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This study aimed to analyze trends and disparities in gastric malignancy mortality across socio-demographic and regional factors in the United States (US) from 1999 to 2020.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A retrospective analysis was conducted using CDC WONDER data from 1999 to 2020 for adults aged\u2009\u2265\u200925\u00a0years. Data on demographics (age, sex, race\/ethnicity), urban\u2013rural classification, and regional trends were extracted. Age-adjusted mortality rates (AAMR) were calculated using the 2000 U.S. population as a reference, with trends analyzed using Joinpoint regression to determine annual percentage changes (APC) with statistical significance (P\u2009&lt;\u20090.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Between 1999 and 2020, 276,023 deaths due to gastric malignancies were recorded, with 59.3% occurring among males. The AAMR declined from 7.94 in 1999 to 4.66 in 2020, with an overall AAMR of 5.82. The 65\u2009+\u2009age group had the highest AAMR (20.83), while the 25\u201344 age group had the lowest (0.74). Males consistently reported higher AAMRs (7.60) than females (4.85). NH Black individuals had the highest overall AAMR (10.82), while NH White individuals had the lowest (4.62). Urban areas had higher AAMRs (5.95) than rural areas (5.07).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Mortality from gastric malignancies has declined in the U.S. from 1999 to 2020; however, higher mortality rates in NH Black individuals, males, and urban dwellers highlight the need for targeted interventions and equitable access to prevention and treatment resources. Future research should focus on identifying actionable solutions to mitigate these gaps.\n<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s12029-025-01295-9","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T10:21:34Z","timestamp":1754389294000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Trends and Disparities in Mortality Due to Gastric Malignancies the United States: A Nationwide Analysis from 1999 to 2020"],"prefix":"10.1007","volume":"56","author":[{"given":"Muhammad","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aizaz","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahreem","family":"Mari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariha","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Sharbatji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malik Waleed Zeb","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jibran","family":"Ikram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"issue":"1","key":"1295_CR1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1097\/MCG.0000000000001811","volume":"58","author":"KS Liu","year":"2024","unstructured":"Liu KS, Raza SA, El-Serag HB, Thrift AP. 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