{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:34:54Z","timestamp":1778319294579,"version":"3.51.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s12029-017-0036-5","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T22:11:55Z","timestamp":1513116715000},"page":"9-15","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Staging, Treatment, and Future Approaches of Gallbladder Carcinoma"],"prefix":"10.1007","volume":"49","author":[{"given":"Sanjeev Kumar","family":"Shukla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Govind","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. S.","family":"Shahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Bhuvan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhat","family":"Pant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"issue":"3","key":"36_CR1","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/j.1572-0241.2000.01860.x","volume":"95","author":"U Dutta","year":"2000","unstructured":"Dutta U, Garg PK, Kumar R, Tandon RK. Typhoid carriers among patients with gallstones are at increased risk for carcinoma of the gallbladder. Am J Gastroenterol. 2000;95(3):784\u20137. https:\/\/doi.org\/10.1111\/j.1572-0241.2000.01860.x.","journal-title":"Am J Gastroenterol"},{"key":"36_CR2","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ejca.2016.10.012","volume":"70","author":"SC Larsson","year":"2017","unstructured":"Larsson SC, Kansson NH, Wolk A. Healthy dietary patterns and incidence of biliary tract and gallbladder cancer in a prospective study of women and men. Eur J Cancer. 2017;70:42\u20137. https:\/\/doi.org\/10.1016\/j.ejca.2016.10.012.","journal-title":"Eur J Cancer"},{"issue":"6","key":"36_CR3","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1111\/hpb.12406","volume":"17","author":"AK Agarwal","year":"2015","unstructured":"Agarwal AK, Javed A, Kalayarasan R, Sakhuja P. Minimally invasive versus the conventional open surgical approach of a radical cholecystectomy for gallbladder cancer: a retrospective comparative study. HPB (Oxford). 2015;17(6):536\u201341. https:\/\/doi.org\/10.1111\/hpb.12406.","journal-title":"HPB (Oxford)"},{"key":"36_CR4","unstructured":"Destoll M. Rationis mendendi. In: Haak et Socios A et J Honkoop, editor. Nosocomio practico vendobonensi, Part I. Lugduni Batavorum; 1788"},{"key":"36_CR5","first-page":"599","volume-title":"Cancer\u2014diagnosis, treatment and prognosis","author":"JA DeRegato","year":"1977","unstructured":"DeRegato JA, Spjut HJ. Digestive tract\/accessory organo gallbladder. In: Ackerman LV, JA DR, editors. Cancer\u2014diagnosis, treatment and prognosis. 5th ed. St Louis: CV Mosby; 1977. p. 599\u2013604.","edition":"5"},{"issue":"3","key":"36_CR6","first-page":"282","volume":"116","author":"E Medina","year":"1988","unstructured":"Medina E. Las enfermedades digestivas en Chile, panorama epidemiologico. Revista Medica De Chile. 1988;116(3):282\u20138.","journal-title":"Revista Medica De Chile"},{"key":"36_CR7","volume-title":"Cancer medicine","author":"CG Moertel","year":"1982","unstructured":"Moertel CG. The gallbladder. In: Holland JF, Frei III E, editors. Cancer medicine. 2nd ed. Philadelphia: Lea Ferbiger; 1982. 1782\u20131785.","edition":"2"},{"issue":"1","key":"36_CR8","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.cdtm.2017.01.003","volume":"3","author":"HX Shen","year":"2017","unstructured":"Shen HX, Song HW, Xu XJ, Jiao ZY, Ti ZY, Li ZY, et al. Clinical epidemiological survey of gallbladder carcinoma in northwestern China. 2009-2013: 2379 cases in 17 centers. Chronic Dis Trans Med. 2017;3(1):60\u20136. https:\/\/doi.org\/10.1016\/j.cdtm.2017.01.003.","journal-title":"Chronic Dis Trans Med"},{"key":"36_CR9","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.canep.2016.07.021","volume":"44","author":"MI Izarzugaza","year":"2016","unstructured":"Izarzugaza MI, Fernandez L, Forman D, Sierra MS. Burden of gallbladder cancer in Central and South America. Cancer Epidemiol. 2016;44:82\u20139.","journal-title":"Cancer Epidemiol"},{"issue":"43","key":"36_CR10","doi-asserted-by":"publisher","first-page":"12211","DOI":"10.3748\/wjg.v21.i43.12211","volume":"21","author":"Goetze TO","year":"2015","unstructured":"Goetze TO. Gallbladder carcinoma: prognostic factors and therapeutic options. World J Gastroenterol. 2015;21(43):12211\u20137. https:\/\/doi.org\/10.3748\/wjg.v21.i43.12211.","journal-title":"World J Gastroenterol"},{"key":"36_CR11","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/annonc\/mdn533","volume":"20","author":"G Randi","year":"2009","unstructured":"Randi G, Malvezzi M, Levi F, Ferlay J, Negri E, Franceschi S, et al. Epidemiology of biliary tract cancers: an update. Ann Oncol. 2009;20:146\u20135.","journal-title":"Ann Oncol"},{"issue":"2","key":"36_CR12","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1001\/archsurg.1990.01410140115019","volume":"125","author":"JH Donohue","year":"1990","unstructured":"Donohue JH, Nagorney DM, Grant CS, Tsushima K, Ilstrup DM, Adson MA. Carcinoma of the gallbladder: does radical resection improve outcome. Arch Surg. 1990;125(2):237\u201341. https:\/\/doi.org\/10.1001\/archsurg.1990.01410140115019.","journal-title":"Arch Surg"},{"issue":"8","key":"36_CR13","doi-asserted-by":"publisher","first-page":"649","DOI":"10.14740\/jocmr2192w","volume":"7","author":"S Gourgiotis","year":"2015","unstructured":"Gourgiotis S, Oikonomou C, Kollia P, Falidas E, Villias C. Persistent coughing as the first symptom of primary mucinous appendiceal adenocarcinoma. J Clin Med Res. 2015;7(8):649\u201352. https:\/\/doi.org\/10.14740\/jocmr2192w.","journal-title":"J Clin Med Res"},{"key":"36_CR14","first-page":"84","volume-title":"TNM classification of malignant tumours","author":"LH Sobin","year":"2002","unstructured":"Sobin LH, Wittekind C. Digestive system: gallbladder. In: TNM classification of malignant tumours. 6th ed. New York: Wiley-Liss; 2002. p. 84\u20136.","edition":"6"},{"issue":"2","key":"36_CR15","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.suc.2015.12.007","volume":"96","author":"M Qadan","year":"2016","unstructured":"Qadan M, Kingham TP. Technical aspects of gallbladder cancer surgery. Surg Clin North Am. 2016;96(2):229\u201345. https:\/\/doi.org\/10.1016\/j.suc.2015.12.007.","journal-title":"Surg Clin North Am"},{"issue":"1","key":"36_CR16","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/1097-0142(197601)37:1<141::AID-CNCR2820370121>3.0.CO;2-Y","volume":"37","author":"JE Nevin","year":"1976","unstructured":"Nevin JE, Moran TJ, Kay S, King R. Carcinoma of the gallbladder: staging, treatment and prognosis. Cancer. 1976;37(1):141\u20138. https:\/\/doi.org\/10.1002\/1097-0142(197601)37:1<141::AID-CNCR2820370121>3.0.CO;2-Y.","journal-title":"Cancer"},{"issue":"2","key":"36_CR17","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1002\/1097-0142(19920715)70:2<410::AID-CNCR2820700207>3.0.CO;2-R","volume":"70","author":"J Albores-Saavedra","year":"1992","unstructured":"Albores-Saavedra J, Henson DE, Sobin LH. The WHO histological classification of tumours of the gallbladder and extra hepatic bile duct a commentary on the second edition. Cancer. 1992;70(2):410\u20134. https:\/\/doi.org\/10.1002\/1097-0142(19920715)70:2<410::AID-CNCR2820700207>3.0.CO;2-R.","journal-title":"Cancer"},{"issue":"3","key":"36_CR18","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/S0016-5085(99)70456-7","volume":"117","author":"JE Everhart","year":"1999","unstructured":"Everhart JE, Khare M, Hill M, Maurer KR. Prevalence and ethnic differences in gallbladder disease in the United States. Gastroenterol. 1999;117(3):632\u20139. https:\/\/doi.org\/10.1016\/S0016-5085(99)70456-7.","journal-title":"Gastroenterol"},{"issue":"2","key":"36_CR19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.gtc.2010.02.010","volume":"39","author":"NG Venneman","year":"2010","unstructured":"Venneman NG, VanErpecum KJ. Pathogenesis of gallstones. Gastroenterol Clin N Am. 2010;39(2):171\u201383. https:\/\/doi.org\/10.1016\/j.gtc.2010.02.010.","journal-title":"Gastroenterol Clin N Am"},{"issue":"S1","key":"36_CR20","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/1097-0142(19950101)75:1+<171::AID-CNCR2820751306>3.0.CO;2-2","volume":"75","author":"M Carriaga","year":"1995","unstructured":"Carriaga M, Henson DE. Liver, gallbladder, extra hepatic bile ducts and pancreas. Cancer. 1995;75(S1):171\u201390. https:\/\/doi.org\/10.1002\/1097-0142(19950101)75:1+<171::AID-CNCR2820751306>3.0.CO;2-2.","journal-title":"Cancer"},{"issue":"11","key":"36_CR21","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1111\/hpb.12046","volume":"15","author":"CH Pilgrim","year":"2013","unstructured":"Pilgrim CH, Groeschl RT, Christians KK, Gamblin TC. Modern perspectives on factors predisposing to the development of gallbladder cancer. HPB (Oxford). 2013;15(11):839\u201344. https:\/\/doi.org\/10.1111\/hpb.12046.","journal-title":"HPB (Oxford)"},{"issue":"78","key":"36_CR22","first-page":"1622","volume":"54","author":"V Sharma","year":"2007","unstructured":"Sharma V, Chauhan VS, Nath G, Kumar A, Shukla VK. Role of bacteria in gallbladder carcinoma. Hepato-Gastroenterology. 2007;54(78):1622\u20135.","journal-title":"Hepato-Gastroenterology"},{"issue":"2","key":"36_CR23","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.gene.2013.08.058","volume":"530","author":"R Rai","year":"2013","unstructured":"Rai R, Sharma KL, Misra S, Kumar A, Mittal B. PSCA gene variants (rs2294008 and rs2978974) confer increased susceptibility of gallbladder carcinoma in females. Gene. 2013;530(2):172\u20137. https:\/\/doi.org\/10.1016\/j.gene.2013.08.058.","journal-title":"Gene"},{"key":"36_CR24","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ijscr.2017.01.020","volume":"32","author":"R Maharaj","year":"2017","unstructured":"Maharaj R, Cave C, Sarran K, Bascombe N, Dan D, Greaves W, et al. A case report of the clear cell variant of gallbladder carcinoma. Int J Surg Case Rep. 2017;32:36\u20139. https:\/\/doi.org\/10.1016\/j.ijscr.2017.01.020.","journal-title":"Int J Surg Case Rep"},{"issue":"25","key":"36_CR25","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1056\/NEJM197012172832502","volume":"283","author":"RE Sampliner","year":"1970","unstructured":"Sampliner RE, Bennett PH, Comers LJ, Rose FA, Burch TA. Gallbladder disease in Pima Indians demonstration of high prevalence and early onset by cholecystography. N Engl J Med. 1970;283(25):1358\u201364. https:\/\/doi.org\/10.1056\/NEJM197012172832502.","journal-title":"N Engl J Med"},{"key":"36_CR26","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1097\/00000658-199104000-00006","volume":"231","author":"F Cetta","year":"1991","unstructured":"Cetta F. The role of bacteria in pigment gallstones disease. Ann Surg. 1991;231:315\u201326.","journal-title":"Ann Surg"},{"issue":"6","key":"36_CR27","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1002\/cncr.25524","volume":"117","author":"AM Landgren","year":"2011","unstructured":"Landgren AM, Landgren O, Gridley G, Dores GM, Linet MS, Morton LM. Autoimmune disease and subsequent risk of developing alimentary tract cancers among 45 million US male veterans. Cancer. 2011;117(6):1163\u201371. https:\/\/doi.org\/10.1002\/cncr.25524.","journal-title":"Cancer"},{"issue":"4","key":"36_CR28","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1200\/JCO.2010.30.1515","volume":"29","author":"J Koshiol","year":"2011","unstructured":"Koshiol J, Lam TK, Gridley G, Check D, Brown LM, Landgren O. Racial differences in chronic immune stimulatory conditions and risk of non-Hodgkin\u2019s lymphoma in veterans from the United States. J Clin Oncol. 2011;29(4):378\u201385. https:\/\/doi.org\/10.1200\/JCO.2010.30.1515.","journal-title":"J Clin Oncol"},{"issue":"6","key":"36_CR29","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.cgh.2013.11.007","volume":"12","author":"FA Castro","year":"2014","unstructured":"Castro FA, Liu X, Forsti A, Ji J, Sundquist J, Sundquist K, et al. Increased risk of hepatobiliary cancers after hospitalization for autoimmune disease. Clin Gastroenterol Hepatol. 2014;12(6):1038\u201345. https:\/\/doi.org\/10.1016\/j.cgh.2013.11.007.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"36_CR30","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/jso.2930560415","volume":"56","author":"VK Shukla","year":"1994","unstructured":"Shukla VK, Shukla PK, Pandey M, Rao BR, Salil KR. Lipid peroxidation product in bile from patients with carcinoma of the gallbladder: a preliminary study. J Surg Oncol. 1994;56(4):258\u201362. https:\/\/doi.org\/10.1002\/jso.2930560415.","journal-title":"J Surg Oncol"},{"issue":"3","key":"36_CR31","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1097\/00008469-200006000-00003","volume":"9","author":"M Pandey","year":"2000","unstructured":"Pandey M, Shukla VK. Fatty acids, biliary bile acids, lipid peroxidation products and gallbladder carcinogenesis. Eur J Cancer Prev. 2000;9(3):165\u201371. https:\/\/doi.org\/10.1097\/00008469-200006000-00003.","journal-title":"Eur J Cancer Prev"},{"issue":"2","key":"36_CR32","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/01.jom.0000111601.85534.12","volume":"46","author":"I Kuzmickiene","year":"2004","unstructured":"Kuzmickiene I, Didziapetris R, Stukonis M. Cancer incidence in the workers cohort of textile manufacturing factory in Alytus, Lithuania. J Occup Environ Med. 2004;46(2):147\u201353. https:\/\/doi.org\/10.1097\/01.jom.0000111601.85534.12.","journal-title":"J Occup Environ Med"},{"issue":"6","key":"36_CR33","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3322\/canjclin.51.6.349","volume":"51","author":"EC Lazcano-Ponce","year":"2001","unstructured":"Lazcano-Ponce EC, Miquel JF, Munoz N, Herrero R, Ferrecio C, Wistuba II, et al. Epidemiology and molecular pathology of gallbladder cancer. CA Cancer J Clin. 2001;51(6):349\u201364. https:\/\/doi.org\/10.3322\/canjclin.51.6.349.","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"36_CR34","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/BF01658722","volume":"15","author":"K Sumiyoshi","year":"1991","unstructured":"Sumiyoshi K, Nagai E, Chijiiwa K, Nakayama F. Pathology of carcinoma of the gallbladder. World J Surg. 1991;15(3):315\u201321. https:\/\/doi.org\/10.1007\/BF01658722.","journal-title":"World J Surg"},{"issue":"1","key":"36_CR35","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0304-3835(01)00562-6","volume":"169","author":"YT Kim","year":"2001","unstructured":"Kim YT, Kim J, Jang YH, Lee WJ, Ryu JK, Park YK, et al. Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. Cancer Lett. 2001;169(1):59\u201368. https:\/\/doi.org\/10.1016\/S0304-3835(01)00562-6.","journal-title":"Cancer Lett"},{"issue":"12","key":"36_CR36","first-page":"2511","volume":"55","author":"II Wistuba","year":"1995","unstructured":"Wistuba II, Sugio K, Hung J, Kishimoto Y, Virmani AK, Roa I, et al. Allele-specific mutations involved in the pathogenesis of endemic gallbladder carcinoma in Chile. Cancer Res. 1995;55(12):2511\u20135.","journal-title":"Cancer Res"},{"issue":"12","key":"36_CR37","doi-asserted-by":"publisher","first-page":"3502","DOI":"10.1111\/j.1572-0241.1999.01614.x","volume":"94","author":"DK Lee","year":"1999","unstructured":"Lee DK, Tarr PI, Haigh WG, Lee SP, Bacterial DNA. In mixed cholesterol gallstones. Am J Gastroenterol. 1999;94(12):3502\u20136. https:\/\/doi.org\/10.1111\/j.1572-0241.1999.01614.x.","journal-title":"Am J Gastroenterol"},{"issue":"27","key":"36_CR38","doi-asserted-by":"publisher","first-page":"23905","DOI":"10.18632\/oncotarget.4163","volume":"6","author":"E Vassella","year":"2015","unstructured":"Vassella E, Langsch S, Dettmer MS, Schlup C, Neuenschwander M, Frattini M, et al. Molecular profiling of lung adenosquamous carcinoma: hybrid orgenuine type. Oncotarget. 2015;6(27):23905\u201316. https:\/\/doi.org\/10.18632\/oncotarget.4163.","journal-title":"Oncotarget"},{"issue":"3","key":"36_CR39","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1097\/01.coc.0000156920.11091.12","volume":"28","author":"LL Lin","year":"2005","unstructured":"Lin LL, Picus J, Drebin JA, Linehan DC, Solis J, Strasberg SM, et al. A phase II study of alternating cycles of split course radiation therapy and gemcitabine chemotherapy for inoperable pancreatic or biliary tract carcinoma. Am J Clin Oncol. 2005;28(3):234\u201341. https:\/\/doi.org\/10.1097\/01.coc.0000156920.11091.12.","journal-title":"Am J Clin Oncol"},{"issue":"6","key":"36_CR40","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/S1091-255X(03)00113-6","volume":"7","author":"JB Ammori","year":"2003","unstructured":"Ammori JB, Colletti LM, Zalupski MM, Eckhauser FE, Greenson JK, Dimick J, et al. Surgical resection following radiation therapy with concurrent gemcitabine in patients with previously unresectable adenocarcinoma of the pancreas. J Gastrointest Surg. 2003;7(6):766\u201372. https:\/\/doi.org\/10.1016\/S1091-255X(03)00113-6.","journal-title":"J Gastrointest Surg"},{"issue":"3","key":"36_CR41","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/s00268-002-6702-0","volume":"27","author":"Y Kaneoka","year":"2003","unstructured":"Kaneoka Y, Yamaguchi A, Isogai M, Harada T, Suzuki M. Hepatoduodenal ligament invasion by gallbladder carcinoma: histologic patterns and surgical recommendation. World J Surg. 2003;27(3):260\u20135. https:\/\/doi.org\/10.1007\/s00268-002-6702-0.","journal-title":"World J Surg"},{"issue":"10","key":"36_CR42","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1158\/0008-5472.CAN-11-2612","volume":"72","author":"IA Prior","year":"2012","unstructured":"Prior IA, Lewis PD, Mattos CA. Comprehensive survey of Ras mutations in cancer. Cancer Res. 2012;72(10):2457\u201367. https:\/\/doi.org\/10.1158\/0008-5472.CAN-11-2612.","journal-title":"Cancer Res"},{"issue":"2","key":"36_CR43","first-page":"41","volume":"5","author":"P Gupta","year":"2012","unstructured":"Gupta P, Agarwal A, Gupta V, Singh PK, Pantola C, Amit S. Expression and clinicopathological significance of estrogen and progesterone receptors in gallbladder cancer. Gastrointest Cancer Res. 2012;5(2):41\u20137.","journal-title":"Gastrointest Cancer Res"},{"issue":"2","key":"36_CR44","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S1535-6108(02)00102-2","volume":"2","author":"CT Sherr","year":"2002","unstructured":"Sherr CT, McCormick F. The RB and p53 pathways in cancer. Cancer Cell. 2002;2(2):103\u201312. https:\/\/doi.org\/10.1016\/S1535-6108(02)00102-2.","journal-title":"Cancer Cell"},{"key":"36_CR45","doi-asserted-by":"publisher","first-page":"117","DOI":"10.2147\/OTT.S74820","volume":"8","author":"D Doval","year":"2015","unstructured":"Doval D, Prabhash K, Patil S, Chaturvedi H, Goswami C, Vaid A, et al. Clinical and epidemiological study of EGFR mutations and EML4-ALK fusion genes among Indian patients with adenocarcinoma of the lung. Onco Targets Ther. 2015;8:117\u201323. https:\/\/doi.org\/10.2147\/OTT.S74820.","journal-title":"Onco Targets Ther"},{"issue":"1","key":"36_CR46","doi-asserted-by":"publisher","first-page":"59","DOI":"10.14670\/HH-20.59","volume":"20","author":"YH Xuan","year":"2005","unstructured":"Xuan YH, Choi YL, Shin YK, Kook MC, Chae SW, Park SM, et al. An immunohistochemical study of the expression of cell-cycle-regulated proteins p53, cyclin D1, RB, p27, Ki67 and MSH2 in gallbladder carcinoma and its precursor lesions. Histol Histopathol. 2005;20(1):59\u201366. https:\/\/doi.org\/10.14670\/HH-20.59.","journal-title":"Histol Histopathol"},{"issue":"1","key":"36_CR47","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.suronc.2010.09.003","volume":"21","author":"SK Maurya","year":"2012","unstructured":"Maurya SK, Tewari M, Mishra RR, Shukla HS. Genetic aberrations in gallbladder cancer. Surg Oncol. 2012;21(1):37\u201343. https:\/\/doi.org\/10.1016\/j.suronc.2010.09.003.","journal-title":"Surg Oncol"},{"issue":"4","key":"36_CR48","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00428-015-1720-0","volume":"466","author":"AP Moy","year":"2015","unstructured":"Moy AP, Shahid M, Ferrone CR, Borger DR, Zhu AX, Ting D, et al. Microsatellite instability in gallbladder carcinoma. Virchows Arch. 2015;466(4):393\u2013402. https:\/\/doi.org\/10.1007\/s00428-015-1720-0.","journal-title":"Virchows Arch"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-017-0036-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-017-0036-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-017-0036-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T12:42:40Z","timestamp":1628599360000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-017-0036-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,12]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["36"],"URL":"https:\/\/doi.org\/10.1007\/s12029-017-0036-5","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,12]]},"assertion":[{"value":"12 December 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"None of the authors of this paper have a financial or personal relationship with other people or organization that could inappropriately influence or bias the content of the paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}