{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:24:20Z","timestamp":1790659460923,"version":"4.1.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s12029-021-00729-4","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T06:02:42Z","timestamp":1637560962000},"page":"268-269","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hereditary Pancreatitis Related to SPINK-1 Mutation. Is There an Increased Risk of Developing Pancreatic Cancer?"],"prefix":"10.1007","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7698-7284","authenticated-orcid":false,"given":"Diego T.","family":"Enjuto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"J. Ceinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ramos Bonilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Llorente-L\u00e1zaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Gonz\u00e1lez Guerreiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Castro-Carbajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"issue":"24","key":"729_CR1","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1001\/jama.2019.19411","volume":"322","author":"VK Singh","year":"2019","unstructured":"Singh VK, et al. Diagnosis and management of chronic pancreatitis: a review. JAMA. 2019;322(24):2422\u201334. https:\/\/doi.org\/10.1001\/jama.2019.19411.","journal-title":"JAMA"},{"key":"729_CR2","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/76088","volume":"25","author":"H Witt","year":"2000","unstructured":"Witt H, et al. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet. 2000;25:213\u20136.","journal-title":"Nat Genet"},{"issue":"7","key":"729_CR3","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1007\/s10620-017-4601-3","volume":"62","author":"E Hegyi","year":"2017","unstructured":"Hegyi E, et al. Genetic risk in chronic pancreatitis: the trypsin-dependent pathway. Dig Dis Sci. 2017;62(7):1692\u2013701.","journal-title":"Dig Dis Sci"},{"issue":"5","key":"729_CR4","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1136\/gutjnl-2015-311168","volume":"65","author":"WB Zou","year":"2016","unstructured":"Zou WB, et al. Clarifying the clinical relevance of SPINK-1 intronic variants in chronic pancreatitis. Gut. 2016;65(5):884\u20136.","journal-title":"Gut"},{"key":"729_CR5","doi-asserted-by":"publisher","unstructured":"Muller, et al. Natural History of SPINK-1 germline mutation. EBioMedicine. 2019 Oct;48:581\u201391. https:\/\/doi.org\/10.1016\/j.ebiom.2019.09.032.","DOI":"10.1016\/j.ebiom.2019.09.032"},{"key":"729_CR6","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.ccr.2011.05.011","volume":"19","author":"C Guerra","year":"2011","unstructured":"Guerra C, et al. Pancreatitis-induced inflammation contributes to pancreatic ancer by inhibiting oncogene-induced senscence. Canc Cell. 2011;19:728\u201339.","journal-title":"Canc Cell"},{"key":"729_CR7","doi-asserted-by":"crossref","unstructured":"Malka D, et al. F. Risk of pancreatic adenocarcinoma in chronic pancreatitis. Gut.\u00a02002;51(6): 849\u201352.","DOI":"10.1136\/gut.51.6.849"},{"key":"729_CR8","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1097\/MPA.0000000000000166","volume":"43","author":"Schubert","year":"2014","unstructured":"Schubert, et al. CFTR, SPINK-1, PRSS1 and CTRC mutations are not associated with pancreatic cancer in German patients. Pancreas. 2014;43:1078\u201382.","journal-title":"Pancreas"},{"key":"729_CR9","doi-asserted-by":"publisher","unstructured":"Greenhalf W, et al. International consensus guidelines on surveillance for pancreatic cancer in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club. Pancreatology.\u00a02020. https:\/\/doi.org\/10.1016\/j.pan.2020.05.011.","DOI":"10.1016\/j.pan.2020.05.011"},{"key":"729_CR10","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ebiom2019.10.065","volume":"50","author":"M Suzuki","year":"2019","unstructured":"Suzuki M, et al. Is Spink1 gene mutation associated with development of pancreatic cancer? New insight from a large retrospective study. EBioMedicine. 2019;50:5\u20136. https:\/\/doi.org\/10.1016\/j.ebiom2019.10.065.","journal-title":"EBioMedicine"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-021-00729-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-021-00729-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-021-00729-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T08:41:41Z","timestamp":1683967301000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-021-00729-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,22]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["729"],"URL":"https:\/\/doi.org\/10.1007\/s12029-021-00729-4","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,22]]},"assertion":[{"value":"4 October 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.\u00a0","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}