{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:56:40Z","timestamp":1786982200286,"version":"build-2736575974"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,5,15]],"date-time":"2010-05-15T00:00:00Z","timestamp":1273881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2010,5,15]],"date-time":"2010-05-15T00:00:00Z","timestamp":1273881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s12029-010-9158-8","type":"journal-article","created":{"date-parts":[[2010,5,14]],"date-time":"2010-05-14T02:11:25Z","timestamp":1273803085000},"page":"281-284","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A Case of Explosive Progression of Hepatocellular Carcinoma in a Patient with Common Variable Immunodeficiency (CVID)"],"prefix":"10.1007","volume":"41","author":[{"given":"Kaushang","family":"Gandhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purvi","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilbert S.","family":"Aronow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harit","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshad","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mala","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arye","family":"Rubinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,15]]},"reference":[{"key":"9158_CR1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s10238-004-0027-2","volume":"3","author":"M Di Renzo","year":"2004","unstructured":"Di Renzo M, Pasqui AL, Auteri A. Common variable immunodeficiency: a review. Clin Exp Med. 2004;3:211\u20137.","journal-title":"Clin Exp Med"},{"key":"9158_CR2","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.gde.2007.04.002","volume":"17","author":"AA Schaffer","year":"2007","unstructured":"Schaffer AA, Salzer U, Hammarstrom L, Grimbacher B. Deconstructing common variable immunodeficiency by genetic analysis. Curr Opin Genet Dev. 2007;17:201\u201312.","journal-title":"Curr Opin Genet Dev"},{"key":"9158_CR3","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1006\/clim.1999.4725","volume":"92","author":"C Cunningham-Rundles","year":"1999","unstructured":"Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol. 1999;92:34\u201348.","journal-title":"Clin Immunol"},{"key":"9158_CR4","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1006\/clim.1999.4799","volume":"93","author":"ME Conley","year":"1999","unstructured":"Conley ME, Notarangelo LD, Etzioni A. Diagnostic criteria for primary immunodeficiencies: representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies). Clin Immunol. 1999;93:190\u20137.","journal-title":"Clin Immunol"},{"key":"9158_CR5","first-page":"31","volume":"86","author":"RA Hermaszewski","year":"1993","unstructured":"Hermaszewski RA, Webster AD. Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications. Q J Med. 1993;86:31\u201342.","journal-title":"Q J Med"},{"key":"9158_CR6","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1007\/s10875-007-9075-1","volume":"27","author":"I Quinti","year":"2007","unstructured":"Quinti I, Soresina A, Spadaro G, Martino S, Donnanno S, Agostini C, et al. Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency. J Clin Immunol. 2007;27:308\u201316.","journal-title":"J Clin Immunol"},{"key":"9158_CR7","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/j.1872-034X.2007.00281.x","volume":"38","author":"K Fukushima","year":"2008","unstructured":"Fukushima K, Ueno Y, Kanegane H, Yamagiwa Y, Inoue J, Kido O, et al. A case of severe recurrent hepatitis with common variable immunodeficiency. Hepatol Res. 2008;38:415\u201320.","journal-title":"Hepatol Res"},{"issue":"4","key":"9158_CR8","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1159\/000226232","volume":"150","author":"S Deane","year":"2009","unstructured":"Deane S, Selmi C, Naguwa SM, Teuber SS, Gershwin ME. Common variable immunodeficiency. Etiological and treatment issues. Int Arch Allergy Immunol. 2009;150(4):311\u201324.","journal-title":"Int Arch Allergy Immunol"},{"key":"9158_CR9","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0140-6736(08)61199-X","volume":"372","author":"MA Park","year":"2008","unstructured":"Park MA, Li JT, Hagan JB, Maddox DE, Abraham RS. Common variable immunodeficiency: a new look at an old disease. Lancet. 2008;372:489\u2013502.","journal-title":"Lancet"},{"key":"9158_CR10","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0140-6736(85)91037-2","volume":"1","author":"LJ Kinlen","year":"1985","unstructured":"Kinlen LJ, Webster AD, Bird AG, Haile R, Peto J, Soothill JF, et al. Prospective study of cancer in patients with hypogammaglobulinaemia. Lancet. 1985;1:263\u20136.","journal-title":"Lancet"},{"key":"9158_CR11","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1046\/j.1365-2249.2002.02004.x","volume":"130","author":"L Mellemkjaer","year":"2002","unstructured":"Mellemkjaer L, Hammarstrom L, Andersen V, et al. Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined Danish and Swedish study. Clin Exp Immunol. 2002;130:495\u2013500.","journal-title":"Clin Exp Immunol"},{"key":"9158_CR12","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/ajh.10050","volume":"69","author":"C Cunningham-Rundles","year":"2002","unstructured":"Cunningham-Rundles C, Cooper DL, Duffy TP, Strauchen J. Lymphomas of mucosal-associated lymphoid tissue in common variable immunodeficiency. Am J Hematol. 2002;69:171\u20138.","journal-title":"Am J Hematol"},{"key":"9158_CR13","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/BF00915550","volume":"7","author":"C Cunningham-Rundles","year":"1987","unstructured":"Cunningham-Rundles C, Siegal FP, Cunningham-Rundles S, Lieberman P. Incidence of cancer in 98 patients with common varied immunodeficiency. J Clin Immunol. 1987;7:294\u20139.","journal-title":"J Clin Immunol"},{"key":"9158_CR14","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1046\/j.1365-2249.2002.02004.x","volume":"130","author":"L Mellemkjaer","year":"2002","unstructured":"Mellemkjaer L, Hammarstrom L, Andersen V, Yuen J, Heilmann C, Barington T, et al. Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined Danish and Swedish study. Clin Exp Immunol. 2002;130:495\u2013500.","journal-title":"Clin Exp Immunol"},{"key":"9158_CR15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1046\/j.1365-2796.1996.514837000.x","volume":"240","author":"T Zenone","year":"1996","unstructured":"Zenone T, Souquet PJ, Cunningham-Rundles C, Bernard JP. Hodgkin\u2019s disease associated with IgA and IgG subclass deficiency. J Intern Med. 1996;240:99\u2013102.","journal-title":"J Intern Med"},{"issue":"7","key":"9158_CR16","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1007\/BF01957899","volume":"155","author":"R Sumazaki","year":"1996","unstructured":"Sumazaki R, Matsubara T, Aoki T, Nagai Y, Shibasaki M, Takita H. Rapidly progressive hepatitis C in a patient with common variable immunodeficiency. Eur J Pediatr. 1996;155(7):532\u20134.","journal-title":"Eur J Pediatr"},{"issue":"5 suppl 1","key":"9158_CR17","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/S1081-1206(10)61142-8","volume":"94","author":"FA Bonilla","year":"2005","unstructured":"Bonilla FA, Bernstein IL, Khan DA, et al. Practice parameter for the diagnosis and management of primary immunodeficiency. Ann Allergy Asthma Immunol. 2005;94(5 suppl 1):S1\u201363.","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-010-9158-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-010-9158-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-010-9158-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-010-9158-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T23:37:11Z","timestamp":1744155431000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-010-9158-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,15]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["9158"],"URL":"https:\/\/doi.org\/10.1007\/s12029-010-9158-8","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,15]]},"assertion":[{"value":"15 May 2010","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}