{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:33:37Z","timestamp":1770068017537,"version":"3.49.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s12029-020-00580-z","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T06:13:55Z","timestamp":1609827235000},"page":"161-169","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of Squamous Cell Carcinoma Anal Canal treated with IMRT-VMAT\u2013based Concurrent Chemoradiation: a Single Institutional Experience"],"prefix":"10.1007","volume":"53","author":[{"given":"Kaalindi","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Sathyamurthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeba Karunya","family":"Ramireddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8676-8499","authenticated-orcid":false,"given":"Thomas Samuel","family":"Ram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"580_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394\u2013424. https:\/\/doi.org\/10.3322\/caac.21492.","journal-title":"CA Cancer J Clin"},{"key":"580_CR2","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/BF02553933","volume":"27","author":"ND Nigro","year":"1984","unstructured":"Nigro ND. An evaluation of combined therapy for squamous cell cancer of the anal canal. Dis Colon Rectum. 1984;27:763\u20136.","journal-title":"Dis Colon Rectum"},{"key":"580_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ijrobp.2012.09.023","volume":"86","author":"LA Kachnic","year":"2013","unstructured":"Kachnic LA, Winter K, Myerson RJ, Goodyear MD, Willins J, Esthappan J, et al. RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal. Int J Radiat Oncol Biol Phys. 2013;86:27\u201333. https:\/\/doi.org\/10.1016\/j.ijrobp.2012.09.023.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"580_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00066-011-0015-x","volume":"188","author":"N Hodapp","year":"2012","unstructured":"Hodapp N. The ICRU Report 83: prescribing, recording and reporting photon-beam intensity-modulated radiation therapy (IMRT). Strahlenther Onkol. 2012;188(1):97\u20139.","journal-title":"Strahlenther Onkol"},{"issue":"3","key":"580_CR5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ijrobp.2009.07.1754","volume":"76","author":"LB Marks","year":"2010","unstructured":"Marks LB, Yorke ED, Jackson A, ten Haken RK, Constine LS, Eisbruch A, et al. Use of normal tissue complication probability models in the clinic. Int J Radiat Oncol Biol Phys. 2010;76(3):10\u2013S19. https:\/\/doi.org\/10.1016\/j.ijrobp.2009.07.1754.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"580_CR6","unstructured":"National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services. Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0. Published: November 27, 2017. Available at https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_8.5x11.pdf"},{"key":"580_CR7","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1038\/sj.bjc.6605605","volume":"102","author":"J Northover","year":"2010","unstructured":"Northover J, Glynne-Jones R, Sebag-Montefiore D, James R, Meadows H, Wan S, et al. Chemoradiation for the treatment of epidermoid anal cancer: 13-year follow-up of the first randomised UKCCCR Anal Cancer Trial (ACT I). Br J Cancer. 2010;102:1123\u20138. https:\/\/doi.org\/10.1038\/sj.bjc.6605605.","journal-title":"Br J Cancer"},{"key":"580_CR8","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1200\/JCO.1997.15.5.2040","volume":"15","author":"H Bartelink","year":"1997","unstructured":"Bartelink H, Roelofsen F, Eschwege F, Rougier P, Bosset JF, Gonzalez DG, et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol. 1997;15:2040\u20139.","journal-title":"J Clin Oncol"},{"key":"580_CR9","doi-asserted-by":"publisher","first-page":"4344","DOI":"10.1200\/JCO.2012.43.8085","volume":"30","author":"LL Gunderson","year":"2012","unstructured":"Gunderson LL, Winter KA, Ajani JA, Pedersen JE, Moughan J, Benson AB III, et al. Longterm update of US GI intergroup RTOG 98\u201311 phase III trial for anal carcinoma:survival, relapse, and colostomy failure with concurrent chemoradiation involving fluorouracil\/mitomycin versus fluorouracil\/cisplatin. J Clin Oncol. 2012;30:4344\u201351. https:\/\/doi.org\/10.1200\/JCO.2012.43.8085.","journal-title":"J Clin Oncol"},{"key":"580_CR10","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/S1470-2045(13)70086-X","volume":"14","author":"RD James","year":"2013","unstructured":"James RD, Glynne-Jones R, Meadows HM, Cunningham D, Myint AS, Saunders MP, et al. Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II):a randomised, phase 3, open-label, 2 _ 2 factorial trial. Lancet Oncol. 2013;14:516\u201324. https:\/\/doi.org\/10.1016\/S1470-2045(13)70086-X.","journal-title":"Lancet Oncol"},{"issue":"4","key":"580_CR11","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.ijrobp.2009.09.029","volume":"78","author":"JL Wright","year":"2010","unstructured":"Wright JL, Patil SM, Temple LK, et al. Squamous cell carcinoma of the anal canal: patterns and predictors of failure and implications for intensity-modulated radiation treatment planning. Int J Radiat Oncol Biol Phys. 2010;78(4):1064\u201372.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"580_CR12","doi-asserted-by":"publisher","first-page":"5061","DOI":"10.1200\/JCO.2010.29.1351","volume":"28","author":"E Ben-Josef","year":"2010","unstructured":"Ben-Josef E, Moughan J, Ajani JA, Flam M, Gunderson L, Pollock JD, et al. Impact of overall treatment time on survival and local control in patients with anal cancer: a pooled data analysis of Radiation Therapy Oncology Group trials 87\u201304 and 98\u201311. J Clin Oncol. 2010;28:5061\u20136. https:\/\/doi.org\/10.1200\/JCO.2010.29.1351.","journal-title":"J Clin Oncol"},{"key":"580_CR13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.radonc.2019.11.016","volume":"144","author":"M Bellefon","year":"2020","unstructured":"Bellefon M, Lemanski C, Castan F, et al. Long-term follow-up experience in anal canal cancer treated with Intensity-Modulated Radiation Therapy: clinical outcomes, patterns of relapse and predictors of failure. Radiother Oncol. 2020;144:141\u20137.","journal-title":"Radiother Oncol"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-020-00580-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-020-00580-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-020-00580-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T09:14:48Z","timestamp":1648026888000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-020-00580-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,5]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["580"],"URL":"https:\/\/doi.org\/10.1007\/s12029-020-00580-z","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,5]]},"assertion":[{"value":"22 December 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was done in compliance with ethical standards as set by the Institutional Review Board.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}