{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:19:22Z","timestamp":1779196762976,"version":"3.51.4"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004919","name":"King Abdulaziz City for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004919","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s12031-019-01332-w","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T11:07:12Z","timestamp":1557486432000},"page":"688-695","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of Auditory Integration Therapy (AIT) on the Plasma Levels of Human Glial Cell Line\u2013Derived Neurotrophic Factor (GDNF) in Autism Spectrum Disorder"],"prefix":"10.1007","volume":"68","author":[{"given":"Laila","family":"Al-Ayadhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afaf","family":"El-Ansary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2632-3935","authenticated-orcid":false,"given":"Geir","family":"Bj\u00f8rklund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Chirumbolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gehan Ahmed","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"1332_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.4137\/AUI.S11463","volume":"5","author":"LY Al-Ayadhi","year":"2013","unstructured":"Al-Ayadhi LY, Al-Drees A, Al-Arfaj AM (2013) Effectiveness of auditory integration therapy in autism spectrum disorders \u2014 prospective study. Autism Insights 5:13\u201320. https:\/\/doi.org\/10.4137\/AUI.S11463","journal-title":"Autism Insights"},{"key":"1332_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12868-015-0142-x","volume":"16","author":"KM Allen","year":"2015","unstructured":"Allen KM, Purves-Tyson TD, Fung SJ, Shannon Weickert C (2015) The effect of adolescent testosterone on hippocampal BDNF and TrkB mRNA expression: relationship with cell proliferation. BMC Neurosci 16:4. https:\/\/doi.org\/10.1186\/s12868-015-0142-x","journal-title":"BMC Neurosci"},{"key":"1332_CR3","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2013","unstructured":"American Psychiatric Association (ed) (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, Washington","edition":"5"},{"key":"1332_CR4","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1111\/j.1460-9568.2006.04743.x","volume":"23","author":"A Bakshi","year":"2006","unstructured":"Bakshi A, Shimizu S, Keck CA, Cho S, LeBold DG, Morales D, Arenas E, Snyder EY, Watson DJ, McIntosh TK (2006) Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury. Eur J Neurosci 23:2119\u20132134","journal-title":"Eur J Neurosci"},{"key":"1332_CR5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1023\/A:1020541906063","volume":"32","author":"GT Baranek","year":"2002","unstructured":"Baranek GT (2002) Efficacy of sensory and motor interventions for children with autism. J Autism Dev Disord 32:397\u2013422","journal-title":"J Autism Dev Disord"},{"key":"1332_CR6","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1177\/153944929701700302","volume":"17","author":"GT Baranek","year":"1997","unstructured":"Baranek GT, Foster LG, Berkson G (1997a) Sensory defensiveness in persons with developmental disabilities. Occup Ther J Res 17:173\u2013185","journal-title":"Occup Ther J Res"},{"key":"1332_CR7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.5014\/ajot.51.2.91","volume":"51","author":"GT Baranek","year":"1997","unstructured":"Baranek GT, Foster LG, Berkson G (1997b) Tactile defensiveness and stereotyped behaviors. Am J Occup Ther 51:91\u201395","journal-title":"Am J Occup Ther"},{"key":"1332_CR8","volume-title":"Hearing equals behavior","author":"G Berard","year":"1993","unstructured":"Berard G (1993) Hearing equals behavior. Keats Publishing, New Canaan"},{"key":"1332_CR9","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nrn3992","volume":"16","author":"T Bourgeron","year":"2015","unstructured":"Bourgeron T (2015) From the genetic architecture to synaptic plasticity in autism spectrum disorder. Nat Rev Neurosci 16:551\u2013563","journal-title":"Nat Rev Neurosci"},{"key":"1332_CR10","doi-asserted-by":"publisher","first-page":"369","DOI":"10.4196\/kjpp.2012.16.6.369","volume":"16","author":"L Chung","year":"2012","unstructured":"Chung L, Bey AL, Jiang YH (2012) Synaptic plasticity in mouse models of autism spectrum disorders. Korean J Physiol Pharmacol 16:369\u2013378","journal-title":"Korean J Physiol Pharmacol"},{"key":"1332_CR11","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1542\/peds.102.2.431","volume":"102","author":"Committee on Children with Disabilities","year":"1998","unstructured":"Committee on Children with Disabilities (1998) Auditory integration training and facilitated communication for autism. Pediatrics 102:431\u2013433. https:\/\/doi.org\/10.1542\/peds.102.2.431","journal-title":"Pediatrics"},{"key":"1332_CR12","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1023\/A:1025014929212","volume":"33","author":"JN Constantino","year":"2003","unstructured":"Constantino JN, Davis SA, Todd RD, Schindler MK, Gross MM, Brophy SL, Metzger LM, Shoushtari CS, Splinter R, Reich W (2003) Validation of a brief quantitative measure of autistic traits: comparison of the Social Responsiveness Scale with the autism diagnostic interview-revised. J Autism Dev Disord 33:427\u2013433","journal-title":"J Autism Dev Disord"},{"key":"1332_CR13","volume-title":"Social Responsiveness Scale (SRS)","author":"JN Constantino","year":"2007","unstructured":"Constantino JN, Gruber CP (2007) Social Responsiveness Scale (SRS). Western Psychological Services, Los Angeles"},{"key":"1332_CR14","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0193-3973(99)00042-8","volume":"21","author":"G Dawson","year":"2000","unstructured":"Dawson G, Osterling J, Meltzoff A, Kuhl P (2000) Case study of the development of an infant with autism from birth to 2 years of age. J Appl Dev Psychol 21:299\u2013313","journal-title":"J Appl Dev Psychol"},{"key":"1332_CR15","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.neuropharm.2011.05.006","volume":"61","author":"V Di Liberto","year":"2011","unstructured":"Di Liberto V, Mud\u00f2 G, Belluardo N (2011) mGluR2\/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1\/2 in mouse striatum. Neuropharmacology 61:638\u2013645. https:\/\/doi.org\/10.1016\/j.neuropharm.2011.05.006","journal-title":"Neuropharmacology"},{"key":"1332_CR16","volume-title":"The sensory profile: examiner\u2019s manual","author":"W Dunn","year":"1999","unstructured":"Dunn W (1999) The sensory profile: examiner\u2019s manual. The psychological corporation, San Antonio"},{"key":"1332_CR17","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1179\/2047387714Y.0000000054","volume":"61","author":"OB Dursun","year":"2014","unstructured":"Dursun OB (2014) The relationship between vitamin D, autistic spectrum disorders, and cognitive development: do glial cell line-derived neurotrophic factor and nerve growth factor play a role in this relationship? Int J Dev Disabil 61:222\u2013230. https:\/\/doi.org\/10.1179\/2047387714Y.0000000054","journal-title":"Int J Dev Disabil"},{"key":"1332_CR18","doi-asserted-by":"publisher","unstructured":"El-Ansary A, Al-Ayadhi L (2012) Neuroinflammation in autism spectrum disorders. J Neuroinflammation 9(265). https:\/\/doi.org\/10.1186\/1742-2094-9-265","DOI":"10.1186\/1742-2094-9-265"},{"key":"1332_CR19","doi-asserted-by":"publisher","first-page":"e0164153","DOI":"10.1371\/journal.pone.0164153","volume":"11","author":"A El-Ansary","year":"2016","unstructured":"El-Ansary A, Hassan WM, Qasem H, Das UN (2016) Identification of biomarkers of impaired sensory profiles among autistic patients. PLoS One 11:e0164153. https:\/\/doi.org\/10.1371\/journal.pone.0164153","journal-title":"PLoS One"},{"key":"1332_CR20","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/j.neurobiolaging.2014.11.017","volume":"36","author":"AQ Farrand","year":"2015","unstructured":"Farrand AQ, Gregory RA, Scofield MD, Helke KL, Boger HA (2015) Effects of aging on glutamate neurotransmission in the substantia nigra of Gdnf heterozygous mice. Neurobiol Aging 36:1569\u20131576","journal-title":"Neurobiol Aging"},{"key":"1332_CR21","doi-asserted-by":"publisher","first-page":"e32337","DOI":"10.17795\/jjcdc-32337","volume":"5","author":"S Ghanbari","year":"2016","unstructured":"Ghanbari S, Amin Rezaei A (2016) The relationship between sensory-processing disorders and sleep disturbances in school-aged autistic children in Shiraz, 2015. Jundishapur J Chronic Dis Care 5:e32337. https:\/\/doi.org\/10.17795\/jjcdc-32337","journal-title":"Jundishapur J Chronic Dis Care"},{"key":"1332_CR22","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1016\/j.celrep.2014.08.040","volume":"8","author":"KM Goodman","year":"2014","unstructured":"Goodman KM, Kjaer S, Beuron F, Knowles PP, Nawrotek A, Burns EM, Purkiss AG, George R, Santoro M, Morris EP, McDonald NQ (2014) RET recognition of GDNF-GFRalpha1 ligand by a composite binding site promotes membrane-proximal self-association. Cell Rep 8:1894\u20131904","journal-title":"Cell Rep"},{"key":"1332_CR23","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.expneurol.2017.01.008","volume":"291","author":"F Hao","year":"2017","unstructured":"Hao F, Yang C, Chen SS, Wang YY, Zhou W, Hao Q, Lu T, Hoffer B, Zhao LR, Duan WM, Xu QY (2017) Long-term protective effects of AAV9 mesencephalic astrocyte derived neurotrophic factor gene transfer in parkinsonian rats. Exp Neurol 291:120\u2013133","journal-title":"Exp Neurol"},{"key":"1332_CR24","first-page":"85","volume":"29","author":"Y Hibi","year":"2009","unstructured":"Hibi Y, Nitta A, Nabeshima T, Yamada K (2009) Possible relation of BDNF and GDNF to neuropsychiatric disorders. Japan J Psychopharmacol 29:85\u201389","journal-title":"Japan J Psychopharmacol"},{"key":"1332_CR25","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.phrs.2018.12.023","volume":"140","author":"N Israelyan","year":"2019","unstructured":"Israelyan N, Margolis KG (2019) Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders. Pharmacol Res 140:115\u2013120. https:\/\/doi.org\/ . https:\/\/doi.org\/10.1016\/j.phrs.2018.12.023","journal-title":"Pharmacol Res"},{"key":"1332_CR26","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.2174\/1381612824666180820150150","volume":"24","author":"A Kabra","year":"2018","unstructured":"Kabra A, Sharma R, Kabra R, Baghel US (2018) Emerging and alternative therapies for Parkinson disease: an updated review. Curr Pharm Des 24:2573\u20132582","journal-title":"Curr Pharm Des"},{"key":"1332_CR27","doi-asserted-by":"publisher","first-page":"530","DOI":"10.5014\/ajot.51.7.530","volume":"51","author":"MA Kientz","year":"1997","unstructured":"Kientz MA, Dunn W (1997) A comparison of the performance of children with and without autism on the Sensory Profile. Am J Occup Ther 51:530\u2013537","journal-title":"Am J Occup Ther"},{"key":"1332_CR28","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1161\/01.STR.29.7.1417","volume":"29","author":"H Kitagawa","year":"1998","unstructured":"Kitagawa H, Hayashi T, Mitsumoto Y, Koga N, Itoyama Y, Abe K (1998) Reduction of ischemic brain injury by topical application of glial cell line-derived neurotrophic factor after permanent middle cerebral artery occlusion in rats. Stroke 29:1417\u20131422","journal-title":"Stroke"},{"key":"1332_CR29","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.neulet.2009.03.017","volume":"454","author":"Y Kosuge","year":"2009","unstructured":"Kosuge Y, Sekikawa-Nishida K, Negi H, Ishige K, Ito Y (2009) Characterization of chronic glutamate-mediated motor neuron toxicity in organotypic spinal cord culture prepared from ALS model mice. Neurosci Lett 454:165\u2013169. https:\/\/doi.org\/ . https:\/\/doi.org\/10.1016\/j.neulet.2009.03.017","journal-title":"Neurosci Lett"},{"key":"1332_CR30","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.bcp.2004.03.023","volume":"68","author":"Y Koyama","year":"2004","unstructured":"Koyama Y, Egawa H, Osakada M, Baba A, Matsuda T (2004) Increase by FK960, a novel cognitive enhancer, in glial cell line-derived neurotrophic factor production in cultured rat astrocytes. Biochem Pharmacol 68:275\u2013282","journal-title":"Biochem Pharmacol"},{"key":"1332_CR31","doi-asserted-by":"publisher","first-page":"3760","DOI":"10.1016\/j.febslet.2015.11.006","volume":"589","author":"ER Kramer","year":"2015","unstructured":"Kramer ER, Liss B (2015) GDNF-ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease. FEBS Lett 589:3760\u20133772","journal-title":"FEBS Lett"},{"key":"1332_CR32","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s12031-019-1258-8","volume":"67","author":"J Kronenberg","year":"2019","unstructured":"Kronenberg J, Merkel L, Heckers S, Gudi V, Schwab HM, Stangel M (2019) Investigation of neuregulin-1 and glial cell-derived neurotrophic factor in rodent astrocytes and microglia. J Mol Neurosci 67:484\u2013493. https:\/\/doi.org\/10.1007\/s12031-019-1258-8","journal-title":"J Mol Neurosci"},{"key":"1332_CR33","doi-asserted-by":"publisher","first-page":"148","DOI":"10.12965\/jer.1632638.319","volume":"12","author":"SM Lee","year":"2016","unstructured":"Lee SM, Kim BK, Kim TW, Ji ES, Choi HH (2016) Music application alleviates short-term memory impairments through increasing cell proliferation in the hippocampus of valproic acid-induced autistic rat pups. J Exerc Rehabil 12:148\u2013155","journal-title":"J Exerc Rehabil"},{"key":"1332_CR34","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jchemneu.2017.02.001","volume":"83-84","author":"KG Margolis","year":"2017","unstructured":"Margolis KG (2017) A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure. J Chem Neuroanat 83-84:36\u201340","journal-title":"J Chem Neuroanat"},{"key":"1332_CR35","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/mp.2010.103","volume":"16","author":"M Martinez-Cengotitabengoa","year":"2011","unstructured":"Martinez-Cengotitabengoa M, MacDowell KS, Alberich S, Diaz FJ, Garcia- Nickl-Jockschat T, Michel TM (2011) The role of neurotrophic factors in autism. Mol Psychiatry 16:478\u2013490","journal-title":"Mol Psychiatry"},{"key":"1332_CR36","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/1742-2094-8-71","volume":"8","author":"GA Mostafa","year":"2011","unstructured":"Mostafa GA, Al-Ayadhi LY (2011) A lack of association between hyperserotonemia and the increased frequency of serum anti-myelin basic protein auto-antibodies in autistic children. J Neuroinflammation 8:71. https:\/\/doi.org\/10.1186\/1742-2094-8-71","journal-title":"J Neuroinflammation"},{"key":"1332_CR37","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.neuroscience.2015.11.010","volume":"321","author":"CL Muller","year":"2016","unstructured":"Muller CL, Anacker AMJ, Veenstra-VanderWeele J (2016) The serotonin system in autism spectrum disorder: from biomarker to animal models. Neuroscience 321:24\u201341","journal-title":"Neuroscience"},{"key":"1332_CR38","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/mp.2010.103","volume":"16","author":"T Nickl-Jockschat","year":"2011","unstructured":"Nickl-Jockschat T, Michel TM (2011) The role of neurotrophic factors in autism. Mol Psychiatry 16:478\u2013490","journal-title":"Mol Psychiatry"},{"key":"1332_CR39","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1159\/000478725","volume":"39","author":"DA Pav\u0103l","year":"2017","unstructured":"Pav\u0103l DA (2017) Dopamine hypothesis of autism spectrum disorder. Dev Neurosci 39:355\u2013360","journal-title":"Dev Neurosci"},{"key":"1332_CR40","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1207\/s15374424jccp3403_8","volume":"34","author":"S Ozonoff","year":"2005","unstructured":"Ozonoff S, Goodlin-Jones BL, Solomon M (2005) Evidence-based assessment of autism spectrum disorders in children and adolescents. J Clin Child Adolesc Psychol 34:523\u2013540","journal-title":"J Clin Child Adolesc Psychol"},{"key":"1332_CR41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3758\/BF03332133","volume":"27","author":"MA Pelleymounter","year":"1999","unstructured":"Pelleymounter MA, Cullen MJ, Baker MB, Healy D (1999) Glial cell line-derived neurotrophic factor (GDNF) improves spatial learning in aged Fischer 344 rats. Psychobiology 27:397\u2013401","journal-title":"Psychobiology"},{"key":"1332_CR42","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s10803-005-0006-9","volume":"35","author":"A Perry","year":"2005","unstructured":"Perry A, Condillac RA, Freeman NL, Dunn-Geier J, Belair J (2005) Multi-site study of the Childhood Autism Rating Scale (CARS) in five clinical groups of young children. J Autism Dev Disord 35:625\u2013634","journal-title":"J Autism Dev Disord"},{"key":"1332_CR43","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1016\/j.neurobiolaging.2007.02.026","volume":"29","author":"M Pertusa","year":"2008","unstructured":"Pertusa M, Garcia-Matas S, Mammeri H, Adell A, Rodrigo T, Mallet J et al (2008) Expression of GDNF transgene in astrocytes improves cognitive deficits in aged rats. Neurobiol Aging 29:1366\u20131379","journal-title":"Neurobiol Aging"},{"key":"1332_CR44","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1134\/S0006297917030099","volume":"82","author":"NK Popova","year":"2017","unstructured":"Popova NK, Ilchibaeva TV, Naumenko VS (2017) Neurotrophic factors (BDNF and GDNF) and the serotonergic system of the brain. Biochemistry (Mosc) 82:308\u2013317","journal-title":"Biochemistry (Mosc)"},{"key":"1332_CR45","first-page":"380","volume":"35","author":"DH Rodrigues","year":"2014","unstructured":"Rodrigues DH, Rocha NP, Sousa LF, Barbosa IG, Kummer A, Teixeira AL (2014) Circulating levels of neurotrophic factors in autism spectrum disorders. Neuro Endocrinol Lett 35:380\u2013384","journal-title":"Neuro Endocrinol Lett"},{"key":"1332_CR46","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1007\/s00702-014-1216-0","volume":"121","author":"DC Rojas","year":"2014","unstructured":"Rojas DC (2014) The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment. J Neural Transm 121:891\u2013905","journal-title":"J Neural Transm"},{"key":"1332_CR47","volume-title":"The Childhood Autism Rating Scale (CARS) for diagnostic screening and classification in autism","author":"E Schopler","year":"1986","unstructured":"Schopler E, Reichler RJ, Renner BR (1986) The Childhood Autism Rating Scale (CARS) for diagnostic screening and classification in autism. Irvington, New York"},{"key":"1332_CR48","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3109\/08039488.2015.1014834","volume":"69","author":"SH Shim","year":"2015","unstructured":"Shim SH, Hwangbo Y, Yoon HJ, Kwon YJ, Lee HY, Hwang JA, Kim YK (2015) Increased levels of plasma glial-derived neurotrophic factor in children with attention deficit hyperactivity disorder. Nordic J Psychiatry 69:546\u2013551","journal-title":"Nordic J Psychiatry"},{"key":"1332_CR49","doi-asserted-by":"publisher","unstructured":"Sinha Y, Silove N, Wheeler D, Williams K (2011) Auditory integration training and other sound therapies for autism spectrum disorders. Cochrane Database Syst Rev (12):CD003681. https:\/\/doi.org\/10.1002\/14651858.CD003681","DOI":"10.1002\/14651858.CD003681"},{"key":"1332_CR50","doi-asserted-by":"publisher","unstructured":"Sinha Y, Silove N, Wheeler D, Williams K (2004) Auditory integration training and other sound therapies for autism spectrum disorders. Cochrane Database Syst Rev (1):CD003681. https:\/\/doi.org\/10.1002\/14651858.CD003681.pub2","DOI":"10.1002\/14651858.CD003681.pub2"},{"key":"1332_CR51","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1136\/adc.2006.094649","volume":"91","author":"Y Sinha","year":"2006","unstructured":"Sinha Y, Silove N, Wheeler D, Williams K (2006) Auditory integration training and other sound therapies for autism spectrum disorders: a systematic review. Arch Dis Child 91:1018\u20131022","journal-title":"Arch Dis Child"},{"key":"1332_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/imm.12717","volume":"151","author":"SD Skaper","year":"2017","unstructured":"Skaper SD (2017) Nerve growth factor: a neuroimmune crosstalk mediator for all seasons. Immunology 151:1\u201315. https:\/\/doi.org\/10.1111\/imm.12717","journal-title":"Immunology"},{"key":"1332_CR53","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s10484-016-9343-z","volume":"41","author":"EM Sokhadze","year":"2016","unstructured":"Sokhadze EM, Casanova MF, Tasman A, Brockett S (2016) Electrophysiological and behavioral outcomes of Berard auditory integration training (AIT) in children with autism spectrum disorder. Appl Psychophysiol Biofeedback 41:405\u2013420","journal-title":"Appl Psychophysiol Biofeedback"},{"key":"1332_CR54","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.jpsychires.2010.01.002","volume":"44","author":"RP Souza","year":"2010","unstructured":"Souza RP, Romano-Silva MA, Lieberman JA, Meltzer HY, MacNeil LT, Culotti JG, Kennedy JL, Wong AH (2010) Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response. J Psychiatr Res 44:700\u2013706","journal-title":"J Psychiatr Res"},{"key":"1332_CR55","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.actbio.2015.10.001","volume":"29","author":"K Tajdaran","year":"2016","unstructured":"Tajdaran K, Gordon T, Wood MD, Shoichet MS, Borschel GH (2016) A glial cell line-derived neurotrophic factor delivery system enhances nerve regeneration across acellular nerve allografts. Acta Biomater 29:62\u201370","journal-title":"Acta Biomater"},{"key":"1332_CR56","first-page":"103","volume":"24","author":"G Trottier","year":"1999","unstructured":"Trottier G, Srivastava L, Walker CD (1999) Etiology of infantile autism. A review of recent advances in genetic and neurological research. J Psychiatry Neurosci 24:103\u2013115","journal-title":"J Psychiatry Neurosci"},{"key":"1332_CR57","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1134\/S0026893314060181","volume":"48","author":"AS Tsybko","year":"2014","unstructured":"Tsybko AS, Il\u2019chibaeva TV, Kondaurova EM, Bazovkina DV, Naumenko VS (2014) The effect of central administration of the neurotrophic factors BDNF and GDNF on the functional activity and expression of the serotonin 5-HT2A receptors in mice genetically predisposed to depressive-like behavior. Mol Biol 48:983\u2013989","journal-title":"Mol Biol"},{"key":"1332_CR58","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1002\/aur.1821","volume":"10","author":"C Vlaskamp","year":"2017","unstructured":"Vlaskamp C, Oranje B, Madsen GF, M\u00f8llegaard Jepsen JR, Durston S, Cantio C, Glenth\u00f8j B, Bilenberg N (2017) Auditory processing in autism spectrum disorder: mismatch negativity deficits. Autism Res 10:1857\u20131865","journal-title":"Autism Res"},{"key":"1332_CR59","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/j.1460-9568.2004.03475.x","volume":"20","author":"V Voikar","year":"2004","unstructured":"Voikar V, Rossi J, Rauvala H, Airaksinen MS (2004) Impaired behavioural flexibility and memory in mice lacking GDNF family receptor alpha 2. Eur J Neurosci 20:308\u2013312","journal-title":"Eur J Neurosci"},{"key":"1332_CR60","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1016\/j.bbapap.2012.10.008","volume":"1834","author":"X Wang","year":"2013","unstructured":"Wang X (2013) Structural studies of GDNF family ligands with their receptors-insights into ligand recognition and activation of receptor tyrosine kinase RET. Biochim Biophys Acta 1834:2205\u20132212","journal-title":"Biochim Biophys Acta"},{"key":"1332_CR61","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1007\/s10803-012-1499-7","volume":"42","author":"J Wang","year":"2012","unstructured":"Wang J, Lee LC, Chen YS, Hsu JW (2012) Assessing autistic traits in a Taiwan preschool population: cross-cultural validation of the Social Responsiveness Scale (SRS). J Autism Dev Disord 42:2450\u20132459","journal-title":"J Autism Dev Disord"},{"key":"1332_CR62","doi-asserted-by":"publisher","first-page":"e1727","DOI":"10.1002\/mpr.1727","volume":"27","author":"F Ye","year":"2018","unstructured":"Ye F, Zhan Q, Xiao W, Sha W, Zhang X (2018) Altered serum levels of glial cell line-derived neurotrophic factor in male chronic schizophrenia patients with tardive dyskinesia. Int J Methods Psychiatr Res 27:e1727. https:\/\/doi.org\/10.1002\/mpr.1727","journal-title":"Int J Methods Psychiatr Res"},{"key":"1332_CR63","doi-asserted-by":"publisher","first-page":"135893","DOI":"10.1155\/2015\/135893","volume":"2015","author":"SH Yeh","year":"2015","unstructured":"Yeh SH, Lin LW, Chuang YK, Liu CL, Tsai LJ, Tsuei FS, Lee MT, Hsiao CY, Yang KD (2015) Effects of music aerobic exercise on depression and brain-derived neurotrophic factor levels in community dwelling women. Biomed Res Int 2015:135893. https:\/\/doi.org\/10.1155\/2015\/135893","journal-title":"Biomed Res Int"},{"key":"1332_CR64","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1097\/ALN.0000000000000352","volume":"121","author":"J Zhang","year":"2014","unstructured":"Zhang J, Tan H, Jiang W, Zuo Z (2014) Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology 121:773\u2013785","journal-title":"Anesthesiology"},{"key":"1332_CR65","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0006-8993(01)02364-2","volume":"903","author":"WR Zhang","year":"2001","unstructured":"Zhang WR, Hayashi T, Iwai M, Nagano I, Sato K, Manabe Y, Abe K (2001) Time dependent amelioration against ischemic brain damage by glial cell line-derived neurotrophic factor after transient middle cerebral artery occlusion in rat. Brain Res 903:253\u2013256","journal-title":"Brain Res"},{"key":"1332_CR66","doi-asserted-by":"publisher","first-page":"e106867","DOI":"10.1371\/journal.pone.0106867","volume":"9","author":"Y Zhao","year":"2014","unstructured":"Zhao Y, Haney MJ, Gupta R, Bohnsack JP, He Z, Kabanov AV, Batrakova EV (2014) GDNF-transfected macrophages produce potent neuroprotective effects in Parkinson\u2019s disease mouse model. PLoS One 9:e106867. https:\/\/doi.org\/10.1371\/journal.pone.0106867","journal-title":"PLoS One"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-019-01332-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-019-01332-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-019-01332-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T20:46:44Z","timestamp":1663447604000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-019-01332-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,9]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["1332"],"URL":"https:\/\/doi.org\/10.1007\/s12031-019-01332-w","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,9]]},"assertion":[{"value":"3 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All procedures performed were in accordance with the ethical standards of the institutional and\/or national research committee, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"In the present study, the small sample size was a limitation. Therefore, further research, on a large scale, is recommended to study the impact of AIT on plasma levels of GDNF.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Limitation of the Study"}}]}}