{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:00:20Z","timestamp":1782421220666,"version":"3.54.5"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T00:00:00Z","timestamp":1449187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T00:00:00Z","timestamp":1449187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1007\/s12029-015-9787-z","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T08:18:42Z","timestamp":1449217122000},"page":"47-54","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of Serum Interleukin-17 (IL-17) Levels as a Diagnostic Marker in Pancreatic Adenocarcinoma"],"prefix":"10.1007","volume":"47","author":[{"given":"Senem","family":"Karabulut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7i\u011fdem Usul","family":"Afsar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Karabulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"Al\u0131\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"K\u0131l\u0131c","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"\u00c7ikot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceren Tilgen","family":"Yasasever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuri Faruk","family":"Aykan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,4]]},"reference":[{"key":"9787_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3322\/caac.21254","volume":"65","author":"RL Siegel","year":"2015","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65:5.","journal-title":"CA Cancer J Clin"},{"key":"9787_CR2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69.","journal-title":"CA Cancer J Clin"},{"key":"9787_CR3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1097\/CEJ.0b013e32809b4ccd","volume":"17","author":"J Zhang","year":"2008","unstructured":"Zhang J, Dhakal I, Ning B, Kesteloot H. Patterns and trends of pancreatic cancer mortality rates in Arkansas, 1969\u20132002: a comparison with the US population. Eur J Cancer Prev. 2008;17:18.","journal-title":"Eur J Cancer Prev"},{"key":"9787_CR4","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/1074-7613(95)90070-5","volume":"3","author":"Z Yao","year":"1995","unstructured":"Yao Z, Franslow WC, Seldin MF, Rousseau A-M, Painter SL, Comeau MR, et al. Herpes virus saimiri encodes a new cytokine IL-17 which binds to novel cytokine receptor. Immunity. 1995;3:811\u201321.","journal-title":"Immunity"},{"key":"9787_CR5","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1006\/cyto.1998.0433","volume":"11","author":"HC Shin","year":"1999","unstructured":"Shin HC, Benbernou N, Esnault S, Guenounou M. Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway. Cytokine. 1999;11:257\u201366.","journal-title":"Cytokine"},{"key":"9787_CR6","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/S0016-5085(00)70351-9","volume":"118","author":"T Kinugasa","year":"2000","unstructured":"Kinugasa T, Sakaguchi T, Gu X, Reinecker HC. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology. 2000;118:1001\u201311.","journal-title":"Gastroenterology"},{"key":"9787_CR7","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.bbrc.2005.09.075","volume":"337","author":"S Schwartz","year":"2005","unstructured":"Schwartz S, Beaulieu JF, Ruemmele FM. Interleukin-17 is a potent immuno-modulator and regulator of normal human intestinal epithelial cell growth. Biochem Biophys Res Commun. 2005;337:505\u20139.","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"9787_CR8","doi-asserted-by":"publisher","first-page":"4063","DOI":"10.4049\/jimmunol.0902609","volume":"185","author":"JL Gnerlich","year":"2010","unstructured":"Gnerlich JL, Mitchem JB, Weir JS, Sankpal NV, Kashiwagi H, Belt BA, et al. Induction of Th17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancer. J Immunol. 2010;185(7):4063\u201371.","journal-title":"J Immunol"},{"issue":"1\u20133","key":"9787_CR9","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0167-4889(02)00250-1","volume":"1591","author":"A Andoh","year":"2002","unstructured":"Andoh A, Shimada M, Bamba S, Okuno T, Araki Y, Fujiyama Y, et al. Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts. Biochim Biophys Acta. 2002;1591(1\u20133):69\u201374.","journal-title":"Biochim Biophys Acta"},{"issue":"164","key":"9787_CR10","doi-asserted-by":"publisher","first-page":"164fs144","DOI":"10.1126\/scitranslmed.3005283","volume":"4","author":"PD Bos","year":"2012","unstructured":"Bos PD, Rudensky AY. Treg cells in cancer: a case of multiple personality disorder. Sci Transl Med. 2012;4(164):164fs144.","journal-title":"Sci Transl Med"},{"key":"9787_CR11","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1006\/bbrc.2001.4618","volume":"282","author":"T Kato","year":"2001","unstructured":"Kato T, Furumoto H, Ogura T, Onishi Y, Irahara M, Yamano S, et al. Expression of IL-17 mRNA in ovarian cancer. Biochem Biophys Res Commun. 2001;282:735\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"9787_CR12","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1007\/s12032-012-0273-1","volume":"29","author":"XY Meng","year":"2012","unstructured":"Meng XY, Zhou CH, Ma J, Jiang C, Ji P. Expression of interleukin-17 and its clinical significance in gastric cancer patients. Med Oncol. 2012;29(5):3024\u20138.","journal-title":"Med Oncol"},{"issue":"6","key":"9787_CR13","doi-asserted-by":"publisher","first-page":"5347","DOI":"10.1007\/s13277-014-1697-3","volume":"35","author":"X Wu","year":"2014","unstructured":"Wu X, Zeng Z, Xu L, Yu J, Cao Q, Chen M, et al. Increased expression of IL17A in human gastric cancer and its potential roles in gastric carcinogenesis. Tumor Biol. 2014;35(6):5347\u201356.","journal-title":"Tumor Biol"},{"issue":"4","key":"9787_CR14","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3109\/1354750X.2014.908954","volume":"19","author":"C Xu","year":"2014","unstructured":"Xu C, Hao K, Yu L, Zhang X. Serum interleukin-17 as a diagnostic and prognostic marker for non-small cell lung cancer. Biomarkers. 2014;19(4):287\u201390.","journal-title":"Biomarkers"},{"key":"9787_CR15","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/2047-783X-19-23","volume":"19","author":"C Xu","year":"2014","unstructured":"Xu C, Yu L, Zhan P, Zhang Y. Elevated pleural effusion IL-17 is a diagnostic marker and outcome predictor in lung cancer patients. Eur J Med Res. 2014;19:23.","journal-title":"Eur J Med Res"},{"issue":"3","key":"9787_CR16","doi-asserted-by":"publisher","first-page":"156","DOI":"10.4110\/in.2014.14.3.156","volume":"14","author":"R Baharlou","year":"2014","unstructured":"Baharlou R, Ahmadi Vasmehjani A, Dehghani A, Ghobadifar MA, Khoubyari M. Reduced interleukin17 and transforming growth factor beta levels in peripheral blood as indicators for following the course of bladder cancer. Immune Netw. 2014;14(3):156\u201363.","journal-title":"Immune Netw"},{"issue":"11","key":"9787_CR17","doi-asserted-by":"publisher","first-page":"7424","DOI":"10.3390\/ijms12117424","volume":"12","author":"S He","year":"2011","unstructured":"He S, Fei M, Wu Y, Zheng D, Wan D, Wang L, et al. Distribution and clinical significance of Th17 cells in the tumor microenvironment and peripheral blood of pancreatic cancer patients. Int J Mol Sci. 2011;12(11):7424\u201337.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"9787_CR18","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1097\/MPA.0000000000000335","volume":"44","author":"T Miura","year":"2015","unstructured":"Miura T, Mitsunaga S, Ikeda M, Shimizu S, Ohno I, Takahashi H, et al. Characterization of patients with advanced pancreatic cancer and high serum interleukin-6 levels. Pancreas. 2015;44(5):756\u201363.","journal-title":"Pancreas"},{"key":"9787_CR19","doi-asserted-by":"publisher","unstructured":"Poutou J, Bunuales M, Gonzalez-Aparicio M, Garcia-Aragoncillo E, Quetglas JI, Casado R, et al. Safety and antitumor effect of oncolytic and helper-dependent adenoviruses expressing interleukin-12 variants in a hamster pancreatic cancer model. Gene Ther 2015. doi: 10.1038\/gt.2015.45.","DOI":"10.1038\/gt.2015.45"},{"issue":"6","key":"9787_CR20","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1111\/cas.12663","volume":"106","author":"T Komura","year":"2015","unstructured":"Komura T, Sakai Y, Harada K, Kawaguchi K, Takabatake H, Kitagawa H, et al. Inflammatory features of pancreatic cancer highlighted by monocytes\/macrophages and CD4+ T cells with clinical impact. Cancer Sci. 2015;106(6):672\u201386.","journal-title":"Cancer Sci"},{"issue":"3","key":"9787_CR21","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1084\/jem.2123insight1","volume":"212","author":"SD Leach","year":"2015","unstructured":"Leach SD. Interleukin interrupted: a new strategy for the treatment of pancreatic cancer. J Exp Med. 2015;212(3):284.","journal-title":"J Exp Med"},{"issue":"3","key":"9787_CR22","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1084\/jem.20141702","volume":"212","author":"HH Wu","year":"2015","unstructured":"Wu HH, Hwang-Verslues WW, Lee WH, Huang CK, Wei PC, Chen CL, et al. Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. J Exp Med. 2015;212(3):333\u201349.","journal-title":"J Exp Med"},{"issue":"6","key":"9787_CR23","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.ccr.2014.04.021","volume":"25","author":"AD Rhim","year":"2014","unstructured":"Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell. 2014;25(6):735\u201347.","journal-title":"Cancer Cell"},{"issue":"1","key":"9787_CR24","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1016\/S0960-9822(00)00038-5","volume":"11","author":"LJ McCawley","year":"2001","unstructured":"McCawley LJ, Matrisian LM. Tumor progression: defining the soil round the tumor seed. Curr Biol. 2001;11(1):R25\u20137.","journal-title":"Curr Biol"},{"issue":"4","key":"9787_CR25","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0960-7404(02)00015-4","volume":"10","author":"B Farrow","year":"2002","unstructured":"Farrow B, Evers BM. Inflammation and the development of pancreatic cancer. Surg Oncol. 2002;10(4):153\u201369.","journal-title":"Surg Oncol"},{"issue":"1","key":"9787_CR26","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.semcancer.2005.07.006","volume":"16","author":"A Ben-Baruch","year":"2006","unstructured":"Ben-Baruch A. Inflammation-associated immune suppression in cancer: the roles played by cytokines, chemokines and additional mediators. Semin Cancer Biol. 2006;16(1):38\u201352.","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"9787_CR27","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s12094-014-1197-3","volume":"17","author":"Y Lin","year":"2015","unstructured":"Lin Y, Xu J, Su H, Zhong W, Yuan Y, Yu Z, et al. Interleukin-17 is a favorable prognostic marker for colorectal cancer. Clin Transl Oncol. 2015;17(1):50\u20136.","journal-title":"Clin Transl Oncol"},{"issue":"5","key":"9787_CR28","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.ccr.2014.03.014","volume":"25","author":"F McAllister","year":"2014","unstructured":"McAllister F, Bailey JM, Alsina J, Nirschl CJ, Sharma R, Fan H, et al. Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia. Cancer Cell. 2014;25(5):621\u201337.","journal-title":"Cancer Cell"},{"issue":"4","key":"9787_CR29","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/dth.12251","volume":"28","author":"AA Gaspari","year":"2015","unstructured":"Gaspari AA, Tyring S. New and emerging biologic therapies for moderate-to-severe plaque psoriasis: mechanistic rationales and recent clinical data for IL-17 and IL-23 inhibitors. Dermatol Ther. 2015;28(4):179\u201393.","journal-title":"Dermatol Ther"},{"key":"9787_CR30","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/s13075-015-0710-6","volume":"17","author":"A Varas","year":"2015","unstructured":"Varas A, Valencia J, Lavocat F, Mart\u00ednez VG, Thiam NN, Hidalgo L, et al. Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-\u03b1 combination in rheumatoid synoviocytes. Arthritis Res Ther. 2015;17:192.","journal-title":"Arthritis Res Ther"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-015-9787-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-015-9787-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-015-9787-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-015-9787-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T11:13:03Z","timestamp":1628593983000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-015-9787-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,4]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["9787"],"URL":"https:\/\/doi.org\/10.1007\/s12029-015-9787-z","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,4]]},"assertion":[{"value":"4 December 2015","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}