{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:46:06Z","timestamp":1775846766317,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s12029-020-00391-2","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T05:09:43Z","timestamp":1584335383000},"page":"1047-1052","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hepatocellular Carcinoma in Paediatric Patients with Alagille Syndrome: Case Series and Review of Literature"],"prefix":"10.1007","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8114-2523","authenticated-orcid":false,"given":"Joseph J.","family":"Valamparampil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naresh","family":"Shanmugam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0149-0294","authenticated-orcid":false,"given":"Mukul","family":"Vij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mettu Srinivas","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Rela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"issue":"1","key":"391_CR1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/MPG.0b013e3181c1601f","volume":"50","author":"BM Kamath","year":"2010","unstructured":"Kamath BM, Schwarz KB, Hadzi\u0107 N. Alagille syndrome and liver transplantation. Pediatr Gastroenterol Nutr. 2010;50(1):11\u20135.","journal-title":"Pediatr Gastroenterol Nutr"},{"issue":"3","key":"391_CR2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/ejhg.2011.181","volume":"20","author":"PD Turnpenny","year":"2012","unstructured":"Turnpenny PD, Ellard S. Alagille syndrome: pathogenesis, diagnosis and management. Eur J Hum Genet. 2012;20(3):251\u20137.","journal-title":"Eur J Hum Genet"},{"key":"391_CR3","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1017\/CBO9781139012102.015","volume-title":"Liver disease in children","author":"BM Kamath","year":"2014","unstructured":"Kamath BM, Spinner NB, Piccoli AD. Alagille syndrome. In: Suchy FJ, Sokol RJ, Balistreri WF, editors. Liver disease in children. 4th ed. Cambridge: Cambridge Univ. Press; 2014. p. 216\u201334.","edition":"4"},{"issue":"6","key":"391_CR4","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1177\/1093526618762550","volume":"21","author":"MC Pacheco","year":"2018","unstructured":"Pacheco MC, Monroe EJ, Horslen SP. Hepatic adenoma arising in a patient with Alagille syndrome: a case report. Pediatr Dev Pathol. 2018;21(6):585\u20139.","journal-title":"Pediatr Dev Pathol"},{"issue":"2","key":"391_CR5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0002-9343(92)90047-F","volume":"93","author":"SJ Schwarzenberg","year":"1992","unstructured":"Schwarzenberg SJ, Grothe RM, Sharp HL, Snover DC, Freese D. Long-term complications of arteriohepatic dysplasia. Am J Med. 1992;93(2):171\u20136.","journal-title":"Am J Med"},{"issue":"1","key":"391_CR6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00005176-198901000-00006","volume":"8","author":"M Rabinovitz","year":"1989","unstructured":"Rabinovitz M, Imperial JC, Schade RR, Van Thiel DH. Hepatocellular carcinoma in Alagille\u2019s syndrome: a family study. J Pediatr Gastroenterol Nutr. 1989;8(1):26\u201330.","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"391_CR7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.prp.2004.11.007","volume":"201","author":"B Kim","year":"2005","unstructured":"Kim B, Park SH, Ran Yang H, Kee Seo J, Sun Kim W, Chi JG. Hepatocellular carcinoma occurring in Alagille syndrome. Pathol Res Pract. 2005;201(1):55\u201360.","journal-title":"Pathol Res Pract"},{"issue":"35","key":"391_CR8","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.3748\/wjg.v24.i35.3980","volume":"24","author":"R Khanna","year":"2018","unstructured":"Khanna R, Verma SK. Pediatric hepatocellular carcinoma. World J Gastroenterol. 2018;24(35):3980\u201399.","journal-title":"World J Gastroenterol"},{"key":"391_CR9","volume-title":"WHO classification of tumours of the digestive system","author":"ND Theise","year":"2010","unstructured":"Theise ND, Curado MP, Franceschi S, et al. Hepatocellular carcinoma. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumours of the digestive system. 4th ed. Lyon: IARC Press; 2010.","edition":"4"},{"key":"391_CR10","doi-asserted-by":"crossref","first-page":"e13579","DOI":"10.1111\/petr.13579","volume":"23","author":"JJ Valamparampil","year":"2019","unstructured":"Valamparampil JJ, Reddy MS, Shanmugam N, Vij M, Kanagavelu RG, Rela M. Living donor liver transplantation in Alagille syndrome\u2014single center experience from South Asia. Pediatr Transplant. 2019;23:e13579.","journal-title":"Pediatr Transplant"},{"issue":"6","key":"391_CR11","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1097\/00004728-198611000-00032","volume":"10","author":"E Ong","year":"1986","unstructured":"Ong E, Williams SM, Anderson JC, Kaplan PA. MR imaging of a hepatoma associated with Alagille syndrome. J Comput Assist Tomogr. 1986;10(6):1047\u20139.","journal-title":"J Comput Assist Tomogr"},{"issue":"6","key":"391_CR12","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/archpedi.1987.04460060114050","volume":"141","author":"SS Kaufman","year":"1987","unstructured":"Kaufman SS. Hepatocarcinoma in a child with the Alagille syndrome. Arch Pediatr Adolesc Med. 1987;141(6):698.","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"1","key":"391_CR13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/mpo.2950200118","volume":"20","author":"AN B\u00e9k\u00e1ssy","year":"1992","unstructured":"B\u00e9k\u00e1ssy AN, Garwicz S, Wiebe T, H\u00e4gerstrand I, Jensen OA. Hepatocellular carcinoma associated with arteriohepatic dysplasia in a 4-year-old girl. Med Pediatr Oncol. 1992;20(1):78\u201383.","journal-title":"Med Pediatr Oncol"},{"issue":"9","key":"391_CR14","first-page":"1446","volume":"88","author":"EB Keeffe","year":"1993","unstructured":"Keeffe EB, Pinson CW, Ragsdale J, Zonana J. Hepatocellular carcinoma in arteriohepatic dysplasia. Am J Gastroenterol. 1993;88(9):1446\u20139.","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"391_CR15","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/01.mpg.0000179759.60048.c4","volume":"41","author":"VA Bhadri","year":"2005","unstructured":"Bhadri VA, Stormon MO, Arbuckle S, Lam AH, Gaskin KJ, Shun A. Hepatocellular carcinoma in children with Alagille syndrome. J Pediatr Gastroenterol Nutr. 2005;41(5):676\u20138.","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"10","key":"391_CR16","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1007\/s00247-010-1784-6","volume":"40","author":"SC Wetli","year":"2010","unstructured":"Wetli SC, Gralla ES, Schibli S, Stranzinger E. Hepatocellular carcinoma and regenerating nodule in a 3-year-old child with Alagille syndrome. Pediatr Radiol. 2010;40(10):1696\u20138.","journal-title":"Pediatr Radiol"},{"issue":"12","key":"391_CR17","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1001\/jamasurg.2015.1847","volume":"150","author":"TA Pham","year":"2015","unstructured":"Pham TA, Gallo AM, Concepcion W, Esquivel CO, Bonham CA. Effect of liver transplant on long-term disease-free survival in children with hepatoblastoma and hepatocellular cancer. JAMA Surg. 2015;150(12):1150\u20138.","journal-title":"JAMA Surg"},{"key":"391_CR18","doi-asserted-by":"crossref","unstructured":"Geramizadeh B, Kashkooe A, Bahador A, et al. Pediatric hepatocellular carcinoma, a single center study from the South of Iran: case series. Hepat Mon. 2017;17(8).","DOI":"10.5812\/hepatmon.11837"},{"issue":"12","key":"391_CR19","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/lt.24847","volume":"23","author":"R Vinayak","year":"2017","unstructured":"Vinayak R, Cruz RJ, Ranganathan S, et al. Pediatric liver transplantation for hepatocellular cancer and rare liver malignancies: US multicenter and single-center experience (1981\u20132015). Liver Transpl. 2017;23(12):1577\u201388.","journal-title":"Liver Transpl"},{"issue":"4","key":"391_CR20","doi-asserted-by":"crossref","first-page":"e13187","DOI":"10.1111\/petr.13187","volume":"22","author":"KE Weiss","year":"2018","unstructured":"Weiss KE, Sze DY, Rangaswami AA, et al. Transarterial chemoembolization in children to treat unresectable hepatocellular carcinoma. Pediatr Transplant. 2018;22(4):e13187.","journal-title":"Pediatr Transplant"},{"issue":"11","key":"391_CR21","doi-asserted-by":"crossref","first-page":"e27293","DOI":"10.1002\/pbc.27293","volume":"65","author":"AM D\u2019Souza","year":"2018","unstructured":"D\u2019Souza AM, Shah R, Gupta A, et al. Surgical management of children and adolescents with upfront completely resected hepatocellular carcinoma. Pediatr Blood Cancer. 2018;65(11):e27293.","journal-title":"Pediatr Blood Cancer"},{"issue":"6","key":"391_CR22","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1399-3046.2007.00751.x","volume":"11","author":"M Beaunoyer","year":"2007","unstructured":"Beaunoyer M, Vanatta JM, Ogihara M, et al. Outcomes of transplantation in children with primary hepatic malignancy: outcomes of OLT in children with liver cancer. Pediatr Transplant. 2007;11(6):655\u201360.","journal-title":"Pediatr Transplant"},{"issue":"8","key":"391_CR23","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/lt.23437","volume":"18","author":"BM Kamath","year":"2012","unstructured":"Kamath BM, Yin W, Miller H, Anand R, Rand EB, Alonso E, et al. Outcomes of liver transplantation for patients with alagille syndrome: the studies of pediatric liver transplantation experience. Liver Transpl. 2012;18(8):940\u20138.","journal-title":"Liver Transpl"},{"issue":"2","key":"391_CR24","first-page":"148","volume":"67","author":"BM Kamath","year":"2018","unstructured":"Kamath BM, Baker A, Houwen R, Todorova L, Kerkar N. Systematic review: the epidemiology, natural history, and burden of Alagille syndrome. JPGN. 2018;67(2):148\u201356.","journal-title":"JPGN."},{"key":"391_CR25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2147\/JHC.S94008","volume":"4","author":"I Schmid","year":"2017","unstructured":"Schmid I, von Schweinitz D. Pediatric hepatocellular carcinoma: challenges and solutions. J Hepatocell Carcinoma. 2017;4:15\u201321.","journal-title":"J Hepatocell Carcinoma"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-020-00391-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-020-00391-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-020-00391-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T12:57:21Z","timestamp":1628600241000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-020-00391-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["391"],"URL":"https:\/\/doi.org\/10.1007\/s12029-020-00391-2","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,16]]},"assertion":[{"value":"16 March 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}