{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:10:42Z","timestamp":1792426242983,"version":"4.5.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s12029-017-0040-9","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T02:02:36Z","timestamp":1513216956000},"page":"93-96","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Clinical and Genetic Implications of DNA Mismatch Repair Deficiency in Biliary Tract Cancers Associated with Lynch Syndrome"],"prefix":"10.1007","volume":"49","author":[{"given":"Jordan M","family":"Cloyd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Shin","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naruhiko","family":"Ikoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Nicolas","family":"Vauthey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tlhomas A.","family":"Aloia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Cuddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Rodriguez-Bigas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Nancy You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"issue":"18","key":"40_CR1","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/jnci\/djs351","volume":"104","author":"AK Win","year":"2012","unstructured":"Win AK, Lindor NM, Young JP, Macrae FA, Young GP, Williamson E, et al. Risks of primary extracolonic cancers following colorectal cancer in Lynch syndrome. J Natl Cancer Inst. 2012;104(18):1363\u201372. https:\/\/doi.org\/10.1093\/jnci\/djs351.","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"40_CR2","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nrclinonc.2009.237","volume":"7","author":"E Vilar","year":"2010","unstructured":"Vilar E, Gruber SB. Microsatellite instability in colorectal cancer-the stable evidence. Nat Rev Clin Oncol. 2010;7(3):153\u201362. https:\/\/doi.org\/10.1038\/nrclinonc.2009.237.","journal-title":"Nat Rev Clin Oncol"},{"issue":"3","key":"40_CR3","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1056\/NEJMoa022289","volume":"349","author":"CM Ribic","year":"2003","unstructured":"Ribic CM, Sargent DJ, Moore MJ, Thibodeau SN, French AJ, Goldberg RM, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med. 2003;349(3):247\u201357. https:\/\/doi.org\/10.1056\/NEJMoa022289.","journal-title":"N Engl J Med"},{"issue":"26","key":"40_CR4","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1056\/NEJMoa1500596","volume":"372","author":"DT Le","year":"2015","unstructured":"Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 2015;372(26):2509\u201320. https:\/\/doi.org\/10.1056\/NEJMoa1500596.","journal-title":"N Engl J Med"},{"issue":"22","key":"40_CR5","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1001\/jama.2011.743","volume":"305","author":"V Bonadona","year":"2011","unstructured":"Bonadona V, Bona\u00efti B, Olschwang S, Grandjouan S, Huiart L, Longy M, et al. Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome. JAMA. 2011;305(22):2304\u201310. https:\/\/doi.org\/10.1001\/jama.2011.743.","journal-title":"JAMA"},{"issue":"36","key":"40_CR6","doi-asserted-by":"publisher","first-page":"38737","DOI":"10.18632\/oncotarget.5395","volume":"6","author":"E Maccaroni","year":"2015","unstructured":"Maccaroni E, Bracci R, Giampieri R, Bianchi F, Belvederesi L, Brugiati C, et al. Prognostic impact of mismatch repair genes germline defects in colorectal cancer patients: are all mutations equal? Oncotarget. 2015;6(36):38737\u201348. https:\/\/doi.org\/10.18632\/oncotarget.5395.","journal-title":"Oncotarget"},{"issue":"11","key":"40_CR7","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1007\/s11605-007-0282-0","volume":"11","author":"H Nathan","year":"2007","unstructured":"Nathan H, Pawlik TM, Wolfgang CL, Choti MA, Cameron JL, Schulick RD. Trends in survival after surgery for cholangiocarcinoma: a 30-year population-based SEER database analysis. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2007;11(11):1488\u20131496; discussion 1496-1497. https:\/\/doi.org\/10.1007\/s11605-007-0282-0.","journal-title":"J Gastrointest Surg Off J Soc Surg Aliment Tract"},{"key":"40_CR8","unstructured":"FDA approves first cancer treatment for any solid tumor with a specific genetic feature [Internet]. [cited 2017 Jun 19]. Available from: https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm560167.htm"},{"key":"40_CR9","doi-asserted-by":"crossref","unstructured":"Silva VWK, Askan G, Daniel TD, Lowery M, Klimstra DS, Abou-Alfa GK, et al. Biliary carcinomas: pathology and the role of DNA mismatch repair deficiency. Chin. Clin. Oncol. [Internet]. 2016 [cited 2017 Feb 21];5. Available from: http:\/\/cco.amegroups.com\/article\/view\/12260","DOI":"10.21037\/cco.2016.10.04"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-017-0040-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-017-0040-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-017-0040-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T12:42:25Z","timestamp":1628599345000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-017-0040-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["40"],"URL":"https:\/\/doi.org\/10.1007\/s12029-017-0040-9","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,14]]},"assertion":[{"value":"14 December 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This retrospective review was approved by the Institutional Review Board and individual patient consent was waived.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}