{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:49:13Z","timestamp":1771660153532,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,8,9]],"date-time":"2014-08-09T00:00:00Z","timestamp":1407542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1007\/s12031-014-0396-2","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T09:48:25Z","timestamp":1407491305000},"page":"587-595","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["BAG1 is Neuroprotective in In Vivo and In Vitro Models of Parkinson\u2019s Disease"],"prefix":"10.1007","volume":"55","author":[{"given":"Pawel","family":"Kermer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"K\u00f6hn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlena","family":"Schnieder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Lingor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"B\u00e4hr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Liman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph Peter","family":"Dohm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,8,9]]},"reference":[{"key":"396_CR1","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1111\/j.1460-9568.2006.05192.x","volume":"24","author":"DW Anderson","year":"2006","unstructured":"Anderson DW, Bradbury KA, Schneider JS (2006) Neuroprotection in Parkinson models varies with toxin administration protocol. Eur J Neurosci 24:3174\u20133182","journal-title":"Eur J Neurosci"},{"key":"396_CR2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0301-0082(01)00003-X","volume":"65","author":"D Blum","year":"2001","unstructured":"Blum D, Torch S, Lambeng N et al (2001) Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson\u2019s disease. Prog Neurobiol 65:135\u2013172","journal-title":"Prog Neurobiol"},{"key":"396_CR3","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1602\/neurorx.2.3.484","volume":"2","author":"J Bove","year":"2005","unstructured":"Bove J, Prou D, Perier C, Przedborski S (2005) Toxin-induced models of Parkinson\u2019s disease. NeuroRx 2:484\u2013494","journal-title":"NeuroRx"},{"key":"396_CR4","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1128\/MCB.9.3.1049","volume":"9","author":"D Burke","year":"1989","unstructured":"Burke D, Gasdaska P, Hartwell L (1989) Dominant effects of tubulin overexpression in Saccharomyces cerevisiae. Mol Cell Biol 9:1049\u20131059","journal-title":"Mol Cell Biol"},{"key":"396_CR5","doi-asserted-by":"crossref","first-page":"a009423","DOI":"10.1101\/cshperspect.a009423","volume":"2","author":"C Cook","year":"2012","unstructured":"Cook C, Stetler C, Petrucelli L (2012) Disruption of protein quality control in Parkinson\u2019s disease. Cold Spring Harb Perspect Med 2:a009423","journal-title":"Cold Spring Harb Perspect Med"},{"key":"396_CR6","first-page":"S21","volume":"54","author":"MC Rijk de","year":"2000","unstructured":"de Rijk MC, Launer LJ, Berger K et al (2000) Prevalence of Parkinson\u2019s disease in Europe: a collaborative study of population-based cohorts. Neurol Dis Elder Res Group Neurol 54:S21\u2013S23","journal-title":"Neurol Dis Elder Res Group Neurol"},{"key":"396_CR7","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1083\/jcb.200904103","volume":"188","author":"S Deeg","year":"2010","unstructured":"Deeg S, Gralle M, Sroka K, Bahr M, Wouters FS, Kermer P (2010) BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity. J Cell Biol 188:505\u2013513","journal-title":"J Cell Biol"},{"key":"396_CR8","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0960-9822(01)00487-0","volume":"11","author":"J Demand","year":"2001","unstructured":"Demand J, Alberti S, Patterson C, Hohfeld J (2001) Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone\/proteasome coupling. Curr Biol 11:1569\u20131577","journal-title":"Curr Biol"},{"key":"396_CR9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000119459","volume":"5","author":"CP Dohm","year":"2008","unstructured":"Dohm CP, Kermer P, Bahr M (2008) Aggregopathy in neurodegenerative diseases: mechanisms and therapeutic implication. Neurodegener Dis 5:321\u2013338","journal-title":"Neurodegener Dis"},{"key":"396_CR10","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/emboj.2009.29","volume":"28","author":"M Gamerdinger","year":"2009","unstructured":"Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C (2009) Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J 28:889\u2013901","journal-title":"EMBO J"},{"key":"396_CR11","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1046\/j.1471-4159.1996.66052004.x","volume":"66","author":"Y Glinka","year":"1996","unstructured":"Glinka Y, Tipton KF, Youdim MB (1996) Nature of inhibition of mitochondrial respiratory complex I by 6-Hydroxydopamine. J Neurochem 66:2004\u20132010","journal-title":"J Neurochem"},{"key":"396_CR12","doi-asserted-by":"crossref","first-page":"E115","DOI":"10.1038\/35041081","volume":"2","author":"MS Goldberg","year":"2000","unstructured":"Goldberg MS, Lansbury PT Jr (2000) Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson\u2019s disease? Nat Cell Biol 2:E115\u2013E119","journal-title":"Nat Cell Biol"},{"key":"396_CR13","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1074\/jbc.M511560200","volume":"281","author":"K Hanrott","year":"2006","unstructured":"Hanrott K, Gudmunsen L, O'Neill MJ, Wonnacott S (2006) 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta. J Biol Chem 281:5373\u20135382","journal-title":"J Biol Chem"},{"key":"396_CR14","doi-asserted-by":"crossref","first-page":"54380","DOI":"10.1074\/jbc.M409282200","volume":"279","author":"H Jiang","year":"2004","unstructured":"Jiang H, Jiang Q, Feng J (2004) Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter. J Biol Chem 279:54380\u201354386","journal-title":"J Biol Chem"},{"key":"396_CR15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/sj.cdd.4400972","volume":"9","author":"P Kermer","year":"2002","unstructured":"Kermer P, Krajewska M, Zapata JM et al (2002) Bag1 is a regulator and marker of neuronal differentiation. Cell Death Differ 9:405\u2013413","journal-title":"Cell Death Differ"},{"key":"396_CR16","doi-asserted-by":"crossref","first-page":"25497","DOI":"10.1074\/jbc.M400255200","volume":"279","author":"J Klucken","year":"2004","unstructured":"Klucken J, Shin Y, Masliah E, Hyman BT, McLean PJ (2004) Hsp70 reduces alpha-synuclein aggregation and toxicity. J Biol Chem 279:25497\u201325502","journal-title":"J Biol Chem"},{"key":"396_CR17","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1128\/MCB.25.9.3715-3725.2005","volume":"25","author":"J Liman","year":"2005","unstructured":"Liman J, Ganesan S, Dohm CP et al (2005) Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity. Mol Cell Biol 25:3715\u20133725","journal-title":"Mol Cell Biol"},{"key":"396_CR18","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1093\/hmg\/11.20.2395","volume":"11","author":"J Lotharius","year":"2002","unstructured":"Lotharius J, Brundin P (2002) Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson\u2019s disease. Hum Mol Genet 11:2395\u20132407","journal-title":"Hum Mol Genet"},{"key":"396_CR19","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1074\/jbc.275.7.4613","volume":"275","author":"J Luders","year":"2000","unstructured":"Luders J, Demand J, Hohfeld J (2000) The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70\/Hsp70 and the proteasome. J Biol Chem 275:4613\u20134617","journal-title":"J Biol Chem"},{"key":"396_CR20","doi-asserted-by":"crossref","first-page":"10918","DOI":"10.1073\/pnas.191107398","volume":"98","author":"H Mochizuki","year":"2001","unstructured":"Mochizuki H, Hayakawa H, Migita M et al (2001) An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson\u2019s disease. Proc Natl Acad Sci U S A 98:10918\u201310923","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR21","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/0024-3205(85)90146-8","volume":"36","author":"WJ Nicklas","year":"1985","unstructured":"Nicklas WJ, Vyas I, Heikkila RE (1985) Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci 36:2503\u20132508","journal-title":"Life Sci"},{"key":"396_CR22","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1073\/pnas.95.10.5789","volume":"95","author":"D Offen","year":"1998","unstructured":"Offen D, Beart PM, Cheung NS et al (1998) Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity. Proc Natl Acad Sci U S A 95:5789\u20135794","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR23","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1471-4159.2008.05407.x","volume":"106","author":"F Opazo","year":"2008","unstructured":"Opazo F, Krenz A, Heermann S, Schulz JB, Falkenburger BH (2008) Accumulation and clearance of alpha-synuclein aggregates demonstrated by time-lapse imaging. J Neurochem 106:529\u2013540","journal-title":"J Neurochem"},{"key":"396_CR24","doi-asserted-by":"crossref","first-page":"e1867","DOI":"10.1371\/journal.pone.0001867","volume":"3","author":"TF Outeiro","year":"2008","unstructured":"Outeiro TF, Putcha P, Tetzlaff JE et al (2008) Formation of toxic oligomeric alpha-synuclein species in living cells. PLoS One 3:e1867","journal-title":"PLoS One"},{"key":"396_CR25","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.1128\/JVI.78.13.6808-6817.2004","volume":"78","author":"JC Paterna","year":"2004","unstructured":"Paterna JC, Feldon J, Bueler H (2004) Transduction profiles of recombinant adeno-associated virus vectors derived from serotypes 2 and 5 in the nigrostriatal system of rats. J Virol 78:6808\u20136817","journal-title":"J Virol"},{"key":"396_CR26","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0361-9230(92)90142-K","volume":"29","author":"AS Perumal","year":"1992","unstructured":"Perumal AS, Gopal VB, Tordzro WK, Cooper TB, Cadet JL (1992) Vitamin E attenuates the toxic effects of 6-hydroxydopamine on free radical scavenging systems in rat brain. Brain Res Bull 29:699\u2013701","journal-title":"Brain Res Bull"},{"key":"396_CR27","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1093\/brain\/awn196","volume":"131","author":"V Planchamp","year":"2008","unstructured":"Planchamp V, Bermel C, Tonges L et al (2008) BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity. Brain 131:2606\u20132619","journal-title":"Brain"},{"key":"396_CR28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1749-6632.2003.tb07476.x","volume":"991","author":"S Przedborski","year":"2003","unstructured":"Przedborski S, Vila M (2003) The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson\u2019s disease. Ann. N.Y. Acad Sci 991:189\u2013198","journal-title":"Acad Sci"},{"key":"396_CR29","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1074\/jbc.271.6.3317","volume":"271","author":"S Schoch","year":"1996","unstructured":"Schoch S, Cibelli G, Thiel G (1996) Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism. J Biol Chem 271:3317\u20133323","journal-title":"J Biol Chem"},{"key":"396_CR30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0005-2728(01)00183-9","volume":"1506","author":"F Schuler","year":"2001","unstructured":"Schuler F, Casida JE (2001) Functional coupling of PSST and ND1 subunits in NADH:ubiquinone oxidoreductase established by photoaffinity labeling. Biochim Biophys Acta 1506:79\u201387","journal-title":"Biochim Biophys Acta"},{"key":"396_CR31","doi-asserted-by":"crossref","first-page":"23727","DOI":"10.1074\/jbc.M503326200","volume":"280","author":"Y Shin","year":"2005","unstructured":"Shin Y, Klucken J, Patterson C, Hyman BT, McLean PJ (2005) The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. J Biol Chem 280:23727\u201323734","journal-title":"J Biol Chem"},{"key":"396_CR32","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1471-4159.2009.06363.x","volume":"111","author":"K Sroka","year":"2009","unstructured":"Sroka K, Voigt A, Deeg S et al (2009) BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution. J Neurochem 111:801\u2013807","journal-title":"J Neurochem"},{"key":"396_CR33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s007020050023","volume":"107","author":"A Storch","year":"2000","unstructured":"Storch A, Kaftan A, Burkhardt K, Schwarz J (2000) 6-Hydroxydopamine toxicity towards human SH-SY5Y dopaminergic neuroblastoma cells: independent of mitochondrial energy metabolism. J Neural Transm 107:281\u2013293","journal-title":"J Neural Transm"},{"key":"396_CR34","doi-asserted-by":"crossref","first-page":"E237","DOI":"10.1038\/ncb1001-e237","volume":"3","author":"S Takayama","year":"2001","unstructured":"Takayama S, Reed JC (2001) Molecular chaperone targeting and regulation by BAG family proteins. Nat Cell Biol 3:E237\u2013E241","journal-title":"Nat Cell Biol"},{"key":"396_CR35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0092-8674(95)90410-7","volume":"80","author":"S Takayama","year":"1995","unstructured":"Takayama S, Sato T, Krajewski S et al (1995) Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell 80:279\u2013284","journal-title":"Cell"},{"key":"396_CR36","first-page":"3116","volume":"58","author":"S Takayama","year":"1998","unstructured":"Takayama S, Krajewski S, Krajewska M et al (1998) Expression and location of Hsp70\/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. Cancer Res 58:3116\u20133131","journal-title":"Cancer Res"},{"key":"396_CR37","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0306-4522(96)00545-3","volume":"77","author":"NA Tatton","year":"1997","unstructured":"Tatton NA, Kish SJ (1997) In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining. Neuroscience 77:1037\u20131048","journal-title":"Neuroscience"},{"key":"396_CR38","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1073\/pnas.051633998","volume":"98","author":"M Vila","year":"2001","unstructured":"Vila M, Jackson-Lewis V, Vukosavic S et al (2001) Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson\u2019s disease. Proc Natl Acad Sci U S A 98:2837\u20132842","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3940(96)13276-6","volume":"221","author":"Y Wu","year":"1996","unstructured":"Wu Y, Blum D, Nissou MF, Benabid AL, Verna JM (1996) Unlike MPP+, apoptosis induced by 6-OHDA in PC12 cells is independent of mitochondrial inhibition. Neurosci Lett 221:69\u201371","journal-title":"Neurosci Lett"},{"key":"396_CR40","doi-asserted-by":"crossref","first-page":"e5515","DOI":"10.1371\/journal.pone.0005515","volume":"4","author":"M Xilouri","year":"2009","unstructured":"Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L (2009) Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS One 4:e5515","journal-title":"PLoS One"},{"key":"396_CR41","doi-asserted-by":"crossref","first-page":"8145","DOI":"10.1523\/JNEUROSCI.18-20-08145.1998","volume":"18","author":"L Yang","year":"1998","unstructured":"Yang L, Matthews RT, Schulz JB et al (1998) 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. J Neurosci 18:8145\u20138152","journal-title":"J Neurosci"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-014-0396-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-014-0396-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-014-0396-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T18:04:25Z","timestamp":1565719465000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-014-0396-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,9]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["396"],"URL":"https:\/\/doi.org\/10.1007\/s12031-014-0396-2","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,9]]}}}