the Gaziantep City Hospital Non-Interventional Clinical Research Ethics Committee (approval no: 452\/2026, Date: 18 January 2026). Given the retrospective design and the use of anonymized data extracted from hospital electronic medical records, the requirement for written informed consent was waived by the Ethics Committee. All patient data were de-identified prior to analysis to ensure confidentiality and data protection.","order":2,"name":"Ethics","label":"Ethical Approval\/Informed Consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that no artificial intelligence (AI)-assisted technologies were used in the design, analysis, or interpretation of the study. AI tools were used only for language editing purposes to improve clarity and readability of the manuscript, and all content has been critically reviewed and approved by the authors.","order":3,"name":"Ethics","label":"Artificial Intelligence Statement","group":{"name":"EthicsHeading","label":"Declarations"}}]}}