{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T09:48:47Z","timestamp":1784972927959,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T00:00:00Z","timestamp":1468022400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science of China","doi-asserted-by":"crossref","award":["30901402\u300130900417"],"award-info":[{"award-number":["30901402\u300130900417"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Educational Department Science Research Foundation of Jiangsu Province","award":["08KJB180011 \u3001 09KJD320008"],"award-info":[{"award-number":["08KJB180011 \u3001 09KJD320008"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s12031-016-0792-x","type":"journal-article","created":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T00:57:38Z","timestamp":1468025858000},"page":"258-266","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of Nectin-1\/c-Src Signaling in the Analgesic Effect of GDNF on a Rat Model of Chronic Constrictive Injury"],"prefix":"10.1007","volume":"60","author":[{"given":"Yuan-Yuan","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ya","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,9]]},"reference":[{"key":"792_CR1","doi-asserted-by":"crossref","first-page":"e92264","DOI":"10.1371\/journal.pone.0092264","volume":"9","author":"AK Chou","year":"2014","unstructured":"Chou AK, Yang MC, Tsai HP, et al. (2014) Adenoviral-mediated glial cell line\u2013derived neurotrophic factor Gene transfer has a protective effect on sciatic nerve following constriction-induced spinal cord injury. PLoS One 9:e92264","journal-title":"PLoS One"},{"key":"792_CR2","first-page":"205","volume":"54","author":"W Cunjin","year":"2014","unstructured":"Cunjin W, Hongjun W, Jun P, et al. (2014) Glial cell-derived neurotrophic factor attenuates neuropathic pain in a mouse model of chronic constriction injury: possible involvement of E-cadherin\/p120ctn signaling. J Mol Neurosci 54:205\u2013229","journal-title":"J Mol Neurosci"},{"key":"792_CR3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1126\/science.290.5489.124","volume":"290","author":"TJ Boucher","year":"2000","unstructured":"Boucher TJ, Okuse K, Bennett DL, et al. (2000) Potent analgesic effects of GDNF in neuropathic pain states. Science 290:124\u2013127","journal-title":"Science"},{"key":"792_CR4","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1126\/science.8493557","volume":"260","author":"LF Lin","year":"1993","unstructured":"Lin LF, Doherty DH, Lile JD, et al. (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130\u20131132","journal-title":"Science"},{"key":"792_CR5","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/373344a0","volume":"373","author":"RW Oppenheim","year":"1995","unstructured":"Oppenheim RW, Houenou LJ, Johnson JE, et al. (1995) Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature 373:344\u2013346","journal-title":"Nature"},{"key":"792_CR6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/35002084","volume":"403","author":"MS Ramer","year":"2000","unstructured":"Ramer MS, Priestley JV, Mcmahon SB (2000) Functional regeneration of sensory axons into the adult spinal cord. Nature 403:312\u2013316","journal-title":"Nature"},{"key":"792_CR7","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0014-4886(03)00183-3","volume":"183","author":"JG Boyd","year":"2003","unstructured":"Boyd JG, Gordon T (2003) Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor sustain the axonal regeneration of chronically axotomized motoneurons in vivo. Exp Neurol 183:610\u2013619","journal-title":"Exp Neurol"},{"key":"792_CR8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1046\/j.1471-4159.1999.0730070.x","volume":"73","author":"P \u00c5kerud","year":"1999","unstructured":"\u00c5kerud P, Alberch J, Eketj\u00e4ll S, et al. (1999) Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons. J Neurochem 73:70\u201378","journal-title":"J Neurochem"},{"key":"792_CR9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-3-211-33081-4_16","volume":"97","author":"NK Patel","year":"2007","unstructured":"Patel NK, Gill SS (2007) GDNF delivery for Parkinson\u2019s disease. Acta Neurochir Suppl 97:135\u2013154","journal-title":"Acta Neurochir Suppl"},{"key":"792_CR10","doi-asserted-by":"crossref","first-page":"e71076","DOI":"10.1371\/journal.pone.0071076","volume":"8","author":"E Ruben","year":"2013","unstructured":"Ruben E, Fred DW, Hoyng SA, et al. (2013) Lentiviral vector-mediated gradients of GDNF in the injured peripheral nerve: effects on nerve coil formation, Schwann cell maturation and myelination. PLoS One 8:e71076","journal-title":"PLoS One"},{"key":"792_CR11","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/0896-6273(95)90024-1","volume":"15","author":"E Arenas","year":"1995","unstructured":"Arenas E, Trupp M, \u00c5kerud P, et al. (1995) GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo. Neuron 15:1465\u20131473","journal-title":"Neuron"},{"key":"792_CR12","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.ymthe.2005.11.026","volume":"13","author":"S Pezet","year":"2006","unstructured":"Pezet S, Krzyzanowska A, Wong LF, et al. (2006) Reversal of neurochemical changes and pain-related behavior in a model of neuropathic pain using modified lentiviral vectors expressing GDNF. Mol Ther 13:1101\u20131109","journal-title":"Mol Ther"},{"key":"792_CR13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0306-4522(02)00958-2","volume":"117","author":"M Fang","year":"2003","unstructured":"Fang M, Wang Y, He QH, et al. (2003) Glial cell line-derived neurotrophic factor contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model. Neuroscience 117:503\u2013512","journal-title":"Neuroscience"},{"key":"792_CR14","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1097\/00001756-199903170-00036","volume":"10","author":"JL Jongen","year":"1999","unstructured":"Jongen JL, Dalm E, Vecht CJ, et al. (1999) Depletion of GDNF from primary afferents in adult rat dorsal horn following peripheral axotomy. Neuroreport 10:867\u2013871","journal-title":"Neuroreport"},{"key":"792_CR15","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn812","volume":"3","author":"MS Airaksinen","year":"2002","unstructured":"Airaksinen MS, Saarma M (2002) The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 3:383\u2013394","journal-title":"Nat Rev Neurosci"},{"key":"792_CR16","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.tins.2008.05.003","volume":"31","author":"G Paratcha","year":"2008","unstructured":"Paratcha G, Ledda F (2008) GDNF and GFR\u03b1: a versatile molecular complex for developing neurons. Trends Neurosci 31:384\u2013391","journal-title":"Trends Neurosci"},{"key":"792_CR17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1242\/jcs.00167","volume":"116","author":"Y Takai","year":"2003","unstructured":"Takai Y, Nakanishi H (2003) Nectin and afadin: novel organizers of intercellular junctions. J Cell Sci 116:17\u201327","journal-title":"J Cell Sci"},{"issue":"8","key":"792_CR18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-4614-8090-7_5","volume":"2014","author":"M Mori","year":"2014","unstructured":"Mori M, Rikitake Y, Mandai K, et al. (2014) Roles of nectins and nectin-like molecules in the nervous system. Adv Neurobiol 2014(8):91\u2013116","journal-title":"Adv Neurobiol"},{"key":"792_CR19","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1349-7006.2003.tb01499.x","volume":"94","author":"Y Takai","year":"2003","unstructured":"Takai Y, Irie K, Shimizu K, et al. (2003) Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization. Cancer Sci 94:655\u2013667","journal-title":"Cancer Sci"},{"key":"792_CR20","doi-asserted-by":"crossref","first-page":"10291","DOI":"10.1074\/jbc.275.14.10291","volume":"275","author":"HK Satoh","year":"2000","unstructured":"Satoh HK, Nakanishi HK, Miyahara M, et al. (2000) Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J Biol Chem 275:10291\u201310299","journal-title":"J Biol Chem"},{"key":"792_CR21","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1515\/BC.2004.116","volume":"385","author":"H Nakanishi","year":"2004","unstructured":"Nakanishi H, Takai Y (2004) Roles of nectins in cell adhesion, migration and polarization. Biol Chem 385:885\u2013892","journal-title":"Biol Chem"},{"key":"792_CR22","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/jb\/mvg198","volume":"134","author":"K Shimizu","year":"2003","unstructured":"Shimizu K, Takai Y (2003) Roles of the intercellular adhesion molecule nectin in intracellular signaling. J Biochem 134:631\u2013636","journal-title":"J Biochem"},{"key":"792_CR23","doi-asserted-by":"crossref","first-page":"e56897","DOI":"10.1371\/journal.pone.0056897","volume":"8","author":"M Fantin","year":"2013","unstructured":"Fantin M, Ma VDK, Grosse J, et al. (2013) A key role for nectin-1 in the ventral hippocampus in contextual fear memory. PLoS One 8:e56897","journal-title":"PLoS One"},{"key":"792_CR24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0304-3959(87)90088-1","volume":"30","author":"S Hunskaar","year":"1987","unstructured":"Hunskaar S, Hole K (1987) The formalin test in mice: dissociation between inflammatory and non\u2013inflammatory pain. Pain 30:103\u2013114","journal-title":"Pain"},{"key":"792_CR25","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/sj.bjp.0705550","volume":"140","author":"N Masatoshi","year":"2003","unstructured":"Masatoshi N, Atsushi S, Naoki T, et al. (2003) Decreased expression of glial cell line-derived neurotrophic factor signaling in rat models of neuropathic pain. Br J Pharmacol 140:1252\u20131260","journal-title":"Br J Pharmacol"},{"key":"792_CR26","first-page":"1197","volume":"6","author":"SL Liu","year":"2010","unstructured":"Liu SL, Yang JP, Wang LN, et al. (2010) Down-regulation of toll-like receptor 4 gene expression by short interfering RNA attenuates bone cancer pain in a rat model. Mol Pain 6:1197\u20131198","journal-title":"Mol Pain"},{"key":"792_CR27","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1111\/j.1460-9568.2012.08087.x","volume":"36","author":"LH Hang","year":"2012","unstructured":"Hang LH, Yang JP, Yin W, et al. (2012) Activation of spinal TDAG8 and its downstream PKA signaling pathway contribute to bone cancer pain in rats. Eur J Neurosci 36:2107\u20132117","journal-title":"Eur J Neurosci"},{"key":"792_CR28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","volume":"32","author":"K Hargreaves","year":"1988","unstructured":"Hargreaves K, Dubner R, Brown F, et al. (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32:77\u201388","journal-title":"Pain"},{"key":"792_CR29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1126\/science.278.5336.275","volume":"278","author":"PW Mantyh","year":"1997","unstructured":"Mantyh PW, Rogers SD, Honore P, et al. (1997) Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Science 278:275\u2013279","journal-title":"Science"},{"key":"792_CR30","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1083\/jcb.200103113","volume":"156","author":"A Mizoguchi","year":"2002","unstructured":"Mizoguchi A, Nakanishi H, Kimura K, et al. (2002) Nectin: an adhesion molecule involved in formation of synapses. J Cell Biol 156:555\u2013565","journal-title":"J Cell Biol"},{"key":"792_CR31","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.pain.2011.01.017","volume":"152","author":"SB Patil","year":"2011","unstructured":"Patil SB, Brock JH, Colman DR, et al. (2011) Neuropathic pain- and glial derived neurotrophic factor-associated regulation of cadherins in spinal circuits of the dorsal horn. Pain 152:924\u2013935","journal-title":"Pain"},{"key":"792_CR32","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00235250","volume":"26","author":"E Knyih\u00e1r","year":"1976","unstructured":"Knyih\u00e1r E, Csillik B (1976) Effect of peripheral anatomy on the fine structure and histochemistry of the Rolando substance: degenerative atrophy of central processes of pseudounipolar cells. Exp Brain Res 26:73\u201387","journal-title":"Exp Brain Res"},{"key":"792_CR33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/355075a0","volume":"355","author":"CJ Woolf","year":"1992","unstructured":"Woolf CJ, Shortland P, Coggeshall RE (1992) Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature 355:75\u201378","journal-title":"Nature"},{"key":"792_CR34","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrm2457","volume":"9","author":"Y Takai","year":"2008","unstructured":"Takai Y, Miyoshi J, Ikeda W, et al. (2008) Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat Rev Mol Cell Biol 9:603\u2013615","journal-title":"Nat Rev Mol Cell Biol"},{"key":"792_CR35","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1074\/jbc.M110.176305","volume":"286","author":"M Aiga","year":"2011","unstructured":"Aiga M, Levinson JN, Bamji SX (2011) N-cadherin and neuroligins cooperate to regulate synapse formation in hippocampal cultures. J Biol Chem 286:851\u2013858","journal-title":"J Biol Chem"},{"key":"792_CR36","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1097\/00005072-199711000-00002","volume":"56","author":"A Seto","year":"1997","unstructured":"Seto A, Hasegawa M, Uchiyama N, et al. (1997) Alteration of E-cadherin and alpha N-catenin immunoreactivity in the mouse spinal cord following peripheral axotomy. J Neuropathol Exp Neurol 56:1182\u20131190","journal-title":"J Neuropathol Exp Neurol"},{"key":"792_CR37","doi-asserted-by":"crossref","first-page":"50749","DOI":"10.1074\/jbc.M209846200","volume":"277","author":"T Kawakatsu","year":"2002","unstructured":"Kawakatsu T, Shimizu KT, Fukuhara T, et al. (2002) Trans-interactions of nectins induce formation of filopodia and lamellipodia through the respective activation of Cdc42 and Rac small G proteins. J Biol Chem 277:50749\u201350755","journal-title":"J Biol Chem"},{"key":"792_CR38","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1365-2443.2003.00649.x","volume":"8","author":"T Honda","year":"2003","unstructured":"Honda T, Shimizu K, Kawakatsu T, et al. (2003) Cdc42 and Rac small G proteins activated by trans-interactions of nectins are involved in activation of c-Jun N-terminal kinase, but not in association of nectins and cadherin to form adherens junctions, in fibroblasts. Genes Cells 8:481\u2013491","journal-title":"Genes Cells"},{"key":"792_CR39","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1074\/jbc.C200707200","volume":"278","author":"K Takekuni","year":"2003","unstructured":"Takekuni K, Ikeda WT, Morimoto K, et al. (2003) Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse. J Biol Chem 278:5497\u20135500","journal-title":"J Biol Chem"},{"key":"792_CR40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00418-008-0418-7","volume":"130","author":"K Ebnet","year":"2008","unstructured":"Ebnet K (2008) Organization of multiprotein complexes at cell-cell junctions. Histochem Cell Biol 130:1\u201320","journal-title":"Histochem Cell Biol"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-016-0792-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-016-0792-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-016-0792-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T14:06:43Z","timestamp":1498313203000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-016-0792-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,9]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["792"],"URL":"https:\/\/doi.org\/10.1007\/s12031-016-0792-x","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,9]]}}}