{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:20:08Z","timestamp":1793330408525,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,3,22]],"date-time":"2015-03-22T00:00:00Z","timestamp":1426982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1007\/s12031-015-0539-0","type":"journal-article","created":{"date-parts":[[2015,3,21]],"date-time":"2015-03-21T08:34:54Z","timestamp":1426926894000},"page":"898-906","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Buyang Huanwu Decoction (BYHWD) Enhances Angiogenic Effect of Mesenchymal Stem Cell by Upregulating VEGF Expression After Focal Cerebral Ischemia"],"prefix":"10.1007","volume":"56","author":[{"given":"Junhong","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunke","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,3,22]]},"reference":[{"key":"539_CR1","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1097\/01.sla.0000225272.52313.e2","volume":"244","author":"A Belizon","year":"2006","unstructured":"Belizon A, Balik E, Feingold DL, Bessler M, Arnell TD, Forde KA, Horst PK, Jain S, Cekic V, Kirman I, Whelan RL (2006) Major abdominal surgery increases plasma levels of vascular endothelial growth factor: open more so than minimally invasive methods. Ann Surg 244:792\u2013798","journal-title":"Ann Surg"},{"key":"539_CR2","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1681\/ASN.2008070798","volume":"20","author":"S Bruno","year":"2009","unstructured":"Bruno S, Grange C, Deregibus MC, Calogero RA, Saviozzi S, Collino F, Morando L, Busca A, Falda M, Bussolati B, Tetta C, Camussi G (2009) Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 20:1053\u20131067","journal-title":"J Am Soc Nephrol"},{"key":"539_CR3","first-page":"591","volume":"22","author":"GX Cai","year":"2010","unstructured":"Cai GX, Liu BY (2010) Effect of ultra-micronized Buyang Huanwu decoction on neurological function, quality of life, and serum vascular endothelial growth factor in patients convalescent from cerebral infarction. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:591\u2013594","journal-title":"Zhongguo Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"539_CR4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jep.2011.02.011","volume":"135","author":"G Chen","year":"2011","unstructured":"Chen G, Wu L, Deng CQ (2011) The effects of BuYang HuanWu decoction and its effective components on proliferation-related factors and ERK1\/2 signal transduction pathway in cultured vascular smooth muscle cells. J Ethnopharmacol 135:7\u201314","journal-title":"J Ethnopharmacol"},{"key":"539_CR5","first-page":"113","volume":"11","author":"YJ Chen","year":"2009","unstructured":"Chen YJ (2009) Effect of Buyang Huanwu decoction on serum vascular endothelial growth factor level of the patients with acute cerebral infarction. J Liaoning Univ Tradit Chin Med 11:113\u2013115","journal-title":"J Liaoning Univ Tradit Chin Med"},{"key":"539_CR6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1474-4422(03)00266-7","volume":"2","author":"VL Feigin","year":"2003","unstructured":"Feigin VL, Lawes CM, Bennett DA, Anderson CS (2003) Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol 2:43\u201353","journal-title":"Lancet Neurol"},{"key":"539_CR7","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.devcel.2008.07.008","volume":"15","author":"JE Fish","year":"2008","unstructured":"Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D (2008) miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell 15:272\u2013284","journal-title":"Dev Cell"},{"key":"539_CR8","first-page":"21","volume":"630124","author":"CZ Hao","year":"2012","unstructured":"Hao CZ, Wu F, Shen J, Lu L, Fu DL, Liao WJ, Zheng GQ (2012) Clinical efficacy and safety of Buyang Huanwu decoction for acute ischemic stroke: a systematic review and meta-analysis of 19 randomized controlled trials. Evid Based Complement Alternat Med 630124:21","journal-title":"Evid Based Complement Alternat Med"},{"key":"539_CR9","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1515\/hsz-2013-0107","volume":"394","author":"F Huang","year":"2013","unstructured":"Huang F, Fang ZF, Hu XQ, Tang L, Zhou SH, Huang JP (2013) Overexpression of miR-126 promotes the differentiation of mesenchymal stem cells toward endothelial cells via activation of PI3K\/Akt and MAPK\/ERK pathways and release of paracrine factors. Biol Chem 394:1223\u20131233","journal-title":"Biol Chem"},{"key":"539_CR10","first-page":"5","volume":"518942","author":"C Jiang","year":"2014","unstructured":"Jiang C, Liu P, Zhang J, Bao W, Qiu S, Liang Y, Jiang L (2014) Clinical study of effects of Jian Ji Ning, a Chinese herbal medicine compound preparation, in treating patients with myasthenia gravis via the regulation of differential microRNAs expression in serum. Evid Based Complement Alternat Med 518942:5","journal-title":"Evid Based Complement Alternat Med"},{"key":"539_CR11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3892\/ijmm.2013.1444","volume":"32","author":"M Katoh","year":"2013","unstructured":"Katoh M (2013) Therapeutics targeting angiogenesis: genetics and epigenetics, extracellular miRNAs and signaling networks (review). Int J Mol Med 32:763\u2013767","journal-title":"Int J Mol Med"},{"key":"539_CR12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1440-1789.2012.01335.x","volume":"33","author":"M Kawabori","year":"2013","unstructured":"Kawabori M, Kuroda S, Ito M, Shichinohe H, Houkin K, Kuge Y, Tamaki N (2013) Timing and cell dose determine therapeutic effects of bone marrow stromal cell transplantation in rat model of cerebral infarct. Neuropathology 33:140\u2013148","journal-title":"Neuropathology"},{"key":"539_CR13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.scr.2009.12.003","volume":"4","author":"RC Lai","year":"2010","unstructured":"Lai RC, Arslan F, Lee MM, Sze NS, Choo A, Chen TS, Salto-Tellez M, Timmers L, Lee CN, El Oakley RM, Pasterkamp G, de Kleijn DP, Lim SK (2010) Exosome secreted by MSC reduces myocardial ischemia\/reperfusion injury. Stem Cell Res 4:214\u2013222","journal-title":"Stem Cell Res"},{"key":"539_CR14","first-page":"18","volume":"971907","author":"RC Lai","year":"2012","unstructured":"Lai RC, Tan SS, Teh BJ, Sze SK, Arslan F, de Kleijn DP, Choo A, Lim SK (2012) Proteolytic potential of the MSC exosome proteome: implications for an exosome-mediated delivery of therapeutic proteasome. Int J Proteomics 971907:18","journal-title":"Int J Proteomics"},{"key":"539_CR15","doi-asserted-by":"crossref","first-page":"e84256","DOI":"10.1371\/journal.pone.0084256","volume":"8","author":"JK Lee","year":"2013","unstructured":"Lee JK, Park SR, Jung BK, Jeon YK, Lee YS, Kim MK, Kim YG, Jang JY, Kim CW (2013) Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells. PLoS One 8:e84256","journal-title":"PLoS One"},{"key":"539_CR16","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1038\/jcbfm.2008.42","volume":"28","author":"CY Lin","year":"2008","unstructured":"Lin CY, Chang C, Cheung WM, Lin MH, Chen JJ, Hsu CY, Chen JH, Lin TN (2008) Dynamic changes in vascular permeability, cerebral blood volume, vascular density, and size after transient focal cerebral ischemia in rats: evaluation with contrast-enhanced magnetic resonance imaging. J Cereb Blood Flow Metab 28:1491\u20131501","journal-title":"J Cereb Blood Flow Metab"},{"key":"539_CR17","doi-asserted-by":"crossref","first-page":"42371","DOI":"10.1074\/jbc.M111.261065","volume":"286","author":"X Liu","year":"2011","unstructured":"Liu X, Cheng Y, Chen X, Yang J, Xu L, Zhang C (2011) MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog 2. J Biol Chem 286:42371\u201342380","journal-title":"J Biol Chem"},{"key":"539_CR18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2967\/jnumed.112.109017","volume":"54","author":"M Miyamoto","year":"2013","unstructured":"Miyamoto M, Kuroda S, Zhao S, Magota K, Shichinohe H, Houkin K, Kuge Y, Tamaki N (2013) Bone marrow stromal cell transplantation enhances recovery of local glucose metabolism after cerebral infarction in rats: a serial 18F-FDG PET study. J Nucl Med 54:145\u2013150","journal-title":"J Nucl Med"},{"key":"539_CR19","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1182\/blood-2006-01-012369","volume":"108","author":"L Poliseno","year":"2006","unstructured":"Poliseno L, Tuccoli A, Mariani L, Evangelista M, Citti L, Woods K, Mercatanti A, Hammond S, Rainaldi G (2006) MicroRNAs modulate the angiogenic properties of HUVECs. Blood 108:3068\u20133071","journal-title":"Blood"},{"key":"539_CR20","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00109-012-0918-8","volume":"90","author":"M Ragusa","year":"2012","unstructured":"Ragusa M, Statello L, Maugeri M, Majorana A, Barbagallo D, Salito L, Sammito M, Santonocito M, Angelica R, Cavallaro A, Scalia M, Caltabiano R, Privitera G, Biondi A, Di Vita M, Cappellani A, Vasquez E, Lanzafame S, Tendi E, Celeste S, Di Pietro C, Basile F, Purrello M (2012) Specific alterations of the microRNA transcriptome and global network structure in colorectal cancer after treatment with MAPK\/ERK inhibitors. J Mol Med 90:1421\u20131438","journal-title":"J Mol Med"},{"key":"539_CR21","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1161\/STROKEAHA.113.001612","volume":"44","author":"H Saito","year":"2013","unstructured":"Saito H, Magota K, Zhao S, Kubo N, Kuge Y, Shichinohe H, Houkin K, Tamaki N, Kuroda S (2013) 123I-iomazenil single photon emission computed tomography visualizes recovery of neuronal integrity by bone marrow stromal cell therapy in rat infarct brain. Stroke 44:2869\u20132874","journal-title":"Stroke"},{"key":"539_CR22","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.neuroscience.2005.08.092","volume":"137","author":"LH Shen","year":"2006","unstructured":"Shen LH, Li Y, Chen J, Zhang J, Vanguri P, Borneman J, Chopp M (2006) Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke. Neuroscience 137:393\u2013399","journal-title":"Neuroscience"},{"key":"539_CR23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.neuroscience.2012.08.001","volume":"223","author":"LH Shen","year":"2012","unstructured":"Shen LH, Ye M, Ding XS, Han Q, Zhang C, Liu XF, Huang H, Wu EB, Huang HF, Gu XS (2012) Protective effects of MCI-186 on transplantation of bone marrow stromal cells in rat ischemic stroke model. Neuroscience 223:315\u2013324","journal-title":"Neuroscience"},{"key":"539_CR24","first-page":"385","volume":"33","author":"YH Sheng","year":"2013","unstructured":"Sheng YH, Jin RM, Yao GT, Zhou L, Qiao JY (2013) Study on early change features of microRNA in the peripheral blood of Sophorae Tonkinensis Radix et Rhizoma induced liver injury rats. Zhongguo Zhong Xi Yi Jie He Za Zhi 33:385\u2013391","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"539_CR25","first-page":"1472","volume":"14","author":"KH Song","year":"2014","unstructured":"Song KH, Kim YH, Kim BY (2014) Sho-saiko-to, a traditional herbal medicine, regulates gene expression and biological function by way of microRNAs in primary mouse hepatocytes. BMC Complement Altern Med 14:1472\u20136882","journal-title":"BMC Complement Altern Med"},{"key":"539_CR26","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00281-010-0234-8","volume":"33","author":"DD Taylor","year":"2011","unstructured":"Taylor DD, Gercel-Taylor C (2011) Exosomes\/microvesicles: mediators of cancer-associated immunosuppressive microenvironments. Semin Immunopathol 33:441\u2013454","journal-title":"Semin Immunopathol"},{"key":"539_CR27","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","volume":"2","author":"C Thery","year":"2002","unstructured":"Thery C, Zitvogel L, Amigorena S (2002) Exosomes: composition, biogenesis and function. Nat Rev Immunol 2:569\u2013579","journal-title":"Nat Rev Immunol"},{"key":"539_CR28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jep.2011.06.033","volume":"138","author":"HW Wang","year":"2011","unstructured":"Wang HW, Liou KT, Wang YH, Lu CK, Lin YL, Lee IJ, Huang ST, Tsai YH, Cheng YC, Lin HJ, Shen YC (2011) Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice. J Ethnopharmacol 138:22\u201333","journal-title":"J Ethnopharmacol"},{"key":"539_CR29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1152\/ajpheart.00287.2013","volume":"306","author":"JY Wang","year":"2014","unstructured":"Wang JY, Gao YB, Zhang N, Zou DW, Xu LP, Zhu ZY, Li JY, Zhou SN, Cui FQ, Zeng XJ, Geng JG, Yang JK (2014) Tongxinluo ameliorates renal structure and function by regulating miR-21-induced epithelial-to-mesenchymal transition in diabetic nephropathy. Am J Physiol Ren Physiol 306:26","journal-title":"Am J Physiol Ren Physiol"},{"key":"539_CR30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.devcel.2008.07.002","volume":"15","author":"S Wang","year":"2008","unstructured":"Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R, Olson EN (2008) The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 15:261\u2013271","journal-title":"Dev Cell"},{"key":"539_CR31","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.gde.2009.04.002","volume":"19","author":"S Wang","year":"2009","unstructured":"Wang S, Olson EN (2009) AngiomiRs\u2014key regulators of angiogenesis. Curr Opin Genet Dev 19:205\u2013211","journal-title":"Curr Opin Genet Dev"},{"key":"539_CR32","first-page":"4","volume":"138484","author":"RL Wei","year":"2013","unstructured":"Wei RL, Teng HJ, Yin B, Xu Y, Du Y, He FP, Chu KT, Luo BY, Zheng GQ (2013) A systematic review and meta-analysis of Buyang Huanwu decoction in animal model of focal cerebral ischemia. Evid Based Complement Alternat Med 138484:4","journal-title":"Evid Based Complement Alternat Med"},{"key":"539_CR33","first-page":"2069","volume":"33","author":"SY Wei","year":"2008","unstructured":"Wei SY, Zhang PX, Yang DM, Zhang HB, Jiang BG (2008) Traditional Chinese medicine and formulas of improving peripheral nerve regeneration. Zhongguo Zhong Yao Za Zhi 33:2069\u20132072","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"539_CR34","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1002\/stem.1129","volume":"30","author":"H Xin","year":"2012","unstructured":"Xin H, Li Y, Buller B, Katakowski M, Zhang Y, Wang X, Shang X, Zhang ZG, Chopp M (2012) Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells 30:1556\u20131564","journal-title":"Stem Cells"},{"key":"539_CR35","first-page":"1145","volume":"7","author":"JN Xu","year":"2009","unstructured":"Xu JN, Que HF, Tang HJ (2009) Effects and action mechanisms of Buyang Huanwu decoction in wound healing of chronic skin ulcers of rats. Zhong Xi Yi Jie He Xue Bao 7:1145\u20131149","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"539_CR36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1142\/S0192415X14500049","volume":"42","author":"Q Zhang","year":"2014","unstructured":"Zhang Q, Zhao YH (2014) Therapeutic angiogenesis after ischemic stroke: Chinese medicines, bone marrow stromal cells (BMSCs) and their combinational treatment. Am J Chin Med 42:61\u201377","journal-title":"Am J Chin Med"},{"key":"539_CR37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0254-6272(10)60056-8","volume":"30","author":"YK Zhang","year":"2010","unstructured":"Zhang YK, Han XY, Che ZY (2010) Effects of Buyang Huanwu tang combined with bone marrow mesenchymal stem cell transplantation on the expression of VEGF and Ki-67 in the brain tissue of the cerebral ischemia-reperfusion model rat. J Tradit Chin Med 30:278\u2013282","journal-title":"J Tradit Chin Med"},{"key":"539_CR38","doi-asserted-by":"crossref","first-page":"933","DOI":"10.2337\/db11-1164","volume":"61","author":"HL Zhao","year":"2012","unstructured":"Zhao HL, Sui Y, Qiao CF, Yip KY, Leung RK, Tsui SK, Lee HM, Wong HK, Zhu X, Siu JJ, He L, Guan J, Liu LZ, Xu HX, Tong PC, Chan JC (2012a) Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression. Diabetes 61:933\u2013943","journal-title":"Diabetes"},{"key":"539_CR39","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jep.2012.01.026","volume":"140","author":"LD Zhao","year":"2012","unstructured":"Zhao LD, Wang JH, Jin GR, Zhao Y, Zhang HJ (2012b) Neuroprotective effect of Buyang Huanwu decoction against focal cerebral ischemia\/reperfusion injury in rats\u2014time window and mechanism. J Ethnopharmacol 140:339\u2013344","journal-title":"J Ethnopharmacol"},{"key":"539_CR40","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.25011\/cim.v31i1.3136","volume":"31","author":"W Zhong","year":"2008","unstructured":"Zhong W, Peng J, He H, Wu D, Han Z, Bi X, Dai Q (2008) Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia. Clin Invest Med 31:E8\u2013E15","journal-title":"Clin Invest Med"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-015-0539-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-015-0539-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-015-0539-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T02:37:42Z","timestamp":1598841462000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-015-0539-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,22]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["539"],"URL":"https:\/\/doi.org\/10.1007\/s12031-015-0539-0","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,22]]}}}