{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:26:55Z","timestamp":1773944815262,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T00:00:00Z","timestamp":1241740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1007\/s12031-009-9205-8","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T08:05:19Z","timestamp":1241683519000},"page":"250-256","source":"Crossref","is-referenced-by-count":40,"title":["Effect of BDNF Val66Met Polymorphism on Digital Working Memory and Spatial Localization in a Healthy Chinese Han Population"],"prefix":"10.1007","volume":"38","author":[{"given":"Pingyuan","family":"Gong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anyun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanhua","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changchao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaocai","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuchang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,5,8]]},"reference":[{"key":"9205_CR1","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/nn1201-1153","volume":"4","author":"R Plomin","year":"2001","unstructured":"Plomin, R., & Kosslyn, S. M. (2001). Genes, brain and cognition. Nature Neuroscience, 4, 1153\u20131154. doi: 10.1038\/nn1201-1153 .","journal-title":"Nature Neuroscience"},{"key":"9205_CR2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1601-183X.2008.00470.x","volume":"8","author":"LM Houlihan","year":"2009","unstructured":"Houlihan, L. M., Harris, S. E., et al. (2009). Replication study of candidate genes for cognitive abilities: The Lothian birth cohort 1936. Genes Brain Behav, 8, 238\u2013247.","journal-title":"Genes Brain Behav"},{"key":"9205_CR3","doi-asserted-by":"crossref","first-page":"12604","DOI":"10.1073\/pnas.0405077101","volume":"101","author":"MF Egan","year":"2004","unstructured":"Egan, M. F., Straub, R. E., et al. (2004). Variation in Grm3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 101, 12604\u201312609. doi: 10.1073\/pnas.0405077101 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"9205_CR4","doi-asserted-by":"crossref","first-page":"12536","DOI":"10.1073\/pnas.0610125104","volume":"104","author":"HY Tan","year":"2007","unstructured":"Tan, H. Y., Chen, Q., et al. (2007). Epistasis between catechol-o-methyltransferase and type Ii metabotropic glutamate receptor 3 genes on working memory brain function. Proceedings of the National Academy of Sciences of the United States of America, 104, 12536\u201312541. doi: 10.1073\/pnas.0610125104 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"9205_CR5","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/0888-7543(92)90060-6","volume":"13","author":"IM Hanson","year":"1992","unstructured":"Hanson, I. M., Seawright, A., et al. (1992). The human Bdnf gene maps between Fshb and Hvbs1 at the boundary of 11p13\u2013P14. Genomics, 13, 1331\u20131333. doi: 10.1016\/0888-7543(92)90060-6 .","journal-title":"Genomics"},{"key":"9205_CR6","doi-asserted-by":"crossref","first-page":"11321","DOI":"10.1074\/jbc.274.16.11321","volume":"274","author":"JB Easton","year":"1999","unstructured":"Easton, J. B., Moody, N. M., et al. (1999). Brain-derived neurotrophic factor induces phosphorylation of fibroblast growth factor receptor substrate 2. The Journal of Biological Chemistry, 274, 11321\u201311327. doi: 10.1074\/jbc.274.16.11321 .","journal-title":"The Journal of Biological Chemistry"},{"key":"9205_CR7","first-page":"934","volume":"38","author":"ZL Wang","year":"2007","unstructured":"Wang, Z. L., Mao, M., et al. (2007). Signaling pathway of Bdnf protecting embryonic cortical neurons from hypoxia. Sichuan Da Xue Xue Bao Yi Xue Ban, 38, 934\u2013937.","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"9205_CR8","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1111\/j.1460-9568.1996.tb01196.x","volume":"8","author":"J Zhou","year":"1996","unstructured":"Zhou, J., Bradford, H. F., et al. (1996). Induction of dopaminergic neurotransmitter phenotype in rat embryonic cerebrocortex by the synergistic action of neurotrophins and dopamine. The European Journal of Neuroscience, 8, 2328\u20132339. doi: 10.1111\/j.1460-9568.1996.tb01196.x .","journal-title":"The European Journal of Neuroscience"},{"key":"9205_CR9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.expneurol.2006.02.129","volume":"201","author":"IK Hwang","year":"2006","unstructured":"Hwang, I. K., Yoo, K. Y., et al. (2006). Correlations between neuronal loss, decrease of memory, and decrease expression of brain-derived neurotrophic factor in the gerbil hippocampus during normal aging. Experimental Neurology, 201, 75\u201383. doi: 10.1016\/j.expneurol.2006.02.129 .","journal-title":"Experimental Neurology"},{"key":"9205_CR10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0014-4886(03)00061-X","volume":"181","author":"HA Bimonte-Nelson","year":"2003","unstructured":"Bimonte-Nelson, H. A., Singleton, R. S., et al. (2003). Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats. Experimental Neurology, 181, 301\u2013312. doi: 10.1016\/S0014-4886(03)00061-X .","journal-title":"Experimental Neurology"},{"key":"9205_CR11","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.neuroscience.2008.03.038","volume":"153","author":"MS Costa","year":"2008","unstructured":"Costa, M. S., Botton, P. H., et al. (2008). Caffeine prevents age-associated recognition memory decline and changes brain-derived neurotrophic factor and tirosine kinase receptor (Trkb) content in mice. Neuroscience, 153, 1071\u20131078. doi: 10.1016\/j.neuroscience.2008.03.038 .","journal-title":"Neuroscience"},{"key":"9205_CR12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.mp.4001799","volume":"11","author":"SE Harris","year":"2006","unstructured":"Harris, S. E., Fox, H., et al. (2006). The brain-derived neurotrophic factor Val66met polymorphism is associated with age-related change in reasoning skills. Molecular Psychiatry, 11, 505\u2013513. doi: 10.1038\/sj.mp. 4001799 .","journal-title":"Molecular Psychiatry"},{"key":"9205_CR13","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1136\/ard.2006.051623","volume":"65","author":"G Oroszi","year":"2006","unstructured":"Oroszi, G., Lapteva, L., et al. (2006). The Met66 allele of the functional Val66met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus. Annals of the Rheumatic Diseases, 65, 1330\u20131335. doi: 10.1136\/ard.2006.051623 .","journal-title":"Annals of the Rheumatic Diseases"},{"key":"9205_CR14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/9780470751251.ch10","volume":"289","author":"B Lu","year":"2008","unstructured":"Lu, B., & Martinowich, K. (2008). Cell biology of Bdnf and its relevance to schizophrenia. Novartis Foundation Symposium, 289, 119\u2013129. discussion 129\u2013135, 193\u2013115.","journal-title":"Novartis Foundation Symposium"},{"key":"9205_CR15","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1586\/14737175.8.7.1101","volume":"8","author":"F Kapczinski","year":"2008","unstructured":"Kapczinski, F., Frey, B. N., et al. (2008). Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder. Expert Review of Neurotherapeutics, 8, 1101\u20131113. doi: 10.1586\/14737175.8.7.1101 .","journal-title":"Expert Review of Neurotherapeutics"},{"key":"9205_CR16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biopsycho.2007.08.009","volume":"77","author":"TE Goldberg","year":"2008","unstructured":"Goldberg, T. E., Iudicello, J., et al. (2008). Bdnf Val66met polymorphism significantly affects D' in verbal recognition memory at short and long delays. Biological Psychology, 77, 20\u201324. doi: 10.1016\/j.biopsycho.2007.08.009 .","journal-title":"Biological Psychology"},{"key":"9205_CR17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0920-9964(02)00505-4","volume":"65","author":"G Szekeres","year":"2003","unstructured":"Szekeres, G., Juhasz, A., et al. (2003). The C270t polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia. Schizophrenia Research, 65, 15\u201318. doi: 10.1016\/S0920-9964(02)00505-4 .","journal-title":"Schizophrenia Research"},{"key":"9205_CR18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/ajmg.b.30406","volume":"144B","author":"X Xu","year":"2007","unstructured":"Xu, X., Mill, J., Zhou, K., Brookes, K., Chen, C. K., & Asherson, P. (2007). Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples. American Journal of Medical Genetics. Part B, Neuropsychiatric genetics: The Official Publication of the International Society of Psychiatric Genetics, 144B, 83\u201386. doi: 10.1002\/ajmg.b.30406 .","journal-title":"American Journal of Medical Genetics. Part B, Neuropsychiatric genetics: The Official Publication of the International Society of Psychiatric Genetics"},{"key":"9205_CR19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3758\/BF03198553","volume":"28","author":"M Hegarty","year":"2000","unstructured":"Hegarty, M., Shah, P., et al. (2000). Constraints on using the dual-task methodology to specify the degree of central executive involvement in cognitive tasks. Memory & Cognition, 28, 376\u2013385.","journal-title":"Memory & Cognition"},{"key":"9205_CR20","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1037\/0278-7393.33.3.615","volume":"33","author":"MJ Kane","year":"2007","unstructured":"Kane, M. J., Conway, A. R., Miura, T. K., & Colflesh, G. J. (2007). Working memory, attention control, and the N-back task: A question of construct validity. Journal of Experimental Psychology. Learning, Memory, and Cognition, 33, 615\u2013622. doi: 10.1037\/0278-7393.33.3.615 .","journal-title":"Journal of Experimental Psychology. Learning, Memory, and Cognition"},{"issue":"4","key":"9205_CR21","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1037\/0882-7974.15.4.635","volume":"15","author":"S Nieuwenhuis","year":"2000","unstructured":"Nieuwenhuis, S., Ridderinkhof, K. R., de Jong, R., Kok, A., & van der Molen, M. W. (2000). Inhibitory inefficiency and failures of intention activation: Age-related decline in the control of saccadic eye movements. Psychology and aging, 15(4), 635\u201347. doi: 10.1037\/0882-7974.15.4.635 .","journal-title":"Psychology and aging"},{"key":"9205_CR22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/cogp.1999.0734","volume":"41","author":"A Miyake","year":"2000","unstructured":"Miyake, A., Friedman, N. P., et al. (2000). The unity and diversity of executive functions and their contributions to complex \u201cfrontal lobe\u201d tasks: A latent variable analysis. Cognitive Psychology, 41, 49\u2013100. doi: 10.1006\/cogp.1999.0734 .","journal-title":"Cognitive Psychology"},{"key":"9205_CR23","first-page":"453","volume":"5","author":"CL Deming Li","year":"2001","unstructured":"Deming Li, C. L., & Li, G. (2001). The construction of \u201cbasic cognitive capacity test\u201d and it's standardization. Journal of Chinese Psychology Acta Psychologica Sinica, 5, 453\u2013460.","journal-title":"Journal of Chinese Psychology Acta Psychologica Sinica"},{"key":"9205_CR24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3109\/00207458608986153","volume":"29","author":"HW Gordon","year":"1986","unstructured":"Gordon, H. W. (1986). The cognitive laterality battery: Tests of specialized cognitive function. The International Journal of Neuroscience, 29, 223\u2013244.","journal-title":"The International Journal of Neuroscience"},{"key":"9205_CR25","first-page":"55","volume":"13","author":"FH Xufeng Liu","year":"2004","unstructured":"Xufeng Liu, F. H., Miao, D., Qi, J., Wang, W., Liu, L., & Chao, Y. (2004). Relationship between spatial ability and variables of mental rotation. Chinese Journal of Behavioral Medical Science, 13, 55\u201356.","journal-title":"Chinese Journal of Behavioral Medical Science"},{"key":"9205_CR26","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1080\/01688639008401004","volume":"12","author":"DI Margolin","year":"1990","unstructured":"Margolin, D. I., Pate, D. S., et al. (1990). Dysnomia in dementia and in stroke patients: Different underlying cognitive deficits. Journal of Clinical and Experimental Neuropsychology, 12, 597\u2013612. doi: 10.1080\/01688639008401004 .","journal-title":"Journal of Clinical and Experimental Neuropsychology"},{"key":"9205_CR27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1207\/S15324826AN0803_5","volume":"8","author":"AS Loonstra","year":"2001","unstructured":"Loonstra, A. S., Tarlow, A. R., et al. (2001). Cowat metanorms across age, education, and gender. Applied Neuropsychology, 8, 161\u2013166. doi: 10.1207\/S15324826AN0803_5 .","journal-title":"Applied Neuropsychology"},{"key":"9205_CR28","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/0010-0285(72)90019-9","volume":"3","author":"HH Clark","year":"1972","unstructured":"Clark, H. H., & Chase, W. G. (1972). On the process of comparing sentences against pictures. Cognitive Psychology, 3, 472\u2013517. doi: 10.1016\/0010-0285(72)90019-9 .","journal-title":"Cognitive Psychology"},{"key":"9205_CR29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/sj.mp.4000792","volume":"6","author":"H Kunugi","year":"2001","unstructured":"Kunugi, H., Ueki, A., et al. (2001). A novel polymorphism of the brain-derived neurotrophic factor (Bdnf) gene associated with late-onset Alzheimer's disease. Molecular Psychiatry, 6, 83\u201386. doi: 10.1038\/sj.mp. 4000792 .","journal-title":"Molecular Psychiatry"},{"key":"9205_CR30","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","volume":"112","author":"MF Egan","year":"2003","unstructured":"Egan, M. F., Kojima, M., et al. (2003). The Bdnf Val66met polymorphism affects activity-dependent secretion of Bdnf and human memory and hippocampal function. Cell, 112, 257\u2013269. doi: 10.1016\/S0092-8674(03)00035-7 .","journal-title":"Cell"},{"key":"9205_CR31","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.4088\/JCP.v69n0710","volume":"69","author":"H Yu","year":"2008","unstructured":"Yu, H., Zhang, Z., et al. (2008). Association study of the decreased serum Bdnf concentrations in amnestic mild cognitive impairment and the Val66met polymorphism in Chinese Han. The Journal of Clinical Psychiatry, 69, 1104\u20131111.","journal-title":"The Journal of Clinical Psychiatry"},{"key":"9205_CR32","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1136\/jmg.2006.044883","volume":"44","author":"R Huang","year":"2007","unstructured":"Huang, R., Huang, J., et al. (2007). Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease. Journal of Medical Genetics, 44, e66. doi: 10.1136\/jmg.2006.044883 .","journal-title":"Journal of Medical Genetics"},{"key":"9205_CR33","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1440-1819.2006.01462.x","volume":"60","author":"JK Rybakowski","year":"2006","unstructured":"Rybakowski, J. K., Borkowska, A., et al. (2006). Prefrontal cognition in schizophrenia and bipolar illness in relation to Val66met polymorphism of the brain-derived neurotrophic factor gene. Psychiatry and Clinical Neurosciences, 60, 70\u201376. doi: 10.1111\/j.1440-1819.2006.01462.x .","journal-title":"Psychiatry and Clinical Neurosciences"},{"key":"9205_CR34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1601-183X.2007.00363.x","volume":"7","author":"F Miyajima","year":"2008","unstructured":"Miyajima, F., Ollier, W., et al. (2008). Brain-derived neurotrophic factor polymorphism Val66met influences cognitive abilities in the elderly. Genes Brain & Behavior, 7, 411\u2013417. doi: 10.1111\/j.1601-183X.2007.00363.x .","journal-title":"Genes Brain & Behavior"},{"key":"9205_CR35","first-page":"444","volume":"43","author":"YJ Li","year":"2005","unstructured":"Li, Y. J., Peng, S. L., Wan, C. Q., Cao, L., & Li, Y. P. (2005). Chronic pain impairs spatial learning and memory ability and down-regulates Bcl-2 and Bdnf Mrna expression in hippocampus of neonatal rats. Chinese Journal of Pediatrics, 43, 444\u2013448.","journal-title":"Chinese Journal of Pediatrics"},{"key":"9205_CR36","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1460-9568.2006.04585.x","volume":"23","author":"N Francia","year":"2006","unstructured":"Francia, N., Cirulli, F., et al. (2006). Spatial memory deficits in middle-aged mice correlate with lower exploratory activity and a subordinate status: Role of hippocampal neurotrophins. The European Journal of Neuroscience, 23, 711\u2013728. doi: 10.1111\/j.1460-9568.2006.04585.x .","journal-title":"The European Journal of Neuroscience"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-009-9205-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-009-9205-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-009-9205-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T02:19:21Z","timestamp":1559441961000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-009-9205-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,8]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["9205"],"URL":"https:\/\/doi.org\/10.1007\/s12031-009-9205-8","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,8]]}}}