{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:48:50Z","timestamp":1792705730057,"version":"4.5.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,1,25]],"date-time":"2015-01-25T00:00:00Z","timestamp":1422144000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1007\/s12031-015-0495-8","type":"journal-article","created":{"date-parts":[[2015,1,24]],"date-time":"2015-01-24T07:47:34Z","timestamp":1422085654000},"page":"768-772","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Study of the Interaction of 1,4- and 1,5-Benzodiazepines with GABAA Receptors of Rat Cerebellum Granule Cells in Culture"],"prefix":"10.1007","volume":"56","author":[{"given":"Periklis","family":"Nikas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aroldo","family":"Cupello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Di Braccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Grossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pellistri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Robello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,25]]},"reference":[{"key":"495_CR1","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1007\/s11064-013-1171-4","volume":"38","author":"A Cupello","year":"2013","unstructured":"Cupello A, Di Braccio M, Gatta E, Grossi G, Nikas P, Pellistri F, Robello M (2013) GABAA receptors of cerebellar granule cells in culture: interaction with benzodiazepines. Neurochem Res 38:2453\u20132462","journal-title":"Neurochem Res"},{"key":"495_CR2","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.neuroscience.2009.05.031","volume":"162","author":"E Gatta","year":"2009","unstructured":"Gatta E, Cupello A, Pellistri F, Robello M (2009) GABAA receptors of cerebellar granule cells in culture: explanation of overall insensitivity to ethanol. Neuroscience 162:1187\u20131191","journal-title":"Neuroscience"},{"key":"495_CR3","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.neuroscience.2010.01.013","volume":"166","author":"E Gatta","year":"2010","unstructured":"Gatta E, Cupello A, Di Braccio M, Grossi G, Ferruzzi R, Roma G, Robello M (2010) New 1,5-benzodiazepine compounds: activity at native GABAA receptors. Neuroscience 166:917\u2013923","journal-title":"Neuroscience"},{"key":"495_CR4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0223-5234(93)90088-V","volume":"28","author":"GC Grossi","year":"1993","unstructured":"Grossi GC, Di Braccio M, Roma G, Ghia M, Brambilla G (1993) 1,5-Benzodiazepines XI. 5-(Dialkylamino) or 5-(alkylthio) substituted 8-chloro-6-phenyl-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepines with anticonvulsant activity. Eur J Med Chem 28:577\u2013584","journal-title":"Eur J Med Chem"},{"key":"495_CR5","first-page":"369","volume-title":"The pharmacological basis of therapeutics","author":"WR Hobbs","year":"1996","unstructured":"Hobbs WR, Rall TW, Verdoorn TA (1996) Hypnotics and sedatives; ethanol. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Goodman Gilman A (eds) The pharmacological basis of therapeutics. McGraw-Hill, New York, p 369"},{"key":"495_CR6","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nn1030","volume":"6","author":"AM Hosie","year":"2003","unstructured":"Hosie AM, Dunne EL, Harvey RJ, Smart TG (2003) Zinc-mediated inhibition of GABAA receptors: discrete binding sites underlie subunit specificity. Nat Neurosci 6:362\u2013369","journal-title":"Nat Neurosci"},{"key":"495_CR7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0026-895X(25)08539-6","volume":"47","author":"ER Korpi","year":"1995","unstructured":"Korpi ER, Kuner T, Seeburg PH, Luddens H (1995) Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol Pharmacol 47:283\u2013289","journal-title":"Mol Pharmacol"},{"key":"495_CR8","first-page":"673","volume":"7","author":"JT Leahy","year":"2011","unstructured":"Leahy JT, Chu-Shore CJ, Fisher JL (2011) Clobazam as an adjunctive therapy in treating seizures associated with Lennox-Gastaut syndrome. Neuropsychiatr Dis Treat 7:673\u2013681","journal-title":"Neuropsychiatr Dis Treat"},{"key":"495_CR9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0006-8993(84)90737-6","volume":"290","author":"G Levi","year":"1984","unstructured":"Levi G, Aloisi F, Ciotti MT, Gallo V (1984) Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cells cultures. Brain Res 290:77\u201386","journal-title":"Brain Res"},{"key":"495_CR10","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/346648a0","volume":"346","author":"H Luddens","year":"1990","unstructured":"Luddens H, Pritchett DB, Kohler M, Killisch I, Keinamen K, Monyer H, Sprengel R, Seeburg PH (1990) Cerebellar GABAA receptors selective for a behavioral alcohol antagonist. Nature 346:648\u2013651","journal-title":"Nature"},{"key":"495_CR11","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1471-4159.1984.tb06102.x","volume":"43","author":"E Meier","year":"1984","unstructured":"Meier E, Dreier J, Schousboe A (1984) GABA induces functionally active low-affinity GABAA receptors on cultured cerebellar granule cells. J Neurochem 43:1737\u20131744","journal-title":"J Neurochem"},{"key":"495_CR12","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neuroscience.2013.04.007","volume":"243","author":"P Nikas","year":"2013","unstructured":"Nikas P, Gatta E, Cupello A, Di Braccio M, Grossi G, Pellistri F, Robello M (2013) Modulation of native GABAA receptor activity by triazolo 1,5-benzodiazepines. Neuroscience 243:158\u2013164","journal-title":"Neuroscience"},{"key":"495_CR13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1124\/pr.108.00505","volume":"60","author":"RW Olsen","year":"2008","unstructured":"Olsen RW, Sieghart W (2008) International Union of Pharmacology. LXX. Subtypes of \u03b3-aminobutyric acidA receptors: classification on the basis of subunit composition, pharmacology, and function. Update. Pharmacol Rev 60:243\u2013260","journal-title":"Pharmacol Rev"},{"key":"495_CR14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0306-4522(93)90291-M","volume":"53","author":"M Robello","year":"1993","unstructured":"Robello M, Amico C, Cupello A (1993) Regulation of GABAA receptors in cerebellar granule cells in culture: differential involvement of kinase activiies. Neuroscience 53:131\u2013138","journal-title":"Neuroscience"},{"key":"495_CR15","first-page":"479","volume":"51","author":"S Rossi","year":"1969","unstructured":"Rossi S, Pirola O, Maggi R (1969) Sintesi di 1,2,4,5-tetraidro-2,4-dicheto-3H-1,5-benzodiazepine. Chim Ind 51:479\u2013483","journal-title":"Chim Ind"},{"key":"495_CR16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2165\/11599020-000000000-00000","volume":"26","author":"R Sankar","year":"2012","unstructured":"Sankar R (2012) GABAA receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazam. CNS Drugs 26:229\u2013244","journal-title":"CNS Drugs"},{"key":"495_CR17","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.1523\/JNEUROSCI.14-11-07077.1994","volume":"14","author":"NC Saxena","year":"1994","unstructured":"Saxena NC, Macdonald RL (1994) Assembly of GABAA receptor subunits: role of the delta subunit. J Neurosci 14:7077\u20137086","journal-title":"J Neurosci"},{"key":"495_CR18","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0026-895X(25)08745-0","volume":"49","author":"NC Saxena","year":"1996","unstructured":"Saxena NC, Macdonald RL (1996) Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms. Mol Pharmacol 49:567\u2013579","journal-title":"Mol Pharmacol"},{"key":"495_CR19","doi-asserted-by":"crossref","first-page":"4936","DOI":"10.1021\/jo01070a038","volume":"26","author":"LH Sternbach","year":"1961","unstructured":"Sternbach LH, Reeder E (1961) Quinazolines and 1,4-benzodiazepines. IV. Transformations of 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide. J Org Chem 26:4936\u20134941","journal-title":"J Org Chem"},{"key":"495_CR20","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1021\/jo01058a010","volume":"27","author":"LH Sternbach","year":"1962","unstructured":"Sternbach LH, Fryer RI, Metlesics W, Reeder E, Sach G, Saucy G, Stempel A (1962) Quinazolines and 1,4-benzodiazepines. VI. Halo-, methyl-, and methoxy-substituted 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-ones. J Org Chem 27:3788\u20133796","journal-title":"J Org Chem"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-015-0495-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-015-0495-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-015-0495-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T18:55:40Z","timestamp":1747508140000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-015-0495-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,25]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["495"],"URL":"https:\/\/doi.org\/10.1007\/s12031-015-0495-8","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,25]]}}}