{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:15:33Z","timestamp":1777565733917,"version":"3.51.4"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2002,8]]},"DOI":"10.1007\/s12031-002-0027-1","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:49:12Z","timestamp":1181080152000},"page":"163-166","source":"Crossref","is-referenced-by-count":19,"title":["Ovariectomy of young mutant amyloid precursor protein transgenic mice leads to increased mortality"],"prefix":"10.1007","volume":"19","author":[{"given":"Justine A.","family":"Levin-Allerhand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"27_CR1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0896-6273(00)80974-5","volume":"19","author":"D. R. Borchelt","year":"1997","unstructured":"Borchelt D. R., Ratovitski T., van Lare J., Lee M. K., Gonzales V., Jenkins N. A., et al. (1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19, 939\u2013945.","journal-title":"Neuron"},{"key":"27_CR2","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1093\/hmg\/6.11.1951","volume":"6","author":"G. A. Carlson","year":"1997","unstructured":"Carlson G. A., Borchelt D. R., Dake A., Turner S., Danielson V., Coffin J. D., et al. (1997) Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice. Hum. Mol. Genet. 6, 1951\u20131959.","journal-title":"Hum. Mol. Genet."},{"key":"27_CR3","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/0896-6273(95)90107-8","volume":"15","author":"K. K. Hsiao","year":"1995","unstructured":"Hsiao K. K., Borchelt D. R., Olson K., Johannsdottir R., Kitt C., Yunis W., et al. (1995) Age-related CNS disorder and early death in transgenic FVB\/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 15, 1203\u20131218.","journal-title":"Neuron"},{"key":"27_CR4","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/0003-2697(78)90586-9","volume":"87","author":"M. A. Markwell","year":"1978","unstructured":"Markwell M. A., Haas S. M., Bieber L. L., and Tolbert N. E. (1978) A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87, 206\u2013210.","journal-title":"Anal. Biochem."},{"key":"27_CR5","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.1074\/jbc.274.10.6483","volume":"274","author":"D. Moechars","year":"1999","unstructured":"Moechars D., Dewachter I., Lorent K., Reverse D., Baekelandt V., Naidu A., et al. (1999) Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J. Biol. Chem. 274, 6483\u20136492.","journal-title":"J. Biol. Chem."},{"key":"27_CR6","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0306-4522(98)00599-5","volume":"91","author":"D. Moechars","year":"1999","unstructured":"Moechars D., Lorent K., and Van Leuven F. (1999) Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis. Neuroscience 91, 819\u2013830.","journal-title":"Neuroscience"},{"key":"27_CR7","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0531-5565(00)00157-1","volume":"35","author":"S. S. Petanceska","year":"2000","unstructured":"Petanceska S. S., Nagy V., Frail D., and Gandy S. (2000) Ovariectomy and 17beta-estradiol modulate the levels of Alzheimer\u2019s amyloid beta peptides in brain. Exp. Gerontol. 35, 1317\u20131325.","journal-title":"Exp. Gerontol."},{"key":"27_CR8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nm0498-447","volume":"4","author":"H. Xu","year":"1998","unstructured":"Xu H., Gouras G. K., Greenfield J. P., Vincent B., Naslund J., Mazzarelli L., et al. (1998) Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat. Med. 4, 447\u2013451.","journal-title":"Nat. Med."}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-002-0027-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-002-0027-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-002-0027-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T02:19:11Z","timestamp":1559441951000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-002-0027-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":8,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["27"],"URL":"https:\/\/doi.org\/10.1007\/s12031-002-0027-1","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}