{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T21:13:39Z","timestamp":1770239619066,"version":"3.49.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T00:00:00Z","timestamp":1556323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T00:00:00Z","timestamp":1556323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s12029-019-00234-9","type":"journal-article","created":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T07:30:09Z","timestamp":1556350209000},"page":"234-241","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical Impact of Circulated miR-1291 in Plasma of Patients with Liver Cirrhosis (LC) and Hepatocellular Carcinoma (HCC): Implication on Glypican-3 Expression"],"prefix":"10.1007","volume":"51","author":[{"given":"Neven A.","family":"Hagag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasser B. M.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed A.","family":"Elsharawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roba M.","family":"Talaat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,27]]},"reference":[{"issue":"9930","key":"234_CR1","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","volume":"383","author":"EA Tsochatzis","year":"2014","unstructured":"Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis. Lancet. 2014;383(9930):1749\u201361.","journal-title":"Lancet."},{"issue":"8","key":"234_CR2","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1007\/s00268-010-0954-x","volume":"35","author":"TR Harring","year":"2011","unstructured":"Harring TR, Guiteau JJ, Nguyen NT, et al. Building a comprehensive genomic program for hepatocellular carcinoma. World J Surg. 2011;35(8):1746\u201350.","journal-title":"World J Surg"},{"issue":"4","key":"234_CR3","first-page":"43","volume":"2","author":"A Omar","year":"2013","unstructured":"Omar A, Abou-Alfa GK, Khairy A, Omar H. Risk factors for developing hepatocellular carcinoma in Egypt. Chin Clin Oncol. 2013;2(4):43.","journal-title":"Chin Clin Oncol"},{"issue":"5","key":"234_CR4","first-page":"2699","volume":"17","author":"A Khairy","year":"2016","unstructured":"Khairy A, Hamza I, Shaker O, Yosry A. Serum miRNA panel in Egyptian patients with chronic hepatitis C related hepatocellular carcinoma. APJCP. 2016;17(5):2699\u2013703.","journal-title":"APJCP"},{"key":"234_CR5","doi-asserted-by":"crossref","unstructured":"Lu M, Kong X, Wang H, et al. A novel microRNAs expression signature for hepatocellular carcinoma diagnosis and prognosis. Oncotarget. 2017:8775\u201384.","DOI":"10.18632\/oncotarget.14452"},{"key":"234_CR6","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1053\/j.seminoncol.2012.05.009","volume":"39","author":"R Masuzaki","year":"2012","unstructured":"Masuzaki R, Karp SJ, Omata M. New serum markers of hepatocellular carcinoma. Semin Oncol. 2012;39:434\u20139.","journal-title":"Semin Oncol"},{"key":"234_CR7","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.4254\/wjh.v7.i12.1632","volume":"7","author":"MH Attwa","year":"2015","unstructured":"Attwa MH, El-Etreby SA. Guide for diagnosis and treatment of hepatocellular carcinoma. World J Hepatol. 2015;7:1632\u201351.","journal-title":"World J Hepatol"},{"key":"234_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1159\/000367727","volume":"4","author":"M Kudo","year":"2015","unstructured":"Kudo M. Surveillance, diagnosis, treatment, and outcome of liver cancer in Japan. Liver Cancer. 2015;4:39\u201350.","journal-title":"Liver Cancer"},{"issue":"8","key":"234_CR9","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1159\/000362583","volume":"1","author":"K Schutte","year":"2014","unstructured":"Schutte K, Schulz C, Malfertheiner P. Hepatocellular carcinoma: current concepts in diagnosis, staging, and treatment. Gastrointest Tumors. 2014;1(8):84\u201392.","journal-title":"Gastrointest Tumors"},{"key":"234_CR10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1172\/JCI200113712","volume":"108","author":"J Filmus","year":"2001","unstructured":"Filmus J, Selleck SB. Glypicans: proteoglycans with a surprise. J Clin Invest. 2001;108:497\u2013501.","journal-title":"J Clin Invest"},{"issue":"2","key":"234_CR11","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/carcin\/bgu245","volume":"36","author":"X Liu","year":"2015","unstructured":"Liu X, Wang S, Zhang K, et al. Expression of glypican three enriched hepatocellular carcinoma development-related genes and associated with carcinogenesis in cirrhotic livers. Carcinogenesis. 2015;36(2):232\u201342.","journal-title":"Carcinogenesis"},{"key":"234_CR12","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0016-5085(03)00689-9","volume":"125","author":"M Capurro","year":"2003","unstructured":"Capurro M, Wanless IR, Sherman M, Deboer G, Shi W, Miyoshi E, et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology. 2003;125:89\u201397.","journal-title":"Gastroenterology"},{"key":"234_CR13","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/nature03677","volume":"435","author":"KA O\u2019Donnell","year":"2005","unstructured":"O\u2019Donnell KA, Wentzel EA, Zeller KI, et al. c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 2005;435:839\u201343.","journal-title":"Nature"},{"key":"234_CR14","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1002\/hep.26095","volume":"57","author":"S Giordano","year":"2013","unstructured":"Giordano S, Columbano A. MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma? Hepatology. 2013;57:840\u20137.","journal-title":"Hepatology."},{"key":"234_CR15","doi-asserted-by":"crossref","unstructured":"Zhang Y, Lib T, Qiu Y, et al. Serum microRNA panel for early diagnosis of the onset of hepatocellular carcinoma. Medicine. 2017:96\u2013102.","DOI":"10.1097\/MD.0000000000005642"},{"key":"234_CR16","doi-asserted-by":"publisher","first-page":"e363","DOI":"10.1371\/journal.pbio.0020363","volume":"2","author":"B John","year":"2004","unstructured":"John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human microRNA targets. PLoS Biol. 2004;2:e363.","journal-title":"PLoS Biol"},{"issue":"2","key":"234_CR17","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1021\/acschembio.5b00615","volume":"11","author":"JL Childs-Disney","year":"2016","unstructured":"Childs-Disney JL, Disney MD. Small molecule targeting of microRNA associated with hepatocellular carcinoma. ACS Chem Biol. 2016;11(2):375\u201380 2016; 11(2); 375\u201380.","journal-title":"ACS Chem Biol"},{"key":"234_CR18","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1111\/jnc.12437","volume":"127","author":"JR Dickson","year":"2013","unstructured":"Dickson JR, Kruse C, Montagna DR, Finsen B, Wolfe MS. Alternative polyadenylation and miR-34family members regulate tau expression. J Neurochem. 2013;127:739\u201349.","journal-title":"J Neurochem"},{"key":"234_CR19","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/HCO.0b013e328345983d","volume":"26","author":"M Han","year":"2011","unstructured":"Han M, Toli J, Abdellatif M. MicroRNAs in the cardiovascular system. Curr Opin Cardiol. 2011;26:181\u20139.","journal-title":"Curr Opin Cardiol"},{"key":"234_CR20","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1373\/clinchem.2014.221341","volume":"61","author":"KW Witwer","year":"2015","unstructured":"Witwer KW. Circulating microRNA biomarker studies: pitfalls and potential solutions. Clin Chem. 2015;61:56\u201363.","journal-title":"Clin Chem"},{"issue":"17","key":"234_CR21","doi-asserted-by":"crossref","first-page":"24076","DOI":"10.18632\/oncotarget.8119","volume":"7","author":"Z Tan","year":"2016","unstructured":"Tan Z, Zheng H, Liu X, Zhang W, Zhu J, Wu G, et al. MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt\/beta-catenin signaling in breast cancer. Oncotarget. 2016;7(17):24076\u201387.","journal-title":"Oncotarget"},{"key":"234_CR22","doi-asserted-by":"publisher","first-page":"95","DOI":"10.7150\/jca.13340","volume":"7","author":"W Yan","year":"2016","unstructured":"Yan W, Qian L, Chen J, Chen W, Shen B. Comparison of prognostic microRNA biomarkers in blood and tissues for gastric cancer. J Cancer. 2016;7:95\u2013106.","journal-title":"J Cancer"},{"key":"234_CR23","doi-asserted-by":"publisher","first-page":"e1000507","DOI":"10.1371\/journal.pcbi.1000507","volume":"5","author":"MS Scott","year":"2009","unstructured":"Scott MS, Avolio F, Ono M, Lamond AI, Barton GJ. Human miRNA precursors with box H\/ACA snoRNA features. PLoS Comput Biol. 2009;5:e1000507.","journal-title":"PLoS Comput Biol"},{"key":"234_CR24","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1093\/nar\/gkq776","volume":"39","author":"M Brameier","year":"2011","unstructured":"Brameier M, Herwig A, Reinhardt R, Walter L, Gruber J. Human box C\/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs. Nucleic Acids Res. 2011;39:675\u201386.","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"234_CR25","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1007\/s11427-013-4451-y","volume":"56","author":"J Yu","year":"2013","unstructured":"Yu J, Ma Q, Zhang B, Ma RJ, Xu XG, Li MS, et al. Clinical application of specific antibody against glypican-3 for hepatocellular carcinoma diagnosis. Sci China Life Sci. 2013;56(3):234\u20139.","journal-title":"Sci China Life Sci"},{"key":"234_CR26","doi-asserted-by":"publisher","first-page":"44","DOI":"10.18632\/oncotarget.417","volume":"3","author":"H Hidaka","year":"2012","unstructured":"Hidaka H, Seki N, Yoshino H, et al. Tumor suppressive microRNA-1285 regulates novel molecular targets: aberrant expression and functional significance in renal cell carcinoma. Oncotarget. 2012;3:44\u201357.","journal-title":"Oncotarget"},{"key":"234_CR27","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1111\/cas.12240","volume":"104","author":"T Yamasaki","year":"2013","unstructured":"Yamasaki T, Seki N, Yoshino H, Itesako T, Yamada Y, Tatarano S, et al. Tumor-suppressive microRNA-1291 directly regulates glucose transporter 1 in renal cell carcinoma. Cancer Sci. 2013;104:1411\u20139.","journal-title":"Cancer Sci"},{"key":"234_CR28","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/hep.25994","volume":"57","author":"M Maurel","year":"2013","unstructured":"Maurel M, Javy S, Ladeiro Y, et al. A functional screening identifies five microRNAs controlling glypican-3: role of miR-1271 down-regulation in hepatocellular carcinoma. Hepatology. 2013;57:195\u2013204.","journal-title":"Hepatology"},{"issue":"1","key":"234_CR29","doi-asserted-by":"publisher","first-page":"S100","DOI":"10.1016\/j.jhep.2004.11.015","volume":"42 Suppl","author":"F Durand","year":"2005","unstructured":"Durand F, Valla D. Assessment of the prognosis of cirrhosis: Child-Pugh versus MELD. J Hepatol. 2005;42 Suppl(1):S100\u20137.","journal-title":"J Hepatol"},{"key":"234_CR30","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.3748\/wjg.v12.i8.1175","volume":"12","author":"L Zhou","year":"2006","unstructured":"Zhou L, Liu J, Luo F. Serum tumor markers for detection of hepatocellular carcinoma. World J Gastroenterol. 2006;12:1175\u201381.","journal-title":"World J Gastroenterol"},{"key":"234_CR31","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1158\/0008-5472.CAN-03-2191","volume":"64","author":"Y Hippo","year":"2004","unstructured":"Hippo Y, Watanabe K, Watanabe A, Midorikawa Y, Yamamoto S, Ihara S, et al. Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma. Cancer Res. 2004;64:2418\u201323.","journal-title":"Cancer Res"},{"key":"234_CR32","first-page":"237","volume":"7","author":"WY Lau","year":"2008","unstructured":"Lau WY, Lai EC. Hepatocellular carcinoma: current management and recent advances. Hepatobiliary Pancreat Dis Int. 2008;7:237\u201357.","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"234_CR33","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S1499-3872(11)60048-9","volume":"10","author":"M Yao","year":"2011","unstructured":"Yao M, Yao DF, Bian YZ, Zhang CG, Qiu LW, Wu W, et al. Oncofetal antigen glypican-3 as a promising early diagnostic marker for hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 2011;10:289\u201394.","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"234_CR34","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/S0006-291X(03)00908-2","volume":"306","author":"T Nakatsura","year":"2003","unstructured":"Nakatsura T, Yoshitake Y, Senju S, Monji M, Komori H, Motomura Y, et al. Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker. Biochem Biophys Res Commun. 2003;306:16\u201325.","journal-title":"Biochem Biophys Res Commun"},{"key":"234_CR35","doi-asserted-by":"crossref","unstructured":"Beale G, Chattopadhyay D, Gray J, et al. AFP, PIVKA III, GP3, SCCA and follisation as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease. BMC Cancer. 2008:8\u2013200.","DOI":"10.1186\/1471-2407-8-200"},{"issue":"35","key":"234_CR36","doi-asserted-by":"publisher","first-page":"4410","DOI":"10.3748\/wjg.v16.i35.4410","volume":"16","author":"H Liu","year":"2010","unstructured":"Liu H, Li P, Zhai Y, Qu CF, Zhang LJ, Tan YF, et al. Diagnostic value of glypican-3 in serum and liver for primary hepatocellular carcinoma. World J Gastroenterol. 2010;16(35):4410\u20135.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"234_CR37","doi-asserted-by":"publisher","first-page":"58","DOI":"10.5604\/01.3001.0012.7863.","volume":"18","author":"D Xu","year":"2018","unstructured":"Xu D, Su C, Sun L, et al. Performance of serum Glypican 3 in diagnosis of hepatocellular carcinoma: a meta-analysis. Ann Hepatol. 2018;18(1):58\u201367. https:\/\/doi.org\/10.5604\/01.3001.0012.7863.","journal-title":"Ann Hepatol"},{"issue":"3","key":"234_CR38","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1007\/s12029-018-0095-2","volume":"50","author":"Ahmed M. Tahon","year":"2018","unstructured":"Tahon AM, El-Ghanam MZ, Zaky S, et al. Significance of Glypican-3 in early detection of hepatocellular carcinoma in cirrhotic patients. J Gastrointest Cancer. 2018. https:\/\/doi.org\/10.1007\/s12029-018-0095-2.","journal-title":"Journal of Gastrointestinal Cancer"},{"issue":"6","key":"234_CR39","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1261\/rna.036483.112","volume":"19","author":"M Maurel","year":"2013","unstructured":"Maurel M, Dejeans N, Taouji S, Chevet E, Grosset CF. MicroRNA-1291-mediated silencing of IRE1\u03b1 enhances Glypican-3 expression. RNA. 2013;19(6):778\u201388.","journal-title":"RNA"},{"issue":"11","key":"234_CR40","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1111\/cas.12240","volume":"104","author":"T Yamasaki","year":"2013","unstructured":"Yamasaki T, Seki N, Yoshino H, Itesako T, Yamada Y, Tatarano S, et al. Tumor-suppressive microRNA-1291 directly regulates glucose transporter 1 in renal cell carcinoma. Cancer Sci. 2013;104(11):1411\u20139.","journal-title":"Cancer Sci"},{"key":"234_CR41","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.3892\/or.2015.4206","volume":"34","author":"H Luo","year":"2015","unstructured":"Luo H, Guo W, Wang F, et al. MiR-1291 targets mucin 1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma. Oncol Rep. 2015;34:2665\u201373.","journal-title":"Oncol Rep"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-019-00234-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-019-00234-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-019-00234-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T13:22:32Z","timestamp":1628601752000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-019-00234-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,27]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["234"],"URL":"https:\/\/doi.org\/10.1007\/s12029-019-00234-9","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,27]]},"assertion":[{"value":"27 April 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The research institute\u2019s committee has approved the study protocol on human research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of Ethics"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}