{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T19:31:19Z","timestamp":1778787079006,"version":"3.51.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,3,16]],"date-time":"2013-03-16T00:00:00Z","timestamp":1363392000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1007\/s12031-013-9993-8","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T15:35:05Z","timestamp":1363361705000},"page":"364-370","source":"Crossref","is-referenced-by-count":13,"title":["Saturable Leptin Transport Across the BBB Persists in EAE Mice"],"prefix":"10.1007","volume":"51","author":[{"given":"Hung","family":"Hsuchou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramod K.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abba J.","family":"Kastin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suidong","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,3,16]]},"reference":[{"key":"9993_CR1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0196-9781(96)00025-3","volume":"17","author":"WA Banks","year":"1996","unstructured":"Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM (1996) Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305\u2013311","journal-title":"Peptides"},{"key":"9993_CR2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1172\/JCI26523","volume":"116","author":"V Rosa De","year":"2006","unstructured":"De Rosa V, Procaccini C, La CA, Chieffi P, Nicoletti GF, Fontana S, Zappacosta S, Matarese G (2006) Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. J Clin Invest 116:447\u2013455","journal-title":"J Clin Invest"},{"key":"9993_CR3","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.peptides.2005.10.006","volume":"27","author":"SA Farr","year":"2006","unstructured":"Farr SA, Banks WA, Morley JE (2006) Effects of leptin on memory processing. Peptides 27:1420\u20131425","journal-title":"Peptides"},{"key":"9993_CR4","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1038\/sj.npp.1301649","volume":"33","author":"JP Godbout","year":"2008","unstructured":"Godbout JP, Moreau M, Lestage J, Chen J, Sparkman NL, O' Connor J, Castanon N, Kelley KW, Dantzer R, Johnson RW (2008) Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system. Neuropsychopharmacology 33:2341\u20132351","journal-title":"Neuropsychopharmacology"},{"key":"9993_CR5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s12031-012-9734-4","volume":"47","author":"H Hsuchou","year":"2012","unstructured":"Hsuchou H, Kastin AJ, Pan W (2012) Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis. J Mol Neurosci 47:267\u2013277","journal-title":"J Mol Neurosci"},{"key":"9993_CR6","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/j.1471-4159.2010.07028.x","volume":"115","author":"H Hsuchou","year":"2010","unstructured":"Hsuchou H, Kastin AJ, Tu H, Abbott NJ, Couraud P-O, Pan W (2010) Role of astrocytic leptin receptor subtypes on leptin permeation across hCMEC\/D3 human brain endothelial cells. J Neurochem 115:1288\u20131298","journal-title":"J Neurochem"},{"key":"9993_CR7","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1038\/jcbfm.2009.79","volume":"29","author":"H Hsuchou","year":"2009","unstructured":"Hsuchou H, Pan W, Wu X, Kastin AJ (2009) Cessation of blood-to-brain influx of interleukin-15 during development of EAE. J Cereb Blood Flow Metab 29:1568\u20131578","journal-title":"J Cereb Blood Flow Metab"},{"key":"9993_CR8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/glia.21082","volume":"59","author":"P Huehnchen","year":"2011","unstructured":"Huehnchen P, Prozorovski T, Klaissle P, Lesemann A, Ingwersen J, Wolf SA, Kupsch A, Aktas O, Steiner B (2011) Modulation of adult hippocampal neurogenesis during myelin-directed autoimmune neuroinflammation. GLIA 59:132\u2013142","journal-title":"GLIA"},{"key":"9993_CR9","doi-asserted-by":"crossref","first-page":"S255","DOI":"10.1007\/s10072-010-0369-3","volume":"31","author":"G Mandolesi","year":"2010","unstructured":"Mandolesi G, Grasselli G, Musumeci G, Centonze D (2010) Cognitive deficits in experimental autoimmune encephalomyelitis: neuroinflammation and synaptic degeneration. Neurol Sci 31:S255\u2013S259","journal-title":"Neurol Sci"},{"key":"9993_CR10","doi-asserted-by":"crossref","first-page":"5150","DOI":"10.1073\/pnas.0408995102","volume":"102","author":"G Matarese","year":"2005","unstructured":"Matarese G, Carrieri PB, La Cava A, Perna F, De Sanna V, De Rossa R, Fontana S, Aufiero D, Zappacosta S (2005) Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells. Proc Natl Acad Sci U S A 102:5150\u20135155","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9993_CR11","doi-asserted-by":"crossref","first-page":"5909","DOI":"10.4049\/jimmunol.166.10.5909","volume":"166","author":"G Matarese","year":"2001","unstructured":"Matarese G, Di Giacomo A, Sanna V, Lord GM, Howard JK, Di TA, Bloom SR, Lechler RI, Zappacosta S, Fontana S (2001a) Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J Immunol 166:5909\u20135916","journal-title":"J Immunol"},{"key":"9993_CR12","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/1521-4141(200105)31:5<1324::AID-IMMU1324>3.0.CO;2-Y","volume":"31","author":"G Matarese","year":"2001","unstructured":"Matarese G, Sanna V, Di Giacomo A, Lord GM, Howard JK, Blood SR, Lechler RI, Fontana S, Zappacosta S (2001b) Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males. Eur J Immunol 31:1324\u20131332","journal-title":"Eur J Immunol"},{"key":"9993_CR13","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000117043","volume":"34","author":"IJ Namer","year":"1994","unstructured":"Namer IJ, Steibel J, Poulet P, Mauss Y, Mohr M, Chambron J (1994) The role of Mycobacterium tuberculosis in experimental allergic encephalomyelitis. Eur Neurol 34:224\u2013227","journal-title":"Eur Neurol"},{"key":"9993_CR14","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainres.2004.04.066","volume":"1016","author":"N Nonaka","year":"2004","unstructured":"Nonaka N, Hileman SM, Shioda S, Vo TQ, Banks WA (2004) Effects of lipopolysaccharide on leptin transport across the blood\u2014brain barrier. Brain Res 1016:58\u201365","journal-title":"Brain Res"},{"key":"9993_CR15","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1016\/j.peptides.2006.07.001","volume":"27","author":"Y Oomura","year":"2006","unstructured":"Oomura Y, Hori N, Shiraishi T, Fukunaga K, Takeda H, Tsuji M, Matsumiya T, Ishibashi M, Aou S, Li XL, Kohno D, Uramura K, Sougawa H, Yada T, Wayner MJ, Sasaki K (2006) Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides 27:2738\u20132749","journal-title":"Peptides"},{"key":"9993_CR16","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0028-3908(98)00141-5","volume":"37","author":"W Pan","year":"1998","unstructured":"Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ (1998) Transport of brain-derived neurotrophic factor across the blood\u2014brain barrier. Neuropharmcol 37:1553\u20131561","journal-title":"Neuropharmcol"},{"key":"9993_CR17","first-page":"E636","volume":"271","author":"W Pan","year":"1996","unstructured":"Pan W, Banks WA, Kennedy MK, Gutierrez EG, Kastin AJ (1996) Differential permeability of the BBB in acute EAE: enhanced transport of TNF-a. Am J Physiol 271:E636\u2013E642","journal-title":"Am J Physiol"},{"key":"9993_CR18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1385\/JMN:21:2:173","volume":"21","author":"W Pan","year":"2003","unstructured":"Pan W, Csernus B, Kastin AJ (2003a) Upregulation of p55 and p75 receptors mediating TNF alpha transport across the injured blood\u2013spinal cord barrier. J Mol Neurosci 21:173\u2013184","journal-title":"J Mol Neurosci"},{"key":"9993_CR19","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.expneurol.2005.11.020","volume":"198","author":"W Pan","year":"2006","unstructured":"Pan W, Ding Y, Yu Y, Ohtaki H, Nakamachi T, Kastin AJ (2006) Stroke upregulates TNFalpha transport across the blood\u2014brain barrier. Exp Neurol 198:222\u2013233","journal-title":"Exp Neurol"},{"key":"9993_CR20","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1210\/en.2007-0893","volume":"149","author":"W Pan","year":"2008","unstructured":"Pan W, Hsuchou H, Tu H, Kastin AJ (2008a) Developmental changes of leptin receptors in cerebral microvessels: unexpected relation to leptin transport. Endocrinology 149:877\u2013885","journal-title":"Endocrinology"},{"key":"9993_CR21","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s12031-010-9470-6","volume":"43","author":"W Pan","year":"2011","unstructured":"Pan W, Hsuchou H, Xu CL, Wu X, Bouret SG, Kastin AJ (2011a) Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese Avy mice. J Mol Neurosci 43:478\u2013484","journal-title":"J Mol Neurosci"},{"key":"9993_CR22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1471-4159.2008.05390.x","volume":"106","author":"W Pan","year":"2008","unstructured":"Pan W, Hsuchou H, Yu C, Kastin AJ (2008b) Permeation of blood-borne IL15 across the blood\u2014brain barrier and the effect of LPS. J Neurochem 106:313\u2013319","journal-title":"J Neurochem"},{"key":"9993_CR23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000054584","volume":"72","author":"W Pan","year":"2000","unstructured":"Pan W, Kastin AJ (2000) Interactions of IGF-1 with the blood\u2014brain barrier in vivo and in situ. Neuroendocrinology 72:171\u2013178","journal-title":"Neuroendocrinology"},{"key":"9993_CR24","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1523\/JNEUROSCI.19-09-03649.1999","volume":"19","author":"W Pan","year":"1999","unstructured":"Pan W, Kastin AJ, Bell RL, Olson RD (1999) Upregulation of tumor necrosis factor a transport across the blood\u2014brain barrier after acute compressive spinal cord injury. J Neurosci 19:3649\u20133655","journal-title":"J Neurosci"},{"key":"9993_CR25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00221-002-1355-7","volume":"149","author":"W Pan","year":"2003","unstructured":"Pan W, Kastin AJ, McLay RN, Rigai T, Pick CG (2003b) Increased hippocampal uptake of TNFa and behavioral changes in mice. Exp Brain Res 149:195\u2013199","journal-title":"Exp Brain Res"},{"key":"9993_CR26","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.2174\/138161211798220918","volume":"17","author":"W Pan","year":"2011","unstructured":"Pan W, Stone KP, Hsuchou H, Manda VK, Zhang Y, Kastin AJ (2011b) Cytokine signaling modulates blood\u2014brain barrier function. Curr Pharm Des 17:3729\u20133740","journal-title":"Curr Pharm Des"},{"key":"9993_CR27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0165-5728(02)00426-5","volume":"134","author":"W Pan","year":"2003","unstructured":"Pan W, Zhang L, Liao J, Csernus B, Kastin AJ (2003c) Selective increase in TNFa permeation across the blood\u2013spinal cord barrier after SCI. J Neuroimmunol 134:111\u2013117","journal-title":"J Neuroimmunol"},{"key":"9993_CR28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1172\/JCI200316721","volume":"111","author":"V Sanna","year":"2003","unstructured":"Sanna V, Di GA, La CA, Lechler RI, Fontana S, Zappacosta S, Matarese G (2003) Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest 111:241\u2013250","journal-title":"J Clin Invest"},{"key":"9993_CR29","doi-asserted-by":"crossref","first-page":"RC186","DOI":"10.1523\/JNEUROSCI.21-24-j0001.2001","volume":"21","author":"LJ Shanley","year":"2001","unstructured":"Shanley LJ, Irving AJ, Harvey J (2001) Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. J Neurosci 21:RC186","journal-title":"J Neurosci"},{"key":"9993_CR30","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1096\/fj.09-143487","volume":"24","author":"H Tu","year":"2010","unstructured":"Tu H, Hsuchou H, Kastin AJ, Wu X, Pan W (2010) Unique leptin trafficking by a tailless receptor. FASEB J 24:2281\u20132291","journal-title":"FASEB J"},{"key":"9993_CR31","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/jcp.21020","volume":"212","author":"H Tu","year":"2007","unstructured":"Tu H, Pan W, Feucht L, Kastin AJ (2007) Convergent trafficking pattern of leptin after endocytosis mediated by ObRa\u2013ObRd. J Cell Physiol 212:215\u2013222","journal-title":"J Cell Physiol"},{"key":"9993_CR32","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1600-0404.1988.tb03680.x","volume":"78","author":"AF Walls","year":"1988","unstructured":"Walls AF, Suckling AJ, Rumsby MG (1988) Autoantibody responses in the cerebrospinal fluid of guinea pigs with chronic relapsing experimental allergic encephalomyelitis. Acta Neurol Scand 78:422\u2013428","journal-title":"Acta Neurol Scand"},{"key":"9993_CR33","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s12031-012-9825-2","volume":"49","author":"X Wu","year":"2013","unstructured":"Wu X, Mishra PK, Hsuchou H, Kastin AJ, Pan W (2013) Upregulation of astrocytic leptin receptor in mice with experimental autoimmune encephalomyelitis. J Mol Neurosci 49:446\u2013456","journal-title":"J Mol Neurosci"},{"key":"9993_CR34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jneuroim.2010.04.001","volume":"223","author":"X Wu","year":"2010","unstructured":"Wu X, Pan W, He Y, Hsuchou H, Kastin AJ (2010) Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis. J Neuroimmunol 223:65\u201372","journal-title":"J Neuroimmunol"},{"key":"9993_CR35","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/labinvest.2010.6","volume":"90","author":"MO Ziehn","year":"2010","unstructured":"Ziehn MO, Avedisian AA, Tiwari-Woodruff S, Voskuhl RR (2010) Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE. Lab Invest 90:774\u2013786","journal-title":"Lab Invest"},{"key":"9993_CR36","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1111\/j.1471-4159.1986.tb01760.x","volume":"46","author":"BV Zlokovic","year":"1986","unstructured":"Zlokovic BV, Begley DJ, Djuricic B, Mitrovic DM (1986) Measurement of solute transport across the blood\u2014brain barrier in the perfused guinea-pig brain: method and application to N-methyl-a-aminoisobutyric acid. J Neurochem 46:1444\u20131451","journal-title":"J Neurochem"},{"key":"9993_CR37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF00999491","volume":"4","author":"BV Zlokovic","year":"1989","unstructured":"Zlokovic BV, Skundric DS, Segal MB, Colover J, Jankov RM, Pejnovic N, Lackovic V, Mackic J, Lipovac MN, Davson H (1989) Blood\u2014brain barrier permeability changes during acute allergic encephalomyelitis induced in the guinea pig. Metab Brain Dis 4:33\u201340","journal-title":"Metab Brain Dis"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-013-9993-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-013-9993-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-013-9993-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T21:10:51Z","timestamp":1562793051000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-013-9993-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,16]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["9993"],"URL":"https:\/\/doi.org\/10.1007\/s12031-013-9993-8","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,16]]}}}