{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:48:24Z","timestamp":1777398504514,"version":"3.51.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s12029-021-00713-y","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T05:02:25Z","timestamp":1635138145000},"page":"1083-1092","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Squamous Cell Carcinoma Arising from Perianal Buschke-Lowenstein Tumor (Giant Condyloma Acuminatum): Comprehensive Literature Review"],"prefix":"10.1007","volume":"53","author":[{"given":"Mustafa","family":"Ates","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6864-7711","authenticated-orcid":false,"given":"Sami","family":"Akbulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adem","family":"Tuncer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emrah","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ertugrul","family":"Karabulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemal Baris","family":"Sarici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"713_CR1","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/s0039-6109(16)46484-4","volume":"74","author":"MA Luchtefeld","year":"1994","unstructured":"Luchtefeld MA. Perianal condylomata acuminata. Surg Clin North Am. 1994;74:1327\u201338. https:\/\/doi.org\/10.1016\/s0039-6109(16)46484-4.","journal-title":"Surg Clin North Am"},{"key":"713_CR2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/BF01647657","volume":"7","author":"T Puy-Montbrun","year":"1992","unstructured":"Puy-Montbrun T, Denis J, Ganansia R, Mathoniere F, Lemarchand N, Arnous-Dubois N. Anorectal lesions in human immunodeficiency virus-infected patients. Int J Colorectal Dis. 1992;7:26\u201330. https:\/\/doi.org\/10.1007\/BF01647657.","journal-title":"Int J Colorectal Dis"},{"key":"713_CR3","first-page":"143","volume":"40","author":"A Kibrit\u00e9","year":"1997","unstructured":"Kibrit\u00e9 A, Zeitouni NC, Cloutier R. Aggressive giant condyloma acuminatum associated with oncogenic human papilloma virus: a case report. Can J Surg. 1997;40:143\u20135.","journal-title":"Can J Surg"},{"key":"713_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1471-2334-13-39","volume":"13","author":"H Patel","year":"2013","unstructured":"Patel H, Wagner M, Singhal P, Kothari S. Systematic review of the incidence and prevalence of genital warts. BMC Infect Dis. 2013;13:39. https:\/\/doi.org\/10.1186\/1471-2334-13-39.","journal-title":"BMC Infect Dis"},{"key":"713_CR5","doi-asserted-by":"publisher","unstructured":"Renzi A, Giordano P, Renzi G, Landolfi V, Del Genio A, Weiss EG.\u00a0Buschke-Lowenstein tumor successful treatment by surgical excision alone: a case report. Surg Innov. 2006;13:69\u201372. https:\/\/doi.org\/10.1177\/155335060601300111.","DOI":"10.1177\/155335060601300111"},{"key":"713_CR6","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/j.1524-4725.2006.32060.x","volume":"32","author":"G Chaidemenos","year":"2006","unstructured":"Chaidemenos G, Kogia M, Souparis A, Kastoridou C, Karakatsanis G, Xenidis E, Mourellou O. Radical excision and mesh-skin grafting for giant anorectal condyloma acuminatum. Dermatol Surg. 2006;32:324\u20138. https:\/\/doi.org\/10.1111\/j.1524-4725.2006.32060.x.","journal-title":"Dermatol Surg"},{"key":"713_CR7","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1159\/000452496","volume":"34","author":"F Fanget","year":"2017","unstructured":"Fanget F, Pasquer A, Djeudji F, Chabanon J, Barth X. Should the surgical management of Buschke-Lowenstein tumors be aggressive? About 10 Cases. Dig Surg. 2017;34:247\u201352. https:\/\/doi.org\/10.1159\/000452496.","journal-title":"Dig Surg"},{"key":"713_CR8","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/1752-1947-7-273","volume":"7","author":"M Ahsaini","year":"2013","unstructured":"Ahsaini M, Tahiri Y, Tazi MF, Elammari J, Mellas S, Khallouk A, El Fassi MJ, Farih MH, Elfatmi H, Amarti A, Stuurman-Wieringa RE. Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke-L\u00f6wenstein tumor): a case report and review of the literature. J Med Case Rep. 2013;7:273. https:\/\/doi.org\/10.1186\/1752-1947-7-273.","journal-title":"J Med Case Rep"},{"key":"713_CR9","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1007\/BF02052606","volume":"37","author":"QD Chu","year":"1994","unstructured":"Chu QD, Vezeridis MP, Libbey NP, Wanebo HJ. Giant condyloma acuminatum (Buschke-Lowenstein tumor) of the anorectal and perianal regions. Analysis of 42 cases. Dis Colon Rectum. 1994;37:950\u20137. https:\/\/doi.org\/10.1007\/BF02052606.","journal-title":"Dis Colon Rectum"},{"key":"713_CR10","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1159\/000365689","volume":"8","author":"M Nordsiek","year":"2015","unstructured":"Nordsiek M, Ross C, Metro M. Successful surgical management of Giant Condyloma Acuminatum (Buschke Lowenstein Tumor) in the urethra of a female patient: a case report. Curr Urol. 2015;8:49\u201352. https:\/\/doi.org\/10.1159\/000365689.","journal-title":"Curr Urol"},{"key":"713_CR11","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1093\/infdis\/jis228","volume":"205","author":"M Blomberg","year":"2012","unstructured":"Blomberg M, Friis S, Munk C, Bautz A, Kjaer SK. Genital warts and risk of cancer: a Danish study of nearly 50 000 patients with genital warts. J Infect Dis. 2012;205:1544\u201353. https:\/\/doi.org\/10.1093\/infdis\/jis228.","journal-title":"J Infect Dis"},{"key":"713_CR12","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1086\/653426","volume":"51","author":"HP Schlecht","year":"2010","unstructured":"Schlecht HP, Fugelso DK, Murphy RK, Wagner KT, Doweiko JP, Proper J, Dezube BJ, Panther LA. Frequency of occult high-grade squamous intraepithelial neoplasia and invasive cancer within anal condylomata in men who have sex with men. Clin Infect Dis. 2010;51:107\u201310. https:\/\/doi.org\/10.1086\/653426.","journal-title":"Clin Infect Dis"},{"key":"713_CR13","doi-asserted-by":"publisher","first-page":"S849","DOI":"10.1093\/cid\/civ813","volume":"61","author":"IU Park","year":"2015","unstructured":"Park IU, Introcaso C, Dunne EF. Human papillomavirus and genital warts: a review of the evidence for the 2015 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines. Clin Infect Dis. 2015;61:S849\u201355. https:\/\/doi.org\/10.1093\/cid\/civ813.","journal-title":"Clin Infect Dis"},{"key":"713_CR14","doi-asserted-by":"publisher","first-page":"4442","DOI":"10.1073\/pnas.89.10.4442","volume":"89","author":"DV Heck","year":"1992","unstructured":"Heck DV, Yee CL, Howley PM, M\u00fcnger K. Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses. Proc Natl Acad Sci U S A. 1992;89:4442\u20136. https:\/\/doi.org\/10.1073\/pnas.89.10.4442.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"713_CR15","doi-asserted-by":"publisher","unstructured":"Orlando G, Fasolo MM, Beretta R, Merli S, Cargnel A.\u00a0Combined surgery and cidofovir is an effective treatment for genital warts in HIV-infected patients. AIDS. 2002;16:447\u2013450. https:\/\/doi.org\/10.1097\/00002030-200202150-00017.","DOI":"10.1097\/00002030-200202150-00017"},{"key":"713_CR16","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/s1479-666x(06)80114-9","volume":"4","author":"MG Tytherleigh","year":"2006","unstructured":"Tytherleigh MG, Birtle AJ, Cohen CE, Glynne-Jones R, Livingstone J, Gilbert J. Combined surgery and chemoradiation as a treatment for the Buschke-L\u00f6wenstein tumour. Surgeon. 2006;4:378\u201383. https:\/\/doi.org\/10.1016\/s1479-666x(06)80114-9.","journal-title":"Surgeon"},{"key":"713_CR17","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1159\/000094979","volume":"38","author":"G De Toma","year":"2006","unstructured":"De Toma G, Cavallaro G, Bitonti A, Polistena A, Onesti MG, Scuderi N. Surgical management of perianal giant condyloma acuminatum (Buschke-L\u00f6wenstein tumor). Report of three cases. Eur Surg Res. 2006;38:418\u201322. https:\/\/doi.org\/10.1159\/000094979.","journal-title":"Eur Surg Res"},{"key":"713_CR18","doi-asserted-by":"publisher","unstructured":"Murray ML, Meadows J, Dor\u00e9 CJ, Copas AJ, Haddow LJ, Lacey C, Jit M, Soldan K, Bennett K, Tetlow M, Nathan M, Gilson R.\u00a0Human papillomavirus infection: protocol for a randomised controlled trial of imiquimod cream (5%) versus podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination in the treatment and prevention of recurrence of anogenital warts (HIPvac trial). BMC Med Res Methodol. 2018;18:125. https:\/\/doi.org\/10.1186\/s12874-018-0581-z.","DOI":"10.1186\/s12874-018-0581-z"},{"key":"713_CR19","doi-asserted-by":"publisher","unstructured":"Shi H, Zhang X, Ma C, Yu N, Wang J, Xia L, Ge X, Liu M, Duan A.\u00a0Clinical analysis of five methods used to treat condylomata acuminata. Dermatology. 2013;227:338\u2013345. https:\/\/doi.org\/10.1159\/000355351.","DOI":"10.1159\/000355351"},{"key":"713_CR20","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1590\/s0100-69912014000200003","volume":"41","author":"S Manzione Tda","year":"2014","unstructured":"Manzione Tda S, Nadal SR, Calore EE, Nadal LR, Manzione CR. Local control of human papillomavirus infection after anal condylomata acuminata eradication. Rev Col Bras Cir. 2014;41:87\u201391. https:\/\/doi.org\/10.1590\/s0100-69912014000200003.","journal-title":"Rev Col Bras Cir"},{"key":"713_CR21","first-page":"47","volume":"5","author":"AD Protasov","year":"2016","unstructured":"Protasov AD, Lipatov IS, Kostinov MP, Tezikov YV, Shmitko AD, Pakhomov DV, Blagovidov DA, Zhestkov AV, Ryzhov AA, Vekhova EV. Anogenital warts: a new way of solving the common problem of urology (results of long-term follow-up). Urologiia. 2016;5:47\u201351.","journal-title":"Urologiia"},{"key":"713_CR22","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1093\/cid\/cir1036","volume":"54","author":"KA Swedish","year":"2012","unstructured":"Swedish KA, Factor SH, Goldstone SE. Prevention of recurrent high-grade anal neoplasia with quadrivalent human papillomavirus vaccination of men who have sex with men: a nonconcurrent cohort study. Clin Infect Dis. 2012;54:891\u20138. https:\/\/doi.org\/10.1093\/cid\/cir1036.","journal-title":"Clin Infect Dis"},{"key":"713_CR23","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3389\/fimmu.2020.00188","volume":"11","author":"AR Garbuglia","year":"2020","unstructured":"Garbuglia AR, Lapa D, Sias C, Capobianchi MR, Del Porto P. The use of both therapeutic and prophylactic vaccines in the therapy of papillomavirus disease. Front Immunol. 2020;11:188. https:\/\/doi.org\/10.3389\/fimmu.2020.00188.","journal-title":"Front Immunol"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-021-00713-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-021-00713-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-021-00713-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T19:20:28Z","timestamp":1667416828000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-021-00713-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,25]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["713"],"URL":"https:\/\/doi.org\/10.1007\/s12029-021-00713-y","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,25]]},"assertion":[{"value":"13 September 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}