{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:59:07Z","timestamp":1740149947308,"version":"3.37.3"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s12029-022-00890-4","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T02:02:32Z","timestamp":1668823352000},"page":"897-902","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enhancing the Anti-angiogenic Effect of Bevacizumab with ACE Inhibition on mCRC"],"prefix":"10.1007","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1250-1297","authenticated-orcid":false,"given":"Efe Cem","family":"Erdat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6590-4444","authenticated-orcid":false,"given":"Elif Berna","family":"Koksoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8445-6993","authenticated-orcid":false,"given":"Gungor","family":"Utkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,19]]},"reference":[{"key":"890_CR1","doi-asserted-by":"publisher","unstructured":"Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer.\u00a02009;350(23):2335\u201342.\u00a0https:\/\/doi.org\/10.1056\/NEJMoa032691.","DOI":"10.1056\/NEJMoa032691"},{"key":"890_CR2","doi-asserted-by":"publisher","unstructured":"Munk VC, De Miguel LS, Petrimpol M, et al. Angiotensin II induces angiogenesis in the hypoxic adult mouse heart in vitro through an AT2-B2 receptor pathway. Hypertension.\u00a02007;[cited 2022 Jan 9];49(5):1178\u201385. Available from: https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.106.080242.","DOI":"10.1161\/HYPERTENSIONAHA.106.080242"},{"key":"890_CR3","doi-asserted-by":"crossref","unstructured":"Si W, Xie W, Deng W, et al. Angiotensin II increases angiogenesis by NF-\u03baB\u2013mediated transcriptional activation of angiogenic factor AGGF1. The FASEB J\u00a02018 [cited 2022 Jan 9];32(9):5051. Available from: https:\/\/www.pmc\/articles\/PMC6103173\/.","DOI":"10.1096\/fj.201701543RR"},{"issue":"6","key":"890_CR4","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.ccell.2020.05.005","volume":"37","author":"Y Shen","year":"2020","unstructured":"Shen Y, Wang X, Lu J, et al. Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer. Cancer Cell. 2020;37(6):800-817.e7.","journal-title":"Cancer Cell"},{"key":"890_CR5","doi-asserted-by":"crossref","unstructured":"Chen X, Yi CH, Ya KG. Renin\u2013angiotensin system inhibitor use and colorectal cancer risk and mortality: a dose\u2013response meta analysis. J Renin Angiotensin Aldosterone Syst. [Internet] 2020 [cited 2022 Jan 17];21(3). Available from: https:\/\/www.pmc\/articles\/PMC7338647\/.","DOI":"10.1177\/1470320319895646"},{"issue":"4","key":"890_CR6","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/j.1440-1746.2006.04797.x","volume":"22","author":"JH Neo","year":"2007","unstructured":"Neo JH, Malcontenti-Wilson C, Muralidharan V, Christophi C. Effect of ACE inhibitors and angiotensin II receptor antagonists in a mouse model of colorectal cancer liver metastases. J Gastroenterol Hepatol. 2007;22(4):577\u201384.","journal-title":"J Gastroenterol Hepatol"},{"key":"890_CR7","doi-asserted-by":"crossref","unstructured":"Roth IM, Wickremesekera AC, Wickremesekera SK, Davis PF, Tan ST. Therapeutic targeting of cancer stem cells via modulation of the renin-angiotensin system. Front Oncol.\u00a02019;9(AUG):745.","DOI":"10.3389\/fonc.2019.00745"},{"key":"890_CR8","first-page":"863","volume":"20","author":"E Tabatabai","year":"2021","unstructured":"Tabatabai E, Khazaei M, Asgharzadeh F, et al. Inhibition of angiotensin II type 1 receptor by candesartan reduces tumor growth and ameliorates fibrosis in colorectal cancer. EXCLI J. 2021;20:863.","journal-title":"EXCLI J"},{"issue":"11","key":"890_CR9","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.1002\/hed.26809","volume":"43","author":"WA Stokes","year":"2021","unstructured":"Stokes WA, Molina E, McDermott JD, et al. Survival impact of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in head and neck cancer. Head Neck. 2021;43(11):3255\u201375.","journal-title":"Head Neck"},{"key":"890_CR10","doi-asserted-by":"publisher","first-page":"8535","DOI":"10.2147\/CMAR.S335543","volume":"13","author":"L Xiong","year":"2021","unstructured":"Xiong L, Wei Y, Zhou X, et al. AGTR1 inhibits the progression of lung adenocarcinoma. Cancer Manag Res. 2021;13:8535\u201350.","journal-title":"Cancer Manag Res"},{"issue":"12","key":"890_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260772","volume":"16","author":"C-N Wu","year":"2021","unstructured":"Wu C-N, Wu S-C, Chen W-C, et al. Angiotensin II receptor blockers and oral squamous cell carcinoma survival: a propensity-score-matched cohort study. PLoS ONE. 2021;16(12): e0260772.","journal-title":"PLoS ONE"},{"key":"890_CR12","doi-asserted-by":"crossref","unstructured":"Ren T, Jia H, Wu Q, et al. Inhibition of angiogenesis and extracellular matrix remodeling: synergistic effect of renin-angiotensin system inhibitors and bevacizumab. Front Oncol.\u00a02022;12.","DOI":"10.3389\/fonc.2022.829059"},{"key":"890_CR13","doi-asserted-by":"crossref","unstructured":"Makar GA, Holmes JH, Yang YX. Angiotensin-converting enzyme inhibitor therapy and colorectal cancer risk. JNCI J Nat Canc Inst.\u00a02014;106(2).","DOI":"10.1093\/jnci\/djt374"},{"issue":"10","key":"890_CR14","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1007\/s00384-019-03379-y","volume":"34","author":"T Ozawa","year":"2019","unstructured":"Ozawa T, Hashiguchi Y, Yagi T, et al. Angiotensin I-converting enzyme inhibitors\/angiotensin II receptor blockers may reduce tumor recurrence in left-sided and early colorectal cancers. Int J Colorectal Dis. 2019;34(10):1731\u20139.","journal-title":"Int J Colorectal Dis"},{"issue":"8","key":"890_CR15","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1093\/aje\/kwz106","volume":"188","author":"Y Cui","year":"2019","unstructured":"Cui Y, Wen W, Zheng T, et al. Use of antihypertensive medications and survival rates for breast, colorectal, lung, or stomach cancer. Am J Epidemiol. 2019;188(8):1512\u201328.","journal-title":"Am J Epidemiol"},{"key":"890_CR16","doi-asserted-by":"publisher","unstructured":"Osumi H, Matsusaka S, Wakatsuki T, Suenaga M, Shinozaki E, Mizunuma N. Angiotensin II type-1 receptor blockers enhance the effects of bevacizumab-based chemotherapy in metastatic colorectal cancer patients. Mol Clin Oncol.\u00a02015 [cited 2022 Jan 17];3(6):1295\u2013300. Available from: https:\/\/doi.org\/10.3892\/mco.2015.630.","DOI":"10.3892\/mco.2015.630"},{"key":"890_CR17","doi-asserted-by":"crossref","unstructured":"Zeman M, Ska\u0142ba W, Wilk AM, Cortez AJ, Maciejewski A, Czarniecka A. Impact of renin-angiotensin system inhibitors on the survival of patients with rectal cancer. BMC Cancer.\u00a02022;22(1).","DOI":"10.1186\/s12885-022-09919-0"},{"issue":"5","key":"890_CR18","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1593\/tlo.13346","volume":"6","author":"DR Engineer","year":"2013","unstructured":"Engineer DR, Burney BO, Hayes TG, Garcia JM. Exposure to ACEI\/ARB and \u03b2-blockers is associated with improved survival and decreased tumor progression and hospitalizations in patients with advanced colon cancer. Transl Oncol. 2013;6(5):539\u201345.","journal-title":"Transl Oncol"},{"key":"890_CR19","doi-asserted-by":"crossref","unstructured":"Deng Y, Xie Y, Wang M, et al. Effects of antihypertensive drugs use on risk and prognosis of colorectal cancer: a meta-analysis of 37 observational studies. Front Pharmacol.\u00a02022;12.","DOI":"10.3389\/fphar.2021.670657"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-022-00890-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-022-00890-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-022-00890-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T07:35:56Z","timestamp":1698478556000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-022-00890-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,19]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["890"],"URL":"https:\/\/doi.org\/10.1007\/s12029-022-00890-4","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"type":"print","value":"1941-6628"},{"type":"electronic","value":"1941-6636"}],"subject":[],"published":{"date-parts":[[2022,11,19]]},"assertion":[{"value":"13 November 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}