{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:52:09Z","timestamp":1791319929988,"version":"4.3.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurocrit Care"],"DOI":"10.1007\/s12028-026-02670-5","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:15:15Z","timestamp":1791317715000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rethinking Platelet Dysfunction in Traumatic Brain Injury: From Platelet Count to Hemostatic Phenotype"],"prefix":"10.1007","author":[{"given":"Manuel","family":"Quintana Diaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Agustin","family":"Godoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"issue":"19-20","key":"2670_CR1","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1089\/neu.2025.0039","volume":"42","author":"L Gu","year":"1990","unstructured":"Gu L, Zhang L, Li C, Jiang L, Zhou J, Xie Y, et al. Global, regional, and national burden of traumatic brain injury, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021. J Neurotrauma. 1990;42(19\u201320):1805\u201315. https:\/\/doi.org\/10.1089\/neu.2025.0039.","journal-title":"J Neurotrauma"},{"key":"2670_CR2","doi-asserted-by":"crossref","unstructured":"GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990\u20132016. Lancet Neurol. 2019;18(1):56\u201387.","DOI":"10.1016\/S1474-4422(18)30444-7"},{"issue":"Suppl 1","key":"2670_CR3","first-page":"28S","volume":"53","author":"M Maegele","year":"2013","unstructured":"Maegele M. Coagulopathy after traumatic brain injury: incidence, pathogenesis, and treatment options. Transfusion. 2013;53(Suppl 1):28S-37S.","journal-title":"Transfusion"},{"issue":"2","key":"2670_CR4","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00701-019-04111-z","volume":"162","author":"JAN van Gent","year":"2020","unstructured":"van Gent JAN, et al. Coagulopathy after hemorrhagic traumatic brain injury. Acta Neurochir. 2020;162(2):329\u201336.","journal-title":"Acta Neurochir"},{"issue":"2","key":"2670_CR5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1055\/s-0040-1702178","volume":"46","author":"M Maegele","year":"2020","unstructured":"Maegele M, et al. Changes in coagulation following brain injury. Semin Thromb Hemost. 2020;46(2):155\u201366.","journal-title":"Semin Thromb Hemost"},{"issue":"6","key":"2670_CR6","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1227\/NEU.0b013e31824d179b","volume":"70","author":"M Laroche","year":"2012","unstructured":"Laroche M, et al. Coagulopathy after traumatic brain injury. Neurosurgery. 2012;70(6):1334\u201345.","journal-title":"Neurosurgery"},{"issue":"7","key":"2670_CR7","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1089\/neu.2020.7301","volume":"38","author":"CM Riojas","year":"2021","unstructured":"Riojas CM, et al. Platelet dysfunction after traumatic brain injury: a review. J Neurotrauma. 2021;38(7):819\u201329.","journal-title":"J Neurotrauma"},{"issue":"2","key":"2670_CR8","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s12028-012-9745-6","volume":"18","author":"PK Davis","year":"2013","unstructured":"Davis PK, et al. Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy. Neurocrit Care. 2013;18(2):201\u20138.","journal-title":"Neurocrit Care"},{"issue":"11","key":"2670_CR9","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1089\/neu.2007.0322","volume":"24","author":"M Nekludov","year":"2007","unstructured":"Nekludov M, et al. Platelet dysfunction in patients with severe traumatic brain injury. J Neurotrauma. 2007;24(11):1699\u2013706.","journal-title":"J Neurotrauma"},{"issue":"5","key":"2670_CR10","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1097\/TA.0000000000000216","volume":"76","author":"FJ Castellino","year":"2014","unstructured":"Castellino FJ, et al. Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats. J Trauma Acute Care Surg. 2014;76(5):1169\u201376.","journal-title":"J Trauma Acute Care Surg"},{"issue":"21","key":"2670_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10215039","volume":"10","author":"JL Bradbury","year":"2021","unstructured":"Bradbury JL, et al. Viscoelastic testing and coagulopathy of traumatic brain injury. J Clin Med. 2021;10(21):5039.","journal-title":"J Clin Med"},{"key":"2670_CR12","volume-title":"Best practices guidelines: the management of traumatic brain injury","author":"American College of Surgeons Committee on Trauma","year":"2024","unstructured":"American College of Surgeons Committee on Trauma. Best practices guidelines: the management of traumatic brain injury. Chicago: American College of Surgeons; 2024."},{"issue":"1","key":"2670_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04327-7","volume":"27","author":"DR Spahn","year":"2023","unstructured":"Spahn DR, et al. The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition. Crit Care. 2023;27(1):80.","journal-title":"Crit Care"},{"issue":"6","key":"2670_CR14","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1093\/neuros\/nyab358","volume":"89","author":"M Maegele","year":"2021","unstructured":"Maegele M. Coagulopathy and progression of intracranial hemorrhage in traumatic brain injury. Neurosurgery. 2021;89(6):954\u201366.","journal-title":"Neurosurgery"},{"issue":"3","key":"2670_CR15","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/s12028-017-0485-5","volume":"28","author":"G Martin","year":"2018","unstructured":"Martin G, et al. Relationship of coagulopathy and platelet dysfunction to transfusion needs after traumatic brain injury. Neurocrit Care. 2018;28(3):330\u20137.","journal-title":"Neurocrit Care"},{"issue":"3","key":"2670_CR16","first-page":"942","volume":"66","author":"WD McMillian","year":"2009","unstructured":"McMillian WD, Rogers FB. Management of prehospital antiplatelet and anticoagulant therapy in traumatic head injury. J Trauma. 2009;66(3):942\u201350.","journal-title":"J Trauma"},{"issue":"1","key":"2670_CR17","first-page":"308","volume":"3","author":"F Mathieu","year":"2022","unstructured":"Mathieu F, et al. Pre-injury antiplatelet therapy and risk of adverse outcomes after traumatic brain injury. Neurotrauma Rep. 2022;3(1):308\u201320.","journal-title":"Neurotrauma Rep."},{"issue":"1","key":"2670_CR18","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.amjsurg.2021.07.050","volume":"223","author":"NE Glass","year":"2022","unstructured":"Glass NE, et al. Platelet dysfunction in patients with traumatic intracranial hemorrhage: do desmopressin and platelet therapy help or harm? Am J Surg. 2022;223(1):131\u20136.","journal-title":"Am J Surg"},{"issue":"22","key":"2670_CR19","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1089\/neu.2014.3728","volume":"32","author":"DY Kim","year":"2015","unstructured":"Kim DY, et al. The effect of platelet and desmopressin administration on early radiographic progression of traumatic intracranial hemorrhage. J Neurotrauma. 2015;32(22):1815\u201321.","journal-title":"J Neurotrauma"},{"issue":"7","key":"2670_CR20","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1007\/s10072-024-07379-x","volume":"45","author":"KM Westfall","year":"2024","unstructured":"Westfall KM, et al. A multicenter study of DDAVP versus platelet transfusions for antiplatelet agent reversal in patients with TBI. Neurol Sci. 2024;45(7):3325\u201332.","journal-title":"Neurol Sci"},{"issue":"2","key":"2670_CR21","doi-asserted-by":"publisher","first-page":"E206","DOI":"10.1503\/cjs.018120","volume":"65","author":"C Wolff","year":"2022","unstructured":"Wolff C, et al. Routine platelet transfusion in patients with traumatic intracranial hemorrhage taking antiplatelet medication: is it warranted? Can J Surg. 2022;65(2):E206\u201311.","journal-title":"Can J Surg"},{"issue":"5","key":"2670_CR22","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1097\/TA.0000000000002047","volume":"85","author":"E Furay","year":"2018","unstructured":"Furay E, et al. Goal-directed platelet transfusions correct platelet dysfunction and may improve survival in patients with severe TBI. J Trauma Acute Care Surg. 2018;85(5):881\u20137.","journal-title":"J Trauma Acute Care Surg"},{"issue":"3","key":"2670_CR23","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1007\/s12028-022-01535-x","volume":"37","author":"S Kvint","year":"2022","unstructured":"Kvint S, et al. Application of a TEG-platelet mapping algorithm to guide reversal of antiplatelet agents in adults with mild-to-moderate TBI. Neurocrit Care. 2022;37(3):638\u201348.","journal-title":"Neurocrit Care"},{"issue":"1","key":"2670_CR24","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s12028-014-0026-4","volume":"22","author":"AL de Oliveira Manoel","year":"2015","unstructured":"de Oliveira Manoel AL, et al. Traumatic brain injury associated coagulopathy. Neurocrit Care. 2015;22(1):34\u201344.","journal-title":"Neurocrit Care"},{"key":"2670_CR25","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jocn.2015.11.024","volume":"29","author":"DS Epstein","year":"2016","unstructured":"Epstein DS, et al. Normalization of coagulopathy is associated with improved outcome after isolated traumatic brain injury. J Clin Neurosci. 2016;29:64\u20139.","journal-title":"J Clin Neurosci"},{"issue":"13\u201314","key":"2670_CR26","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1080\/02699052.2018.1536805","volume":"32","author":"AR Guillotte","year":"2018","unstructured":"Guillotte AR, et al. Effects of platelet dysfunction and platelet transfusion on outcomes in traumatic brain injury patients. Brain Inj. 2018;32(13\u201314):1849\u201357.","journal-title":"Brain Inj"},{"issue":"1","key":"2670_CR27","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1097\/TA.0000000000002521","volume":"88","author":"EJ Furay","year":"2020","unstructured":"Furay EJ, et al. Desmopressin is a transfusion-sparing option to reverse platelet dysfunction in patients with severe TBI. J Trauma Acute Care Surg. 2020;88(1):80\u20136.","journal-title":"J Trauma Acute Care Surg"},{"issue":"1","key":"2670_CR28","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1227\/NEU.0000000000001401","volume":"80","author":"PA Choi","year":"2017","unstructured":"Choi PA, et al. Use of aspirin and P2Y12 response assays in detecting reversal of platelet inhibition with platelet transfusion in patients with TBI on antiplatelet therapy. Neurosurgery. 2017;80(1):98\u2013104.","journal-title":"Neurosurgery"},{"issue":"1","key":"2670_CR29","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1227\/NEU.0000000000001406","volume":"80","author":"PV Parry","year":"2017","unstructured":"Parry PV, et al. Utility of the aspirin and P2Y12 response assays to determine the effect of antiplatelet agents on platelet reactivity in TBI. Neurosurgery. 2017;80(1):92\u20136.","journal-title":"Neurosurgery"}],"container-title":["Neurocritical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-026-02670-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12028-026-02670-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12028-026-02670-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:15:17Z","timestamp":1791317717000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12028-026-02670-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":29,"alternative-id":["2670"],"URL":"https:\/\/doi.org\/10.1007\/s12028-026-02670-5","relation":{},"ISSN":["1541-6933","1556-0961"],"issn-type":[{"value":"1541-6933","type":"print"},{"value":"1556-0961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"2 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"Artificial intelligence was used to assist with grammatical revision and table and figure illustration (Claude, Anthropic, San Francisco, CA, USA; ChatGPT, Open AI).","order":2,"name":"Ethics","label":"Artificial Intelligence","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}