{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:47:32Z","timestamp":1780469252372,"version":"3.54.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2002,8]]},"DOI":"10.1007\/s12031-002-0026-2","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T17:49:12Z","timestamp":1181065752000},"page":"155-161","source":"Crossref","is-referenced-by-count":111,"title":["Statin therapy for Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"19","author":[{"given":"Suzana S.","family":"Petanceska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"DeRosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Olm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichole","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Thomas-Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Duff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Pappolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo M.","family":"Refolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"26_CR1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","volume":"21","author":"H. Akiyama","year":"2000","unstructured":"Akiyama H., Barger S., Barnum S., et al. (2000) Inflammation and Alzheimer\u2019s disease. Neurobiol. Aging 21, 383\u2013421.","journal-title":"Neurobiol. Aging"},{"key":"26_CR2","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1074\/jbc.271.8.4436","volume":"271","author":"S. Bodovitz","year":"1996","unstructured":"Bodovitz S. and Klein W. L. (1996) Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein. J. Biol. Chem. 271, 4436\u20134440.","journal-title":"J. Biol. Chem."},{"key":"26_CR3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0002-8703(00)90033-4","volume":"4","author":"R. S. Blumenthal","year":"2000","unstructured":"Blumenthal R. S. (2000) Statins: effective antiatherosclerotic therapy. Am. Heart 4, 577\u2013583.","journal-title":"Am. Heart"},{"key":"26_CR4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0022-510X(01)00529-9","volume":"187","author":"B. Cucchiara","year":"2001","unstructured":"Cucchiara B. and Kasner S. E. (2001) Use of statins in CNS disorders. J. Neurol. Sci. 187, 81\u201389.","journal-title":"J. Neurol. Sci."},{"key":"26_CR5","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1212\/WNL.54.1.240","volume":"54","author":"R. M. Evans","year":"2000","unstructured":"Evans R. M., Emsley C. L., Gao S., Sahota A., Hall K. S., Farlow M. R., and Hendrie H. (2000) Serum cholesterol, APOE genotype, and the risk of Alzheimer\u2019s disease: a population-based study of African Americans. Neurology 54, 240\u2013242.","journal-title":"Neurology"},{"key":"26_CR6","doi-asserted-by":"crossref","first-page":"5856","DOI":"10.1073\/pnas.081620098","volume":"98","author":"K. Fassbender","year":"2001","unstructured":"Fassbender K., Simons M., Bergmann C., et al. (2001) Simvastatin strongly reduces levels of Alzheimer\u2019s disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc. Natl. Acad. Sci. USA 98, 5856\u20135861.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"26_CR7","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1097\/00001756-199906030-00014","volume":"10","author":"E. R. Frears","year":"1999","unstructured":"Frears E. R., Stephens D. J., Walters C. E., Davies H., and Austen B. M. (1999) The role of cholesterol in the biosynthesis of beta-amyloid. Neuroreport 10, 1699\u20131705.","journal-title":"Neuroreport"},{"key":"26_CR8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1017\/S1461145701002310","volume":"4","author":"L. T. Friedhoff","year":"2001","unstructured":"Friedhoff L. T., Cullen E. I., Geoghagen N. S., et al. (2001) Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide. Int. J. Neuropsychopharmacol. 4, 127\u2013130.","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"26_CR9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0165-6147(97)01147-4","volume":"19","author":"B. A. Hamelin","year":"1998","unstructured":"Hamelin B. A. and Turgeon J. (1998) Hydrophilicity\/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. Trends Pharmacol. Sci. 19, 26\u201337.","journal-title":"Trends Pharmacol. Sci."},{"key":"26_CR10","doi-asserted-by":"crossref","first-page":"16576","DOI":"10.1074\/jbc.273.26.16576","volume":"273","author":"D. S. Howland","year":"1998","unstructured":"Howland D. S., Trusko S. P., Savage M. J., et al. (1998) Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol. J. Biol. Chem. 273, 16576\u201316582.","journal-title":"J. Biol. Chem."},{"key":"26_CR11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nm0198-097","volume":"4","author":"L. Holcomb","year":"1998","unstructured":"Holcomb L., Gordon M. N., McGowan E., et al. (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4, 97\u2013100.","journal-title":"Nat. Med."},{"key":"26_CR12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1042\/bse0330117","volume":"33","author":"M. Hutton","year":"1998","unstructured":"Hutton M., Perez-Tur J., and Hardy J. (1998) Genetics of Alzheimer\u2019s disease. Essays Biochem. 33, 117\u2013131.","journal-title":"Essays Biochem."},{"key":"26_CR13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/gepi.1370110407","volume":"11","author":"G. P. Jarvik","year":"1994","unstructured":"Jarvik G. P., Austin M. A., Fabsitz R. R., et al. (1994) Genetic influences on age-related change in total cholesterol, low-density lipoprotein-cholesterol, and triglyceride levels: longitudinal apolipoprotein E genotype effects. Genet. Epidemiol. 11, 375\u2013384.","journal-title":"Genet. Epidemiol."},{"key":"26_CR14","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1212\/WNL.45.6.1092","volume":"45","author":"G. P. Jarvik","year":"1995","unstructured":"Jarvik G. P., Wijsman E. M., Kukull W. A., et al. (1995) Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer\u2019s disease: a case-control study. Neurology 45, 1092\u20131096.","journal-title":"Neurology"},{"key":"26_CR15","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(00)03155-X","volume":"356","author":"H. Jick","year":"2000","unstructured":"Jick H., Zornberg G. L., Jick S. S., Seshadri S., and Drachman D. A. (2000) Statins and the risk of dementia. Lancet 356, 1627\u20131631.","journal-title":"Lancet"},{"key":"26_CR16","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/ana.410420514","volume":"42","author":"S. Kalmijn","year":"1997","unstructured":"Kalmijn S., Launer L. J., Ott A., et al. (1997) Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann. Neurol. 42, 776\u2013782.","journal-title":"Ann. Neurol."},{"key":"26_CR17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1161\/01.CIR.101.2.207","volume":"101","author":"D. J. Maron","year":"2000","unstructured":"Maron D. J., Fazio S., and Linton M. F. (2000) Current perspectives on statins. Circulation 101, 207\u2013213.","journal-title":"Circulation"},{"key":"26_CR18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0005-2736(98)00097-2","volume":"1373","author":"T. Mizuno","year":"1998","unstructured":"Mizuno T., Haass C., Michikawa M., et al. (1998) Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK cells. Biochim. Biophys. Acta 1373, 119\u2013130.","journal-title":"Biochim. Biophys. Acta"},{"key":"26_CR19","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0024-3205(99)00199-X","volume":"13","author":"M. H. Moghadasian","year":"1999","unstructured":"Moghadasian M. H. (1999) Clinical pharmacology of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Life Sci. 13, 1329\u20131337.","journal-title":"Life Sci."},{"key":"26_CR20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000026149","volume":"17","author":"I. L. Notkola","year":"1998","unstructured":"Notkola I. L., Sulkava R., Pekkanen J., et al. (1998) Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer\u2019s disease. Neuroepidemiology 17, 14\u201320.","journal-title":"Neuroepidemiology"},{"key":"26_CR21","doi-asserted-by":"crossref","unstructured":"Puglielli L., Konopka G., Pack-Chung E., et al. (2001) Acylcoenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat. Cell Biol. 905\u2013912.","DOI":"10.1038\/ncb1001-905"},{"key":"26_CR22","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/nbdi.2000.0304","volume":"7","author":"L. M. Refolo","year":"2000","unstructured":"Refolo L. M., Pappolla M. A., Malester B., et al. (2000) Hypercholesterolemia accelerates the Alzheimer\u2019s amyloid pathology in a transgenic mouse model. Neurobiol. Dis. 7, 321\u2013331.","journal-title":"Neurobiol. Dis."},{"key":"26_CR23","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1006\/nbdi.2001.0422","volume":"5","author":"L. M. Refolo","year":"2001","unstructured":"Refolo L. M., Pappolla M. A., LaFrancois J., et al. (2001) A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer\u2019s disease. Neurobiol. Dis. 5, 890\u2013899.","journal-title":"Neurobiol. Dis."},{"key":"26_CR24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3109\/13506129909007315","volume":"6","author":"A. E. Roher","year":"1999","unstructured":"Roher A. E., Kuo Y. M., Kokjohn K. M., et al. (1999) Amyloid and lipids in the pathology of Alzheimer disease. Amyloid 6, 136\u2013145.","journal-title":"Amyloid"},{"key":"26_CR25","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.1073\/pnas.95.11.6460","volume":"95","author":"M. Simons","year":"1998","unstructured":"Simons M., Keller P., De Strooper B., et al. (1998) Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc. Natl. Acad. Sci. USA 95, 6460\u20136464.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"26_CR26","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/exnr.1994.1044","volume":"126","author":"D. L. Sparks","year":"1994","unstructured":"Sparks D. L., Scheff S. W., Hunsaker J. C., et al. (1994) Induction of Alzheimer\u2019s-like beta-amyloid immunore-activity in brains of rabbits with dietary cholesterol. Exp. Neurol. 126, 88\u201394.","journal-title":"Exp. Neurol."},{"key":"26_CR27","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1749-6632.1997.tb48466.x","volume":"826","author":"D. L. Sparks","year":"1997","unstructured":"Sparks D. L. (1997) Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer\u2019s disease? Ann. NY Acad. Sci. 826, 128\u2013146.","journal-title":"Ann. NY Acad. Sci."},{"key":"26_CR28","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/1097-0029(20000815)50:4<287::AID-JEMT7>3.0.CO;2-L","volume":"50","author":"D. L. Sparks","year":"2000","unstructured":"Sparks D. L., Martin T. A., Gross D. G., and Hunsaker J. C. III (2000) Link between heart disease, cholesterol, and alzheimer\u2019s disease: a review. Microscopy Res. Technique 50, 287\u2013290.","journal-title":"Microscopy Res. Technique"},{"key":"26_CR29","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/ana.112","volume":"49","author":"T. Tokuda","year":"2001","unstructured":"Tokuda T., Tamaoka A., Matsuno S., et al. (2001) Plasma levels of amyloid beta proteins did not differ between subjects taking statins and those not taking statins. Ann. Neurol. 49, 546\u2013547.","journal-title":"Ann. Neurol."},{"key":"26_CR30","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/archneur.57.10.1439","volume":"57","author":"B. Wolozin","year":"2000","unstructured":"Wolozin B., Kellman W., Ruosseau P., et al. (2000) Decreased prevalence of Alzheimer\u2019s disease associated with 3-hydroxy3-methylglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 57, 1439\u20131443.","journal-title":"Arch. Neurol."},{"key":"26_CR31","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1073\/pnas.101123198","volume":"98","author":"B. Wolozin","year":"2001","unstructured":"Wolozin B. (2001) A fluid connection: cholesterol and Abeta. Proc. Natl. Acad. Sci. USA 98, 5371\u20135373.","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-002-0026-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-002-0026-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-002-0026-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T22:19:11Z","timestamp":1559427551000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-002-0026-2"}},"subtitle":["Will it work?"],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":31,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["26"],"URL":"https:\/\/doi.org\/10.1007\/s12031-002-0026-2","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}