{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:20:59Z","timestamp":1783596059568,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Gastrointest Canc"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s12029-024-01034-6","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T01:01:40Z","timestamp":1708909300000},"page":"888-899","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prognostic Significance of Sarcopenia and Systemic Inflammatory Markers in Biliary Tract Cancer: A Retrospective Cohort Study"],"prefix":"10.1007","volume":"55","author":[{"given":"Masashi","family":"Utsumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kitada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Tokunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Yonoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Okabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Hamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Miyasou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousuke","family":"Tsunemitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Otsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"1034_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7\u201334. https:\/\/doi.org\/10.3322\/caac.21551.","journal-title":"CA Cancer J Clin"},{"key":"1034_CR2","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1007\/s00268-007-9001-y","volume":"31","author":"S Hasegawa","year":"2007","unstructured":"Hasegawa S, Ikai I, Fujii H, Hatano E, Shimahara Y. Surgical resection of hilar cholangiocarcinoma: analysis of survival and postoperative complications. World J Surg. 2007;31:1256\u201363. https:\/\/doi.org\/10.1007\/s00268-007-9001-y.","journal-title":"World J Surg"},{"key":"1034_CR3","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.hpb.2017.04.014","volume":"19","author":"S Buettner","year":"2017","unstructured":"Buettner S, van Vugt JLA, Gaspersz MP, Coelen RJS, Roos E, Labeur TA, Margonis GA, Ethun CG, Maithel SK, Poultsides G, Tran T, Idrees K, Isom CA, Fields RC, Krasnick BA, Weber SM, Salem A, Martin RCG, Scoggins CR, Shen P, Mogal HD, Schmidt C, Beal E, Hatzaras I, Shenoy R, IJermans JNM IJzermans, van Gulik TM, Pawlik TM, Groot Koerkamp B. Survival after resection of perihilar cholangiocarcinoma in patients with lymph node metastases. HPB (Oxford). 2017;19:735\u201340. https:\/\/doi.org\/10.1016\/j.hpb.2017.04.014.","journal-title":"HPB (Oxford)"},{"key":"1034_CR4","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.surg.2015.10.027","volume":"159","author":"H Saito","year":"2016","unstructured":"Saito H, Noji T, Okamura K, Tsuchikawa T, Shichinohe T, Hirano S. A new prognostic scoring system using factors available preoperatively to predict survival after operative resection of perihilar cholangiocarcinoma. Surgery. 2016;159:842\u201351. https:\/\/doi.org\/10.1016\/j.surg.2015.10.027.","journal-title":"Surgery"},{"key":"1034_CR5","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.nut.2014.07.005","volume":"31","author":"T Hanai","year":"2015","unstructured":"Hanai T, Shiraki M, Nishimura K, Ohnishi S, Imai K, Suetsugu A, Takai K, Shimizu M, Moriwaki H. Sarcopenia impairs prognosis of patients with liver cirrhosis. Nutrition. 2015;31:193\u20139. https:\/\/doi.org\/10.1016\/j.nut.2014.07.005.","journal-title":"Nutrition"},{"key":"1034_CR6","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.surg.2015.08.047","volume":"159","author":"S Okumura","year":"2016","unstructured":"Okumura S, Kaido T, Hamaguchi Y, Fujimoto Y, Kobayashi A, Iida T, Yagi S, Taura K, Hatano E, Uemoto S. Impact of the preoperative quantity and quality of skeletal muscle on outcomes after resection of extrahepatic biliary malignancies. Surgery. 2016;159:821\u201333. https:\/\/doi.org\/10.1016\/j.surg.2015.08.047.","journal-title":"Surgery"},{"key":"1034_CR7","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1093\/ajcn\/83.6.1345","volume":"83","author":"Fearon KC, Voss AC, Hustead DS; Cancer Cachexia Study Group","year":"2006","unstructured":"Fearon KC, Voss AC, Hustead DS, Cancer Cachexia Study Group. Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis. Am J Clin Nutr. 2006;83:1345\u201350. https:\/\/doi.org\/10.1093\/ajcn\/83.6.1345.","journal-title":"Am J Clin Nutr"},{"key":"1034_CR8","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1245\/s10434-017-5836-0","volume":"24","author":"JL Davis","year":"2017","unstructured":"Davis JL, Langan RC, Panageas KS, Zheng J, Postow MA, Brady MS, Ariyan C, Coit DG. Elevated blood neutrophil-to-lymphocyte ratio: a readily available biomarker associated with death due to disease in high risk nonmetastatic melanoma. Ann Surg Oncol. 2017;24:1989\u201396. https:\/\/doi.org\/10.1245\/s10434-017-5836-0.","journal-title":"Ann Surg Oncol"},{"key":"1034_CR9","doi-asserted-by":"publisher","first-page":"5805","DOI":"10.1158\/1078-0432.CCR-10-2245","volume":"16","author":"SC Kao","year":"2010","unstructured":"Kao SC, Pavlakis N, Harvie R, Vardy JL, Boyer MJ, van Zandwijk N, Clarke SJ. High blood neutrophil-to-lymphocyte ratio is an indicator of poor prognosis in malignant mesothelioma patients undergoing systemic therapy. Clin Cancer Res. 2010;16:5805\u201313. https:\/\/doi.org\/10.1158\/1078-0432.CCR-10-2245.","journal-title":"Clin Cancer Res"},{"key":"1034_CR10","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/jso.20329","volume":"91","author":"SR Walsh","year":"2005","unstructured":"Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol. 2005;91:181\u20134. https:\/\/doi.org\/10.1002\/jso.20329.","journal-title":"J Surg Oncol"},{"key":"1034_CR11","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.amjsurg.2007.12.057","volume":"197","author":"RA Smith","year":"2009","unstructured":"Smith RA, Bosonnet L, Raraty M, Sutton R, Neoptolemos JP, Campbell F, Ghaneh P. Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma. Am J Surg. 2009;197:466\u201372. https:\/\/doi.org\/10.1016\/j.amjsurg.2007.12.057.","journal-title":"Am J Surg"},{"key":"1034_CR12","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.asjsur.2022.07.122","volume":"46","author":"H Hayashi","year":"2023","unstructured":"Hayashi H, Shimizu A, Kubota K, Notake T, Masuo H, Yoshizawa T, Hosoda K, Sakai H, Yasukawa K, Soejima Y. Combination of sarcopenia and prognostic nutritional index to predict long-term outcomes in patients undergoing initial hepatectomy for hepatocellular carcinoma. Asian J Surg. 2023;46:816\u201323. https:\/\/doi.org\/10.1016\/j.asjsur.2022.07.122.","journal-title":"Asian J Surg"},{"key":"1034_CR13","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.3389\/fonc.2020.01581","volume":"10","author":"BM Lee","year":"2020","unstructured":"Lee BM, Cho Y, Kim JW, Jeung HC, Lee IJ. Prognostic significance of sarcopenia in advanced biliary tract cancer patients. Front Oncol. 2020;10:1581. https:\/\/doi.org\/10.3389\/fonc.2020.01581.","journal-title":"Front Oncol"},{"key":"1034_CR14","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00534-005-0999-7","volume":"12","author":"SM Strasberg","year":"2005","unstructured":"Strasberg SM. Nomenclature of hepatic anatomy and resections: a review of the Brisbane 2000 system. J Hepatobiliary Pancreat Surg. 2005;12:351\u20135. https:\/\/doi.org\/10.1007\/s00534-005-0999-7.","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"1034_CR15","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","volume":"250","author":"PA Clavien","year":"2009","unstructured":"Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, De Santiba\u00f1es E, Pekolj J, Slankamenac K, Bassi C, Graf R, Vonlanthen R, Padbury R, Cameron JL, Makuuchi M. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg. 2009;250:187\u201396. https:\/\/doi.org\/10.1097\/SLA.0b013e3181b13ca2.","journal-title":"Ann Surg"},{"key":"1034_CR16","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.surg.2015.02.002","volume":"157","author":"S Okumura","year":"2015","unstructured":"Okumura S, Kaido T, Hamaguchi Y, Fujimoto Y, Masui T, Mizumoto M, Hammad A, Mori A, Takaori K, Uemoto S. Impact of preoperative quality as well as quantity of skeletal muscle on survival after resection of pancreatic cancer. Surgery. 2015;157:1088\u201398. https:\/\/doi.org\/10.1016\/j.surg.2015.02.002.","journal-title":"Surgery"},{"key":"1034_CR17","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1002\/bjs.7305","volume":"98","author":"M Kanda","year":"2011","unstructured":"Kanda M, Fujii T, Kodera Y, Nagai S, Takeda S, Nakao A. Nutritional predictors of postoperative outcome in pancreatic cancer. Br J Surg. 2011;98:268\u201374. https:\/\/doi.org\/10.1002\/bjs.7305.","journal-title":"Br J Surg"},{"key":"1034_CR18","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/sj.bjc.6605855","volume":"103","author":"MJ Proctor","year":"2010","unstructured":"Proctor MJ, Talwar D, Balmar SM, O\u2019Reilly DS, Foulis AK, Horgan PG, Morrison DS, McMillan DC. The relationship between the presence and site of cancer, an inflammation-based prognostic score and biochemical parameters. Initial results of the Glasgow Inflammation Outcome Study. Br J Cancer. 2010;103:870\u20136. https:\/\/doi.org\/10.1038\/sj.bjc.6605855.","journal-title":"Br J Cancer"},{"key":"1034_CR19","doi-asserted-by":"publisher","first-page":"30","DOI":"10.7861\/clinmedicine.9-1-30","volume":"9","author":"E Fairclough","year":"2009","unstructured":"Fairclough E, Cairns E, Hamilton J, Kelly C. Evaluation of a modified early warning system for acute medical admissions and comparison with C-reactive protein\/albumin ratio as a predictor of patient outcome. Clin Med (Lond). 2009;9:30\u20133. https:\/\/doi.org\/10.7861\/clinmedicine.9-1-30.","journal-title":"Clin Med (Lond)"},{"key":"1034_CR20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.currproblcancer.2011.01.001","volume":"35","author":"NP Gullett","year":"2011","unstructured":"Gullett NP, Mazurak VC, Hebbar G, Ziegler TR. Nutritional interventions for cancer-induced cachexia. Curr Probl Cancer. 2011;35:58\u201390. https:\/\/doi.org\/10.1016\/j.currproblcancer.2011.01.001.","journal-title":"Curr Probl Cancer"},{"key":"1034_CR21","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1002\/jcsm.12431","volume":"10","author":"SB Yoon","year":"2019","unstructured":"Yoon SB, Choi MH, Song M, Lee JH, Lee IS, Lee MA, Hong TH, Jung ES, Choi MG. Impact of preoperative body compositions on survival following resection of biliary tract cancer. J Cachexia Sarcopenia Muscle. 2019;10:794\u2013802. https:\/\/doi.org\/10.1002\/jcsm.12431.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"1034_CR22","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1186\/s12876-021-01957-5","volume":"21","author":"M Utsumi","year":"2021","unstructured":"Utsumi M, Kitada K, Tokunaga N, Kato T, Narusaka T, Hamano R, Miyasou H, Tsunemitsu Y, Otsuka S, Inagaki M. A combined prediction model for biliary tract cancer using the prognostic nutritional index and pathological findings: a single-center retrospective study. BMC Gastroenterol. 2021;21:375. https:\/\/doi.org\/10.1186\/s12876-021-01957-5.","journal-title":"BMC Gastroenterol"},{"key":"1034_CR23","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1002\/jso.23900","volume":"111","author":"G Spolverato","year":"2015","unstructured":"Spolverato G, Maqsood H, Kim Y, Margonis GA, Luo T, Ejaz A, Pawlik TM. Neutrophil-lymphocyte and platelet-lymphocyte ratio in patients after resection for hepato-pancreatico-biliary malignancies. J Surg Oncol. 2015;111:868\u201374. https:\/\/doi.org\/10.1002\/jso.23900.","journal-title":"J Surg Oncol"},{"key":"1034_CR24","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1245\/s10434-020-08728-8","volume":"28","author":"J Wang","year":"2021","unstructured":"Wang J, Bo X, Li M, Nan L, Wang C, Gao Z, Suo T, Ni X, Liu H, Han J, Lu P, Liu H, Wang Y. Prediction efficacy for clinical outcome of prognostic nutritional index in patients with resectable biliary tract cancer depends on sex and obstructive jaundice status. Ann Surg Oncol. 2021;28:430\u20138. https:\/\/doi.org\/10.1245\/s10434-020-08728-8.","journal-title":"Ann Surg Oncol"},{"key":"1034_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229597","volume":"15","author":"YJ Yoo","year":"2020","unstructured":"Yoo YJ, Kang CM, Choi M, Rho SY, Hwang HK, Lee WJ, Kim EW, Lee JA. Preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer. PLoS ONE. 2020;15: e0229597. https:\/\/doi.org\/10.1371\/journal.pone.0229597.","journal-title":"PLoS ONE"},{"key":"1034_CR26","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1038\/bjc.2012.456","volume":"107","author":"T Kantola","year":"2012","unstructured":"Kantola T, Klintrup K, V\u00e4yrynen JP, Vornanen J, Bloigu R, Karhu T, Herzig KH, N\u00e4p\u00e4nkangas J, M\u00e4kel\u00e4 J, Karttunen TJ, Tuomisto A, M\u00e4kinen MJ. Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma. Br J Cancer. 2012;107:1729\u201336. https:\/\/doi.org\/10.1038\/bjc.2012.456.","journal-title":"Br J Cancer"},{"key":"1034_CR27","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.arr.2016.09.008","volume":"35","author":"A Kalinkovich","year":"2017","unstructured":"Kalinkovich A, Livshits G. Sarcopenic obesity or obese sarcopenia: a cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis. Ageing Res Rev. 2017;35:200\u201321. https:\/\/doi.org\/10.1016\/j.arr.2016.09.008.","journal-title":"Ageing Res Rev"},{"key":"1034_CR28","doi-asserted-by":"publisher","first-page":"4935","DOI":"10.2147\/CMAR.S175421","volume":"10","author":"J Lin","year":"2018","unstructured":"Lin J, Zhang W, Huang Y, Chen W, Wu R, Chen X, Lou N, Wang P. Sarcopenia is associated with the neutrophil\/lymphocyte and platelet\/lymphocyte ratios in operable gastric cancer patients: a prospective study. Cancer Manag Res. 2018;10:4935\u201344. https:\/\/doi.org\/10.2147\/CMAR.S175421.","journal-title":"Cancer Manag Res"},{"key":"1034_CR29","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1111\/ajt.12221","volume":"13","author":"T Kaido","year":"2013","unstructured":"Kaido T, Ogawa K, Fujimoto Y, Ogura Y, Hata K, Ito T, Tomiyama K, Yagi S, Mori A, Uemoto S. Impact of sarcopenia on survival in patients undergoing living donor liver transplantation. Am J Transplant. 2013;13:1549\u201356. https:\/\/doi.org\/10.1111\/ajt.12221.","journal-title":"Am J Transplant"},{"key":"1034_CR30","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.surg.2011.07.045","volume":"150","author":"NE Mayo","year":"2011","unstructured":"Mayo NE, Feldman L, Scott S, Zavorsky G, Kim DJ, Charlebois P, Stein B, Carli F. Impact of preoperative change in physical function on postoperative recovery: argument supporting prehabilitation for colorectal surgery. Surgery. 2011;150:505\u201314. https:\/\/doi.org\/10.1016\/j.surg.2011.07.045.","journal-title":"Surgery"}],"container-title":["Journal of Gastrointestinal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-024-01034-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12029-024-01034-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12029-024-01034-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T01:10:01Z","timestamp":1718845801000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12029-024-01034-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["1034"],"URL":"https:\/\/doi.org\/10.1007\/s12029-024-01034-6","relation":{},"ISSN":["1941-6628","1941-6636"],"issn-type":[{"value":"1941-6628","type":"print"},{"value":"1941-6636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,26]]},"assertion":[{"value":"15 February 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of the National Hospital Organization Fukuyama Medical Center, Fukuyama, Hiroshima, Japan (No. ERB2022027).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The requirement for written informed consent was waived owing to the retrospective nature of the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}