{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T21:54:52Z","timestamp":1776808492239,"version":"3.51.2"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T00:00:00Z","timestamp":1591401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T00:00:00Z","timestamp":1591401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/08481-1"],"award-info":[{"award-number":["2018\/08481-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/02008-2"],"award-info":[{"award-number":["2018\/02008-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s12029-020-00432-w","type":"journal-article","created":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T00:02:45Z","timestamp":1591401765000},"page":"569-574","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Decrease of miR-125a-5p in Gastritis and Gastric Cancer and Its Possible Association with H. pylori"],"prefix":"10.1007","volume":"52","author":[{"given":"M\u00f4nica Pezenatto","family":"dos Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica Nunes","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger Willian","family":"De Labio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian Carla","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaqueline Correia","family":"Pontes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica Santiago","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia De Arruda Cardoso","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer Lu\u00edz Marques","family":"Pay\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-2257","authenticated-orcid":false,"given":"Lucas Trevizani","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,6]]},"reference":[{"key":"432_CR1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s13304-018-0543-3","volume":"70","author":"VE Strong","year":"2018","unstructured":"Strong VE. Progress in gastric cancer. Updat Surg. 2018;70:157\u20139. https:\/\/doi.org\/10.1007\/s13304-018-0543-3 [Internet]. Springer International Publishing.","journal-title":"Updat Surg"},{"key":"432_CR2","doi-asserted-by":"publisher","first-page":"4721","DOI":"10.1111\/jcmm.13716","volume":"22","author":"M Cai","year":"2018","unstructured":"Cai M, Chen Q, Shen J, Lv C, Cai L. Epigenetic silenced miR-125a-5p could be self-activated through targeting Suv39h1 in gastric cancer. J Cell Mol Med. 2018;22:4721\u201331. https:\/\/doi.org\/10.1111\/jcmm.13716.","journal-title":"J Cell Mol Med"},{"key":"432_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12935-019-0930-y","volume":"19","author":"Y Pei","year":"2019","unstructured":"Pei Y, Tang Z, Cai M, Yao Q, Xie B, Zhang X. The E2F3\/miR-125a\/DKK3 regulatory axis promotes the development and progression of gastric cancer. Cancer Cell Int. 2019;19:1\u201312. https:\/\/doi.org\/10.1186\/s12935-019-0930-y [Internet]. BioMed Central.","journal-title":"Cancer Cell Int"},{"key":"432_CR4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.gene.2019.02.058","volume":"699","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Dong Y, Hua J, Xue H, Hu J, Jiang T, et al. A five-miRNA signature predicts survival in gastric cancer using bioinformatics analysis. Gene. 2019;699:125\u201334. https:\/\/doi.org\/10.1016\/j.gene.2019.02.058 [Internet]. Elsevier B.V.","journal-title":"Gene"},{"key":"432_CR5","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s10096-019-03502-5","volume":"38","author":"P Sabbagh","year":"2019","unstructured":"Sabbagh P, Javanian M, Koppolu V, Vasigala VKR, Ebrahimpour S. Helicobacter pylori infection in children: an overview of diagnostic methods. Eur J Clin Microbiol Infect Dis. 2019;38:1035\u201345. https:\/\/doi.org\/10.1007\/s10096-019-03502-5.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"432_CR6","doi-asserted-by":"publisher","first-page":"5119","DOI":"10.3892\/ol.2018.7983","volume":"15","author":"Y Cao","year":"2018","unstructured":"Cao Y, Tan S, Tu Y, Zhang G, Liu Y, Li D, et al. MicroRNA-125a-5p inhibits invasion and metastasis of gastric cancer cells by targeting BRMS1 expression. Oncol Lett. 2018;15:5119\u201330. https:\/\/doi.org\/10.3892\/ol.2018.7983.","journal-title":"Oncol Lett"},{"key":"432_CR7","doi-asserted-by":"publisher","unstructured":"Sonkoly E, Pivarcsi A. Advances in microRNAs: implications for immunity and inflammatory diseases. J Cell Mol Med. 2009;13:24\u201338. https:\/\/doi.org\/10.1111\/j.1582-4934.2008.00534.x.","DOI":"10.1111\/j.1582-4934.2008.00534.x"},{"key":"432_CR8","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1111\/cmi.12587","volume":"18","author":"AFT Rossi","year":"2016","unstructured":"Rossi AFT, Cadamuro ACT, Biselli-P\u00e9rico JM, Leite KRM, Severino FE, Reis PP, et al. Interaction between inflammatory mediators and miRNAs in Helicobacter pylori infection. Cell Microbiol. 2016;18:1444-58. https:\/\/doi.org\/10.1111\/cmi.12587.","journal-title":"Cell Microbiol"},{"key":"432_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcimb.2011.00021","volume":"1","author":"JM Noto","year":"2012","unstructured":"Noto JM, Peek RM. The role of microRNAs in Helicobacter pylori pathogenesis and gastric carcinogenesis. Front Cell Infect Microbiol. 2012;1:1-19. https:\/\/doi.org\/10.3389\/fcimb.2011.00021.","journal-title":"Front Cell Infect Microbiol"},{"key":"432_CR10","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.3892\/ijo.2012.1363","volume":"40","author":"Y Hashiguchi","year":"2012","unstructured":"Hashiguchi Y, Nishida N, Mimori K, Sudo T, Tanaka F, Shibata K, et al. Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathological significance. Int J Oncol. 2012;40:1477-82. https:\/\/doi.org\/10.3892\/ijo.2012.1363.","journal-title":"Int J Oncol"},{"key":"432_CR11","doi-asserted-by":"publisher","first-page":"4441","DOI":"10.3892\/ol.2017.6809","volume":"14","author":"L Hou","year":"2017","unstructured":"Hou L, Luo P, Ma Y, Jia C, Yu F, Lv Z, et al. MicroRNA-125a-3p downregulation correlates with tumorigenesis and poor prognosis in patients with non-small cell lung cancer. Oncol Lett. 2017;14:4441-8. https:\/\/doi.org\/10.3892\/ol.2017.6809.","journal-title":"Oncol Lett"},{"key":"432_CR12","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1155\/2001\/367832","volume":"15","author":"M Stolte","year":"2001","unstructured":"Stolte M, Meining A. The updated Sydney system: classification and grading of gastritis as the basis of diagnosis and treatment. Can J Gastroenterol. 2001;15:591-8. https:\/\/doi.org\/10.1155\/2001\/367832.","journal-title":"Can J Gastroenterol"},{"key":"432_CR13","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1097\/00019606-199708000-00008","volume":"6","author":"GH Scholte","year":"1997","unstructured":"Scholte GH, van Doorn LJ, Quint WG, Lindeman J. Polymerase chain reaction for the detection of Helicobacter pylori in formaldehyde-sublimate fixed, paraffin-embedded gastric biopsies. Diagn Mol Pathol. 1997;6:238-43. https:\/\/doi.org\/10.1097\/00019606-199708000-00008.","journal-title":"Diagn Mol Pathol"},{"key":"432_CR14","doi-asserted-by":"publisher","unstructured":"Santos M, Sallas L, Zapparoli D, Orcini WA, Chen E, Smith M, et al. Lack of association between IL-6 polymorphisms and haplotypes with gastric cancer. 2018;120:9448-54. https:\/\/doi.org\/10.1002\/jcb.28220.","DOI":"10.1002\/jcb.28220"},{"key":"432_CR15","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/met.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method. Methods. 2001;25:402-8. https:\/\/doi.org\/10.1006\/met.2001.1262.","journal-title":"Methods."},{"key":"432_CR16","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1002\/ijc.29627","volume":"138","author":"T Ishimoto","year":"2016","unstructured":"Ishimoto T, Baba H, Izumi D, Sugihara H, Kurashige J, Iwatsuki M, et al. Current perspectives toward the identification of key players in gastric cancer microRNA dysregulation. Int J Cancer. 2016;138:1337-49. https:\/\/doi.org\/10.1002\/ijc.29627.","journal-title":"Int J Cancer"},{"key":"432_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4236\/aim.2017.71001","volume":"07","author":"ML Sallas","year":"2017","unstructured":"Sallas ML, Melchiades JL, Zabaglia LM, do Prado Moreno JR, Orcini WA, Chen ES, et al. Prevalence of Helicobacter pylori vacA, cagA, dupA and oipA genotypes in patients with gastric disease. Adv Microbiol. 2017;07:1-9. https:\/\/doi.org\/10.4236\/aim.2017.71001.","journal-title":"Adv Microbiol"},{"key":"432_CR18","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.canlet.2013.08.016","volume":"345","author":"F Wang","year":"2014","unstructured":"Wang F, Meng W, Wang B, Qiao L. Helicobacter pylori-induced gastric inflammation and gastric cancer. Cancer Lett. 2014;345:196-202. https:\/\/doi.org\/10.1016\/j.canlet.2013.08.016 [Internet]. Elsevier Ireland Ltd.","journal-title":"Cancer Lett"},{"key":"432_CR19","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1099\/jmm.0.2008\/000570-0","volume":"57","author":"Y Yamaoka","year":"2008","unstructured":"Yamaoka Y. Roles of the plasticity regions of Helicobacter pylori in gastroduodenal pathogenesis. J Med Microbiol. 2008;57:545-53. https:\/\/doi.org\/10.1099\/jmm.0.2008\/000570-0.","journal-title":"J Med Microbiol"},{"key":"432_CR20","doi-asserted-by":"publisher","first-page":"46611","DOI":"10.18632\/oncotarget.16679","volume":"8","author":"Q Zheng","year":"2017","unstructured":"Zheng Q, Chen C, Guan H, Kang W, Yu C. Prognostic role of microRNAs in human gastrointestinal cancer: a systematic review and meta-analysis. Oncotarget. 2017;8:46611-23. https:\/\/doi.org\/10.18632\/oncotarget.16679.","journal-title":"Oncotarget"},{"key":"432_CR21","doi-asserted-by":"publisher","first-page":"101042831769757","DOI":"10.1177\/1010428317697579","volume":"39","author":"L Zhong","year":"2017","unstructured":"Zhong L, Sun S, Shi J, Cao F, Han X, Chen Z. MicroRNA-125a-5p plays a role as a tumor suppressor in lung carcinoma cells by directly targeting STAT3. Tumor Biol. 2017;39:101042831769757. https:\/\/doi.org\/10.1177\/1010428317697579.","journal-title":"Tumor Biol"},{"key":"432_CR22","doi-asserted-by":"publisher","first-page":"214","DOI":"10.5483\/BMBRep.2019.52.3.308","volume":"52","author":"Y Park","year":"2019","unstructured":"Park Y, Kim J. Regulation of IL-6 signaling by miR-125a and let-7e in endothelial cells controls vasculogenic mimicry formation of breast cancer cells. BMB Rep. 2019;52:214-9. https:\/\/doi.org\/10.5483\/BMBRep.2019.52.3.308.","journal-title":"BMB Rep"},{"key":"432_CR23","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.3748\/wjg.v17.i31.3645","volume":"17","author":"WY Wu","year":"2011","unstructured":"Wu WY, Xue XY, Chen ZJ, Han SL, Huang YP, Zhang LF, et al. Potentially predictive microRNAs of gastric cancer with metastasis to lymph node. World J Gastroenterol. 2011;17:3645-51. https:\/\/doi.org\/10.3748\/wjg.v17.i31.3645.","journal-title":"World J Gastroenterol"},{"key":"432_CR24","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.canlet.2019.04.015","volume":"454","author":"JK Wang","year":"2019","unstructured":"Wang JK, Wang Z, Li G. MicroRNA-125 in immunity and cancer. Cancer Lett. 2019;454:134-45. https:\/\/doi.org\/10.1016\/j.canlet.2019.04.015 [Internet]. Elsevier.","journal-title":"Cancer Lett"},{"key":"432_CR25","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.3892\/ijo.2015.3171","volume":"47","author":"J Dai","year":"2015","unstructured":"Dai J, Wang J, Yang L, Xiao Y, Ruan Q. MIR-125a regulates angiogenesis of gastric cancer by targeting vascular endothelial growth factor A. Int J Oncol. 2015;47:1801-10. https:\/\/doi.org\/10.3892\/ijo.2015.3171.","journal-title":"Int J Oncol"},{"key":"432_CR26","doi-asserted-by":"publisher","first-page":"384","DOI":"10.5483\/bmbrep.2017.50.7.085","volume":"50","author":"HN Jo","year":"2017","unstructured":"Jo HN, Kang H, Lee A, Choi J, Chang W, Lee MS, et al. Endothelial miR-26a regulates VEGF-Nogo-B receptor-mediated angiogenesis. BMB Rep. 2017;50:384-9. https:\/\/doi.org\/10.5483\/bmbrep.2017.50.7.085.","journal-title":"BMB Rep"},{"key":"432_CR27","doi-asserted-by":"publisher","unstructured":"Lu G, Ma Y, Jia C, Yang H, Xie R, Luo P, et al. Reduced miR-125a levels associated with poor survival of patients with hepatocellular cancer. Oncol Lett. 2017;14:5952-8. https:\/\/doi.org\/10.3892\/ol.2017.6902.","DOI":"10.3892\/ol.2017.6902"},{"key":"432_CR28","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1002\/jcb.27503","volume":"120","author":"M Sun","year":"2019","unstructured":"Sun M, Guo S, Yao J, Xiao Y, Sun R, Ma W, et al. MicroRNA-125a suppresses cell migration, invasion, and regulates hyaluronic acid synthase 1 expression by targeting signal transducers and activators of transcription 3 in renal cell carcinoma cells. J Cell Biochem. 2019;120:1894-902. https:\/\/doi.org\/10.1002\/jcb.27503.","journal-title":"J Cell Biochem"},{"key":"432_CR29","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.molonc.2012.09.006","volume":"48","author":"FL Kiselev","year":"2014","unstructured":"Kiselev FL. MicroRNA and cancer. Mol Biol (Mosk). 2014;48:232-42. https:\/\/doi.org\/10.1016\/j.molonc.2012.09.006 [Internet]. Elsevier B.V.","journal-title":"Mol Biol (Mosk)"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-020-00432-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-020-00432-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-020-00432-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T13:20:25Z","timestamp":1628601625000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-020-00432-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,6]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["432"],"URL":"https:\/\/doi.org\/10.1007\/s12029-020-00432-w","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,6]]},"assertion":[{"value":"6 June 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Approved by the Ethics and Research Committee of Sagrado Cora\u00e7\u00e3o University, located in Bauru, State of S\u00e3o Paulo, Brazil (case number 1.119.830), and all subjects signed the consent form.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}