{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:01:07Z","timestamp":1784869267162,"version":"3.55.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s12029-020-00471-3","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T02:02:34Z","timestamp":1597370554000},"page":"728-737","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic Significances of NEDD-9 and FOXL-1 Expression in Intestinal Type Gastric Carcinoma: an Immunohistochemical Study"],"prefix":"10.1007","volume":"52","author":[{"given":"Noha F.","family":"Elaidy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4396-3101","authenticated-orcid":false,"given":"Ola A.","family":"Harb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel Motaleb","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab","family":"Hemeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba F.","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Samir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Elsayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsayed I El.","family":"Hendawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"issue":"6","key":"471_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394\u2013424.","journal-title":"CA Cancer J Clin"},{"key":"471_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","author":"P Lauren","year":"1965","unstructured":"Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 1965;64:31\u201349.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"471_CR3","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.3892\/ol.2016.4337","volume":"16","author":"J Ma","year":"2016","unstructured":"Ma J, Shen H, Kapesa L, Zeng S. Lauren classification and individualized chemotherapy in gastric cancer (review). Oncol Lett. 2016;16:2959\u201364.","journal-title":"Oncol Lett"},{"issue":"12","key":"471_CR4","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1016\/j.cgh.2017.05.023","volume":"15","author":"M Rugge","year":"2017","unstructured":"Rugge M, Genta RM, di Mario F, Mf D, et al. Gastric cancer as preventable disease. Clin Gastroenterol Hepatol. 2017;15(12):1833\u2013184.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"471_CR5","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/ng.2983","volume":"46","author":"K Wang","year":"2014","unstructured":"Wang K, Yuen ST, Xu J, Lee SP, Yan HHN, Shi ST, et al. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nat Genet. 2014;46(6):573\u201382.","journal-title":"Nat Genet"},{"key":"471_CR6","doi-asserted-by":"publisher","first-page":"129","DOI":"10.5230\/jgc.2013.13.3.129","volume":"13","author":"JY Cho","year":"2013","unstructured":"Cho JY. Molecular diagnosis for personalized target therapy in gastric cancer. J Gastric Cancer. 2013;13:129\u201335.","journal-title":"J Gastric Cancer"},{"key":"471_CR7","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s12013-007-0036-3","volume":"48","author":"M Singh","year":"2007","unstructured":"Singh M, Cowell L, Seo S, et al. Molecular basis for HEF1\/NEDD9\/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle. Cell Biochem Biophys. 2007;48:54\u201372.","journal-title":"Cell Biochem Biophys"},{"key":"471_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2015.04.086","volume":"567","author":"E Shagisultanova","year":"2015","unstructured":"Shagisultanova E, Gaponova AV, Gabbasov R, Nicolas E, Golemis EA. Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases. Gene. 2015;567:1\u201311.","journal-title":"Gene"},{"key":"471_CR9","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/nrc3539","volume":"13","author":"EW Lam","year":"2013","unstructured":"Lam EW, Brosens JJ, Gomes AR, Koo CY. Forkhead box proteins: tuning forks for transcriptional harmony. Nat Rev Cancer. 2013;13:482\u201395.","journal-title":"Nat Rev Cancer"},{"key":"471_CR10","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/S0012-1606(02)00088-X","volume":"255","author":"K Fukuda","year":"2003","unstructured":"Fukuda K, Yoshida H, Sato T, Furumoto TA, Mizutani-Koseki Y, Suzuki Y, et al. Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut associated lymphoid organs. Dev Biol. 2003;255:278\u201389.","journal-title":"Dev Biol"},{"key":"471_CR11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3322\/caac.21388","volume":"67","author":"MB Amin","year":"2017","unstructured":"Amin MB, Greene FL, Edge SB, Gershenwald JE, Brookland RK, et al. The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging. CA Cancer J Clin. 2017;67:93\u20139.","journal-title":"CA Cancer J Clin"},{"key":"471_CR12","first-page":"577","volume":"29","author":"SM Hsu","year":"1981","unstructured":"Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J HistochemCytochem. 1981;29:577\u201380.","journal-title":"J HistochemCytochem"},{"issue":"4","key":"471_CR13","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.1007\/s12032-012-0213-0","volume":"29","author":"J Chang","year":"2012","unstructured":"Chang J, Gao F, Zhao G, Zhang G. Expression and clinical significance of NEDD9 in lung tissues. Med Oncol. 2012;29(4):2654\u201360.","journal-title":"Med Oncol"},{"issue":"1","key":"471_CR14","first-page":"110","volume":"7","author":"FQ Yang","year":"2014","unstructured":"Yang FQ, Yang FP, Li W, Liu M, Wang GC, Che JP, et al. Foxl1 inhibits tumor invasion and predicts outcome in human renal cancer. Int J Clin Exp Pathol. 2014;7(1):110\u201322.","journal-title":"Int J Clin Exp Pathol"},{"key":"471_CR15","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1172\/JCI39104","volume":"l119","author":"R Kalluri","year":"2009","unstructured":"Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;l119:1420\u20138.","journal-title":"J Clin Invest"},{"key":"471_CR16","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.clinre.2017.04.011","volume":"41","author":"S Zhou","year":"2017","unstructured":"Zhou S, Xu M, Shen J, Liu X, Chen M, Cai X. Overexpression of NEDD9 promotes cell invasion and metastasis in hepatocellular carcinoma. Clin Res Hepatol Gastroenterol. 2017;41:677\u201386.","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"5\u20136","key":"471_CR17","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1177\/1947601912458585","volume":"3","author":"MS Guerrero","year":"2012","unstructured":"Guerrero MS, Parsons JT, Bouton AH. Cas and NEDD9 contribute to tumor progression through dynamic regulation of the cytoskeleton. Genes Cancer. 2012;3(5\u20136):371\u201381.","journal-title":"Genes Cancer"},{"key":"471_CR18","doi-asserted-by":"publisher","first-page":"5751","DOI":"10.2147\/OTT.S113768","volume":"9","author":"P Li","year":"2016","unstructured":"Li P, Sun T, Yuan Q, Pan G, Zhang J, Sun D. The expressions of NEDD9 and E-cadherin correlate with metastasis and poor prognosis in triple-negative breast cancer patients. Onco Targets Ther. 2016;9:5751\u20139.","journal-title":"Onco Targets Ther"},{"key":"471_CR19","doi-asserted-by":"crossref","unstructured":"Miao Y, Li A-L, Wang L, Fan CF, Zhang XP, Xu HT, et al. Overexpression of NEDD9 is associated with altered expression of E-cadherin, \u03b2-catenin and N-cadherin and predictive of poor prognosis in non-small cell lung cancer. Pathol Oncol Res. 2013;(2):281\u20136.","DOI":"10.1007\/s12253-012-9580-2"},{"key":"471_CR20","first-page":"8021","volume":"14","author":"J Wang","year":"2017","unstructured":"Wang J, Wang S, Luan Y, Zhang W, Sun C, Cheng G, et al. Overexpression of NEDD9 in renal cell carcinoma is associated with tumor migration and invasion. Oncol Lett. 2017;14:8021\u20137.","journal-title":"Oncol Lett"},{"key":"471_CR21","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.18632\/oncotarget.13852","volume":"8","author":"Z Wang","year":"2017","unstructured":"Wang Z, Shen M, Lu P, Li X, Zhu S, Yue S. NEDD9 may regulate hepatocellular carcinoma cell metastasis by promoting epithelial-mesenchymal-transition and stemness via repressing Smad7. Oncotarget. 2017;8:1714\u201324.","journal-title":"Oncotarget"},{"key":"471_CR22","first-page":"2565","volume":"7","author":"P Li","year":"2014","unstructured":"Li P, Zhou H, Zhu X, Ma G, Liu C, Lin B, et al. High expression of NEDD9 predicts adverse outcomes of colorectal cancer patients. Int J Clin Exp Pathol. 2014;7:2565\u201370.","journal-title":"Int J Clin Exp Pathol"},{"key":"471_CR23","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.humpath.2013.10.005","volume":"45","author":"H Wang","year":"2014","unstructured":"Wang H, Mu X, Zhou S, Zhang J, Dai J, Tang L, et al. NEDD9 overexpression is associated with the progression of and an unfavorable prognosis in epithelial ovarian cancer. Hum.Pathol. 2014;45:401\u20138.","journal-title":"Hum.Pathol"},{"key":"471_CR24","doi-asserted-by":"publisher","first-page":"3621","DOI":"10.1007\/s13277-014-2999-1","volume":"36","author":"J Feng","year":"2015","unstructured":"Feng J, Zhao J, Xie H, Yin Y, Luo G, Zhang J, et al. Involvement of NEDD9 in the invasion and migration of gastric cancer. Tumour Biol. 2015;36:3621\u20138.","journal-title":"Tumour Biol"},{"key":"471_CR25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s12032-014-0033-5","volume":"31","author":"Q Zhang","year":"2014","unstructured":"Zhang Q, Wang H, Ma Y, Zhang J, He X, Ma J, et al. Overexpression of Nedd9 is a prognostic marker of human gastric cancer. Med Oncol. 2014;31:33.","journal-title":"Med Oncol"},{"key":"471_CR26","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1007\/s12032-014-0852-4","volume":"31","author":"R Shi","year":"2014","unstructured":"Shi R, Wang L, Wang T, Xu J, Wang F, Xu M. NEDD9 overexpression correlates with the progression and prognosis in gastric carcinoma. Med Oncol. 2014;31:852.","journal-title":"Med Oncol"},{"key":"471_CR27","first-page":"633","volume":"8","author":"SS Zhang","year":"2015","unstructured":"Zhang SS, Wu LH, Liu Q, Chen KS, Zhang XF. Elevated expression of NEDD9 is associated with metastatic activity in gastric cancer. OncoTargets and therapy. 2015;8:633\u201340.","journal-title":"OncoTargets and therapy"},{"key":"471_CR28","doi-asserted-by":"publisher","first-page":"6351","DOI":"10.1007\/s13277-014-1839-7","volume":"35","author":"Y Liu","year":"2014","unstructured":"Liu Y, Wang D, Zhao KL, Zhu JW, Yin HB, Wei YZ, et al. NEDD9 overexpression correlates with poor prognosis in gastric cancer. Tumour Biol. 2014;35:6351\u20136.","journal-title":"Tumour Biol"},{"key":"471_CR29","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1038\/onc.2010.632","volume":"30","author":"Y Li","year":"2011","unstructured":"Li Y, Bavarva JH, Wang Z, Guo J, Qian C, Thibodeau SN, et al. HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression. Oncogene. 2011;30:2633\u201343.","journal-title":"Oncogene"},{"key":"471_CR30","doi-asserted-by":"crossref","unstructured":"Zhao S, Min P, Liu L, Zhang L, Zhang Y, et al. NEDD9 facilitates hypoxia-induced gastric cancer cell migration via MICAL1 related Rac1 activation. Front Pharmacol. 2019:10\u2013291.","DOI":"10.3389\/fphar.2019.00291"},{"issue":"3","key":"471_CR31","first-page":"3456","volume":"10","author":"Z Li","year":"2017","unstructured":"Li Z, Li L, Wu C, Wang Z, et al. NEDD9 is a novel prognostic marker in gastric cancer patients. Int J Clin Exp Pathol. 2017;10(3):3456\u201360.","journal-title":"Int J Clin Exp Pathol"},{"key":"471_CR32","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.2147\/OTT.S205760","volume":"12","author":"Y Gu","year":"2019","unstructured":"Gu Y, Lu J, Chen C, Zheng F. NEDD9 overexpression predicts poor prognosis in solid cancers: a meta-analysis. Onco Targets Ther. 2019 May 28;12:4213\u201322.","journal-title":"Onco Targets Ther"},{"key":"471_CR33","doi-asserted-by":"publisher","first-page":"11331","DOI":"10.1007\/s13277-016-4890-8","volume":"37","author":"Z Ertao","year":"2016","unstructured":"Ertao Z, Jianhui C, Chuangqi C, Changjiang Q, Sile C, et al. Low level of FOXL1 indicates a worse prognosis for gastric cancer patients. Tumour Biol. 2016;37:11331\u20137.","journal-title":"Tumour Biol"},{"key":"471_CR34","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1101\/gad.1260605","volume":"19","author":"N Perreault","year":"2005","unstructured":"Perreault N, Sackett SD, Katz JP, Furth EE, Kaestner KH. Foxl1 is a mesenchymal modifier of Min in carcinogenesis of stomach and colon. Genes Dev. 2005;19:311\u20135.","journal-title":"Genes Dev"},{"key":"471_CR35","doi-asserted-by":"publisher","first-page":"5416","DOI":"10.1158\/0008-5472.CAN-13-0362","volume":"73","author":"G Zhang","year":"2013","unstructured":"Zhang G, He P, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, et al. FOXL1, a novel candidate tumor suppressor, inhibits tumor aggressiveness and predicts outcome in human pancreatic cancer. Cancer Res. 2013;73:5416\u201325.","journal-title":"Cancer Res"},{"key":"471_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102084","volume":"9","author":"Y Qin","year":"2014","unstructured":"Qin Y, Gong W, Zhang M, Wang J, Tang Z, Quan Z. Forkhead box L1 is frequently downregulated in gallbladder cancer and inhibits cell growth through apoptosis induction by mitochondrial dysfunction. PLoS One. 2014;9:e102084.","journal-title":"PLoS One"},{"key":"471_CR37","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3892\/or.2015.3969","volume":"34","author":"X Chen","year":"2015","unstructured":"Chen X, Deng M, Ma L, Zhou J, Xiao Y, Zhou X, et al. Inhibitory effects of forkhead box L1 gene on osteosarcoma growth through the induction of cell cycle arrest and apoptosis. Oncol Rep. 2015;34:265\u201371.","journal-title":"Oncol Rep"},{"issue":"8","key":"471_CR38","first-page":"8640","volume":"10","author":"Y Xue","year":"2017","unstructured":"Xue Y, Wu T, Dai Y, Sheng YY, Wu YM, Xia BL, et al. NEDD9 expression is correlated with epithelial-to-mesenchymal transition markers in colorectal cancer. Int J Clin Exp Pathol. 2017;10(8):8640\u20136.","journal-title":"Int J Clin Exp Pathol"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-020-00471-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-020-00471-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-020-00471-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T22:18:03Z","timestamp":1667773083000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-020-00471-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["471"],"URL":"https:\/\/doi.org\/10.1007\/s12029-020-00471-3","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,14]]},"assertion":[{"value":"14 August 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}