{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T19:54:05Z","timestamp":1760730845719,"version":"3.37.3"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81271436","No.81370028"],"award-info":[{"award-number":["No. 81271436","No.81370028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s12031-016-0795-7","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T01:43:21Z","timestamp":1468979001000},"page":"223-231","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Down-Regulated Expression of Liver X Receptor beta in Cortical Lesions of Patients with Focal Cortical Dysplasia"],"prefix":"10.1007","volume":"60","author":[{"given":"Xin","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,7,20]]},"reference":[{"key":"795_CR1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/cns.12345","volume":"21","author":"S Abdijadid","year":"2015","unstructured":"Abdijadid S, Mathern GW, Levine MS, Cepeda C (2015) Basic mechanisms of epileptogenesis in pediatric cortical dysplasia. CNS Neurosci Ther 21:92\u2013103. doi: 10.1111\/cns.12345","journal-title":"CNS Neurosci Ther"},{"key":"795_CR2","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1093\/brain\/awh331","volume":"128","author":"L Alonso-Nanclares","year":"2005","unstructured":"Alonso-Nanclares L, Garbelli R, Sola RG, Pastor J, Tassi L, Spreafico R, DeFelipe J (2005) Microanatomy of the dysplastic neocortex from epileptic patients. Brain 128:158\u2013173. doi: 10.1093\/brain\/awh331","journal-title":"Brain"},{"key":"795_CR3","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1097\/01.jnen.0000240473.50661.d8","volume":"66","author":"VM Andre","year":"2007","unstructured":"Andre VM et al (2007) Cytomegalic interneurons: a new abnormal cell type in severe pediatric cortical dysplasia. J Neuropathol Exp Neurol 66:491\u2013504. doi: 10.1097\/01.jnen.0000240473.50661.d8","journal-title":"J Neuropathol Exp Neurol"},{"key":"795_CR4","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1002\/ar.a.20015","volume":"277","author":"JS Annicotte","year":"2004","unstructured":"Annicotte JS, Schoonjans K, Auwerx J (2004) Expression of the liver X receptor alpha and beta in embryonic and adult mice. Anat Rec A: Discov Mol Cell Evol Biol 277:312\u2013316. doi: 10.1002\/ar.a.20015","journal-title":"Anat Rec A: Discov Mol Cell Evol Biol"},{"key":"795_CR5","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1161\/01.ATV.0000120374.59826.1b","volume":"24","author":"I Bjorkhem","year":"2004","unstructured":"Bjorkhem I, Meaney S (2004) Brain cholesterol: long secret life behind a barrier. Arterioscler Thromb Vasc Biol 24:806\u2013815. doi: 10.1161\/01.ATV.0000120374.59826.1b","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"795_CR6","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/j.1528-1167.2010.02777.x","volume":"52","author":"I Blumcke","year":"2011","unstructured":"Blumcke I et al (2011) The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia 52:158\u2013174. doi: 10.1111\/j.1528-1167.2010.02777.x","journal-title":"Epilepsia"},{"key":"795_CR7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.yebeh.2006.05.012","volume":"9","author":"C Cepeda","year":"2006","unstructured":"Cepeda C, Andre VM, Levine MS, Salamon N, Miyata H, Vinters HV, Mathern GW (2006) Epileptogenesis in pediatric cortical dysplasia: the dysmature cerebral developmental hypothesis. Epilepsy Behav E&B 9:219\u2013235. doi: 10.1016\/j.yebeh.2006.05.012","journal-title":"Epilepsy Behav E&B"},{"key":"795_CR8","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/cns.12494","volume":"22","author":"X Chen","year":"2016","unstructured":"Chen X et al (2016) Increased expression of transient receptor potential vanilloid 4 in Cortical lesions of patients with focal cortical dysplasia. CNS Neurosci Ther 22:280\u2013290. doi: 10.1111\/cns.12494","journal-title":"CNS Neurosci Ther"},{"key":"795_CR9","unstructured":"Engel J (1987) Surgical treatment of the epilepsies. Raven\u00a0Press, New York"},{"key":"795_CR10","doi-asserted-by":"publisher","first-page":"13445","DOI":"10.1073\/pnas.0806974105","volume":"105","author":"X Fan","year":"2008","unstructured":"Fan X, Kim HJ, Bouton D, Warner M, Gustafsson JA (2008) Expression of liver X receptor beta is essential for formation of superficial cortical layers and migration of later-born neurons. Proc Natl Acad Sci U S A 105:13445\u201313450. doi: 10.1073\/pnas.0806974105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"795_CR11","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/nn.2855","volume":"14","author":"SP Fancy","year":"2011","unstructured":"Fancy SP et al (2011) Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci 14:1009\u20131016. doi: 10.1038\/nn.2855","journal-title":"Nat Neurosci"},{"key":"795_CR12","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1126\/science.1223616","volume":"337","author":"SJ Franco","year":"2012","unstructured":"Franco SJ, Gil-Sanz C, Martinez-Garay I, Espinosa A, Harkins-Perry SR, Ramos C, Mueller U (2012) Fate-restricted neural progenitors in the mammalian cerebral cortex. Science 337:746\u2013749. doi: 10.1126\/science.1223616","journal-title":"Science"},{"key":"795_CR13","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1111\/epi.13200","volume":"56","author":"R Guerrini","year":"2015","unstructured":"Guerrini R et al (2015) Diagnostic methods and treatment options for focal cortical dysplasia. Epilepsia 56:1669\u20131686. doi: 10.1111\/epi.13200","journal-title":"Epilepsia"},{"key":"795_CR14","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.neuron.2013.09.037","volume":"80","author":"C Guo","year":"2013","unstructured":"Guo C, Eckler MJ, McKenna WL, McKinsey GL, Rubenstein JL, Chen B (2013) Fezf2 expression identifies a multipotent progenitor for neocortical projection neurons, astrocytes, and oligodendrocytes. Neuron 80:1167\u20131174. doi: 10.1016\/j.neuron.2013.09.037","journal-title":"Neuron"},{"key":"795_CR15","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.neuint.2014.03.009","volume":"71","author":"L Guo","year":"2014","unstructured":"Guo L et al (2014) Liver X receptor beta delays transformation of radial glial cells into astrocytes during mouse cerebral cortical development. Neurochem Int 71:8\u201316. doi: 10.1016\/j.neuint.2014.03.009","journal-title":"Neurochem Int"},{"key":"795_CR16","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00401-010-0686-x","volume":"120","author":"G Hadjivassiliou","year":"2010","unstructured":"Hadjivassiliou G, Martinian L, Squier W, Blumcke I, Aronica E, Sisodiya SM, Thom M (2010) The application of cortical layer markers in the evaluation of cortical dysplasias in epilepsy. Acta Neuropathol 120:517\u2013528. doi: 10.1007\/s00401-010-0686-x","journal-title":"Acta Neuropathol"},{"key":"795_CR17","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","volume":"32","author":"A Kriegstein","year":"2009","unstructured":"Kriegstein A, Alvarez-Buylla A (2009) The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 32:149\u2013184. doi: 10.1146\/annurev.neuro.051508.135600","journal-title":"Annu Rev Neurosci"},{"key":"795_CR18","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1093\/brain\/awm175","volume":"130","author":"P Lamparello","year":"2007","unstructured":"Lamparello P, Baybis M, Pollard J, Hol EM, Eisenstat DD, Aronica E, Crino PB (2007) Developmental lineage of cell types in cortical dysplasia with balloon cells. Brain 130:2267\u20132276. doi: 10.1093\/brain\/awm175","journal-title":"Brain"},{"key":"795_CR19","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1242\/dev.085852","volume":"140","author":"P Malatesta","year":"2013","unstructured":"Malatesta P, Goetz M (2013) Radial glia\u2014from boring cables to stem cell stars. Development 140:483\u2013486. doi: 10.1242\/dev.085852","journal-title":"Development"},{"key":"795_CR20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00401-014-1304-0","volume":"128","author":"IM Najm","year":"2014","unstructured":"Najm IM, Tassi L, Sarnat HB, Holthausen H, Russo GL (2014) Epilepsies associated with focal cortical dysplasias (FCDs). Acta Neuropathol 128:5\u201319. doi: 10.1007\/s00401-014-1304-0","journal-title":"Acta Neuropathol"},{"key":"795_CR21","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1523\/JNEUROSCI.22-08-03161.2002","volume":"22","author":"SC Noctor","year":"2002","unstructured":"Noctor SC, Flint AC, Weissman TA, Wong WS, Clinton BK, Kriegstein AR (2002) Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia. J Neurosci Off J Soc Neurosci 22:3161\u20133173","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"795_CR22","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1002\/glia.22365","volume":"60","author":"J Relucio","year":"2012","unstructured":"Relucio J, Menezes MJ, Miyagoe-Suzuki Y, Takeda S, Colognato H (2012) Laminin regulates postnatal oligodendrocyte production by promoting oligodendrocyte progenitor survival in the subventricular zone. Glia 60:1451\u20131467. doi: 10.1002\/glia.22365","journal-title":"Glia"},{"key":"795_CR23","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/nn1426","volume":"8","author":"G Saher","year":"2005","unstructured":"Saher G et al (2005) High cholesterol level is essential for myelin membrane growth. Nat Neurosci 8:468\u2013475. doi: 10.1038\/nn1426","journal-title":"Nat Neurosci"},{"key":"795_CR24","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1750-3639.2007.00059.x","volume":"17","author":"V Schick","year":"2007","unstructured":"Schick V et al (2007) Differential Pi3K-pathway activation in cortical tubers and focal cortical dysplasias with balloon cells. Brain Pathol 17:165\u2013173. doi: 10.1111\/j.1750-3639.2007.00059.x","journal-title":"Brain Pathol"},{"key":"795_CR25","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1111\/epi.12143","volume":"54","author":"C Shepherd","year":"2013","unstructured":"Shepherd C, Liu J, Goc J, Martinian L, Jacques TS, Sisodiya SM, Thom M (2013) A quantitative study of white matter hypomyelination and oligodendroglial maturation in focal cortical dysplasia type II. Epilepsia 54:898\u2013908. doi: 10.1111\/epi.12143","journal-title":"Epilepsia"},{"key":"795_CR26","doi-asserted-by":"publisher","first-page":"12305","DOI":"10.1073\/pnas.1006162107","volume":"107","author":"XJ Tan","year":"2010","unstructured":"Tan XJ, Fan XT, Kim HJ, Butler R, Webb P, Warner M, Gustafsson JA (2010) Liver X receptor beta and thyroid hormone receptor alpha in brain cortical layering. Proc Natl Acad Sci U S A 107:12305\u201312310. doi: 10.1073\/pnas.1006162107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"795_CR27","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1136\/jnnp.34.4.369","volume":"34","author":"DC Taylor","year":"1971","unstructured":"Taylor DC, Falconer MA, Bruton CJ, Corsellis JA (1971) Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 34:369\u2013387","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"795_CR28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1528-1157.2002.38201.x","volume":"43","author":"H Urbach","year":"2002","unstructured":"Urbach H et al (2002) Focal cortical dysplasia of Taylor\u2019s balloon cell type: a clinicopathological entity with characteristic neuroimaging and histopathological features, and favorable postsurgical outcome. Epilepsia 43:33\u201340","journal-title":"Epilepsia"},{"key":"795_CR29","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/mp.2014.23","volume":"20","author":"M Warner","year":"2015","unstructured":"Warner M, Gustafsson JA (2015) Estrogen receptor beta and Liver X receptor beta: biology and therapeutic potential in CNS diseases. Mol Psychiatry 20:18\u201322. doi: 10.1038\/mp.2014.23","journal-title":"Mol Psychiatry"},{"key":"795_CR30","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1111\/j.1471-4159.2010.07053.x","volume":"115","author":"Y Xing","year":"2010","unstructured":"Xing Y, Fan X, Ying D (2010) Liver X receptor agonist treatment promotes the migration of granule neurons during cerebellar development. J Neurochem 115:1486\u20131494. doi: 10.1111\/j.1471-4159.2010.07053.x","journal-title":"J Neurochem"},{"key":"795_CR31","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/mp.2014.60","volume":"19","author":"P Xu","year":"2014","unstructured":"Xu P et al (2014) Liver X receptor beta is essential for the differentiation of radial glial cells to oligodendrocytes in the dorsal cortex. Mol Psychiatry 19:947\u2013957. doi: 10.1038\/mp.2014.60","journal-title":"Mol Psychiatry"},{"key":"795_CR32","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/nn.2333","volume":"12","author":"F Ye","year":"2009","unstructured":"Ye F et al (2009) HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci 12:829\u2013838. doi: 10.1038\/nn.2333","journal-title":"Nat Neurosci"},{"key":"795_CR33","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1523\/jneurosci.4717-05.2006","volume":"26","author":"T Yue","year":"2006","unstructured":"Yue T, Xian K, Hurlock E, Xin M, Kernie SG, Parada LF, Lu QR (2006) A critical role for dorsal progenitors in cortical myelination. J Neurosci Off J Soc Neurosci 26:1275\u20131280. doi: 10.1523\/jneurosci.4717-05.2006","journal-title":"J Neurosci Off J Soc Neurosci"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-016-0795-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-016-0795-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-016-0795-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T08:01:09Z","timestamp":1568188869000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-016-0795-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,20]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["795"],"URL":"https:\/\/doi.org\/10.1007\/s12031-016-0795-7","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"type":"print","value":"0895-8696"},{"type":"electronic","value":"1559-1166"}],"subject":[],"published":{"date-parts":[[2016,7,20]]}}}