{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:26:54Z","timestamp":1760369214085},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T00:00:00Z","timestamp":1416441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s12031-014-0436-y","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T15:16:35Z","timestamp":1416582995000},"page":"836-844","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Neural Cell Adhesion Molecule NrCAM Is Expressed in the Mammalian Inner Ear and Modulates Spiral Ganglion Neurite Outgrowth in an In Vitro Alternate Choice Assay"],"prefix":"10.1007","volume":"55","author":[{"given":"Yves","family":"Brand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang","family":"Pak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Chavez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Radojevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Bodmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen F.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,11,20]]},"reference":[{"key":"436_CR1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10162001000086","volume":"2","author":"C Aletsee","year":"2001","unstructured":"Aletsee C, Beros A, Mullen L et al (2001) Ras\/MEK but not p38 signaling mediates NT-3-induced neurite extension from spiral ganglion neurons. J Assoc Res Otolaryngol 2:377\u2013387","journal-title":"J Assoc Res Otolaryngol"},{"key":"436_CR2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/mp.2012.37","volume":"17","author":"M Ayalew","year":"2012","unstructured":"Ayalew M, Le-Niculescu H, Levey DF et al (2012) Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. Mol Psychiatry 17:887\u2013905","journal-title":"Mol Psychiatry"},{"key":"436_CR3","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/sj.ejhg.5201315","volume":"13","author":"E Bonora","year":"2005","unstructured":"Bonora E, Lamb JA, Barnby G et al (2005) Mutation screening and association analysis of six candidate genes for autism on chromosome 7q. Eur J Hum Genet 13:198\u2013207","journal-title":"Eur J Hum Genet"},{"key":"436_CR4","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s12031-013-0040-6","volume":"51","author":"Y Brand","year":"2013","unstructured":"Brand Y, Sung M, Chavez E et al (2013) Neural cell adhesion molecule L1 modulates type I but not type II inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay. J Mol Neurosci 51:663\u2013670","journal-title":"J Mol Neurosci"},{"key":"436_CR5","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0959-4388(96)80089-4","volume":"6","author":"T Br\u00fcmmendorf","year":"1996","unstructured":"Br\u00fcmmendorf T, Rathjen FG (1996) Structure\/function relationships of axon-associated adhesion receptors of the immunoglobulin superfamily. Curr Opin Neurobiol 6:584\u2013593","journal-title":"Curr Opin Neurobiol"},{"key":"436_CR6","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.semcdb.2013.04.003","volume":"24","author":"TM Coate","year":"2013","unstructured":"Coate TM, Kelly MW (2013) Making connections in the inner ear: recent insights into the development of spiral ganglion neurons and their connectivity with sensory hair cells. Semin Cell Dev Biol 24:460\u2013469","journal-title":"Semin Cell Dev Biol"},{"key":"436_CR7","doi-asserted-by":"crossref","first-page":"e73000","DOI":"10.1371\/journal.pone.0073000","volume":"8","author":"J Dai","year":"2013","unstructured":"Dai J, Buhusi M, Demyanenko GP et al (2013) Neuron glia-related cell adhesion molecule (NrCAM) promotes topographic retinocollicular mapping. PLoS ONE 8:e73000","journal-title":"PLoS ONE"},{"key":"436_CR8","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1523\/JNEUROSCI.4467-10.2011","volume":"31","author":"GP Demyanenko","year":"2011","unstructured":"Demyanenko GP, Riday TT, Tran TS et al (2011) NrCAM deletion causes topographic mistargeting of thalamocortical axons to the visual cortex and disrupts visual acuity. J Neurosci 31:1545\u20131558","journal-title":"J Neurosci"},{"key":"436_CR9","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1073\/pnas.89.14.6324","volume":"89","author":"SM Echteler","year":"1992","unstructured":"Echteler SM (1992) Development segregation in the afferent projections to mammlian auditory hair cells. Proc Natl Acad Sci U S A 89:6324\u20136327","journal-title":"Proc Natl Acad Sci U S A"},{"key":"436_CR10","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/1096-9861(20000925)425:3<436::AID-CNE8>3.0.CO;2-1","volume":"425","author":"SM Echteler","year":"2000","unstructured":"Echteler SM, Nofsinger YC (2000) Development of ganglion cell topography in the postnatal cochlea. J Comp Neurol 425:436\u2013446","journal-title":"J Comp Neurol"},{"key":"436_CR11","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/0896-6273(95)90263-5","volume":"14","author":"P Ernfors","year":"1995","unstructured":"Ernfors P, Van De Water T, Loring J, Jaenisch R (1995) Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron 14:1153\u20131164","journal-title":"Neuron"},{"key":"436_CR12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mcn.2012.12.004","volume":"54","author":"S Euteneuer","year":"2013","unstructured":"Euteneuer S, Yang KH, Chavez E et al (2013) Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM). Mol Cell Neurosci 54:30\u201343","journal-title":"Mol Cell Neurosci"},{"key":"436_CR13","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/dneu.20540","volume":"67","author":"A Evans","year":"2007","unstructured":"Evans A, Euteneuer S, Chavez E et al (2007) Laminin and fibronectin modulate inner ear spiral ganglion neurite outgrowth in an in vitro alternative choice assay. Dev Neurobiol 67:1721\u20131730","journal-title":"Dev Neurobiol"},{"key":"436_CR14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/neu.10282","volume":"58","author":"G Gallo","year":"2004","unstructured":"Gallo G, Letourneau PC (2004) Regulation of growth cone actin filament by guidance cues. J Neurobiol 58:92\u2013102","journal-title":"J Neurobiol"},{"key":"436_CR15","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1046\/j.1440-1681.2003.03909.x","volume":"30","author":"LN Gillespie","year":"2003","unstructured":"Gillespie LN (2003) Regulation of axonal growth and guidance by the neurotrophin family of neurotrophic factors. Clin Exp Pharmacol Physiol 30:724\u2013733","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"436_CR16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijdevneu.2003.12.002","volume":"22","author":"A Hari","year":"2004","unstructured":"Hari A, Djohar B, Skutella T, Montazeri S (2004) Neurotrophins and extracellular matrix molecules modulate sensory axon outgrowth. Int J Dev Neurosci 22:113\u2013117","journal-title":"Int J Dev Neurosci"},{"key":"436_CR17","first-page":"141","volume":"43","author":"CM Henley 3rd","year":"1989","unstructured":"Henley CM 3rd, Owings MH, Stagner BB, Martin GK, Lonsbury-Martin BL (1989) Postnatal development of 2f1-f2 otoacoustic emissions in pigmented rat. Hear Res 43:141\u2013148","journal-title":"Hear Res"},{"key":"436_CR18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neuroscience.2008.04.080","volume":"155","author":"A Heyden","year":"2008","unstructured":"Heyden A, Angenstein F, Sallaz M, Seidenbecher C, Montag D (2008) Abnormal axonal guidance and brain anatomy in mouse mutants for cell recognition molecules close homolog of L1 and NgCAM-related cell adhesion molecule. Neuroscience 155:221\u2013233","journal-title":"Neuroscience"},{"key":"436_CR19","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0896-6273(00)80192-0","volume":"17","author":"M Hortsch","year":"1996","unstructured":"Hortsch M (1996) The L1 family of neural cell adhesion molecules: old proteins preforming new tricks. Neuron 17:587\u2013593","journal-title":"Neuron"},{"key":"436_CR20","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1242\/dev.001925","volume":"134","author":"LC Huang","year":"2007","unstructured":"Huang LC, Thorne PR, Housley GD, Montgomery JM (2007) Spatiotemporal definition of neurite outgrowth, refinement and retraction in the developing mouse cochlea. Development 134:2925\u20132933","journal-title":"Development"},{"key":"436_CR21","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2350-5-12","volume":"5","author":"HB Hutcheson","year":"2004","unstructured":"Hutcheson HB, Olson LM, Bradford Y et al (2004) Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes. BMC Med Genet 5:2","journal-title":"BMC Med Genet"},{"key":"436_CR22","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/sj.npp.1300855","volume":"31","author":"H Ishiguro","year":"2006","unstructured":"Ishiguro H, Liu QR, Gong JP et al (2006) NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. Neuropsychopharmacol 31:572\u2013584","journal-title":"Neuropsychopharmacol"},{"key":"436_CR23","doi-asserted-by":"crossref","unstructured":"Ishiguro H., Hall F.S., Horiuchi Y. et al. (2012) NrCAM-regulating neural systems and addiction-related behaviors. Addict. Biol. (epub ahead of print)","DOI":"10.1111\/j.1369-1600.2012.00469.x"},{"key":"436_CR24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1440-1819.2008.01893.x","volume":"63","author":"HJ Kim","year":"2009","unstructured":"Kim HJ, Kim HG, Kim MH et al (2009) Association between neuronal cell adhesion molecule (NRCAM) single nucleotide polymorphisms and schizophrenia in a Korean population. Psychiatry Clin Neurosci 63:123\u2013124","journal-title":"Psychiatry Clin Neurosci"},{"key":"436_CR25","doi-asserted-by":"crossref","first-page":"14078","DOI":"10.1523\/JNEUROSCI.3765-07.2007","volume":"27","author":"EJ Kondakjian","year":"2007","unstructured":"Kondakjian EJ, Appler JL, Goodrich LV (2007) Aditory neurons make stereotyped wiring decision before maturation of their targets. J Neurosci 27:14078\u201314088","journal-title":"J Neurosci"},{"key":"436_CR26","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3109\/00207454.2013.764497","volume":"123","author":"K Kondo","year":"2013","unstructured":"Kondo K, Pak K, Chavez E, Mullen L, Euteneuer S, Ryan AF (2013) Changes in responsiveness of rat spiral ganglion neurons to neurotrophins across age: differential regulation of survival and neuritogenesis. Int J Neurosci 123:465\u2013475","journal-title":"Int J Neurosci"},{"key":"436_CR27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.neuroscience.2007.08.032","volume":"150","author":"F Lallemend","year":"2007","unstructured":"Lallemend F, Vandenbosch R, Hadjab S et al (2007) New insights into peripherin expression in cochlear neurons. Neurosci 150:212\u2013222","journal-title":"Neurosci"},{"key":"436_CR28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cell.2005.01.020","volume":"121","author":"T Marquardt","year":"2005","unstructured":"Marquardt T, Shirasaki R, Ghosh S et al (2005) Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. Cell 121:127\u2013139","journal-title":"Cell"},{"key":"436_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1461145708009127","volume":"12","author":"T Marui","year":"2009","unstructured":"Marui T, Funatogawa I, Koishi S et al (2009) Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism. Int J Neuropsychopharmacol 12:1\u201310","journal-title":"Int J Neuropsychopharmacol"},{"key":"436_CR30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainres.2011.10.054","volume":"1430","author":"LM Mullen","year":"2012","unstructured":"Mullen LM, Pak KK, Chavez E, Kondo K, Brand Y, Ryan AF (2012) Ras\/p38 and PI3K\/Akt but not Mek\/Erk signaling mediate BDNF- induced neurite formation on neonatal cochlear spiral ganglion explants. Brain Res 1430:25\u201334","journal-title":"Brain Res"},{"key":"436_CR31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.heares.2011.04.003","volume":"278","author":"BA Nayagam","year":"2011","unstructured":"Nayagam BA, Muniak MA, Ryugo DK (2011) The spiral ganglion: connecting the peripheral and central auditory systems. Hear Res 278:2\u201320","journal-title":"Hear Res"},{"key":"436_CR32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.semcdb.2003.09.006","volume":"15","author":"SF Oster","year":"2004","unstructured":"Oster SF, Deiner M, Birgbauer E, Sretavan DW (2004) Ganglion cell axon pathfinding in the retina and optic nerve. Semin Cell Dev Biol 15:125\u201336","journal-title":"Semin Cell Dev Biol"},{"key":"436_CR33","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature09146","volume":"466","author":"D Pinto","year":"2010","unstructured":"Pinto D, Pagnamenta AT, Klei L et al (2010) Functional impact of global rare copy number variation in autism spectrum disorders. Nature 466:368\u2013372","journal-title":"Nature"},{"key":"436_CR34","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0378-5955(91)90024-4","volume":"52","author":"U Pirvola","year":"1991","unstructured":"Pirvola U, Lehtonen E, Ylikoski J (1991) Spatiotemporal development of cochlear innervation and hair cell differentiation in the rat. Hear Res 52:345\u2013355","journal-title":"Hear Res"},{"key":"436_CR35","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1523\/JNEUROSCI.3923-03.2004","volume":"24","author":"MA Reid","year":"2004","unstructured":"Reid MA, Flores-Otero J, Davis RL (2004) Firing patterns of type II spiral ganglion neurons in vitro. J Neurosci 24:733\u2013742","journal-title":"J Neurosci"},{"key":"436_CR36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5955(92)90115-4","volume":"59","author":"LP Rybak","year":"1992","unstructured":"Rybak LP, Whitworth C, Scott V (1992) Development of endocochlear potential and compound action potential in the rat. Hear Res 59:189\u2013194","journal-title":"Hear Res"},{"key":"436_CR37","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/01.ypg.0000242196.81891.c9","volume":"16","author":"T Sakurai","year":"2006","unstructured":"Sakurai T, Ramoz N, Reichert JG et al (2006) Association analysis of the NrCAM gene in autism and in subsets of families with severe obsessive-compulsive or self-stimulatory behaviors. Psychiatr Genet 16:251\u2013257","journal-title":"Psychiatr Genet"},{"key":"436_CR38","first-page":"1309","volume":"5","author":"DD Simmons","year":"1994","unstructured":"Simmons DD (1994) A transient afferent innervation of outer hair cells in the postnatal cochlea. Neuroreport 5:1309\u20131312","journal-title":"Neuroreport"},{"key":"436_CR39","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3109\/00016487109125368","volume":"71","author":"Van de Water T.R. and Ruben R.J","year":"1971","unstructured":"Van de Water T.R. and Ruben R.J (1971) Organ culture of the mammalian inner ear. Acta Otolaryngol 71:303\u2013312","journal-title":"Acta Otolaryngol"},{"key":"436_CR40","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1023\/A:1007038609456","volume":"28","author":"DS Whitlon","year":"1999","unstructured":"Whitlon DS, Zhang X, Pecelunas K, Greiner MA (1999) A temporospatial map of adhesive molecules in the organ of Corti of the mouse cochlea. J Neurocytol 28:955\u2013968","journal-title":"J Neurocytol"},{"key":"436_CR41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.conb.2004.01.005","volume":"14","author":"S Yoshikawa","year":"2004","unstructured":"Yoshikawa S, Thomas JB (2004) Secreted cell signaling molecules in axcon guidance. Curr Opin Neurobiol 14:45\u201360","journal-title":"Curr Opin Neurobiol"},{"key":"436_CR42","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1242\/dev.01934","volume":"132","author":"P Zelina","year":"2005","unstructured":"Zelina P, Avci HX, Thelen K, Pollerberg GE (2005) The cell adhesion molecule NrCAM is crucial for growth cone behaviour and pathfinding of retinal ganglion cell axons. Development 132:3609\u20133618","journal-title":"Development"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-014-0436-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-014-0436-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-014-0436-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T17:52:39Z","timestamp":1566064359000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-014-0436-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,20]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["436"],"URL":"https:\/\/doi.org\/10.1007\/s12031-014-0436-y","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,20]]}}}