{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:20:19Z","timestamp":1790014819612,"version":"4.0.1"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T00:00:00Z","timestamp":1376352000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1007\/s12031-013-0074-9","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T10:38:44Z","timestamp":1376303924000},"page":"851-862","source":"Crossref","is-referenced-by-count":69,"title":["Geraniol Ameliorates the Motor Behavior and Neurotrophic Factors Inadequacy in MPTP-Induced Mice Model of Parkinson\u2019s Disease"],"prefix":"10.1007","volume":"51","author":[{"given":"Karamkolly R.","family":"Rekha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govindasamy P.","family":"Selvakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramaniam","family":"Sethupathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karunanidhi","family":"Santha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramu Inmozhi","family":"Sivakamasundari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,8,13]]},"reference":[{"key":"74_CR1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ar.1090940210","volume":"94","author":"M Abercrombie","year":"1946","unstructured":"Abercrombie M (1946) Estimation of nuclear population from microtome sections. Anat Rec 94:239\u2013247","journal-title":"Anat Rec"},{"key":"74_CR2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.nbd.2010.07.012","volume":"40","author":"D Afonso-Oramas","year":"2010","unstructured":"Afonso-Oramas D, Cruz-Muros I, Barroso-Chinea P, Alvarez de la Rosa D, CastroHernandez J, Salas-Hernandez J, Giraldez T, Gonzalez-Hernandez T (2010) The dopamine transporter is differentially regulated after dopaminergic lesion. Neurobiol Dis 40:518\u2013530","journal-title":"Neurobiol Dis"},{"key":"74_CR3","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1046\/j.1471-4159.1997.69031326.x","volume":"69","author":"ZI Alam","year":"1997","unstructured":"Alam ZI, Daniel SE, Lees AJ, Marsden DC (1997) A generalized increase in protein carbonyls in the brain in Parkinson\u2019s but not incidental Lewy body disease. J Neurochem 69:1326\u20131329","journal-title":"J Neurochem"},{"key":"74_CR4","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0079-6123(03)46030-5","volume":"146","author":"P Anand","year":"2004","unstructured":"Anand P (2004) Neurotrophic factors and their receptors in human sensory neuropathies. Prog Brain Res 146:477\u2013492","journal-title":"Prog Brain Res"},{"key":"74_CR5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.tips.2006.12.005","volume":"28","author":"MM Bespalov","year":"2007","unstructured":"Bespalov MM, Saarma M (2007) GDNF family receptor complexes are emerging drug targets. Trends Pharmacol Sci 28:68\u201374","journal-title":"Trends Pharmacol Sci"},{"key":"74_CR6","doi-asserted-by":"crossref","first-page":"10999","DOI":"10.1523\/JNEUROSCI.23-35-10999.2003","volume":"23","author":"E Bezard","year":"2003","unstructured":"Bezard E, Dovero S, Belin D (2003) Enriched environment confers resistance to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine and cocaine: involvement of dopamine transporter and trophic factors. J Neurosci 23:10999\u201311007","journal-title":"J Neurosci"},{"key":"74_CR7","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.expneurol.2006.06.006","volume":"202","author":"HA Boger","year":"2006","unstructured":"Boger HA, Middaugh LD, Huang P, Zaman V, Smith AC, Hoffer BJ, Tomac AC (2006) A partial GDNF depletion leads to earlier age related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra. Exp Neurol 202:336\u2013347","journal-title":"Exp Neurol"},{"key":"74_CR8","doi-asserted-by":"crossref","first-page":"8816","DOI":"10.1523\/JNEUROSCI.1067-07.2007","volume":"27","author":"HA Boger","year":"2007","unstructured":"Boger HA, Middaugh LD, Patrick KS (2007) Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice. J Neurosci 27:8816\u20138825","journal-title":"J Neurosci"},{"key":"74_CR9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tins.2008.02.010","volume":"31","author":"WM Caudle","year":"2008","unstructured":"Caudle WM, Colebrooke RE, Emson PC, Mille GW (2008) Altered vesicular dopamine storage in Parkinson\u2019s disease: a premature demise. Trends Neurosci 31:303\u2013308","journal-title":"Trends Neurosci"},{"key":"74_CR10","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1073\/pnas.0813361106","volume":"106","author":"PC Chen","year":"2009","unstructured":"Chen PC, Vargas MR, Pani AK, Smeyne RJ, Johnson DA, Kan YW (2009) Nrf2 mediated neuroprotection in the MPTP mouse model of Parkinson\u2019s disease: critical role for the astrocyte. Proc Natl Acad Sci 106:2933\u20132938","journal-title":"Proc Natl Acad Sci"},{"key":"74_CR11","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.neuropharm.2011.01.043","volume":"60","author":"YC Chung","year":"2011","unstructured":"Chung YC, Kim SR, Park JY, Chung ES, Park KW, Won SY, Bok E, Jin M, Park ES, Yoon SH, Ko HW, Kim YS, Jin BK (2011) Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation. Neuropharmacology 60:963\u2013974","journal-title":"Neuropharmacology"},{"key":"74_CR12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrn3039","volume":"12","author":"TJ Collier","year":"2011","unstructured":"Collier TJ, Kanaan NM, Kordower JH (2011) Aging as a primary risk factor for Parkinson\u2019s disease: evidence from studies of nonhuman primates. Nat Rev Neurosci 12:359\u2013366","journal-title":"Nat Rev Neurosci"},{"key":"74_CR13","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1097\/00001756-199807130-00039","volume":"9","author":"I Date","year":"1998","unstructured":"Date I, Aoi M, Tomita S, Collins F, Ohmoto T (1998) GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged Parkinsonian mice. NeuroReport 9:2365\u20132369","journal-title":"NeuroReport"},{"key":"74_CR14","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1111\/j.1460-9568.2005.04414.x","volume":"22","author":"E Dowd","year":"2005","unstructured":"Dowd E, Monville C, Torres EM, Wong LF, Azzouz M, Mazarakis ND, Dunnett SB (2005) Lentivector mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model. Eur J Neurosci 22:2587\u20132595","journal-title":"Eur J Neurosci"},{"key":"74_CR15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-4274(02)00428-9","volume":"139","author":"O Eberhardt","year":"2003","unstructured":"Eberhardt O, Schulz JB (2003) Apoptotic mechanisms and antiapoptotic therapy in the MPTP model of Parkinson\u2019s disease. Toxicol Lett 139:135\u2013151","journal-title":"Toxicol Lett"},{"key":"74_CR16","doi-asserted-by":"crossref","first-page":"5166","DOI":"10.1073\/pnas.93.10.5166","volume":"93","author":"JD Erickson","year":"1996","unstructured":"Erickson JD, Schafer MK, Bonner TI, Eiden LE, Weihe E (1996) Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter. Proc Natl Acad Sci 93:5166\u20135171","journal-title":"Proc Natl Acad Sci"},{"key":"74_CR17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0304-3940(97)00498-9","volume":"230","author":"G Escames","year":"1997","unstructured":"Escames G, Guerrero JM, Reiter RJ, Garcia JJ, MunozHoyos A, Ortiz GG (1997) Melatonin and vitamin E limit nitric oxide induced lipid peroxidation in rat brain homogenates. Neurosci Lett 230:147\u2013150","journal-title":"Neurosci Lett"},{"key":"74_CR18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","volume":"11","author":"H Esterbauer","year":"1991","unstructured":"Esterbauer H, Schaur RJ, Zollner H (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes. Free Radic Biol Med 11:81\u2013128","journal-title":"Free Radic Biol Med"},{"key":"74_CR19","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0028-3908(86)90205-4","volume":"25","author":"TN Ferraro","year":"1986","unstructured":"Ferraro TN, Golden GT, DeMattei M, Hare TA, Fariello RG (1986) Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutathione in the extrapyramidal system of the mouse. Neuropharmacology 25:1071\u20131074","journal-title":"Neuropharmacology"},{"key":"74_CR20","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/WNR.0b013e32832aa95b","volume":"20","author":"NM Filipov","year":"2009","unstructured":"Filipov NM, Norwood AB, Sistrunk SC (2009) Strain-specific sensitivity to MPTP of C57BL\/6 and BALB\/c mice is age dependent. Neuroreport 20:713\u2013717","journal-title":"Neuroreport"},{"key":"74_CR21","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1523\/JNEUROSCI.21-07-02247.2001","volume":"21","author":"A Hartmann","year":"2001","unstructured":"Hartmann A, Troadec J, Hunot S, Kikly K, Baptiste A (2001) Caspase-8 Is an effector in apoptotic death of dopaminergic neurons in Parkinson\u2019s disease, but pathway inhibition results in neuronal necrosis. J Neurosci 21:2247\u20132255","journal-title":"J Neurosci"},{"key":"74_CR22","doi-asserted-by":"crossref","unstructured":"Hirsch EC (2007) Animal models in neurodegenerative diseases. J Neural TransmSuppl 87\u201390","DOI":"10.1007\/978-3-211-73574-9_11"},{"key":"74_CR23","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1586\/14737175.8.7.1125","volume":"8","author":"M Hong","year":"2008","unstructured":"Hong M, Mukhida K, Mendez I (2008) GDNF therapy for Parkinson\u2019s disease. Expert Rev Neurother 8:1125\u20131139","journal-title":"Expert Rev Neurother"},{"key":"74_CR24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ana.410440712","volume":"44","author":"P Jenner","year":"1998","unstructured":"Jenner P, Olanow CW (1998) Understanding cell death in Parkinson\u2019s disease. Ann Neurol 44:72\u201384","journal-title":"Ann Neurol"},{"key":"74_CR25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","volume":"11","author":"D Jollow","year":"1974","unstructured":"Jollow D, Mitchell L, Zampaglione N, Gillete J (1974) Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3, 4-bromobenzenoxide as the hepatotoxic intermediate. Pharmacology 11:151\u2013169","journal-title":"Pharmacology"},{"key":"74_CR26","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/FBP.0b013e32833d4186","volume":"21","author":"MM Khan","year":"2010","unstructured":"Khan MM, Hoda MN, Ishrat T, Ahmad A, Khan MB, Khuwaja G, Raza SS, Safhi MM, Islam F (2010) Amelioration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced behavioral dysfunction and oxidative stress by Pycnogenol in mouse model of Parkinson\u2019s disease. Behav Pharmacol 21:563\u2013571","journal-title":"Behav Pharmacol"},{"key":"74_CR27","doi-asserted-by":"crossref","first-page":"10440","DOI":"10.1073\/pnas.93.19.10440","volume":"93","author":"PA Kingston","year":"1996","unstructured":"Kingston PA, Zufall F, Barnstable CJ (1996) Rat hippocampal neurons express genes for both rod retinal and olfactory cyclic nucleotide gated channels: novel targets for cAMP\/cGMP function. Proc Natl Acad Sci 93:10440\u201310445","journal-title":"Proc Natl Acad Sci"},{"key":"74_CR28","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1126\/science.290.5492.767","volume":"290","author":"JH Kordower","year":"2000","unstructured":"Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L, McBride J, Chen EY, Palfi S (2000) Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson\u2019s disease. Science 290:767\u2013773","journal-title":"Science"},{"key":"74_CR29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1023\/A:1023863003093","volume":"18","author":"R Kurosaki","year":"2003","unstructured":"Kurosaki R, Muramatsu Y, Watanabe H, Michimata M, Matsubara M, Imai Y, Araki T (2003) Role of dopamine transporter against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice. Metab Brain Dis 18:139\u2013146","journal-title":"Metab Brain Dis"},{"key":"74_CR30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0006-8993(97)01495-9","volume":"789","author":"PA Lapchak","year":"1998","unstructured":"Lapchak PA, Araujo DM, Hilt DC, Jiao S, Collin F, Miyoshi Y, Yi A, Zhang Z, Gash DM (1998) Topographical distribution of [125I]-glial cell line derived neurotrophic factor in unlesioned and MPTP-lesioned rhesus monkey\u00a0brain\u00a0following a bolus intraventricular injection. Brain Res 789:9\u201322","journal-title":"Brain Res"},{"key":"74_CR31","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.neures.2005.04.010","volume":"52","author":"YS Lau","year":"2005","unstructured":"Lau YS, Novikova L, Roels C (2005) MPTP treatment in mice does not transmit and cause Parkinsonian neurotoxicity in non-treated cagemates through close contact. Neurosci Res 52:371\u2013378","journal-title":"Neurosci Res"},{"key":"74_CR32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0197-0186(03)00113-X","volume":"44","author":"AM Lin","year":"2004","unstructured":"Lin AM, Yang CH, Ueng YF, Luh TY, Liu TY, Lay YP, Ho LT (2004) Differential effects of carboxyfullerene on MPP+\/MPTP-induced neurotoxicity. Neurochem Int 44:99\u2013105","journal-title":"Neurochem Int"},{"key":"74_CR33","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1126\/science.8493557","volume":"260","author":"LF Lin","year":"1993","unstructured":"Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F (1993) GDNF: a glial cell line derived neurotrophic factor for midbrain. Science 260:1130\u20131132","journal-title":"Science"},{"key":"74_CR34","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0166-2236(94)90099-X","volume":"17","author":"RM Lindsay","year":"1994","unstructured":"Lindsay RM, Wiegand SJ, Altar CA, DiStefano PS (1994) Neurotrophic factors: from molecule to man. Trends Neurosci 17:182\u2013190","journal-title":"Trends Neurosci"},{"key":"74_CR35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"74_CR36","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejphar.2013.02.048","volume":"705","author":"A Madankumar","year":"2013","unstructured":"Madankumar A, Jayakumar S, Gokuladhas K, Rajan B, Raghunandhakumar S, Asokkumar S, Devaki T (2013) Geraniol modulates tongue and hepatic phase I and phase II conjugation activities and may contribute directly to the chemopreventive activity against experimental oral carcinogenesis. Eur J Pharmacol 705:148\u2013155","journal-title":"Eur J Pharmacol"},{"key":"74_CR37","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1146\/annurev.bi.52.070183.003431","volume":"52","author":"A Meister","year":"1983","unstructured":"Meister A, Anderson ME (1983) Glutathione. Annu Rev Biochem 52:711\u2013760","journal-title":"Annu Rev Biochem"},{"key":"74_CR38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3940(99)00463-2","volume":"270","author":"M Mogi","year":"1999","unstructured":"Mogi M, Togari A, Kondo T, Mizuno Y, Komure O, Kuno S, Ichinose H, Nagatsu T (1999) Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson\u2019s disease. Neurosci Lett 270:45\u201348","journal-title":"Neurosci Lett"},{"key":"74_CR39","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s12640-009-9037-x","volume":"15","author":"M Moon","year":"2009","unstructured":"Moon M, Kim HG, Hwang L, Seo JH, Kim S, Hwang S, Kim S, Lee D, Chung H, Oh MS, Lee KT, Park S (2009) Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson\u2019s disease by blocking microglial activation. Neurotox Res 15:332\u2013347","journal-title":"Neurotox Res"},{"key":"74_CR40","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1096\/fasebj.12.10.905","volume":"12","author":"D Muralikrishnan","year":"1998","unstructured":"Muralikrishnan D, Mohanakumar KP (1998) Neuroprotection by bromocriptine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice. FASEB J 12:905\u2013912","journal-title":"FASEB J"},{"key":"74_CR41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/mds.21235","volume":"22","author":"AP Nicholas","year":"2007","unstructured":"Nicholas AP (2007) Levodopa induced hyperactivity in mice treated with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. Mov Disord 22:99\u2013104","journal-title":"Mov Disord"},{"key":"74_CR42","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.nurt.2008.02.003","volume":"5","author":"AL Peterson","year":"2008","unstructured":"Peterson AL, Nutt JG (2008) Treatment of Parkinson\u2019s disease with trophic factors. Neurotherapeutics 5:270\u2013280","journal-title":"Neurotherapeutics"},{"key":"74_CR43","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1023\/B:JOBB.0000041771.66775.d5","volume":"36","author":"S Przedborski","year":"2004","unstructured":"Przedborski S, Tieu K, Perier C, Vila M (2004) MPTP as a mitochondrial neurotoxic model of Parkinson\u2019s disease. J Bioenerg Biomembr 36:375\u2013379","journal-title":"J Bioenerg Biomembr"},{"key":"74_CR44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0925-4439(95)00008-R","volume":"1271","author":"DJ Reed","year":"1995","unstructured":"Reed DJ, Savage MK (1995) Influence of metabolic inhibitors on mitochondrial permeability transition and glutathione status. Biochim Biophys Acta 1271:43\u201350","journal-title":"Biochim Biophys Acta"},{"key":"74_CR45","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0165-0270(98)00078-8","volume":"83","author":"G Rozas","year":"1998","unstructured":"Rozas G, Lopez-Martin E, Guerra MJ, Labandeira-Garcia JL (1998) The overall rod performance test in the MPTP-treated mouse model of Parkinsonism. J Neurosci Methods 83:165\u2013175","journal-title":"J Neurosci Methods"},{"key":"74_CR46","doi-asserted-by":"crossref","first-page":"6968","DOI":"10.1046\/j.1432-1327.2000.01826.x","volume":"267","author":"M Saarma","year":"2000","unstructured":"Saarma M (2000) GDNF\u2014a stranger in the TGF-beta superfamily? Eur J Biochem 267:6968\u20136971","journal-title":"Eur J Biochem"},{"key":"74_CR47","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2174\/0929867013372922","volume":"8","author":"LM Sayre","year":"2001","unstructured":"Sayre LM, Smith MA, Perry G (2001) Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem 8:721\u2013738","journal-title":"Curr Med Chem"},{"key":"74_CR48","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00441-004-0938-y","volume":"318","author":"A Schober","year":"2004","unstructured":"Schober A (2004) Classic toxin-induced animal models of Parkinson\u2019s disease: 6-OHDA and MPTP. Cell Tissue Res 318:215\u2013224","journal-title":"Cell Tissue Res"},{"key":"74_CR49","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0006-8993(91)90170-Z","volume":"554","author":"RK Schwarting","year":"1991","unstructured":"Schwarting RK, Bonatz AE, Carey RJ, Huston JP (1991) Relationships between indices of behavioral asymmetries and neurochemical changes following mesencephalic 6-hydroxydopamine injections. Brain Res 554:46\u201355","journal-title":"Brain Res"},{"key":"74_CR50","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0301-0082(96)00040-8","volume":"50","author":"RK Schwarting","year":"1996","unstructured":"Schwarting RK, Huston JP (1996) The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery, and treatments. Prog Neurobiol 50:275\u2013331","journal-title":"Prog Neurobiol"},{"key":"74_CR51","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molbrainres.2004.09.017","volume":"134","author":"RJ Smeyne","year":"2005","unstructured":"Smeyne RJ, Jackson-Lewis V (2005) The MPTP model of Parkinson\u2019s disease. Brain Res Mol Brain Res 134:57\u201366","journal-title":"Brain Res Mol Brain Res"},{"key":"74_CR52","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3727\/000000007783464704","volume":"16","author":"DT Stephenson","year":"2007","unstructured":"Stephenson DT, Childs MA, Li Q, Carvajal-Gonzalez S, Opsahl A (2007) Differential loss of presynaptic dopaminergic markers in Parkinsonian monkeys. Cell Transplant 16:229\u2013244","journal-title":"Cell Transplant"},{"key":"74_CR53","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-8993(90)91656-2","volume":"528","author":"E Sundstrom","year":"1990","unstructured":"Sundstrom E, Fredriksson A, Archer T (1990) Chronic neurochemical and behavioral changes in MPTP-lesioned C57BL\/6 mice: a model for Parkinson\u2019s disease. Brain Res 528:181\u2013188","journal-title":"Brain Res"},{"key":"74_CR54","doi-asserted-by":"crossref","unstructured":"ansey MG, McCoy MK, Frank-Cannon TC (2007) Neuroinflammatory mechanisms in Parkinson\u2019s disease: potential environmental triggers, pathways, and targets for early therapeutic intervention. Exp Neurol 208:1\u201325","DOI":"10.1016\/j.expneurol.2007.07.004"},{"key":"74_CR55","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1006\/exnr.2002.8021","volume":"178","author":"JL Tillerson","year":"2002","unstructured":"Tillerson JL, Caudle WM, Reveron ME, Miller GW (2002) Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Exp Neurol 178:80\u201390","journal-title":"Exp Neurol"},{"key":"74_CR56","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.tiv.2008.12.014","volume":"23","author":"M Tiwari","year":"2009","unstructured":"Tiwari M, Kakkar P (2009) Plant-derived antioxidants geraniol and camphene protect rat alveolar macrophages against t-BHP-induced oxidative stress. Toxicol In Vitro 23:295\u2013301","journal-title":"Toxicol In Vitro"},{"key":"74_CR57","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ejphar.2011.09.171","volume":"670","author":"S Tsai","year":"2011","unstructured":"Tsai S, Chao C, Yin M (2011) Preventive and therapeutic effects of caffeic acid against inflammatory injury in striatum of MPTP-treated mice. Eur J Pharmacol 670:441\u2013447","journal-title":"Eur J Pharmacol"},{"key":"74_CR58","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.nbd.2008.02.011","volume":"30","author":"R Viaro","year":"2008","unstructured":"Viaro R, Sanchez-Pernaute R, Marti M, Trapella C, Isacson O, Morari M (2008) Nociceptin\/orphanin FQ receptor blockade attenuates MPTP-induced Parkinsonism. Neurobiol Dis 30:430\u2013438","journal-title":"Neurobiol Dis"},{"key":"74_CR59","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.gt.3301682","volume":"9","author":"L Wang","year":"2002","unstructured":"Wang L, Muramatsu S, Lu Y, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Hanazono Y, Kume A, Urano F, Ichinose H, Nagatsu T, Nakano I, Ozawa K (2002) Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson\u2019s disease. Gene Ther 9:381\u2013389","journal-title":"Gene Ther"},{"key":"74_CR60","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1096\/fj.00-0202rev","volume":"14","author":"E Weihe","year":"2000","unstructured":"Weihe E, Eiden LE (2000) Chemical neuroanatomy of the vesicular amine transporters. FASEB J 14:2435\u20132449","journal-title":"FASEB J"},{"key":"74_CR61","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0006-8993(97)01551-5","volume":"788","author":"AM Wright","year":"1998","unstructured":"Wright AM, Bempong J, Kirby ML, Barlow RL, Bloomquist JR (1998) Effects of haloperidol metabolites on neurotransmitter uptake and release: possible role in neurotoxicity and tardive dyskinesia. Brain Res 788:215\u2013222","journal-title":"Brain Res"},{"key":"74_CR62","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1523\/JNEUROSCI.22-05-01763.2002","volume":"22","author":"DC Wu","year":"2002","unstructured":"Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, Przedborski S (2002) Blockade of microglial activation is neuroprotective in the1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson\u2019s Disease. J Neurosci 22:1763\u20131771","journal-title":"J Neurosci"},{"key":"74_CR63","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2165\/00023210-200519090-00001","volume":"19","author":"SS Wu","year":"2005","unstructured":"Wu SS, Frucht SJ (2005) Treatment of Parkinson\u2019s disease\u2014what\u2019s on the horizon? CNS Drugs 19:723\u2013743","journal-title":"CNS Drugs"},{"key":"74_CR64","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroscience.2010.01.048","volume":"167","author":"G Xu","year":"2010","unstructured":"Xu G, Xiongy Z, Yong Y, Wang Z, Ke Z, Xia Z, Hu Y (2010) Catalpol attenuates MPTP\u2013induced neuronal degeneration of niagral striatal dopaminergic pathway in mice through elevating glial cell derived neurotropic factor in striatum. Neuroscience 167:174\u2013184","journal-title":"Neuroscience"},{"key":"74_CR65","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/jgm.1377","volume":"11","author":"X Yang","year":"2009","unstructured":"Yang X, Mertens B, Lehtonen E, Vercammen L, Bockstael O, Chtarto A, Levivier M, Brotchi J, Michotte Y, Baekelandt V, Sarre S, Tenenbaum L (2009) Reversible neurochemical changes mediated by delayed intrastriatal glial cell line derived neurotrophic factor gene delivery in a partial Parkinson\u2019s disease rat model. J Gene Med 11:899\u2013912","journal-title":"J Gene Med"},{"key":"74_CR66","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneuroim.2008.08.003","volume":"204","author":"Y Yasuda","year":"2008","unstructured":"Yasuda Y, Shimoda T, Uno K, Tateishi N, Furuya S, Yagi K (2008) The effects of MPTP on the activation of microglia\/astrocytes and cytokine\/chemokine levels in different mice strains. J Neuroimmunol 204:43\u201351","journal-title":"J Neuroimmunol"},{"key":"74_CR67","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0006-8993(00)03217-0","volume":"891","author":"DM Yurek","year":"2001","unstructured":"Yurek DM, Fletcher-Turner A (2001) Differential expression of GDNF, BDNF, and NT-3 in the aging nigrostriatal system following a neurotoxic lesion. Brain Res 891:228\u2013235","journal-title":"Brain Res"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-013-0074-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-013-0074-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-013-0074-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T15:35:49Z","timestamp":1646321749000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-013-0074-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,13]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["74"],"URL":"https:\/\/doi.org\/10.1007\/s12031-013-0074-9","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,13]]}}}