{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:45:24Z","timestamp":1789055124939,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s12029-021-00611-3","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T01:11:54Z","timestamp":1614042714000},"page":"326-332","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ZAK\u00a0Gene Expression in Patients with Helicobacter pylori Infection"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-811X","authenticated-orcid":false,"given":"Delniya","family":"Khani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0654-8918","authenticated-orcid":false,"given":"Manouchehr Ahmadi","family":"Hedayati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3113-7694","authenticated-orcid":false,"given":"Sherko","family":"Nasseri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2067-5032","authenticated-orcid":false,"given":"Farshad","family":"Sheikhesmaeili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2749-8270","authenticated-orcid":false,"given":"Roghaie","family":"Ghadiany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"issue":"2","key":"611_CR1","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1053\/j.gastro.2017.04.022","volume":"153","author":"JKY Hooi","year":"2017","unstructured":"Hooi JKY, Lai WY, Ng WK, Suen MMY, Underwood FE, Tanyingoh D, Malfertheiner P, Graham DY, Wong VWS, Wu JCY, Chan FKL, Sung JJY, Kaplan GG, Ng SC. Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology. 2017;153(2):420\u20139. https:\/\/doi.org\/10.1053\/j.gastro.2017.04.022. (Epub 27 Apr 2017 PMID: 28456631).","journal-title":"Gastroenterology"},{"issue":"2","key":"611_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1177\/1753425916681077","volume":"23","author":"CT Tran","year":"2017","unstructured":"Tran CT, Garcia M, Garnier M, Burucoa C, Bodet C. Inflammatory signaling pathways induced by Helicobacter pylori in primary human gastric epithelial cells. Innate Immun. 2017;23(2):165\u201374. https:\/\/doi.org\/10.1177\/1753425916681077. (Epub 5 Dec 2016 PMID: 27913793).","journal-title":"Innate Immun"},{"key":"611_CR3","doi-asserted-by":"publisher","unstructured":"Kao CY, Sheu BS, Wu JJ. Helicobacter pylori infection: An overview of bacterial virulence factors and pathogenesis. Biomed J. 2016;39(1):14\u201323.\u00a0https:\/\/doi.org\/10.1016\/j.bj.2015.06. Epub 1 Apr 2016 PMID: 27105595; PMCID: PMC6138426.","DOI":"10.1016\/j.bj.2015.06"},{"key":"611_CR4","doi-asserted-by":"crossref","unstructured":"Jones KR, Whitmire JM, Merrell DS. A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease. Front Microbiol. 2010;1:115.","DOI":"10.3389\/fmicb.2010.00115"},{"key":"611_CR5","doi-asserted-by":"crossref","unstructured":"Sue S, Shibata W, Maeda S. Helicobacter pylori-induced Signaling Pathways Contribute to Intestinal Metaplasia and Gastric Carcinogenesis. Biomed Res Int. 2015;2015:737621.","DOI":"10.1155\/2015\/737621"},{"key":"611_CR6","doi-asserted-by":"publisher","unstructured":"Krachler AM, Woolery AR, Orth K. Manipulation of kinase signaling by bacterial pathogens. J Cell Biol. 2011;195(7):1083\u201392. https:\/\/doi.org\/10.1083\/JCB.201107132. Epub 28 Nov 2011 PMID: 22123833; PMCID: PMC3246894.","DOI":"10.1083\/JCB.201107132"},{"issue":"6","key":"611_CR7","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1111\/j.1349-7006.2010.01537.x","volume":"101","author":"JJ Yang","year":"2010","unstructured":"Yang JJ, Lee YJ, Hung HH, Tseng WP, Tu CC, Lee H, Wu WJ. ZAK inhibits human lung adenocarcinoma cell growth via ERK and JNK activation in an AP-1-dependent manner. Adenocarcinoma Sci. 2010;101(6):1374\u201381. https:\/\/doi.org\/10.1111\/j.1349-7006.2010.01537.x. (Epub 18 Feb 2010 PMID: 20331627).","journal-title":"Adenocarcinoma Sci"},{"key":"611_CR8","doi-asserted-by":"publisher","unstructured":"Braicu C, Buse M, Busuioc C, et al. A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer. Cancers (Basel). 2019;11(10):1618. Published 22 Oct 2019.\u00a0https:\/\/doi.org\/10.3390\/cancers11101618.","DOI":"10.3390\/cancers11101618"},{"issue":"9","key":"611_CR9","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.3748\/wjg.v23.i9.1521.PMID:28321154;PMCID:PMC5340805","volume":"23","author":"M Chmiela","year":"2017","unstructured":"Chmiela M, Karwowska Z, Gonciarz W, Allushi B, St\u0105czek P. Host-pathogen interactions in Helicobacter pylori-related gastric cancer. World J Gastroenterol. 2017;23(9):1521\u201340. https:\/\/doi.org\/10.3748\/wjg.v23.i9.1521.PMID:28321154;PMCID:PMC5340805.","journal-title":"World J Gastroenterol"},{"issue":"9","key":"611_CR10","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1016\/j.bbadis.2016.05.022","volume":"1862","author":"SM Craige","year":"2016","unstructured":"Craige SM, Reif MM, Kant S. Mixed-lineage protein kinases (MLKs) in inflammation, metabolism, and other disease states. Biochim Biophys Acta. 2016;1862(9):1581\u20136. https:\/\/doi.org\/10.1016\/j.bbadis.2016.05.022. (Epub 31 May 2016 PMID: 27259981).","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"611_CR11","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3390\/toxins8090259.PMID:27598200;PMCID:PMC5037485","volume":"8","author":"DM Jandhyala","year":"2016","unstructured":"Jandhyala DM, Wong J, Mantis NJ, Magun BE, Leong JM, Thorpe CM. A novel zak knockout mouse with a defective ribotoxic stress response. Toxins (Basel). 2016;8(9):259. https:\/\/doi.org\/10.3390\/toxins8090259.PMID:27598200;PMCID:PMC5037485.","journal-title":"Toxins (Basel)"},{"issue":"1","key":"611_CR12","doi-asserted-by":"publisher","first-page":"56","DOI":"10.4161\/cbt.22628","volume":"14","author":"J Wong","year":"2013","unstructured":"Wong J, Smith LB, Magun EA, et al. Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of doxorubicin. Cancer Biol Ther. 2013;14(1):56\u201363. https:\/\/doi.org\/10.4161\/cbt.22628.","journal-title":"Cancer Biol Ther"},{"key":"611_CR13","doi-asserted-by":"publisher","unstructured":"Li L, Su N, Zhou T, et al. Mixed lineage kinase ZAK promotes epithelial-mesenchymal transition in cancer progression. Cell Death Dis. 2018;9(2):143. Published 2 Feb 2018. https:\/\/doi.org\/10.1038\/s41419-017-0161-x.","DOI":"10.1038\/s41419-017-0161-x"},{"issue":"11","key":"611_CR14","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1038\/onc.2016.304","volume":"36","author":"T Zhan","year":"2017","unstructured":"Zhan T, Rindtorff N, Boutros M. Wnt signaling in cancer. Oncogene. 2017;36(11):1461\u201373. https:\/\/doi.org\/10.1038\/onc.2016.304.","journal-title":"Oncogene"},{"key":"611_CR15","doi-asserted-by":"publisher","unstructured":"Polakis P. Wnt signaling in cancer. Cold Spring Harb Perspect Biol. 2012;4(5):a008052. Published 1 May 2012.\u00a0https:\/\/doi.org\/10.1101\/cshperspect.a008052.","DOI":"10.1101\/cshperspect.a008052"},{"key":"611_CR16","doi-asserted-by":"publisher","unstructured":"Cui J, Yin Y, Ma Q, Wang G, Olman V, Zhang Y, Chou WC, Hong CS, Zhang C, Cao S, Mao X, Li Y, Qin S, Zhao S, Jiang J, Hastings P, Li F, Xu Y. Comprehensive characterization of the genomic alterations in human gastric cancer. Int J Cancer. 2015;137(1):86\u201395.\u00a0https:\/\/doi.org\/10.1002\/ijc.29352. Epub 3 Dec 2014 PMID: 25422082; PMCID: PMC4776643.","DOI":"10.1002\/ijc.29352"},{"key":"611_CR17","doi-asserted-by":"publisher","unstructured":"Rattanasinchai C, Gallo KA. MLK3 Signaling in Cancer Invasion. Cancers (Basel). 2016;8(5):51. Published 19 May 2016.\u00a0https:\/\/doi.org\/10.3390\/cancers8050051.","DOI":"10.3390\/cancers8050051"},{"issue":"24","key":"611_CR18","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.1038\/onc.2015.379","volume":"35","author":"C Rey","year":"2016","unstructured":"Rey C, Faustin B, Mahouche I, Ruggieri R, Brulard C, Ichas F, Soubeyran I, Lartigue L, De Giorgi F. The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer. Oncogene. 2016;35(24):3190\u2013200. https:\/\/doi.org\/10.1038\/onc.2015.379. Epub 2 Nov 2015 PMID: 26522728.","journal-title":"Oncogene"},{"key":"611_CR19","doi-asserted-by":"crossref","unstructured":"M Ahmadi Hedayati, D Khani. Relationship of social risk factors and Helicobacter pylori infection with pathological characteristics of Gastric carcinoma. Iran J Med Microbiol. 20;14 (1):43\u201330.","DOI":"10.30699\/ijmm.14.1.43"},{"issue":"2","key":"611_CR20","doi-asserted-by":"publisher","first-page":"121","DOI":"10.4103\/0253-7176.116232","volume":"35","author":"J Charan","year":"2013","unstructured":"Charan J, Biswas T. How to calculate sample size for different study designs in medical research? Indian J Psychol Med. 2013;35(2):121\u20136. https:\/\/doi.org\/10.4103\/0253-7176.116232.","journal-title":"Indian J Psychol Med"},{"issue":"2","key":"611_CR21","doi-asserted-by":"publisher","first-page":"85","DOI":"10.4103\/0301-4738.77005","volume":"59","author":"BK Nayak","year":"2011","unstructured":"Nayak BK, Hazra A. How to choose the right statistical test? Indian J Ophthalmol. 2011;59(2):85\u20136. https:\/\/doi.org\/10.4103\/0301-4738.77005.","journal-title":"Indian J Ophthalmol"},{"key":"611_CR22","doi-asserted-by":"crossref","unstructured":"Atherton JC, Cao P, Peek RM Jr, Tummuru MK, Blaser MJ, Cover TL. Cover Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem. 1995; 270:17771\u201317777.","DOI":"10.1074\/jbc.270.30.17771"},{"key":"611_CR23","doi-asserted-by":"crossref","unstructured":"van Doorn LJ1, Figueiredo C, Sanna R, Plaisier A, Schneeberger P, de Boer W, et al. Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori. Gastroenterology. 1998; 115(1):58\u201366.","DOI":"10.1016\/S0016-5085(98)70365-8"},{"issue":"2","key":"611_CR24","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1523-5378.2011.00919.x","volume":"17","author":"LA Sicinschi","year":"2012","unstructured":"Sicinschi LA, Correa P, Bravo LE, et al. Non-invasive genotyping of Helicobacter pylori cagA, vacA, and hopQ from asymptomatic children. Helicobacter. 2012;17(2):96\u2013106.","journal-title":"Helicobacter"},{"key":"611_CR25","doi-asserted-by":"publisher","unstructured":"Kralik P, Ricchi M. A Basic Guide to Real Time PCR in Microbial Diagnostics: Definitions, Parameters, and Everything. Front Microbiol. 2017;8:108. Published 2 Feb 2017.\u00a0https:\/\/doi.org\/10.3389\/fmicb.2017.00108.","DOI":"10.3389\/fmicb.2017.00108"},{"issue":"2","key":"611_CR26","doi-asserted-by":"publisher","first-page":"543","DOI":"10.3892\/ol.2016.5506","volume":"13","author":"XY Zhang","year":"2017","unstructured":"Zhang XY, Zhang PY, Aboul-Soud MA. From inflammation to gastric cancer: role of Helicobacter pylori. Oncol Lett. 2017;13(2):543\u20138. https:\/\/doi.org\/10.3892\/ol.2016.5506.","journal-title":"Oncol Lett"},{"key":"611_CR27","doi-asserted-by":"crossref","unstructured":"Kalali B, Mejias-Luque R, Javaheri A, Gerhard M. H. pylori virulence factors: influence on immune system and pathology. Mediators Inflamm. 2014;2014:426309.","DOI":"10.1155\/2014\/426309"},{"key":"611_CR28","doi-asserted-by":"publisher","unstructured":"Chmiela M, Kupcinskas J. Review: Pathogenesis of Helicobacter pylori infection. Helicobacter. 2019;24 Suppl 1(Suppl Suppl 1):e12638. https:\/\/doi.org\/10.1111\/hel.12638.","DOI":"10.1111\/hel.12638"},{"issue":"5","key":"611_CR29","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s00430-013-0301-6","volume":"202","author":"L Chiariotti","year":"2013","unstructured":"Chiariotti L, Angrisano T, Keller S, Florio E, Affinito O, Pallante P, Perrino C, Pero R, Lembo F. Epigenetic modifications induced by Helicobacter pylori infection through a direct microbe-gastric epithelial cells cross-talk. Med Microbiol Immunol. 2013;202(5):327\u201337. https:\/\/doi.org\/10.1007\/s00430-013-0301-6. (Epub 29 May 2013 PMID: 23715627).","journal-title":"Med Microbiol Immunol"},{"issue":"36","key":"611_CR30","doi-asserted-by":"publisher","first-page":"12767","DOI":"10.3748\/wjg.v20.i36.12767","volume":"20","author":"S Alzahrani","year":"2014","unstructured":"Alzahrani S, Lina TT, Gonzalez J, Pinchuk IV, Beswick EJ, Reyes VE. Effect of Helicobacter pylori on gastric epithelial cells. World J Gastroenterol. 2014;20(36):12767\u201380. https:\/\/doi.org\/10.3748\/wjg.v20.i36.12767.","journal-title":"World J Gastroenterol"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-021-00611-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-021-00611-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-021-00611-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T19:15:01Z","timestamp":1654629301000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-021-00611-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["611"],"URL":"https:\/\/doi.org\/10.1007\/s12029-021-00611-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-195060\/v1","asserted-by":"object"}]},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,23]]},"assertion":[{"value":"11 February 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The institutional review board has approved the study as no published patients\u2019 names were involved in the research project.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare that they have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}