{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:06:11Z","timestamp":1767863171040,"version":"3.49.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T00:00:00Z","timestamp":1290470400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1007\/s12031-010-9477-z","type":"journal-article","created":{"date-parts":[[2010,11,22]],"date-time":"2010-11-22T09:50:01Z","timestamp":1290419401000},"page":"60-67","source":"Crossref","is-referenced-by-count":33,"title":["Inhibition of Endogenous Hydrogen Sulfide Generation is Associated with Homocysteine-Induced Neurotoxicity: Role of ERK1\/2 Activation"],"prefix":"10.1007","volume":"45","author":[{"given":"Xiao-Qing","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Tian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-E","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong-Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Kai","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng-Rong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Yuan","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,11,23]]},"reference":[{"key":"9477_CR1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.neuroscience.2005.05.048","volume":"135","author":"G Baydas","year":"2005","unstructured":"Baydas G, Reiter RJ, Akbulut M, Tuzcu M, Tamer S (2005) Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels. Neuroscience 135:879\u2013886","journal-title":"Neuroscience"},{"key":"9477_CR2","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","volume":"55","author":"R Clarke","year":"1998","unstructured":"Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM (1998) Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 55:1449\u20131455","journal-title":"Arch Neurol"},{"key":"9477_CR3","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1742-7843.2008.00314.x","volume":"104","author":"WG Duan","year":"2009","unstructured":"Duan WG, Shang J, Jiang ZZ, Yao JC, Yun Y, Yan M, Shu B, Lin Q, Yu ZP, Zhang LY (2009) Rho kinase inhibitor Y-27632 down-regulates norepinephrine synthesis and release in PC12 cells. Basic Clin Pharmacol Toxicol 104:434\u2013440","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"9477_CR4","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.freeradbiomed.2004.03.009","volume":"36","author":"BE Dwyer","year":"2004","unstructured":"Dwyer BE, Raina AK, Perry G, Smith MA (2004) Homocysteine and Alzheimer's disease: a modifiable risk? Free Radic Biol Med 36:1471\u20131475","journal-title":"Free Radic Biol Med"},{"key":"9477_CR5","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0006-291X(02)00422-9","volume":"293","author":"K Eto","year":"2002","unstructured":"Eto K, Asada T, Arima K, Makifuchi T, Kimura H (2002) Brain hydrogen sulfide is severely decreased in Alzheimer's disease. Biochem Biophys Res Commun 293:1485\u20131488","journal-title":"Biochem Biophys Res Commun"},{"key":"9477_CR6","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.bbrc.2004.04.094","volume":"318","author":"B Geng","year":"2004","unstructured":"Geng B, Chang L, Pan C, Qi Y, Zhao J, Pang Y, Du J, Tang C (2004) Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol. Biochem Biophys Res Commun 318:756\u2013763","journal-title":"Biochem Biophys Res Commun"},{"key":"9477_CR7","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1073\/pnas.73.7.2424","volume":"73","author":"LA Greene","year":"1976","unstructured":"Greene LA, Tischler AS (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73:2424\u20132428","journal-title":"Proc Natl Acad Sci USA"},{"key":"9477_CR8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.taap.2009.10.010","volume":"242","author":"L Gu","year":"2010","unstructured":"Gu L, Hu X, Xue Z, Yang J, Wan L, Ren Y, Hertz L, Peng L (2010) Potent homocysteine-induced ERK phosphorylation in cultured neurons depends on self-sensitization via system Xc(\u2212). Toxicol Appl Pharmacol 242:209\u2013223","journal-title":"Toxicol Appl Pharmacol"},{"key":"9477_CR9","doi-asserted-by":"crossref","first-page":"10098","DOI":"10.1016\/S0021-9258(18)61082-8","volume":"262","author":"JW Heinecke","year":"1987","unstructured":"Heinecke JW, Rosen H, Suzuki LA, Chait A (1987) The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells. J Biol Chem 262:10098\u201310103","journal-title":"J Biol Chem"},{"key":"9477_CR10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1471-4159.2001.00384.x","volume":"78","author":"PI Ho","year":"2001","unstructured":"Ho PI, Collins SC, Dhitavat S, Ortiz D, Ashline D, Rogers E, Shea TB (2001) Homocysteine potentiates beta-amyloid neurotoxicity: role of oxidative stress. J Neurochem 78:249\u2013253","journal-title":"J Neurochem"},{"key":"9477_CR11","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/jnr.10416","volume":"70","author":"PI Ho","year":"2002","unstructured":"Ho PI, Ortiz D, Rogers E, Shea TB (2002) Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage. J Neurosci Res 70:694\u2013702","journal-title":"J Neurosci Res"},{"key":"9477_CR12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0006-8993(87)91531-9","volume":"437","author":"JP Kim","year":"1987","unstructured":"Kim JP, Koh JY, Choi DW (1987) l-Homocysteate is a potent neurotoxin on cultured cortical neurons. Brain Res 437:103\u2013110","journal-title":"Brain Res"},{"key":"9477_CR13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/MN:26:1:013","volume":"26","author":"H Kimura","year":"2002","unstructured":"Kimura H (2002) Hydrogen sulfide as a neuromodulator. Mol Neurobiol 26:13\u201319","journal-title":"Mol Neurobiol"},{"key":"9477_CR14","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1096\/fj.04-1815fje","volume":"18","author":"Y Kimura","year":"2004","unstructured":"Kimura Y, Kimura H (2004) Hydrogen sulfide protects neurons from oxidative stress. FASEB J 18:1165\u20131167","journal-title":"FASEB J"},{"key":"9477_CR15","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1523\/JNEUROSCI.20-18-06920.2000","volume":"20","author":"II Kruman","year":"2000","unstructured":"Kruman II, Culmsee C, Chan SL, Kruman Y, Guo Z, Penix L, Mattson MP (2000) Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci 20:6920\u20136926","journal-title":"J Neurosci"},{"key":"9477_CR16","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/glycob\/8.6.597","volume":"8","author":"R Li","year":"1998","unstructured":"Li R, Kong Y, Ladisch S (1998) Nerve growth factor-induced neurite formation in PC12 cells is independent of endogenous cellular gangliosides. Glycobiology 8:597\u2013603","journal-title":"Glycobiology"},{"key":"9477_CR17","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.nbd.2006.06.010","volume":"23","author":"M Linnebank","year":"2006","unstructured":"Linnebank M, Lutz H, Jarre E, Vielhaber S, Noelker C, Struys E, Jakobs C, Klockgether T, Evert BO, Kunz WS et al (2006) Binding of copper is a mechanism of homocysteine toxicity leading to COX deficiency and apoptosis in primary neurons, PC12 and SHSY-5Y cells. Neurobiol Dis 23:725\u2013730","journal-title":"Neurobiol Dis"},{"key":"9477_CR18","doi-asserted-by":"crossref","first-page":"5923","DOI":"10.1073\/pnas.94.11.5923","volume":"94","author":"SA Lipton","year":"1997","unstructured":"Lipton SA, Kim WK, Choi YB, Kumar S, D'Emilia DM, Rayudu PV, Arnelle DR, Stamler JS (1997) Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor. Proc Natl Acad Sci USA 94:5923\u20135928","journal-title":"Proc Natl Acad Sci USA"},{"key":"9477_CR19","first-page":"4","volume":"59","author":"E Lowicka","year":"2007","unstructured":"Lowicka E, Beltowski J (2007) Hydrogen sulfide (H2S)\u2014the third gas of interest for pharmacologists. Pharmacol Rep 59:4\u201324","journal-title":"Pharmacol Rep"},{"key":"9477_CR20","first-page":"126","volume":"57","author":"JW Miller","year":"1999","unstructured":"Miller JW (1999) Homocysteine and Alzheimer's disease. Nutr Rev 57:126\u2013129","journal-title":"Nutr Rev"},{"key":"9477_CR21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/01.shk.0000183393.83272.de","volume":"24","author":"H Mitsuhashi","year":"2005","unstructured":"Mitsuhashi H, Yamashita S, Ikeuchi H, Kuroiwa T, Kaneko Y, Hiromura K, Ueki K, Nojima Y (2005) Oxidative stress-dependent conversion of hydrogen sulfide to sulfite by activated neutrophils. Shock 24:529\u2013534","journal-title":"Shock"},{"key":"9477_CR22","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tips.2003.10.007","volume":"24","author":"PK Moore","year":"2003","unstructured":"Moore PK, Bhatia M, Moochhala S (2003) Hydrogen sulfide: from the smell of the past to the mediator of the future? Trends Pharmacol Sci 24:609\u2013611","journal-title":"Trends Pharmacol Sci"},{"key":"9477_CR23","first-page":"599","volume":"19","author":"RB Parsons","year":"1998","unstructured":"Parsons RB, Waring RH, Ramsden DB, Williams AC (1998) In vitro effect of the cysteine metabolites homocysteic acid, homocysteine and cysteic acid upon human neuronal cell lines. Neurotoxicology 19:599\u2013603","journal-title":"Neurotoxicology"},{"key":"9477_CR24","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1471-4159.2009.06207.x","volume":"110","author":"R Poddar","year":"2009","unstructured":"Poddar R, Paul S (2009) Homocysteine-NMDA receptor-mediated activation of extracellular signal-regulated kinase leads to neuronal cell death. J Neurochem 110:1095\u20131106","journal-title":"J Neurochem"},{"key":"9477_CR25","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1073\/pnas.0509531103","volume":"103","author":"A Prudova","year":"2006","unstructured":"Prudova A, Bauman Z, Braun A, Vitvitsky V, Lu SC, Banerjee R (2006) S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci USA 103:6489\u20136494","journal-title":"Proc Natl Acad Sci USA"},{"key":"9477_CR26","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.neuroscience.2005.03.034","volume":"133","author":"K Robert","year":"2005","unstructured":"Robert K, Pages C, Ledru A, Delabar J, Caboche J, Janel N (2005) Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus. Neuroscience 133:925\u2013935","journal-title":"Neuroscience"},{"key":"9477_CR27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.nutr.19.1.217","volume":"19","author":"J Selhub","year":"1999","unstructured":"Selhub J (1999) Homocysteine metabolism. Annu Rev Nutr 19:217\u2013246","journal-title":"Annu Rev Nutr"},{"key":"9477_CR28","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMoa011613","volume":"346","author":"S Seshadri","year":"2002","unstructured":"Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346:476\u2013483","journal-title":"N Engl J Med"},{"key":"9477_CR29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1046\/j.1471-4159.1995.65010218.x","volume":"65","author":"MS Shearman","year":"1995","unstructured":"Shearman MS, Hawtin SR, Tailor VJ (1995) The intracellular component of cellular 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by beta-amyloid peptides. J Neurochem 65:218\u2013227","journal-title":"J Neurochem"},{"key":"9477_CR30","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","volume":"6","author":"C Szabo","year":"2007","unstructured":"Szabo C (2007) Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov 6:917\u2013935","journal-title":"Nat Rev Drug Discov"},{"key":"9477_CR31","doi-asserted-by":"crossref","unstructured":"Tang XQ, Fan LL, Li YJ, Shen XT, Zhuan YY, He JQ, Xu JH, and Hu B (2010a) Inhibition of hydrogen sulfide generation contributes to 1-methy-4-phenylpyridinium ion-induced neurotoxicity. Neurotox Res. doi: 10.1007\/s12640-010-9180-4","DOI":"10.1007\/s12640-010-9180-4"},{"key":"9477_CR32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neures.2010.07.2039","volume":"68","author":"XQ Tang","year":"2010","unstructured":"Tang XQ, Shen XT, Huang YE, Ren YK, Chen RQ, Hu B, He JQ, Yin WL, Xu JH, Jiang ZS (2010b) Hydrogen sulfide antagonizes homocysteine-induced neurotoxicity in PC12 cells. Neurosci Res 68:241\u2013249","journal-title":"Neurosci Res"},{"key":"9477_CR33","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1440-1681.2007.04799.x","volume":"35","author":"XQ Tang","year":"2008","unstructured":"Tang XQ, Yang CT, Chen J, Yin WL, Tian SW, Hu B, Feng JQ, Li YJ (2008) Effect of hydrogen sulphide on beta-amyloid-induced damage in PC12 cells. Clin Exp Pharmacol Physiol 35:180\u2013186","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"9477_CR34","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.archger.2008.03.009","volume":"48","author":"F Dam Van","year":"2009","unstructured":"Van Dam F, Van Gool WA (2009) Hyperhomocysteinemia and Alzheimer's disease: a systematic review. Arch Gerontol Geriatr 48:425\u2013430","journal-title":"Arch Gerontol Geriatr"},{"key":"9477_CR35","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s002340050119","volume":"37","author":"M Berg van den","year":"1995","unstructured":"van den Berg M, van der Knaap MS, Boers GH, Stehouwer CD, Rauwerda JA, Valk J (1995) Hyperhomocysteinaemia; with reference to its neuroradiological aspects. Neuroradiology 37:403\u2013411","journal-title":"Neuroradiology"},{"key":"9477_CR36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0009-8981(03)00086-X","volume":"331","author":"S Walrand","year":"2003","unstructured":"Walrand S, Valeix S, Rodriguez C, Ligot P, Chassagne J, Vasson MP (2003) Flow cytometry study of polymorphonuclear neutrophil oxidative burst: a comparison of three fluorescent probes. Clin Chim Acta 331:103\u2013110","journal-title":"Clin Chim Acta"},{"key":"9477_CR37","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","volume":"16","author":"R Wang","year":"2002","unstructured":"Wang R (2002) Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? FASEB J 16:1792\u20131798","journal-title":"FASEB J"},{"key":"9477_CR38","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/jnr.21999","volume":"87","author":"S Wang","year":"2009","unstructured":"Wang S, Hu CP, Jiang DJ, Peng J, Zhou Z, Yuan Q, Nie SD, Jiang JL, Li YJ, Huang KL (2009) All-trans retinoic acid inhibits cobalt chloride-induced apoptosis in PC12 cells: role of the dimethylarginine dimethylaminohydrolase\/asymmetric dimethylarginine pathway. J Neurosci Res 87:1938\u20131946","journal-title":"J Neurosci Res"},{"key":"9477_CR39","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1046\/j.1471-4159.2001.00178.x","volume":"76","author":"AR White","year":"2001","unstructured":"White AR, Huang X, Jobling MF, Barrow CJ, Beyreuther K, Masters CL, Bush AI, Cappai R (2001) Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways. J Neurochem 76:1509\u20131520","journal-title":"J Neurochem"},{"key":"9477_CR40","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1471-4159.2004.02617.x","volume":"90","author":"M Whiteman","year":"2004","unstructured":"Whiteman M, Armstrong JS, Chu SH, Jia-Ling S, Wong BS, Cheung NS, Halliwell B, Moore PK (2004) The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite \u2018scavenger\u2019? J Neurochem 90:765\u2013768","journal-title":"J Neurochem"},{"key":"9477_CR41","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbrc.2004.11.110","volume":"326","author":"M Whiteman","year":"2005","unstructured":"Whiteman M, Cheung NS, Zhu YZ, Chu SH, Siau JL, Wong BS, Armstrong JS, Moore PK (2005) Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain? Biochem Biophys Res Commun 326:794\u2013798","journal-title":"Biochem Biophys Res Commun"},{"key":"9477_CR42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/02699050500284218","volume":"24","author":"S Yoon","year":"2006","unstructured":"Yoon S, Seger R (2006) The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24:21\u201344","journal-title":"Growth Factors"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-010-9477-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-010-9477-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-010-9477-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T11:52:24Z","timestamp":1711972344000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-010-9477-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,23]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["9477"],"URL":"https:\/\/doi.org\/10.1007\/s12031-010-9477-z","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,23]]}}}