{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:24:54Z","timestamp":1782789894008,"version":"3.54.5"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s12029-020-00498-6","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T04:12:02Z","timestamp":1598328722000},"page":"1197-1199","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Management of Recurrent HCC After Liver Transplantation"],"prefix":"10.1007","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9595-1906","authenticated-orcid":false,"given":"Baris","family":"Sarici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2395-3985","authenticated-orcid":false,"given":"Burak","family":"Isik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-0297","authenticated-orcid":false,"given":"Sezai","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"498_CR1","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1056\/NEJM199603143341104","volume":"334","author":"V Mazzaferro","year":"1996","unstructured":"Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334:693\u20139.","journal-title":"N Engl J Med"},{"key":"498_CR2","doi-asserted-by":"publisher","first-page":"531","DOI":"10.6002\/ect.2012.0085","volume":"10","author":"J Rubin","year":"2012","unstructured":"Rubin J, Ayoub N, Kaldas F, Saab S. Management of recurrent hepatocellular carcinoma in liver transplant recipients: a systematic review. Exp Clin Transplant. 2012;10:531\u201343.","journal-title":"Exp Clin Transplant"},{"key":"498_CR3","doi-asserted-by":"publisher","first-page":"11185","DOI":"10.3748\/wjg.v21.i39.11185","volume":"21","author":"N de'Angelis","year":"2015","unstructured":"de'Angelis N, Landi F, Carra MC, Azoulay D. Managements of recurrent hepatocellular carcinoma after liver transplantation: a systematic review. World J Gastroenterol. 2015;21:11185\u201398.","journal-title":"World J Gastroenterol"},{"key":"498_CR4","doi-asserted-by":"publisher","first-page":"261","DOI":"10.4254\/wjh.v11.i3.261","volume":"11","author":"NA Filgueira","year":"2019","unstructured":"Filgueira NA. Hepatocellular carcinoma recurrence after liver transplantation: risk factors, screening and clinical presentation. World J Hepatol. 2019;11:261\u201372.","journal-title":"World J Hepatol"},{"key":"498_CR5","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1097\/SLA.0000000000001894","volume":"266","author":"AS Bodzin","year":"2017","unstructured":"Bodzin AS, Lunsford KE, Markovic D, Harlander-Locke MP, Busuttil RW, Agopian VG. Predicting mortality in patients developing recurrent hepatocellular carcinoma after liver transplantation: impact of treatment modality and recurrence characteristics. Ann Surg. 2017;266:118\u201325.","journal-title":"Ann Surg"},{"key":"498_CR6","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1111\/ctr.12644","volume":"29","author":"S Nagai","year":"2015","unstructured":"Nagai S, Mangus RS, Kubal CA, Ekser B, Fridell JA, Klingler KR, et al. Prognosis after recurrence of hepatocellular carcinoma in liver transplantation: predictors for successful treatment and survival. Clin Transpl. 2015;29:1156\u201363.","journal-title":"Clin Transpl"},{"key":"498_CR7","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1245\/s10434-014-4273-6","volume":"22","author":"G Sapisochin","year":"2015","unstructured":"Sapisochin G, Goldaracena N, Astete S, Laurence JM, Davidson D, Rafael E, et al. Benefit of treating hepatocellular carcinoma recurrence after liver transplantation and analysis of prognostic factors for survival in a large Euro-American series. Ann Surg Oncol. 2015;22:2286\u201394.","journal-title":"Ann Surg Oncol"},{"key":"498_CR8","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1002\/lt.20128","volume":"10","author":"S Roayaie","year":"2004","unstructured":"Roayaie S, Schwartz JD, Sung MW, Emre SH, Miller CM, Gondolesi GE, et al. Recurrence of hepatocellular carcinoma after liver transplant: patterns and prognosis. Liver Transpl. 2004;10:534\u201340.","journal-title":"Liver Transpl"},{"key":"498_CR9","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s00534-012-0528-4","volume":"20","author":"C Toso","year":"2013","unstructured":"Toso C, Cader S, Mentha-Dugerdil A, Meeberg G, Majno P, Morard I, et al. Factors predicting survival after post-transplant hepatocellular carcinoma recurrence. J Hepatobiliary Pancreat Sci. 2013;20:342\u20137.","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"498_CR10","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1111\/j.1600-6143.2011.03689.x","volume":"10","author":"C Toso","year":"2011","unstructured":"Toso C, Mentha G, Majno P. Liver transplantation for hepatocellular carcinoma: five steps to prevent recurrence. Am J Transplant. 2011;10:2031\u20135.","journal-title":"Am J Transplant"},{"key":"498_CR11","first-page":"190","volume":"9","author":"B Ringe","year":"1995","unstructured":"Ringe B, B\u00f6ker K, Schlitt HJ, Sproviero J, Hundrieser J, Tillmann HL, et al. Recurrence of hepatitis B virus cirrhosis and hepatocellular carcinoma: an indication for retransplantation? Clin Transpl. 1995;9:190\u20136.","journal-title":"Clin Transpl"},{"key":"498_CR12","doi-asserted-by":"publisher","first-page":"5081","DOI":"10.3748\/wjg.v24.i45.5081","volume":"24","author":"KP Au","year":"2018","unstructured":"Au KP, Chok KSH. Multidisciplinary approach for post-liver transplant recurrence of hepatocellular carcinoma: a proposed management algorithm. World J Gastroenterol. 2018;24:5081\u201394.","journal-title":"World J Gastroenterol"},{"key":"498_CR13","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.trre.2015.02.003","volume":"29","author":"C Duvoux","year":"2015","unstructured":"Duvoux C, Toso C. mTOR inhibitor therapy: does it prevent HCC recurrence after liver transplantation? Transplant Rev (Orlando). 2015;29:168\u201374.","journal-title":"Transplant Rev (Orlando)"},{"key":"498_CR14","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1111\/tri.12372","volume":"27","author":"E Cholongitas","year":"2014","unstructured":"Cholongitas E, Mamou C, Rodr\u00edguez-Castro KI, Burra P. Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review. Transpl Int. 2014;27:1039\u201349.","journal-title":"Transpl Int"},{"key":"498_CR15","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1111\/ajt.14623","volume":"18","author":"LB Jeng","year":"2018","unstructured":"Jeng LB, Lee SG, Soin AS, Lee WC, Suh KS, Joo DJ, et al. Efficacy and safety of everolimus with reduced tacrolimus in living-donor liver transplant recipients: 12-month results of a randomized multicenter study. Am J Transplant. 2018;18:1435\u201346.","journal-title":"Am J Transplant"},{"key":"498_CR16","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1097\/TP.0000000000000965","volume":"100","author":"EK Geissler","year":"2016","unstructured":"Geissler EK, Schnitzbauer AA, Z\u00fclke C, Lamby PE, Proneth A, Duvoux C, et al. Sirolimus use in liver transplant recipients with hepatocellular carcinoma: a randomized, multicenter, open-label phase 3 trial. Transplantation. 2016;100:116\u201325.","journal-title":"Transplantation."},{"key":"498_CR17","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1177\/1526924816664083","volume":"26","author":"N de\u2019Angelis","year":"2016","unstructured":"de\u2019Angelis N, Landi F, Nencioni M, Palen A, Lahat E, Salloum C, et al. Role of sorafenib in patients with recurrent hepatocellular carcinoma after liver transplantation. Prog Transplant. 2016;26:348\u201355.","journal-title":"Prog Transplant"},{"key":"498_CR18","first-page":"12","volume":"1","author":"Y Gunay","year":"2014","unstructured":"Gunay Y, Guler N, Akyildiz M, Yaprak O, Dayangac M, Yuzer Y, et al. Management of patients with recurrent hepatocellular carcinoma following living donor liver transplantation: a single center experience. Gulf J Oncol. 2014;1:12\u20138.","journal-title":"Gulf J Oncol"},{"key":"498_CR19","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1007\/s00268-012-1533-0","volume":"36","author":"S Hwang","year":"2012","unstructured":"Hwang S, Kim YH, Kim DK, Ahn CS, Moon DB, Kim KH, et al. Resection of pulmonary metastases from hepatocellular carcinoma following liver transplantation. World J Surg. 2012;36:1592\u2013602.","journal-title":"World J Surg"},{"key":"498_CR20","first-page":"S1499\u20133872(20)3","volume":"7","author":"Z Yang","year":"2020","unstructured":"Yang Z, Wang S, Tian XY, Xie QF, Zhuang L, Li QY, et al. Impact of treatment modalities on patients with recurrent hepatocellular carcinoma after liver transplantation: Preliminary experience. Hepatobiliary Pancreat Dis Int. 2020;7:S1499\u20133872(20)30116\u20138.","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"498_CR21","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jss.2015.07.033","volume":"200","author":"J Huang","year":"2016","unstructured":"Huang J, Yan L, Wu H, Yang J, Liao M, Zeng Y. Is radiofrequency ablation applicable for recurrent hepatocellular carcinoma after liver transplantation? J Surg Res. 2016;200:122\u201330.","journal-title":"J Surg Res"},{"key":"498_CR22","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1159\/000343043","volume":"5","author":"BI Carr","year":"2012","unstructured":"Carr BI. Hepatic artery chemoembolization for hepatocellular carcinoma recurrence confined to the transplanted liver. Case Rep Oncol. 2012;5:506\u201310.","journal-title":"Case Rep Oncol"},{"key":"498_CR23","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.12998\/wjcc.v8.i13.2758","volume":"8","author":"KP Au","year":"2020","unstructured":"Au KP, Chiang CL, Chan ACY, Cheung TT, Lo CM, Chok KSH. Initial experience with stereotactic body radiotherapy for intrahepatic hepatocellular carcinoma recurrence after liver transplantation. World J Clin Cases. 2020;8:2758\u201368.","journal-title":"World J Clin Cases"},{"key":"498_CR24","doi-asserted-by":"publisher","first-page":"142","DOI":"10.7182\/pit2014632","volume":"24","author":"E Gringeri","year":"2014","unstructured":"Gringeri E, Boetto R, Bassi D, D'Amico FE, Polacco M, Romano M, et al. Laparoscopic microwave thermal ablation for late recurrence of local hepatocellular carcinoma after liver transplant: case report. Prog Transplant. 2014;24:142\u20135.","journal-title":"Prog Transplant"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-020-00498-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-020-00498-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-020-00498-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T23:48:38Z","timestamp":1629848918000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-020-00498-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,25]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["498"],"URL":"https:\/\/doi.org\/10.1007\/s12029-020-00498-6","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,25]]},"assertion":[{"value":"25 August 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}