{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:47:54Z","timestamp":1773874074230,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,4,14]],"date-time":"2012-04-14T00:00:00Z","timestamp":1334361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1007\/s12031-012-9763-z","type":"journal-article","created":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T06:17:06Z","timestamp":1334297826000},"page":"721-729","source":"Crossref","is-referenced-by-count":9,"title":["Pretreatment with Nonselective Cationic Channel Inhibitors Blunts the PACAP-Induced Increase in Guinea Pig Cardiac Neuron Excitability"],"prefix":"10.1007","volume":"48","author":[{"given":"Laura A.","family":"Merriam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn W.","family":"Roman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin N.","family":"Baran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice M.","family":"Girard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney L.","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,4,14]]},"reference":[{"key":"9763_CR1","first-page":"1","volume-title":"Basic and clinical neurocardiology","author":"DJ Adams","year":"2004","unstructured":"Adams DJ, Cuevas J (2004) Electrophysiological properties of intrinsic cardiac neurons. In: Armour JA, Ardell JL (eds) Basic and clinical neurocardiology. Oxford University Press, Oxford, pp 1\u201360"},{"key":"9763_CR2","doi-asserted-by":"crossref","unstructured":"Beaudet MM, Parsons RL, Braas KM, May V (2000) Mechanisms mediating pituitary adenylate cyclase-activating polypeptide depolarization of rat sympathetic neurons. J Neurosci 20:7353\u20137361","DOI":"10.1523\/JNEUROSCI.20-19-07353.2000"},{"key":"9763_CR3","doi-asserted-by":"crossref","first-page":"27702","DOI":"10.1074\/jbc.274.39.27702","volume":"39","author":"KM Braas","year":"1999","unstructured":"Braas KM, May V (1999) Pituitary adenylate cyclase-activating polypeptides directly stimulate sympathetic neuron neuropeptide Y release through PAC1 receptor activation of specific intracellular signaling pathways. J Biol Chem 39:27702\u201327710","journal-title":"J Biol Chem"},{"key":"9763_CR4","doi-asserted-by":"crossref","first-page":"9766","DOI":"10.1523\/JNEUROSCI.18-23-09766.1998","volume":"18","author":"KM Braas","year":"1998","unstructured":"Braas KM, May V, Harakall SA, Hardwick JC, Parsons RL (1998) Pituitary adenylate cyclase-activating polypeptide expression and modulation of neuronal excitability in guinea pig cardiac ganglia. J Neurosci 18:9766\u20139779","journal-title":"J Neurosci"},{"key":"9763_CR5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neuroscience.2004.04.007","volume":"126","author":"KM Braas","year":"2004","unstructured":"Braas KM, Rossignal TM, Girard BM, May V, Parsons RL (2004) Pituitary adenylyl cyclase activating polypeptide (PACAP) decreases neuronal somatostatin immunoreactivity in cultured guinea-pig parasympathetic cardiac ganglia. Neurosci 126:335\u2013346","journal-title":"Neurosci"},{"key":"9763_CR6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/1096-9861(20000717)423:1<26::AID-CNE3>3.0.CO;2-C","volume":"423","author":"MA Calupca","year":"2000","unstructured":"Calupca MA, Vizzard MA, Parsons RL (2000) Origin of pituitary adenylate cyclase-activating polypeptide (PACAP)-immunoreactive fibers innervating guinea pig parasympathetic cardiac ganglia. J Comp Neurol 423:26\u201339","journal-title":"J Comp Neurol"},{"key":"9763_CR7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/cne.10322","volume":"450","author":"MA Calupca","year":"2002","unstructured":"Calupca MA, Locknar SA, Parsons RL (2002) TRPC6 immunoreactivity is colocalized with neuronal nitric oxide synthase in extrinsic fibers innervating guinea pig intrinsic cardiac ganglia. J Comp Neurol 450:283\u2013291","journal-title":"J Comp Neurol"},{"key":"9763_CR8","doi-asserted-by":"crossref","first-page":"32226","DOI":"10.1074\/jbc.271.50.32226","volume":"271","author":"TK Chatterjee","year":"1996","unstructured":"Chatterjee TK, Sharmi RV, Fisher RA (1996) Molecular cloning of a novel variant of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor that stimulates calcium influx by activation of L-type calcium channels. J Biol Chem 271:32226\u201332232","journal-title":"J Biol Chem"},{"key":"9763_CR9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/35077544","volume":"2","author":"DE Clapham","year":"2001","unstructured":"Clapham DE, Runnels LW, Strubing C (2001) The TRP ion channel family. Nat Rev Neurosci 2:387\u2013396","journal-title":"Nat Rev Neurosci"},{"key":"9763_CR10","doi-asserted-by":"crossref","unstructured":"Edwards FR, Hirst GD, Klemm MF, Steele PA (1995) Different types of ganglion cell in the cardiac plexus of guinea-pigs. J Physiol 486:453\u2013471","DOI":"10.1113\/jphysiol.1995.sp020825"},{"key":"9763_CR11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1124\/jpet.109.155747","volume":"331","author":"DB Hoover","year":"2009","unstructured":"Hoover DB, Tompkins JD, Parsons RL (2009) Differential activation of guinea pig intrinsic cardiac neurons by the PAC1 agonists maxadilan and pituitary adenylate cyclase-activating polypeptide 27 (PACAP27). J Pharmacol Exp Ther 331:197\u2013203","journal-title":"J Pharmacol Exp Ther"},{"key":"9763_CR12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/PL00005336","volume":"359","author":"CR Jan","year":"1999","unstructured":"Jan CR, Ho CM, Wu SN, Tseng CJ (1999) Multiple effects of 1-[\u03b2-[3-(4-methoxyphenyl) propoxy]-4-methoxy-phenyl]-1H-imidazole hydrochloride (SKF 96365) on Ca2+ signaling in MDCK cells: depletion of thapsigargin-sensitive Ca2+ store followed by capacitative Ca2+ entry, activation of direct Ca2+ entry, and inhibition of thapsigargin-induced capacitative Ca2+ entry. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 359:92\u2013101","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"9763_CR13","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/cne.21874","volume":"511","author":"S Liu","year":"2008","unstructured":"Liu S, Qu MH, Ren W et al (2008) Differential expression of canonical (classical) transient receptor potential channels in guinea pig enteric nervous system. J Comp Neurol 511:847\u2013862","journal-title":"J Comp Neurol"},{"key":"9763_CR14","doi-asserted-by":"crossref","unstructured":"Merriam LA, Barstow KL, Parsons RL (2004) Pituitary adenylate cyclase-activating polypeptide enhances the hyperpolarization-activated nonselective cationic conductance, Ih, in dissociated guinea pig intracardiac neurons. Regul Pept 123:123\u2013133","DOI":"10.1016\/j.regpep.2004.04.019"},{"key":"9763_CR15","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1152\/ajpcell.00036.2010","volume":"299","author":"LA Merriam","year":"2010","unstructured":"Merriam LA, Locknar SA, Girard BM, Parsons RL (2010) Somatic ATP release from guinea pig sympathetic neurons does not require calcium-induced calcium release from internal stores. Am J Physiol Cell Physiol 299:836\u2013843","journal-title":"Am J Physiol Cell Physiol"},{"key":"9763_CR16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00441-005-0074-3","volume":"323","author":"RL Parsons","year":"2006","unstructured":"Parsons RL, Locknar SA, Young BA, Hoard JL, Hoover DB (2006) Presence and co-localization of vasoactive intestinal polypeptide (VIP) with neuronal nitric oxide synthase (nNOS) in cells and nerve fibers within guinea pig intrinsic cardiac ganglia and cardiac tissue. Cell Tiss Res 323:197\u2013209","journal-title":"Cell Tiss Res"},{"key":"9763_CR17","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0896-6273(01)00240-9","volume":"29","author":"C Strubing","year":"2001","unstructured":"Strubing C, Krapivinsky G, Krapivinsky L, Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:645\u2013655","journal-title":"Neuron"},{"key":"9763_CR18","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s12031-008-9086-2","volume":"36","author":"JD Tompkins","year":"2008","unstructured":"Tompkins JD, Parsons RL (2008) Identification of intracellular signaling cascades mediating the PACAP-induced increase in guinea pig cardiac neuron excitability. J Mol Neurosci 36:292\u2013298","journal-title":"J Mol Neurosci"},{"key":"9763_CR19","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1152\/jn.01077.2005","volume":"95","author":"JD Tompkins","year":"2006","unstructured":"Tompkins JD, Hardwick JC, Locknar SA, Merriam LA, Parsons RL (2006) Ca2+ influx, but not Ca2+ release from internal stores, is required for the PACAP-induced increase in excitability in guinea pig intracardiac neurons. J Neurophysiol 95:2134\u20132142","journal-title":"J Neurophysiol"},{"key":"9763_CR20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1113\/jphysiol.2007.134965","volume":"582","author":"JD Tompkins","year":"2007","unstructured":"Tompkins JD, Ardell JL, Hoover DB, Parsons RL (2007) Neurally released pituitary adenylate cyclase-activating polypeptide enhances guinea pig intrinsic cardiac neuron excitability. J Physiol 582:87\u201393","journal-title":"J Physiol"},{"key":"9763_CR21","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1152\/ajpregu.00039.2009","volume":"297","author":"JD Tompkins","year":"2009","unstructured":"Tompkins JD, Lawrence YT, Parsons RL (2009) Enhancement of I h, but not inhibition of I M, is a key mechanism underlying the PACAP-induced increase in excitability of guinea pig intrinsic cardiac neurons. Am J Physiol Regul Integr Comp Physiol 297:R52\u2013R59","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"9763_CR22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1124\/pr.109.001370","volume":"61","author":"D Vaudry","year":"2009","unstructured":"Vaudry D, Falluel-Morel A, Bourgault S et al (2009) Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev 61:283\u2013357","journal-title":"Pharmacol Rev"},{"key":"9763_CR23","doi-asserted-by":"crossref","first-page":"10038","DOI":"10.1523\/JNEUROSCI.1042-09.2009","volume":"29","author":"HD Yan","year":"2009","unstructured":"Yan HD, Villalobos C, Andrade R (2009) TRPC channels mediate a muscarinic receptor-induced after depolarization in cerebral cortex. J Neurosci 29:10038\u201310046","journal-title":"J Neurosci"},{"key":"9763_CR24","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1113\/jphysiol.2010.193037","volume":"588","author":"HJ Yau","year":"2010","unstructured":"Yau HJ, Baranauskas G, Martina M (2010) Flufenamic acid decreases neuronal excitability through modulation of voltage-gated sodium channel gating. J Physiol 588:3869\u20133882","journal-title":"J Physiol"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-012-9763-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-012-9763-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-012-9763-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T06:49:01Z","timestamp":1561618141000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-012-9763-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,14]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["9763"],"URL":"https:\/\/doi.org\/10.1007\/s12031-012-9763-z","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,14]]}}}