{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:28:47Z","timestamp":1791876527651,"version":"4.3.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"The study was supported by Innlandet Hospital research foundation, Norway."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1007\/s12031-016-0847-z","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T23:04:45Z","timestamp":1476227085000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Cytokine Profile in Autism Spectrum Disorders in Children"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-2990","authenticated-orcid":false,"given":"Vesna","family":"Bryn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Christian Dalsbotten","family":"Aass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola H.","family":"Skjeldal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Isaksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola Didrik","family":"Saugstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Ormstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,12]]},"reference":[{"key":"847_CR1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bbi.2010.08.003","volume":"25","author":"P Ashwood","year":"2011","unstructured":"Ashwood P et al (2011a) Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun 25:40\u20135","journal-title":"Brain Behav Immun"},{"key":"847_CR2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jneuroim.2010.10.025","volume":"232","author":"P Ashwood","year":"2011","unstructured":"Ashwood P et al (2011b) Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. J Neuroimmunol 232:196\u20139","journal-title":"J Neuroimmunol"},{"key":"847_CR3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1542\/peds.2008-2445","volume":"124","author":"HO Atladottir","year":"2009","unstructured":"Atladottir HO et al (2009) Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics 124:687\u201394","journal-title":"Pediatrics"},{"key":"847_CR4","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0140-6736(06)69041-7","volume":"368","author":"G Baird","year":"2006","unstructured":"Baird G et al (2006) Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet 368:210\u20135","journal-title":"Lancet"},{"key":"847_CR5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrn2054","volume":"8","author":"S Bauer","year":"2007","unstructured":"Bauer S, Kerr BJ, Patterson PH (2007) The neuropoietic cytokine family in development, plasticity, disease and injury. Nat Rev Neurosci 8:221\u201332","journal-title":"Nat Rev Neurosci"},{"key":"847_CR6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1001\/archneurol.2011.2506","volume":"69","author":"D Braunschweig","year":"2012","unstructured":"Braunschweig D, Van de Water J (2012) Maternal autoantibodies in autism. Arch Neurol 69:693\u20139","journal-title":"Arch Neurol"},{"key":"847_CR7","first-page":"226","volume":"29","author":"D Braunschweig","year":"2008","unstructured":"Braunschweig D et al (2008) Autism: maternally derived antibodies specific for fetal brain proteins. Neurotoxicology 29:226\u201331","journal-title":"Neurotoxicology"},{"key":"847_CR8","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/dneu.22024","volume":"72","author":"AS Brown","year":"2012","unstructured":"Brown AS (2012) Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism. Dev Neurobiol 72:1272\u20136","journal-title":"Dev. Neurobiol"},{"key":"847_CR9","doi-asserted-by":"crossref","unstructured":"Coleman M, Gillberg C, Gillberg, C.B.o.t.a.s (2012). The autisms, Vol., Oxford University Press, New York; Oxford","DOI":"10.1093\/med\/9780199732128.001.0001"},{"key":"847_CR10","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1177\/088307389901400608","volume":"14","author":"AM Comi","year":"1999","unstructured":"Comi AM et al (1999) Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. J Child Neurol 14:388\u201394","journal-title":"J Child Neurol"},{"key":"847_CR11","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/OGX.0000000000000236","volume":"70","author":"CN Cordeiro","year":"2015","unstructured":"Cordeiro CN, Tsimis M, Burd I (2015) Infections and brain development. Obstet Gynecol Surv 70:644\u201355","journal-title":"Obstet Gynecol Surv"},{"key":"847_CR12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1001\/archpedi.159.2.151","volume":"159","author":"LA Croen","year":"2005","unstructured":"Croen LA et al (2005) Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case\u2013control study. Arch Pediatr Adolesc Med 159:151\u20137","journal-title":"Arch Pediatr Adolesc Med"},{"key":"847_CR13","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.biopsych.2008.05.006","volume":"64","author":"LA Croen","year":"2008","unstructured":"Croen LA et al (2008) Maternal mid-pregnancy autoantibodies to fetal brain protein: the early markers for autism study. Biol Psychiatry 64:583\u20138","journal-title":"Biol Psychiatry"},{"key":"847_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000048665","volume":"45","author":"J Croonenberghs","year":"2002","unstructured":"Croonenberghs J et al (2002) Activation of the inflammatory response system in autism. Neuropsychobiology 45:1\u20136","journal-title":"Neuropsychobiology"},{"key":"847_CR15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ejphar.2004.07.040","volume":"500","author":"R Dantzer","year":"2004","unstructured":"Dantzer R (2004) Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity. Eur J Pharmacol 500:399\u2013411","journal-title":"Eur J Pharmacol"},{"key":"847_CR16","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.neulet.2010.01.033","volume":"471","author":"E Emanuele","year":"2010","unstructured":"Emanuele E et al (2010) Low-grade endotoxemia in patients with severe autism. Neurosci Lett 471:162\u20135","journal-title":"Neurosci Lett"},{"key":"847_CR17","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1203\/PDR.0b013e31819e7203","volume":"65","author":"E Fombonne","year":"2009","unstructured":"Fombonne E (2009) Epidemiology of pervasive developmental disorders. Pediatr Res 65:591\u20138","journal-title":"Pediatr Res"},{"key":"847_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2013.05.005","volume":"44","author":"B Gesundheit","year":"2013","unstructured":"Gesundheit B et al (2013) Immunological and autoimmune considerations of autism spectrum disorders. J Autoimmun 44:1\u20137","journal-title":"J Autoimmun"},{"key":"847_CR19","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.ejpn.2012.01.014","volume":"16","author":"J Isaksen","year":"2012","unstructured":"Isaksen J et al (2012) Observed prevalence of autism spectrum disorders in two Norwegian counties. Eur J Paediatr Neurol 16:592\u20138","journal-title":"Eur J Paediatr Neurol"},{"key":"847_CR20","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejpn.2012.08.004","volume":"17","author":"J Isaksen","year":"2013","unstructured":"Isaksen J et al (2013) Children with autism spectrum disorders\u2014the importance of medical investigations. Eur J Paediatr Neurol 17:68\u201376","journal-title":"Eur J Paediatr Neurol"},{"key":"847_CR21","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0736-5748(97)00029-4","volume":"15","author":"LF Jarskog","year":"1997","unstructured":"Jarskog LF et al (1997) Cytokine regulation of embryonic rat dopamine and serotonin neuronal survival in vitro. Int J Dev Neurosci 15:711\u20136","journal-title":"Int J Dev Neurosci"},{"key":"847_CR22","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(09)61376-3","volume":"374","author":"SE Levy","year":"2009","unstructured":"Levy SE, Mandell DS, Schultz RT (2009) Autism Lancet 374:1627\u201338","journal-title":"Autism Lancet"},{"key":"847_CR23","doi-asserted-by":"crossref","unstructured":"Masi A, Quintana, DS, (2015). Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis. 20, 440\u20136","DOI":"10.1038\/mp.2014.59"},{"key":"847_CR24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.imlet.2014.11.006","volume":"163","author":"J Mead","year":"2015","unstructured":"Mead J, Ashwood P (2015) Evidence supporting an altered immune response in ASD. Immunol Lett 163:49\u201355","journal-title":"Immunol Lett"},{"key":"847_CR25","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/schbul\/sbn022","volume":"35","author":"U Meyer","year":"2009","unstructured":"Meyer U, Feldon J, Yee BK (2009) A review of the fetal brain cytokine imbalance hypothesis of schizophrenia. Schizophr Bull 35:959\u201372","journal-title":"Schizophr Bull"},{"key":"847_CR26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1469-8749.2007.00429.x","volume":"49","author":"SE Mouridsen","year":"2007","unstructured":"Mouridsen SE et al (2007) Autoimmune diseases in parents of children with infantile autism: a case\u2013control study. Dev Med Child Neurol 49:429\u201332","journal-title":"Dev Med Child Neurol"},{"key":"847_CR27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/cyto.1998.0381","volume":"11","author":"A Mousa","year":"1999","unstructured":"Mousa A et al (1999) Human first trimester forebrain cells express genes for inflammatory and anti-inflammatory cytokines. Cytokine 11:55\u201360","journal-title":"Cytokine"},{"key":"847_CR28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1742-2094-10-38","volume":"10","author":"V Napolioni","year":"2013","unstructured":"Napolioni V et al (2013) Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder. J Neuroinflammation 10:38","journal-title":"J Neuroinflammation"},{"key":"847_CR29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neures.2006.06.002","volume":"56","author":"H Nawa","year":"2006","unstructured":"Nawa H, Takei N (2006) Recent progress in animal modeling of immune inflammatory processes in schizophrenia: implication of specific cytokines. Neurosci Res 56:2\u201313","journal-title":"Neurosci Res"},{"key":"847_CR30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbi.2013.01.084","volume":"30","author":"CW Nordahl","year":"2013","unstructured":"Nordahl CW et al (2013) Maternal autoantibodies are associated with abnormal brain enlargement in a subgroup of children with autism spectrum disorder. Brain Behav Immun 30:61\u20135","journal-title":"Brain Behav Immun"},{"key":"847_CR31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.bbi.2011.08.007","volume":"26","author":"C Onore","year":"2012","unstructured":"Onore C, Careaga M, Ashwood P (2012) The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun 26:383\u201392","journal-title":"Brain Behav Immun"},{"key":"847_CR32","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tins.2006.05.010","volume":"29","author":"AM Persico","year":"2006","unstructured":"Persico AM, Bourgeron T (2006) Searching for ways out of the autism maze: genetic, epigenetic and environmental clues. Trends Neurosci 29:349\u201358","journal-title":"Trends Neurosci"},{"key":"847_CR33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/mrdd.20027","volume":"10","author":"SJ Rogers","year":"2004","unstructured":"Rogers SJ (2004) Developmental regression in autism spectrum disorders. Ment Retard Dev Disabil Res Rev 10:139\u201343","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"847_CR34","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2217\/bmm.14.39","volume":"8","author":"D Rose","year":"2014","unstructured":"Rose D, Ashwood P (2014) Potential cytokine biomarkers in autism spectrum disorders. Biomark Med 8:1171\u201381","journal-title":"Biomark Med"},{"key":"847_CR35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jneuroim.2007.11.004","volume":"194","author":"HS Singer","year":"2008","unstructured":"Singer HS et al (2008) Antibodies against fetal brain in sera of mothers with autistic children. J Neuroimmunol 194:165\u201372","journal-title":"J Neuroimmunol"},{"key":"847_CR36","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S0090-1229(05)80015-7","volume":"61","author":"VK Singh","year":"1991","unstructured":"Singh VK et al (1991) Changes of soluble interleukin-2, interleukin-2 receptor, T8 antigen, and interleukin-1 in the serum of autistic children. Clin Immunol Immunopathol 61:448\u201355","journal-title":"Clin Immunol Immunopathol"},{"key":"847_CR37","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1203\/PDR.0b013e31819e7168","volume":"65","author":"SJ Spence","year":"2009","unstructured":"Spence SJ, Schneider MT (2009) The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatr Res 65:599\u2013606","journal-title":"Pediatr Res"},{"key":"847_CR38","volume":"6","author":"K Suzuki","year":"2011","unstructured":"Suzuki K et al (2011) Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. PLoS One 6, e20470","journal-title":"PLoS One"},{"key":"847_CR39","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.biopsych.2003.09.001","volume":"55","author":"TL Sweeten","year":"2004","unstructured":"Sweeten TL et al (2004) High nitric oxide production in autistic disorder: a possible role for interferon-gamma. Biol Psychiatry 55:434\u20137","journal-title":"Biol Psychiatry"},{"key":"847_CR40","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1016\/j.vaccine.2014.04.085","volume":"32","author":"LE Taylor","year":"2014","unstructured":"Taylor LE, Swerdfeger AL, Eslick GD (2014) Vaccines are not associated with autism: an evidence-based meta-analysis of case\u2013control and cohort studies. Vaccine 32:3623\u20139","journal-title":"Vaccine"},{"key":"847_CR41","doi-asserted-by":"crossref","first-page":"531518","DOI":"10.1155\/2015\/531518","volume":"2015","author":"N Xu","year":"2015","unstructured":"Xu N, Li X, Zhong Y (2015) Inflammatory cytokines: potential biomarkers of immunologic dysfunction in autism spectrum disorders. Mediat Inflamm 2015:531518","journal-title":"Mediat. Inflamm"},{"key":"847_CR42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pediatrneurol.2005.03.014","volume":"33","author":"AW Zimmerman","year":"2005","unstructured":"Zimmerman AW et al (2005) Cerebrospinal fluid and serum markers of inflammation in autism. Pediatr Neurol 33:195\u2013201","journal-title":"Pediatr Neurol"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-016-0847-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-016-0847-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-016-0847-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T06:46:59Z","timestamp":1749624419000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-016-0847-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,12]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["847"],"URL":"https:\/\/doi.org\/10.1007\/s12031-016-0847-z","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,12]]}}}