{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:56:12Z","timestamp":1758970572245},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,3,4]],"date-time":"2012-03-04T00:00:00Z","timestamp":1330819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s12031-012-9725-5","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T14:42:28Z","timestamp":1330958548000},"page":"465-469","source":"Crossref","is-referenced-by-count":10,"title":["Common Variants in the TPH2 Promoter Confer Susceptibility to Paranoid Schizophrenia"],"prefix":"10.1007","volume":"47","author":[{"given":"Zhenghui","family":"Yi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dentang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiru","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,3,4]]},"reference":[{"key":"9725_CR1","volume-title":"Handbook of psychiatric measures","author":"American Psychiatric Association","year":"2000","unstructured":"American Psychiatric Association (2000) Handbook of psychiatric measures. American Psychiatric Association, Washington, DC"},{"key":"9725_CR2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/YCO.0b013e32835035dd","volume":"25","author":"SE Bergen","year":"2012","unstructured":"Bergen SE, Petryshen TL (2012) Genome-wide association studies of schizophrenia: does bigger lead to better results? Curr Opin Psychiatry 25:76\u201382","journal-title":"Curr Opin Psychiatry"},{"key":"9725_CR3","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/sj.mp.4001716","volume":"10","author":"SM Brown","year":"2005","unstructured":"Brown SM, Peet E, Manuck SB, Williamson DE, Dahl RE, Ferrell RE, Hariri AR (2005) A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Mol Psychiatry 10:884\u2013888","journal-title":"Mol Psychiatry"},{"key":"9725_CR4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/gepi.20320","volume":"32","author":"A Bureau","year":"2008","unstructured":"Bureau A, Labbe A, Croteau J, M\u00e9rette C (2008) Using disease symptoms to improve detection of linkage under genetic heterogeneity. Genet Epidemiol 32:476\u2013486","journal-title":"Genet Epidemiol"},{"key":"9725_CR5","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s00702-005-0391-4","volume":"112","author":"T Canli","year":"2005","unstructured":"Canli T, Congdon E, Gutknecht L, Constable RT, Lesch KP (2005) Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. J Neural Transm 112:1479\u20131485","journal-title":"J Neural Transm"},{"key":"9725_CR6","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00439-007-0443-y","volume":"122","author":"GL Chen","year":"2008","unstructured":"Chen GL, Vallender EJ, Miller GM (2008) Functional characterization of the human TPH2 5\u2032 regulatory region: untranslated region and polymorphisms modulate gene expression in vitro. Hum Genet 122:645\u2013657","journal-title":"Hum Genet"},{"key":"9725_CR7","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.neubiorev.2010.01.002","volume":"34","author":"SY Cherlyn","year":"2010","unstructured":"Cherlyn SY, Woon PS, Liu JJ, Ong WY, Tsai GC, Sim K (2010) Genetic association studies of glutamate, GABA and related genes in schizophrenia and bipolar disorder: a decade of advance. Neurosci Biobehav Rev 34:958\u2013977","journal-title":"Neurosci Biobehav Rev"},{"key":"9725_CR8","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s00213-005-0191-4","volume":"183","author":"V Luca De","year":"2005","unstructured":"De Luca V, Likhodi O, Van Tol HH, Kennedy JL, Wong AH (2005) Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia. Psychopharmacology (Berl) 183:378\u2013382","journal-title":"Psychopharmacology (Berl)"},{"key":"9725_CR9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.neuron.2010.06.006","volume":"67","author":"M Demarque","year":"2010","unstructured":"Demarque M, Spitzer NC (2010) Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior. Neuron 67:321\u2013334","journal-title":"Neuron"},{"key":"9725_CR10","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.neubiorev.2009.09.004","volume":"34","author":"VM Goghari","year":"2010","unstructured":"Goghari VM, Sponheim SR, MacDonald AW 3rd (2010) The functional neuroanatomy of symptom dimensions in schizophrenia: a qualitative and quantitative review of a persistent question. Neurosci Biobehav Rev 34:468\u2013486","journal-title":"Neurosci Biobehav Rev"},{"key":"9725_CR11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/YPG.0b013e328011c01a","volume":"17","author":"S Higashi","year":"2007","unstructured":"Higashi S, Ohnuma T, Shibata N, Higashi M, Matsubara Y, Arai H (2007) No genetic association between tryptophan hydroxylase 2 gene polymorphisms and Japanese schizophrenia. Psychiatr Genet 17:123","journal-title":"Psychiatr Genet"},{"key":"9725_CR12","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1001\/archpsyc.64.9.1015","volume":"64","author":"YM Lin","year":"2007","unstructured":"Lin YM, Chao SC, Chen TM, Lai TJ, Chen JS, Sun HS (2007) Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese. Arch Gen Psychiatry 64:1015\u20131024","journal-title":"Arch Gen Psychiatry"},{"key":"9725_CR13","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biopsych.2006.09.008","volume":"62","author":"C Lopez de Lara","year":"2007","unstructured":"Lopez de Lara C, Brezo J, Rouleau G, Lesage A, Dumont M, Alda M, Benkelfat C, Turecki G (2007) Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression. Biol Psychiatry 62:72\u201380","journal-title":"Biol Psychiatry"},{"key":"9725_CR14","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.biopsych.2007.01.015","volume":"62","author":"K Scheuch","year":"2007","unstructured":"Scheuch K, Lautenschlager M, Grohmann M, Stahlberg S, Kirchheiner J, Zill P, Heinz A, Walther DJ, Priller J (2007) Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biol Psychiatry 62:1288\u20131294","journal-title":"Biol Psychiatry"},{"key":"9725_CR15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1385\/JMN:26:1:033","volume":"26","author":"A Shamir","year":"2005","unstructured":"Shamir A, Shaltiel G, Levi I, Belmaker RH, Agam G (2005) Postmortem parietal cortex TPH2 expression is not altered in schizophrenic, unipolar-depressed, and bipolar patients vs control subjects. J Mol Neurosci 26:33\u201337","journal-title":"J Mol Neurosci"},{"key":"9725_CR16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/sj.cr.7290272","volume":"15","author":"YY Shi","year":"2005","unstructured":"Shi YY, He L (2005) SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15:97\u201398","journal-title":"Cell Res"},{"key":"9725_CR17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neulet.2010.02.003","volume":"472","author":"K Shiroiwa","year":"2010","unstructured":"Shiroiwa K, Hishimoto A, Mouri K, Fukutake M, Supriyanto I, Nishiguchi N, Shirakawa O (2010) Common genetic variations in TPH1\/TPH2 genes are not associated with schizophrenia in Japanese population. Neurosci Lett 472:194\u2013198","journal-title":"Neurosci Lett"},{"key":"9725_CR18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0074-7742(04)59006-2","volume":"59","author":"MS Sodhi","year":"2004","unstructured":"Sodhi MS, Sanders-Bush E (2004) Serotonin and brain development. Int Rev Neurobiol 59:111\u2013174","journal-title":"Int Rev Neurobiol"},{"key":"9725_CR19","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.4238\/vol9-3gmr789","volume":"9","author":"SF Tee","year":"2010","unstructured":"Tee SF, Chow TJ, Tang PY, Loh HC (2010) Linkage of schizophrenia with TPH2 and 5-HTR2A gene polymorphisms in the Malay population. Genet Mol Res 9:1274\u20131278","journal-title":"Genet Mol Res"},{"key":"9725_CR20","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/sj.mp.4001734","volume":"10","author":"S Walitza","year":"2005","unstructured":"Walitza S, Renner TJ, Dempfle A, Konrad K, Wewetzer Ch, Halbach A, Herpertz-Dahlmann B, Remschmidt H, Smidt J, Linder M, Flierl L, Kn\u00f6lker U, Friedel S, Sch\u00e4fer H, Gross C, Hebebrand J, Warnke A, Lesch KP (2005) Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit\/hyperactivity disorder. Mol Psychiatry 10:1126\u20131132","journal-title":"Mol Psychiatry"},{"key":"9725_CR21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.1078197","volume":"299","author":"DJ Walther","year":"2003","unstructured":"Walther DJ, Peter JU, Bashammakh S, H\u00f6rtnagl H, Voits M, Fink H, Bader M (2003) Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299:76","journal-title":"Science"},{"key":"9725_CR22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00018-005-5417-4","volume":"63","author":"X Zhang","year":"2006","unstructured":"Zhang X, Beaulieu JM, Gainetdinov RR, Caron MG (2006) Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2. Cell Mol Life Sci 63:6\u201311","journal-title":"Cell Mol Life Sci"},{"key":"9725_CR23","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s12031-010-9458-2","volume":"43","author":"C Zhang","year":"2011","unstructured":"Zhang C, Li Z, Shao Y, Xie B, Du Y, Fang Y, Yu S (2011) Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population. J Mol Neurosci 43:406\u2013411","journal-title":"J Mol Neurosci"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-012-9725-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-012-9725-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-012-9725-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T22:24:46Z","timestamp":1559427886000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-012-9725-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,4]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["9725"],"URL":"https:\/\/doi.org\/10.1007\/s12031-012-9725-5","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,4]]}}}