{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:40:55Z","timestamp":1782805255044,"version":"3.54.5"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,5,5]],"date-time":"2019-05-05T00:00:00Z","timestamp":1557014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460518"],"award-info":[{"award-number":["81460518"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s12031-019-01330-y","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T14:13:09Z","timestamp":1557151989000},"page":"679-687","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["TP53 Polymorphism Contributes to the Susceptibility to Bipolar Disorder but Not to Schizophrenia in the Chinese Han Population"],"prefix":"10.1007","volume":"68","author":[{"given":"Jialei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xulong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1435-9669","authenticated-orcid":false,"given":"Li","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,5]]},"reference":[{"key":"1330_CR1","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.7754\/Clin.Lab.2015.151102","volume":"62","author":"MM Abdel-Aziz","year":"2016","unstructured":"Abdel-Aziz MM, Elshal MF, Abass AT, El-Kafrawy S, Ezzat S, Abdel-Wahab M (2016) Comparison of AFP-L3 and p53 antigen concentration with alpha-fetoprotein as serum markers for hepatocellular carcinoma. Clin Lab 62:1121\u20131129","journal-title":"Clin Lab"},{"key":"1330_CR2","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/ng.171","volume":"40","author":"NC Allen","year":"2008","unstructured":"Allen NC, Bagade S, McQueen MB, Ioannidis JPA, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L (2008) Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 40:827\u2013834. \n                    https:\/\/doi.org\/10.1038\/ng.171","journal-title":"Nat Genet"},{"key":"1330_CR3","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1083\/jcb.143.6.1691","volume":"143","author":"RS Aloyz","year":"1998","unstructured":"Aloyz RS, Bamji SX, Pozniak CD, Toma JG, Atwal J, Kaplan DR, Miller FD (1998) p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors. J Cell Biol 143:1691\u20131703","journal-title":"J Cell Biol"},{"key":"1330_CR4","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/S0960-9822(95)00183-7","volume":"5","author":"JF Armstrong","year":"1995","unstructured":"Armstrong JF, Kaufman MH, Harrison DJ, Clarke AR (1995) High-frequency developmental abnormalities in p53-deficient mice. Current biology: CB 5:931\u2013936","journal-title":"Current biology: CB"},{"key":"1330_CR5","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1001\/archpsyc.60.4.359","volume":"60","author":"FM Benes","year":"2003","unstructured":"Benes FM, Walsh J, Bhattacharyya S, Sheth A, Berretta S (2003) DNA fragmentation decreased in schizophrenia but not bipolar disorder. Arch Gen Psychiatry 60:359\u2013364. \n                    https:\/\/doi.org\/10.1001\/archpsyc.60.4.359","journal-title":"Arch Gen Psychiatry"},{"key":"1330_CR6","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/nrn.2017.125","volume":"18","author":"R Birnbaum","year":"2017","unstructured":"Birnbaum R, Weinberger DR (2017) Genetic insights into the neurodevelopmental origins of schizophrenia. Nat Rev Neurosci 18:727\u2013740. \n                    https:\/\/doi.org\/10.1038\/nrn.2017.125","journal-title":"Nat Rev Neurosci"},{"key":"1330_CR7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.24869\/psyd.2017.24","volume":"29","author":"M Buoli","year":"2017","unstructured":"Buoli M, Serati M, Caldiroli A, Cremaschi L, Altamura AC (2017) Neurodevelopmental versus neurodegenerative model of schizophrenia and bipolar disorder: comparison with physiological brain development and aging. Psychiatr Danub 29:24\u201327","journal-title":"Psychiatr Danub"},{"key":"1330_CR8","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/nrg2381","volume":"9","author":"M Burmeister","year":"2008","unstructured":"Burmeister M, McInnis MG, Zollner S (2008) Psychiatric genetics: progress amid controversy. Nat Rev Genet 9:527\u2013540. \n                    https:\/\/doi.org\/10.1038\/nrg2381","journal-title":"Nat Rev Genet"},{"key":"1330_CR9","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1111\/trf.14209","volume":"57","author":"X Cai","year":"2017","unstructured":"Cai X, Qian C, Wu W, Lei H, Ding Q, Zou W, Xiang D, Wang X (2017) An exonic missense mutation c.28G>A is associated with weak B blood group by affecting RNA splicing of the ABO gene. Transfusion 57:2140\u20132149. \n                    https:\/\/doi.org\/10.1111\/trf.14209","journal-title":"Transfusion"},{"key":"1330_CR10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1001\/archpsyc.55.1.67","volume":"55","author":"TD Cannon","year":"1998","unstructured":"Cannon TD, Kaprio J, Lonnqvist J, Huttunen M, Koskenvuo M (1998) The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study. Arch Gen Psychiatry 55:67\u201374","journal-title":"Arch Gen Psychiatry"},{"key":"1330_CR11","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S0920-9964(99)00077-8","volume":"41","author":"VS Catts","year":"2000","unstructured":"Catts VS, Catts SV (2000) Apoptosis and schizophrenia: is the tumour suppressor gene, p53, a candidate susceptibility gene? Schizophr Res 41:405\u2013415","journal-title":"Schizophr Res"},{"key":"1330_CR12","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.clinre.2013.12.009","volume":"38","author":"C Cheng","year":"2014","unstructured":"Cheng C, Lingyan W, Yi H, Cheng Z, Huadan Y, Xuting X, Leiting X, Meng Y, Shiwei D (2014) Association between TLR2, MTR, MTRR, XPC, TP73, TP53 genetic polymorphisms and gastric cancer: a meta-analysis. Clin Res Hepatol Gastroenterol 38:346\u2013359. \n                    https:\/\/doi.org\/10.1016\/j.clinre.2013.12.009","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"1330_CR13","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0165-1781(01)00328-6","volume":"105","author":"HJ Chiu","year":"2001","unstructured":"Chiu HJ, Wang YC, Chen JY, Hong CJ, Tsai SJ (2001) Association study of the p53-gene Pro72Arg polymorphism in schizophrenia. Psychiatry Res 105:279\u2013283","journal-title":"Psychiatry Res"},{"key":"1330_CR14","doi-asserted-by":"publisher","first-page":"98094","DOI":"10.18632\/oncotarget.21453","volume":"8","author":"WJ Ding","year":"2017","unstructured":"Ding WJ, Zeng T, Wang LJ, Lei HB, Ge W, Wang Z (2017) Genes with mutation significance were highly associated with the clinical pattern of patients with breast cancer. Oncotarget 8:98094\u201398102. \n                    https:\/\/doi.org\/10.18632\/oncotarget.21453","journal-title":"Oncotarget"},{"key":"1330_CR15","doi-asserted-by":"publisher","first-page":"344","DOI":"10.3324\/haematol.2017.178327","volume":"103","author":"I Donadon","year":"2018","unstructured":"Donadon I, McVey JH, Garagiola I, Branchini A, Mortarino M, Peyvandi F, Bernardi F, Pinotti M (2018) Clustered F8 missense mutations cause hemophilia A by combined alteration of splicing and protein biosynthesis and activity. Haematologica 103:344\u2013350. \n                    https:\/\/doi.org\/10.3324\/haematol.2017.178327","journal-title":"Haematologica"},{"key":"1330_CR16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/ng1093","volume":"33","author":"P Dumont","year":"2003","unstructured":"Dumont P, Leu JI, Della Pietra AC 3rd, George DL, Murphy M (2003) The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet 33:357\u2013365. \n                    https:\/\/doi.org\/10.1038\/ng1093","journal-title":"Nat Genet"},{"key":"1330_CR17","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.cdtm.2017.04.001","volume":"3","author":"S Fan","year":"2017","unstructured":"Fan S, Hao ZY, Zhang M, Liang CZ (2017) Association between the rs1042522 polymorphism in TP53 and prostate cancer risk: an updated meta-analysis. Chronic Dis Transl Med 3:95\u2013104. \n                    https:\/\/doi.org\/10.1016\/j.cdtm.2017.04.001","journal-title":"Chronic Dis Transl Med"},{"key":"1330_CR18","doi-asserted-by":"publisher","first-page":"5913","DOI":"10.1007\/s12035-017-0814-x","volume":"55","author":"M Gao","year":"2018","unstructured":"Gao M, Zhao LR (2018) Turning death to growth: hematopoietic growth factors promote neurite outgrowth through MEK\/ERK\/p53 pathway. Mol Neurobiol 55:5913\u20135925. \n                    https:\/\/doi.org\/10.1007\/s12035-017-0814-x","journal-title":"Mol Neurobiol"},{"key":"1330_CR19","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/sj.cdd.4400663","volume":"7","author":"FJ Geske","year":"2000","unstructured":"Geske FJ, Nelson AC, Lieberman R, Strange R, Sun T, Gerschenson LE (2000) DNA repair is activated in early stages of p53-induced apoptosis. Cell Death Differ 7:393\u2013401. \n                    https:\/\/doi.org\/10.1038\/sj.cdd.4400663","journal-title":"Cell Death Differ"},{"key":"1330_CR20","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1097\/01.yco.0000245751.98749.52","volume":"19","author":"SN Ghaemi","year":"2006","unstructured":"Ghaemi SN (2006) Paradigms of psychiatry: eclecticism and its discontents. Curr Opin Psychiatry 19:619\u2013624. \n                    https:\/\/doi.org\/10.1097\/01.yco.0000245751.98749.52","journal-title":"Curr Opin Psychiatry"},{"key":"1330_CR21","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1385\/NMM:2:2:197","volume":"2","author":"CP Gilman","year":"2002","unstructured":"Gilman CP, Mattson MP (2002) Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility? NeuroMolecular Med 2:197\u2013214. \n                    https:\/\/doi.org\/10.1385\/NMM:2:2:197","journal-title":"NeuroMolecular Med"},{"key":"1330_CR22","doi-asserted-by":"publisher","first-page":"15533","DOI":"10.1073\/pnas.0507666102","volume":"102","author":"SJ Glatt","year":"2005","unstructured":"Glatt SJ, Everall IP, Kremen WS, Corbeil J, a ik R, Khanlou N, Han M, Liew CC, Tsuang MT (2005) Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia. Proc Natl Acad Sci U S A 102:15533\u201315538. \n                    https:\/\/doi.org\/10.1073\/pnas.0507666102","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1330_CR23","doi-asserted-by":"publisher","first-page":"925","DOI":"10.4161\/cc.8.6.7937","volume":"8","author":"GV Glinsky","year":"2009","unstructured":"Glinsky GV (2009) Human genome connectivity code links disease-associated SNPs, microRNAs and pyknons. Cell Cycle 8:925\u2013930. \n                    https:\/\/doi.org\/10.4161\/cc.8.6.7937","journal-title":"Cell Cycle"},{"key":"1330_CR24","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12524","volume":"18","author":"X Guo","year":"2018","unstructured":"Guo X, Yang J, Huang J, Chen Z, Wu X, Zhu L, Huang G, Long J, Su L (2018) Influence of CTNNB1 rs2953 polymorphism on schizophrenia susceptibility in Chinese Han population through modifying miR-485 binding to CTNNB1. Genes Brain Behav 18:e12524. \n                    https:\/\/doi.org\/10.1111\/gbb.12524","journal-title":"Genes Brain Behav"},{"key":"1330_CR25","doi-asserted-by":"publisher","unstructured":"Khan RA et al. (2016) Analysis of association between common variants in the SLCO6A1 gene with schizophrenia, bipolar disorder and major depressive disorder in the Han Chinese population. The world journal of biological psychiatry: the official journal of the World Federation of Societies of Biological Psychiatry 17:140\u2013146 doi:\n                    https:\/\/doi.org\/10.3109\/15622975.2015.1126676","DOI":"10.3109\/15622975.2015.1126676"},{"key":"1330_CR26","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1093\/emboj\/16.6.1391","volume":"16","author":"EA Komarova","year":"1997","unstructured":"Komarova EA, Chernov MV, Franks R, Wang K, Armin G, Zelnick CR, Chin DM, Bacus SS, Stark GR, Gudkov AV (1997) Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo. EMBO J 16:1391\u20131400. \n                    https:\/\/doi.org\/10.1093\/emboj\/16.6.1391","journal-title":"EMBO J"},{"key":"1330_CR27","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.arcmed.2012.12.009","volume":"44","author":"B Lajin","year":"2013","unstructured":"Lajin B, Alachkar A, Michati R, Alhaj Sakur A (2013) Association between polymorphisms in the genes for tumor suppressor protein p53 and its regulator NAD(P)H: quinone oxidoreductase 1 (NQO1) and schizophrenia in a Syrian study cohort. Arch Med Res 44:121\u2013126. \n                    https:\/\/doi.org\/10.1016\/j.arcmed.2012.12.009","journal-title":"Arch Med Res"},{"key":"1330_CR28","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1016\/j.bcp.2008.02.023","volume":"75","author":"DH Lee","year":"2008","unstructured":"Lee DH, Kim C, Zhang L, Lee YJ (2008) Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. Biochem Pharmacol 75:2020\u20132033. \n                    https:\/\/doi.org\/10.1016\/j.bcp.2008.02.023","journal-title":"Biochem Pharmacol"},{"key":"1330_CR29","doi-asserted-by":"publisher","first-page":"e998","DOI":"10.1038\/tp.2016.268","volume":"7","author":"S Liu","year":"2017","unstructured":"Liu S, Zhang F, Shugart YY, Yang L, Li X, Liu Z, Sun N, Yang C, Guo X, Shi J, Wang L, Cheng L, Zhang K, Yang T, Xu Y (2017) The early growth response protein 1-miR-30a-5p-neurogenic differentiation factor 1 axis as a novel biomarker for schizophrenia diagnosis and treatment monitoring. Transl Psychiatry 7:e998. \n                    https:\/\/doi.org\/10.1038\/tp.2016.268","journal-title":"Transl Psychiatry"},{"key":"1330_CR30","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/acps.12296","volume":"130","author":"J Long","year":"2014","unstructured":"Long J, Huang G, Liang W, Liang B, Chen Q, Xie J, Jiang J, Su L (2014) The prevalence of schizophrenia in mainland China: evidence from epidemiological surveys. Acta Psychiatr Scand 130:244\u2013256. \n                    https:\/\/doi.org\/10.1111\/acps.12296","journal-title":"Acta Psychiatr Scand"},{"issue":"214","key":"1330_CR31","doi-asserted-by":"publisher","first-page":"e211","DOI":"10.1016\/j.neurobiolaging.2017.02.008","volume":"54","author":"S Luzzi","year":"2017","unstructured":"Luzzi S, Colleoni L, Corbetta P, Baldinelli S, Fiori C, Girelli F, Silvestrini M, Caroppo P, Giaccone G, Tagliavini F, Rossi G (2017) Missense mutation in GRN gene affecting RNA splicing and plasma progranulin level in a family affected by frontotemporal lobar degeneration. Neurobiol Aging 54(214):e211\u2013214 e216. \n                    https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.02.008","journal-title":"Neurobiol Aging"},{"key":"1330_CR32","doi-asserted-by":"publisher","first-page":"223","DOI":"10.21101\/cejph.a4301","volume":"24","author":"S Mahmood","year":"2016","unstructured":"Mahmood S, Evinova A, Skerenova M, Ondrejka I, Lehotsky J (2016) Association of EGF, IGFBP-3 and TP53 gene polymorphisms with major depressive disorder in Slovak population. Cent Eur J Public Health 24:223\u2013230. \n                    https:\/\/doi.org\/10.21101\/cejph.a4301","journal-title":"Cent Eur J Public Health"},{"key":"1330_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189739","volume":"12","author":"E Mellerup","year":"2017","unstructured":"Mellerup E, Andreassen OA, Bennike B, Dam H, Djurovic S, Jorgensen MB, Kessing LV, Koefoed P, Melle I, Mors O, Moeller GL (2017) Combinations of genetic variants associated with bipolar disorder. PLoS One 12:e0189739. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0189739","journal-title":"PLoS One"},{"key":"1330_CR34","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1136\/jech.43.1.43","volume":"43","author":"PB Mortensen","year":"1989","unstructured":"Mortensen PB (1989) The incidence of cancer in schizophrenic patients. J Epidemiol Community Health 43:43\u201347","journal-title":"J Epidemiol Community Health"},{"key":"1330_CR35","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0920-9964(94)90028-0","volume":"12","author":"PB Mortensen","year":"1994","unstructured":"Mortensen PB (1994) The occurrence of cancer in first admitted schizophrenic patients. Schizophr Res 12:185\u2013194","journal-title":"Schizophr Res"},{"key":"1330_CR36","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.neulet.2005.06.050","volume":"388","author":"X Ni","year":"2005","unstructured":"Ni X, Trakalo J, Valente J, Azevedo MH, Pato MT, Pato CN, Kennedy JL (2005) Human p53 tumor suppressor gene (TP53) and schizophrenia: case-control and family studies. Neurosci Lett 388:173\u2013178. \n                    https:\/\/doi.org\/10.1016\/j.neulet.2005.06.050","journal-title":"Neurosci Lett"},{"key":"1330_CR37","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.gene.2013.09.002","volume":"531","author":"C Pan","year":"2013","unstructured":"Pan C, Wu C, Jia W, Xu Y, Lei C, Hu S, Lan X, Chen H (2013) A critical functional missense mutation (H173R) in the bovine PROP1 gene significantly affects growth traits in cattle. Gene 531:398\u2013402. \n                    https:\/\/doi.org\/10.1016\/j.gene.2013.09.002","journal-title":"Gene"},{"key":"1330_CR38","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.neulet.2004.03.049","volume":"363","author":"S Papiol","year":"2004","unstructured":"Papiol S, Arias B, Barrantes-Vidal N, Guitart M, Salgado P, Catalan R, Fananas L (2004) Analysis of polymorphisms at the tumor suppressor gene p53 (TP53) in contributing to the risk for schizophrenia and its associated neurocognitive deficits. Neurosci Lett 363:78\u201380. \n                    https:\/\/doi.org\/10.1016\/j.neulet.2004.03.049","journal-title":"Neurosci Lett"},{"key":"1330_CR39","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.1038\/sj.onc.1209325","volume":"25","author":"W Qiu","year":"2006","unstructured":"Qiu W, Schonleben F, Thaker HM, Goggins M, Su GH (2006) A novel mutation of STK11\/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma. Oncogene 25:2937\u20132942. \n                    https:\/\/doi.org\/10.1038\/sj.onc.1209325","journal-title":"Oncogene"},{"key":"1330_CR40","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.exer.2018.01.017","volume":"169","author":"LX Ran","year":"2018","unstructured":"Ran LX, Zheng ZY, Xie B, Nie XM, Chen XW, Su G, Cai SJ (2018) A mouse model of a novel missense mutation (Gly83Arg) in a Chinese kindred manifesting vitreous amyloidosis only. Exp Eye Res 169:13\u201319. \n                    https:\/\/doi.org\/10.1016\/j.exer.2018.01.017","journal-title":"Exp Eye Res"},{"key":"1330_CR41","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1002\/ajmg.b.31062","volume":"153B","author":"B Rollins","year":"2010","unstructured":"Rollins B, Martin MV, Morgan L, Vawter MP (2010) Analysis of whole genome biomarker expression in blood and brain. Am J Med Genet B, Neuropsychiatric Genet: Off Publ Int Soc Psychiatric Genet 153B:919\u2013936. \n                    https:\/\/doi.org\/10.1002\/ajmg.b.31062","journal-title":"Am J Med Genet B, Neuropsychiatric Genet: Off Publ Int Soc Psychiatric Genet"},{"key":"1330_CR42","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0304-3940(03)00049-1","volume":"340","author":"H Rosenmann","year":"2003","unstructured":"Rosenmann H, Meiner Z, Kahana E, Aladjem Z, Friedman G, Ben-Yehuda A, Grenader T, Wertman E, Abramsky O (2003) An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer\u2019s disease. Neurosci Lett 340:29\u201332","journal-title":"Neurosci Lett"},{"key":"1330_CR43","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/ejhg.2013.246","volume":"22","author":"M Rossi","year":"2014","unstructured":"Rossi M, Kilpinen H, Muona M, Surakka I, Ingle C, Lahtinen J, Hennah W, Ripatti S, Hovatta I (2014) Allele-specific regulation of DISC1 expression by miR-135b-5p. Eur J Hum Genet: EJHG 22:840\u2013843. \n                    https:\/\/doi.org\/10.1038\/ejhg.2013.246","journal-title":"Eur J Hum Genet: EJHG"},{"key":"1330_CR44","doi-asserted-by":"publisher","first-page":"7955","DOI":"10.7314\/APJCP.2014.15.18.7955","volume":"15","author":"Z Saadatian","year":"2014","unstructured":"Saadatian Z, Gharesouran J, Ghojazadeh M, Ghohari-Lasaki S, Tarkesh-Esfahani N, Mohaddes Ardebili SM (2014) Association of rs1219648 in FGFR2 and rs1042522 in TP53 with premenopausal breast cancer in an Iranian Azeri population. Asian Pac J Cancer Prev: APJCP 15:7955\u20137958","journal-title":"Asian Pac J Cancer Prev: APJCP"},{"key":"1330_CR45","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4103\/ijmr.IJMR_1386_16","volume":"145","author":"R Sagar","year":"2017","unstructured":"Sagar R, Pattanayak RD (2017) Potential biomarkers for bipolar disorder: where do we stand? Indian J Med Res 145:7\u201316. \n                    https:\/\/doi.org\/10.4103\/ijmr.IJMR_1386_16","journal-title":"Indian J Med Res"},{"key":"1330_CR46","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/ng0695-175","volume":"10","author":"VP Sah","year":"1995","unstructured":"Sah VP, Attardi LD, Mulligan GJ, Williams BO, Bronson RT, Jacks T (1995) A subset of p53-deficient embryos exhibit exencephaly. Nat Genet 10:175\u2013180. \n                    https:\/\/doi.org\/10.1038\/ng0695-175","journal-title":"Nat Genet"},{"key":"1330_CR47","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/ajmg.b.32246","volume":"165B","author":"T Saito","year":"2014","unstructured":"Saito T, Kondo K, Iwayama Y, Shimasaki A, Aleksic B, Yamada K, Toyota T, Hattori E, Esaki K, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Ikeda M, Iwata N (2014) Replication and cross-phenotype study based upon schizophrenia GWASs data in the Japanese population: support for association of MHC region with psychosis. Am J Med Genet B, Neuropsychiatric Genet: Off Publ Int Soc Psychiatric Genet 165B:421\u2013427. \n                    https:\/\/doi.org\/10.1002\/ajmg.b.32246","journal-title":"Am J Med Genet B, Neuropsychiatric Genet: Off Publ Int Soc Psychiatric Genet"},{"key":"1330_CR48","doi-asserted-by":"publisher","first-page":"7525","DOI":"10.1073\/pnas.91.16.7525","volume":"91","author":"S Sakhi","year":"1994","unstructured":"Sakhi S, Bruce A, Sun N, Tocco G, Baudry M, Schreiber SS (1994) p53 induction is associated with neuronal damage in the central nervous system. Proc Natl Acad Sci U S A 91:7525\u20137529","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1330_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142911","volume":"10","author":"M Schummer","year":"2015","unstructured":"Schummer M, Thorpe J, Giraldez MD, Bergan L, Tewari M, Urban N (2015) Evaluating serum markers for hormone receptor-negative breast cancer. PLoS One 10:e0142911. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0142911","journal-title":"PLoS One"},{"key":"1330_CR50","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.schres.2008.06.016","volume":"104","author":"J Shi","year":"2008","unstructured":"Shi J, Gershon ES, Liu C (2008) Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. Schizophr Res 104:96\u2013107. \n                    https:\/\/doi.org\/10.1016\/j.schres.2008.06.016","journal-title":"Schizophr Res"},{"key":"1330_CR51","doi-asserted-by":"publisher","first-page":"13434","DOI":"10.1074\/jbc.M113.535203","volume":"289","author":"S Shi","year":"2014","unstructured":"Shi S, Leites C, He D, Schwartz D, Moy W, Shi J, Duan J (2014) MicroRNA-9 and microRNA-326 regulate human dopamine D2 receptor expression, and the microRNA-mediated expression regulation is altered by a genetic variant. J Biol Chem 289:13434\u201313444. \n                    https:\/\/doi.org\/10.1074\/jbc.M113.535203","journal-title":"J Biol Chem"},{"key":"1330_CR52","doi-asserted-by":"publisher","first-page":"4183","DOI":"10.1002\/hbm.24238","volume":"39","author":"DJA Smit","year":"2018","unstructured":"Smit DJA, Wright MJ, Meyers JL, Martin NG, Ho YYW, Malone SM, Zhang J, Burwell SJ, Chorlian DB, de Geus EJC, Denys D, Hansell NK, Hottenga JJ, McGue M, van Beijsterveldt CEM, Jahanshad N, Thompson PM, Whelan CD, Medland SE, Porjesz B, Lacono WG, Boomsma DI (2018) Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity. Hum Brain Mapp 39:4183\u20134195. \n                    https:\/\/doi.org\/10.1002\/hbm.24238","journal-title":"Hum Brain Mapp"},{"key":"1330_CR53","doi-asserted-by":"publisher","first-page":"4540","DOI":"10.1002\/jcb.26591","volume":"119","author":"G Sun","year":"2018","unstructured":"Sun G, Wang Y, Zhang J, Lin N, You Y (2018) MiR-15b\/HOTAIR\/p53 form a regulatory loop that affects the growth of glioma cells. J Cell Biochem 119:4540\u20134547. \n                    https:\/\/doi.org\/10.1002\/jcb.26591","journal-title":"J Cell Biochem"},{"key":"1330_CR54","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-015-0050-4","volume":"8","author":"YG Tak","year":"2015","unstructured":"Tak YG, Farnham PJ (2015) Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome. Epigenetics Chromatin 8:57. \n                    https:\/\/doi.org\/10.1186\/s13072-015-0050-4","journal-title":"Epigenetics Chromatin"},{"key":"1330_CR55","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1128\/MCB.19.2.1092","volume":"19","author":"M Thomas","year":"1999","unstructured":"Thomas M, Kalita A, Labrecque S, Pim D, Banks L, Matlashewski G (1999) Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol Cell Biol 19:1092\u20131100","journal-title":"Mol Cell Biol"},{"key":"1330_CR56","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.18632\/oncotarget.13589","volume":"8","author":"X Tian","year":"2017","unstructured":"Tian X, Dai S, Sun J, Jiang S, Jiang Y (2017) The association between the TP53 Arg72Pro polymorphism and colorectal cancer: an updated meta-analysis based on 32 studies. Oncotarget 8:1156\u20131165. \n                    https:\/\/doi.org\/10.18632\/oncotarget.13589","journal-title":"Oncotarget"},{"key":"1330_CR57","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/ajmg.b.32150","volume":"162B","author":"DS Tylee","year":"2013","unstructured":"Tylee DS, Kawaguchi DM, Glatt SJ (2013) On the outside, looking in: a review and evaluation of the comparability of blood and brain -omes. Am J Med Genet B, Neuropsychiatric Genet: Off Publ Int Soc Psychiatric Genet 162B:595\u2013603. \n                    https:\/\/doi.org\/10.1002\/ajmg.b.32150","journal-title":"Am J Med Genet B, Neuropsychiatric Genet: Off Publ Int Soc Psychiatric Genet"},{"key":"1330_CR58","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.rpsm.2011.11.005","volume":"5","author":"E Uribe","year":"2012","unstructured":"Uribe E, Wix R (2012) Neuronal migration, apoptosis and bipolar disorder. Rev Psiquiatr Salud Mental 5:127\u2013133. \n                    https:\/\/doi.org\/10.1016\/j.rpsm.2011.11.005","journal-title":"Rev Psiquiatr Salud Mental"},{"key":"1330_CR59","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07737-0","volume":"7","author":"J Wang","year":"2017","unstructured":"Wang J, Liu Q, Yuan S, Xie W, Liu Y, Xiang Y, Wu N, Wu L, Ma X, Cai T, Zhang Y, Sun Z, Li Y (2017) Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies. Sci Rep 7:8371. \n                    https:\/\/doi.org\/10.1038\/s41598-017-07737-0","journal-title":"Sci Rep"},{"key":"1330_CR60","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0401-1","volume":"32","author":"GC Wu","year":"2015","unstructured":"Wu GC, Zhang ZT (2015) Genetic association of single nucleotide polymorphisms in P53 pathway with gastric cancer risk in a Chinese Han population. Med Oncol 32:401. \n                    https:\/\/doi.org\/10.1007\/s12032-014-0401-1","journal-title":"Med Oncol"},{"key":"1330_CR61","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ydbio.2004.01.014","volume":"269","author":"X Yang","year":"2004","unstructured":"Yang X, Klein R, Tian X, Cheng HT, Kopan R, Shen J (2004a) Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol 269:81\u201394. \n                    https:\/\/doi.org\/10.1016\/j.ydbio.2004.01.014","journal-title":"Dev Biol"},{"key":"1330_CR62","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.neulet.2004.07.068","volume":"369","author":"Y Yang","year":"2004","unstructured":"Yang Y, Xiao Z, Chen W, Sang H, Guan Y, Peng Y, Zhang D, Gu Z, Qian M, He G, Qin W, Li D, Gu N, He L (2004b) Tumor suppressor gene TP53 is genetically associated with schizophrenia in the Chinese population. Neurosci Lett 369:126\u2013131. \n                    https:\/\/doi.org\/10.1016\/j.neulet.2004.07.068","journal-title":"Neurosci Lett"},{"key":"1330_CR63","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.jad.2016.08.062","volume":"207","author":"L Zhang","year":"2017","unstructured":"Zhang L, Cao XL, Wang SB, Zheng W, Ungvari GS, Ng CH, Zhong BL, Wang G, Xiang YT (2017) The prevalence of bipolar disorder in China: a meta-analysis. J Affect Disord 207:413\u2013421. \n                    https:\/\/doi.org\/10.1016\/j.jad.2016.08.062","journal-title":"J Affect Disord"},{"key":"1330_CR64","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s10238-018-0496-3","volume":"18","author":"W Zhao","year":"2018","unstructured":"Zhao W, Zhang SC, Huang WK, Li XL (2018) Mutations in Smad-interacting protein 1 gene are responsible for absence of its expression in Hirschsprung\u2019s disease. Clin Exp Med 18:445\u2013451. \n                    https:\/\/doi.org\/10.1007\/s10238-018-0496-3","journal-title":"Clin Exp Med"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-019-01330-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-019-01330-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-019-01330-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T23:07:05Z","timestamp":1588547225000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-019-01330-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,5]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["1330"],"URL":"https:\/\/doi.org\/10.1007\/s12031-019-01330-y","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,5]]},"assertion":[{"value":"3 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All procedures performed in studies involving human participants were approved by the local ethical committee. The work described has been carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}