{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:52:40Z","timestamp":1770511960788,"version":"3.49.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,4,29]],"date-time":"2012-04-29T00:00:00Z","timestamp":1335657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1007\/s12031-012-9774-9","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T23:35:16Z","timestamp":1335569716000},"page":"501-507","source":"Crossref","is-referenced-by-count":20,"title":["Protective Effects of Vasoactive Intestinal Peptide (VIP) in Ischemic Retinal Degeneration"],"prefix":"10.1007","volume":"48","author":[{"given":"K.","family":"Szabadfi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Danyadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tamas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Fabian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Reglodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,4,29]]},"reference":[{"key":"9774_CR1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ygcen.2006.12.022","volume":"153","author":"T Atlasz","year":"2007","unstructured":"Atlasz T, Babai N, Kiss P et al (2007a) Pituitary adenylate cyclase activating polypeptide is protective in bilateral carotid occlusion-induced retinal lesion in rats. Gen Comp Endocrinol 153:108\u2013114","journal-title":"Gen Comp Endocrinol"},{"key":"9774_CR2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF03033919","volume":"12","author":"T Atlasz","year":"2007","unstructured":"Atlasz T, Babai N, Reglodi D et al (2007b) Diazoxide is protective in the rat retina against ischemic injury induced by bilateral carotid occlusion and glutamate-induced degeneration. Neurotox Res 12:105\u2013111","journal-title":"Neurotox Res"},{"key":"9774_CR3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12031-008-9059-5","volume":"36","author":"T Atlasz","year":"2008","unstructured":"Atlasz T, Szabadfi K, Kiss P et al (2008) PACAP-mediated neuroprotection of neurochemically identified cell types in MSG-induced retinal regeneration. J Mol Neurosci 36:97\u2013104","journal-title":"J Mol Neurosci"},{"key":"9774_CR4","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1749-6632.2008.03650.x","volume":"1163","author":"T Atlasz","year":"2009","unstructured":"Atlasz T, Szabadfi K, Reglodi D et al (2009) Effects of pituitary adenylate cyclase activating polypeptide (PACAP1-38) and its fragments on retinal degeneration induced by neonatal MSG treatment. Ann N Y Acad Sci 1163:348\u2013352","journal-title":"Ann N Y Acad Sci"},{"key":"9774_CR5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.brainresbull.2009.09.004","volume":"81","author":"T Atlasz","year":"2010","unstructured":"Atlasz T, Szabadfi K, Kiss P et al (2010a) Evaluation of the protective effects of PACAP with cell-specific markers in ischemia-induced retinal degeneration. Brain Res Bull 81:497\u2013504","journal-title":"Brain Res Bull"},{"key":"9774_CR6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1749-6632.2010.05512.x","volume":"1200","author":"T Atlasz","year":"2010","unstructured":"Atlasz T, Szabadfi K, Kiss P et al (2010b) Pituitary adenylate cyclase activating polypeptide in the retina: focus on the retinoprotective effects. Ann N Y Acad Sci 1200:128\u2013139","journal-title":"Ann N Y Acad Sci"},{"key":"9774_CR7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12031-010-9392-3","volume":"43","author":"T Atlasz","year":"2011","unstructured":"Atlasz T, Szabadfi K, Kiss P et al (2011) Effects of PACAP in UV-A radiation-induced retinal degeneration models in rats. J Mol Neurosci 43:51\u201357","journal-title":"J Mol Neurosci"},{"key":"9774_CR8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1196\/annals.1317.003","volume":"1070","author":"N Babai","year":"2006","unstructured":"Babai N, Atlasz T, Tamas A et al (2006) Search for the optimal monosodium glutamate treatment schedule to study the neuroprotective effects of PACAP in the retina. Ann N Y Acad Sci 1070:149\u2013155","journal-title":"Ann N Y Acad Sci"},{"key":"9774_CR9","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1111\/j.1755-3768.2010.02041.x","volume":"89","author":"M Belokopytov","year":"2011","unstructured":"Belokopytov M, Shulman S, Dubinsky G, Gozes I, Belkin M, Rosner M (2011) Ameliorative effect of NAP on laser-induced retinal damage. Acta Ophthalmol 89:e126\u2013e131","journal-title":"Acta Ophthalmol"},{"key":"9774_CR10","first-page":"307","volume":"57","author":"A Dejda","year":"2005","unstructured":"Dejda A, Sokolowska P, Nowak JZ (2005) Neuroprotective potential of three neuropeptides PACAP, VIP and PHI. Pharmacol Rep 57:307\u2013320","journal-title":"Pharmacol Rep"},{"key":"9774_CR11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s12031-010-9434-x","volume":"43","author":"K Endo","year":"2011","unstructured":"Endo K, Nakamachi T, Seki T et al (2011) Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse. J Mol Neurosci 43:22\u201329","journal-title":"J Mol Neurosci"},{"key":"9774_CR12","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresrev.2007.01.003","volume":"54","author":"E Farkas","year":"2007","unstructured":"Farkas E, Luiten PG, Bari F (2007) Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res Rev 54:162\u2013180","journal-title":"Brain Res Rev"},{"key":"9774_CR13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/154411130201300303","volume":"13","author":"D Ganea","year":"2002","unstructured":"Ganea D, Delgado M (2002) Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) as modulators of both innate and adaptive immunity. Crit Rev Oral Biol Med 13:229\u2013237","journal-title":"Crit Rev Oral Biol Med"},{"key":"9774_CR14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1385\/JMN:14:1-2:061","volume":"14","author":"I Gozes","year":"2000","unstructured":"Gozes I, Brenneman DE (2000) A new concept in neuroprotection. J Mol Neurosci 14:61\u201368","journal-title":"J Mol Neurosci"},{"key":"9774_CR15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1385\/JMN:20:3:315","volume":"20","author":"I Gozes","year":"2003","unstructured":"Gozes I, Divinsky I, Pilzer I, Fridkin M, Brenneman DE, Spier AD (2003) From vasoactive intestinal peptide (VIP) through activity-dependent neuroprotective protein (ADNP) to NAP. J Mol Neurosci 20:315\u2013322","journal-title":"J Mol Neurosci"},{"key":"9774_CR16","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s00417-007-0746-7","volume":"246","author":"T Jehle","year":"2008","unstructured":"Jehle T, Dimitriu C, Auer S et al (2008) The neuropeptide NAP provides neuroprotection against retinal ganglion cell damage after retinal ischemia and optic nerve crush. Graefes Arch Clin Exp Ophthalmol 246:1255\u20131263","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"9774_CR17","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.peptides.2007.04.026","volume":"28","author":"M Laburthe","year":"2007","unstructured":"Laburthe M, Couvineau A, Tan V (2007) Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology. Peptides 28:1631\u20131639","journal-title":"Peptides"},{"key":"9774_CR18","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1167\/iovs.04-0766","volume":"46","author":"WA Lagreze","year":"2005","unstructured":"Lagreze WA, Pielen A, Steingart R et al (2005) The peptides ADNF-9 and NAP increase survival and neurite outgrowth of rat retinal ganglion cells in vitro. Invest Opthalmol Vis Sci 46:933\u2013938","journal-title":"Invest Opthalmol Vis Sci"},{"key":"9774_CR19","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.peptides.2007.05.015","volume":"28","author":"O Masmoudi-Kouki","year":"2007","unstructured":"Masmoudi-Kouki O, Gandolfo P, Castel H et al (2007) Role of PACAP and VIP in astroglial functions. Peptides 28:1753\u20131760","journal-title":"Peptides"},{"key":"9774_CR20","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s12640-009-9049-6","volume":"18","author":"L Mester","year":"2009","unstructured":"Mester L, Szabo A, Atlasz T et al (2009) Protection against chronic hypoperfusion-induced retinal neurodegeneration by PARP inhibition via activation of PI3-kinase Akt pathway and suppression of JNK and p38 MAP kinases. Neurotox Res 18:68\u201376","journal-title":"Neurotox Res"},{"key":"9774_CR21","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1016\/j.peptides.2006.06.007","volume":"27","author":"I Pilzer","year":"2006","unstructured":"Pilzer I, Gozes I (2006) VIP provides cellular protection through a specific splice variant of the PACAP receptor: a new neuroprotection target. Peptides 27:2867\u20132876","journal-title":"Peptides"},{"key":"9774_CR22","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1124\/jpet.105.086405","volume":"314","author":"CM Rangon","year":"2005","unstructured":"Rangon CM, Goursaud S, Medja F et al (2005) VPAC2 receptors mediate vasoactive intestinal peptide induced neuroprotection against neonatal excitotoxic brain lesions in mice. J Pharm Exp Therap 314:745\u2013752","journal-title":"J Pharm Exp Therap"},{"key":"9774_CR23","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1196\/annals.1317.074","volume":"1070","author":"T Seki","year":"2006","unstructured":"Seki T, Nakatani M, Taki C et al (2006) Neuroprotective effect of PACAP against kainic acid (KA)-induced neurotoxicity in rat retina. Ann N Y Acad Sci 1070:531\u2013534","journal-title":"Ann N Y Acad Sci"},{"key":"9774_CR24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s12031-008-9091-5","volume":"36","author":"T Seki","year":"2008","unstructured":"Seki T, Itoh H, Nakamachi T, Shioda S (2008) Suppression of ganglion cell death by PACAP following optic nerve transection in the rat. J Mol Neurosci 36:57\u201360","journal-title":"J Mol Neurosci"},{"key":"9774_CR25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s12031-010-9410-5","volume":"43","author":"T Seki","year":"2011","unstructured":"Seki T, Itoh H, Nakamachi T et al (2011) Suppression of rat retinal ganglion cell death by PACAP following transient ischemia induced by high intraocular pressure. J Mol Neurosci 43:30\u201334","journal-title":"J Mol Neurosci"},{"key":"9774_CR26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0006-8993(98)00789-6","volume":"809","author":"K Shoge","year":"1998","unstructured":"Shoge K, Mishima HK, Saitoh T et al (1998) Protective effects of vasoactive intestinal peptide against delayed glutamate neurotoxicity in cultured retina. Brain Res 809:127\u2013136","journal-title":"Brain Res"},{"key":"9774_CR27","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0006-8993(99)01690-X","volume":"839","author":"K Shoge","year":"1999","unstructured":"Shoge K, Mishima HK, Saitoh T et al (1999) Attenuation by PACAP of glutamate-induced neurotoxicity in cultured retinal neurons. Brain Res 839:66\u201373","journal-title":"Brain Res"},{"issue":"23","key":"9774_CR28","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.2174\/1381612043383548","volume":"10","author":"A Somogyvari-Vigh","year":"2004","unstructured":"Somogyvari-Vigh A, Reglodi D (2004) Pituitary adenylate cyclase activating polypeptide: a potential neuroprotective peptide. Curr Pharm Des 10(23):2861\u20132889","journal-title":"Curr Pharm Des"},{"key":"9774_CR29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neulet.2009.03.013","volume":"455","author":"K Szabadfi","year":"2009","unstructured":"Szabadfi K, Atlasz T, Reglodi D et al (2009) Urocortin 2 protects against retinal degeneration following bilateral common carotid artery occlusion in the rat. Neurosci Lett 455:42\u201345","journal-title":"Neurosci Lett"},{"key":"9774_CR30","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3390\/ijms11020544","volume":"11","author":"K Szabadfi","year":"2010","unstructured":"Szabadfi K, Mester L, Reglodi D et al (2010) Novel neuroprotective strategies in ischemic retinal lesions. Int J Mol Sci 11:544\u2013561","journal-title":"Int J Mol Sci"},{"key":"9774_CR31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00441-012-1349-0","volume":"348","author":"K Szabadfi","year":"2012","unstructured":"Szabadfi K, Atlasz T, Kiss P et al (2012a) Protective effects of the neuropeptide PACAP in diabetic retinopathy. Cell Tissue Res 348:37\u201346","journal-title":"Cell Tissue Res"},{"key":"9774_CR32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12640-011-9254-y","volume":"21","author":"K Szabadfi","year":"2012","unstructured":"Szabadfi K, Atlasz T, Kiss P et al (2012b) Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) are more susceptible to retinal ischemic injury in vivo. Neurotox Res 21:41\u201348","journal-title":"Neurotox Res"},{"key":"9774_CR33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neulet.2004.09.021","volume":"372","author":"A Tamas","year":"2004","unstructured":"Tamas A, Gabriel R, Racz B et al (2004) Effects of pituitary adenylate cyclase activating polypeptide in retinal degeneration induced by monosodium-glutamate. Neurosci Lett 372:110\u2013113","journal-title":"Neurosci Lett"},{"key":"9774_CR34","first-page":"1045","volume":"42","author":"J Troger","year":"2001","unstructured":"Troger J, Neyer S, Heufler C et al (2001) Substance P and vasoactive intestinal polypeptide in the streptozotocin-induced diabetic rat retina. Invest Ophthalmol Vis Sci 42:1045\u20131050","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9774_CR35","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1749-6632.1996.tb17509.x","volume":"805","author":"N Tuncel","year":"1996","unstructured":"Tuncel N, Basmak H, Uzuner K et al (1996) Protection of rat retina from ischemia-reperfusion injury by vasoactive intestinal peptide (VIP): the effects of VIP on lipid peroxidation and antioxidant enzyme activity of retina and choroid. Ann N Y Acad Sci 805:489\u2013498","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"9774_CR36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1124\/pr.109.001370","volume":"61","author":"D Vaudry","year":"2009","unstructured":"Vaudry D, Falluel-Morel A, Bourgault S et al (2009) Pituitary adenylate cyclase-activating polypeptide and its receptors: 20\u00a0years after the discovery. Pharmacol Rev 61(3):283\u2013357","journal-title":"Pharmacol Rev"},{"key":"9774_CR37","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.brainres.2011.05.007","volume":"1398","author":"J Yang","year":"2011","unstructured":"Yang J, Song TB, Zhao ZH, Qiu SD, Hu XD, Chang L (2011) Vasoactive intestinal peptide protects against ischemic brain damage induced by focal cerebral ischemia in rats. Brain Res 1398:94\u2013101","journal-title":"Brain Res"},{"key":"9774_CR38","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.biopha.2010.01.016","volume":"64","author":"Y Zheng","year":"2010","unstructured":"Zheng Y, Zeng H, She H, Liu H, Sun N (2010) Expression of peptide NAP in rat retinal Muller cells prevents hypoxia-induced retinal injuries and promotes retinal neurons growth. Biomed Pharmacother 64:417\u2013423","journal-title":"Biomed Pharmacother"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-012-9774-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-012-9774-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-012-9774-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T22:24:49Z","timestamp":1559427889000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-012-9774-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,29]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["9774"],"URL":"https:\/\/doi.org\/10.1007\/s12031-012-9774-9","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,29]]}}}