{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:47:45Z","timestamp":1740138465750,"version":"3.37.3"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the National Key Basic Research and Development Program of China","award":["2017YFC0907704"],"award-info":[{"award-number":["2017YFC0907704"]}]},{"name":"the Fundamental Research Funds for the Central Universities of China","award":["2017SCU11049"],"award-info":[{"award-number":["2017SCU11049"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s12031-019-01467-w","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T10:03:56Z","timestamp":1578650636000},"page":"610-617","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Decreased mRNA Expressions of CD40L in Patients with Neuromyelitis Optica Spectrum Disorder"],"prefix":"10.1007","volume":"70","author":[{"given":"Ziyan","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyun","family":"Lian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7637-1305","authenticated-orcid":false,"given":"Hongyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"1467_CR1","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.3389\/fimmu.2017.01791","volume":"8","author":"S Aarts","year":"2017","unstructured":"Aarts S, Seijkens T, van Dorst K et al (2017) The CD40-CD40L dyad in experimental autoimmune encephalomyelitis and multiple sclerosis. Front Immunol 8:1791","journal-title":"Front Immunol"},{"key":"1467_CR2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2165\/00063030-199809010-00004","volume":"9","author":"A Anstey","year":"1998","unstructured":"Anstey A, Lear JT (1998) Azathioprine: clinical pharmacology and current indications in autoimmune disorders. BioDrugs 9:33\u201347","journal-title":"BioDrugs"},{"key":"1467_CR3","doi-asserted-by":"publisher","first-page":"e104","DOI":"10.1212\/NXI.0000000000000104","volume":"2","author":"JL Bennett","year":"2015","unstructured":"Bennett JL, O'Connor KC, Bar-Or A et al (2015) B lymphocytes in neuromyelitis optica. Neurol Neuroimmunol Neuroinflamm 2:e104","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"1467_CR4","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S1359-6101(03)00024-8","volume":"14","author":"GA Bishop","year":"2003","unstructured":"Bishop GA, Hostager BS (2003) The CD40-CD154 interaction in B cell-T cell liaisons. Cytokine Growth Factor Rev 14:297\u2013309","journal-title":"Cytokine Growth Factor Rev"},{"key":"1467_CR5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.autrev.2018.01.001","volume":"17","author":"A Bruscolini","year":"2018","unstructured":"Bruscolini A, Sacchetti M, La Cava M et al (2018) Diagnosis and management of neuromyelitis optica spectrum disorders - an update. Autoimmun Rev 17:195\u2013200","journal-title":"Autoimmun Rev"},{"key":"1467_CR6","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/ene.13186","volume":"24","author":"H Chen","year":"2017","unstructured":"Chen H, Qiu W, Zhang Q et al (2017) Comparisons of the efficacy and tolerability of mycophenolate mofetil and azathioprine as treatments for neuromyelitis optica and neuromyelitis optica spectrum disorder. Eur J Neurol 24:219\u2013226","journal-title":"Eur J Neurol"},{"key":"1467_CR7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S1568-9972(03)00006-5","volume":"2","author":"GS Cooper","year":"2003","unstructured":"Cooper GS, Stroehla BC (2003) The epidemiology of autoimmune diseases. Autoimmun Rev 2:119\u2013125","journal-title":"Autoimmun Rev"},{"key":"1467_CR8","first-page":"5314541","volume":"2016","author":"PG Dos","year":"2016","unstructured":"Dos PG, Sato DK, Becker J, Fujihara K (2016) Th17 cells pathways in multiple sclerosis and Neuromyelitis Optica Spectrum disorders: pathophysiological and therapeutic implications. Mediat Inflamm 2016:5314541","journal-title":"Mediat Inflamm"},{"key":"1467_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2007.05.002","volume":"29","author":"WW Eaton","year":"2007","unstructured":"Eaton WW, Rose NR, Kalaydjian A, Pedersen MG, Mortensen PB (2007) Epidemiology of autoimmune diseases in Denmark. J Autoimmun 29:1\u20139","journal-title":"J Autoimmun"},{"key":"1467_CR10","doi-asserted-by":"publisher","first-page":"638968","DOI":"10.1155\/2015\/638968","volume":"2015","author":"X Fan","year":"2015","unstructured":"Fan X, Lin C, Han J et al (2015) Follicular helper CD4+ T cells in human Neuroautoimmune diseases and their animal models. Mediat Inflamm 2015:638968","journal-title":"Mediat Inflamm"},{"key":"1467_CR11","first-page":"e127080","volume":"10","author":"J Field","year":"2015","unstructured":"Field J, Shahijanian F, Schibeci S et al (2015) The MS risk allele of CD40 is associated with reduced cell-membrane bound expression in antigen presenting cells: implications for gene function. PLoS One 10:e127080","journal-title":"PLoS One"},{"key":"1467_CR12","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1146\/annurev.immunol.14.1.591","volume":"14","author":"TM Foy","year":"1996","unstructured":"Foy TM, Aruffo A, Bajorath J, Buhlmann JE, Noelle RJ (1996) Immune regulation by CD40 and its ligand GP39. Annu Rev Immunol 14:591\u2013617","journal-title":"Annu Rev Immunol"},{"key":"1467_CR13","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1073\/pnas.93.6.2499","volume":"93","author":"K Gerritse","year":"1996","unstructured":"Gerritse K, Laman JD, Noelle RJ, Aruffo A, Ledbetter JA, Boersma WJ, Claassen E (1996) CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci U S A 93:2499\u20132504","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1467_CR14","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1212\/WNL.0000000000004611","volume":"89","author":"H Houzen","year":"2017","unstructured":"Houzen H, Kondo K, Niino M, Horiuchi K, Takahashi T, Nakashima I, Tanaka K (2017) Prevalence and clinical features of neuromyelitis optica spectrum disorders in northern Japan. Neurology 89:1995\u20132001","journal-title":"Neurology"},{"key":"1467_CR15","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1073\/pnas.0810769106","volume":"106","author":"G Iezzi","year":"2009","unstructured":"Iezzi G, Sonderegger I, Ampenberger F, Schmitz N, Marsland BJ, Kopf M (2009) CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells. Proc Natl Acad Sci U S A 106:876\u2013881","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1467_CR16","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/bpa.12084","volume":"23","author":"S Jarius","year":"2013","unstructured":"Jarius S, Wildemann B (2013) Aquaporin-4 antibodies (NMO-IgG) as a serological marker of neuromyelitis optica: a critical review of the literature. Brain Pathol 23:661\u2013683","journal-title":"Brain Pathol"},{"key":"1467_CR17","doi-asserted-by":"publisher","first-page":"e1003487","DOI":"10.1371\/journal.pgen.1003487","volume":"9","author":"G Li","year":"2013","unstructured":"Li G, Diogo D, Wu D et al (2013) Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway. PLoS Genet 9:e1003487","journal-title":"PLoS Genet"},{"key":"1467_CR18","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jneuroim.2018.10.013","volume":"325","author":"J Liu","year":"2018","unstructured":"Liu J, Zhang Q, Shi Z, Yang M, Lian Z, Chen H, Feng H, du Q, Zhang Y, Miao X, Li H, Zhou H (2018) Increased expression of the membrane-bound CD40 ligand on peripheral CD4(+) T cells in the acute phase of AQP4-IgG-seropositive neuromyelitis optica spectrum disorders. J Neuroimmunol 325:64\u201368","journal-title":"J Neuroimmunol"},{"key":"1467_CR19","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"1467_CR20","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jneuroim.2017.01.024","volume":"305","author":"H Masuda","year":"2017","unstructured":"Masuda H, Mori M, Uchida T, Uzawa A, Ohtani R, Kuwabara S (2017) Soluble CD40 ligand contributes to blood-brain barrier breakdown and central nervous system inflammation in multiple sclerosis and neuromyelitis optica spectrum disorder. J Neuroimmunol 305:102\u2013107","journal-title":"J Neuroimmunol"},{"key":"1467_CR21","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1001\/jamaneurol.2013.5699","volume":"71","author":"MA Mealy","year":"2014","unstructured":"Mealy MA, Wingerchuk DM, Palace J, Greenberg BM, Levy M (2014) Comparison of relapse and treatment failure rates among patients with neuromyelitis optica: multicenter study of treatment efficacy. JAMA Neurol 71:324\u2013330","journal-title":"JAMA Neurol"},{"key":"1467_CR22","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1177\/1352458515572406","volume":"21","author":"L Pandit","year":"2015","unstructured":"Pandit L, Asgari N, Apiwattanakul M, Palace J, Paul F, Leite MI, Kleiter I, Chitnis T, GJCF International Clinical Consortium & Biorepository for Neuromyelitis Optica (2015) Demographic and clinical features of neuromyelitis optica: a review. Mult Scler 21:845\u2013853","journal-title":"Mult Scler"},{"key":"1467_CR23","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1016\/j.biocel.2012.06.013","volume":"44","author":"J Ratelade","year":"2012","unstructured":"Ratelade J, Verkman AS (2012) Neuromyelitis optica: aquaporin-4 based pathogenesis mechanisms and new therapies. Int J Biochem Cell Biol 44:1519\u20131530","journal-title":"Int J Biochem Cell Biol"},{"key":"1467_CR24","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S1357-2725(00)00016-9","volume":"32","author":"U Schonbeck","year":"2000","unstructured":"Schonbeck U, Mach F, Libby P (2000) CD154 (CD40 ligand). Int J Biochem Cell Biol 32:687\u2013693","journal-title":"Int J Biochem Cell Biol"},{"key":"1467_CR25","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1146\/annurev-immunol-020711-075027","volume":"30","author":"AR Shaffer","year":"2012","unstructured":"Shaffer AR, Young RM, Staudt LM (2012) Pathogenesis of human B cell lymphomas. Annu Rev Immunol 30:565\u2013610","journal-title":"Annu Rev Immunol"},{"key":"1467_CR26","doi-asserted-by":"publisher","first-page":"5236","DOI":"10.1007\/s12035-016-0070-5","volume":"54","author":"Z Shi","year":"2017","unstructured":"Shi Z, Zhang Q, Chen H, Miao X, Liu J, Lian Z, Feng H, Zhou H (2017) Association of CD40 gene polymorphisms with susceptibility to Neuromyelitis Optica Spectrum disorders. Mol Neurobiol 54:5236\u20135242","journal-title":"Mol Neurobiol"},{"key":"1467_CR27","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.23.021704.115707","volume":"23","author":"M Sospedra","year":"2005","unstructured":"Sospedra M, Martin R (2005) Immunology of multiple sclerosis. Annu Rev Immunol 23:683\u2013747","journal-title":"Annu Rev Immunol"},{"key":"1467_CR28","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/0167-5699(96)10060-I","volume":"17","author":"RD Stout","year":"1996","unstructured":"Stout RD, Suttles J (1996) The many roles of CD40 in cell-mediated inflammatory responses. Immunol Today 17:487\u2013492","journal-title":"Immunol Today"},{"issue":"Pt 1","key":"1467_CR29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1042\/bj3330175","volume":"333","author":"F Takahashi","year":"1998","unstructured":"Takahashi F, Morita K, Katai K et al (1998) Effects of dietary pi on the renal Na+\u2212dependent pi transporter NaPi-2 in thyroparathyroidectomized rats. Biochem J 333(Pt 1):175\u2013181","journal-title":"Biochem J"},{"key":"1467_CR30","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/ana.23651","volume":"72","author":"M Varrin-Doyer","year":"2012","unstructured":"Varrin-Doyer M, Spencer CM, Schulze-Topphoff U, Nelson PA, Stroud RM, Cree BA, Zamvil SS (2012) Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter. Ann Neurol 72:53\u201364","journal-title":"Ann Neurol"},{"key":"1467_CR31","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1136\/ard.2010.146530","volume":"70","author":"VM Vazgiourakis","year":"2011","unstructured":"Vazgiourakis VM, Zervou MI, Choulaki C, Bertsias G, Melissourgaki M, Yilmaz N, Sidiropoulos P, Plant D, Trouw LA, Toes RE, Kardassis D, Yavuz S, Boumpas DT, Goulielmos GN (2011) A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis. Ann Rheum Dis 70:2184\u20132190","journal-title":"Ann Rheum Dis"},{"key":"1467_CR32","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1007\/s12031-015-0490-0","volume":"56","author":"M Wagner","year":"2015","unstructured":"Wagner M, Sobczynski M, Bilinska M et al (2015) MS risk allele rs1883832T is associated with decreased mRNA expression of CD40. J Mol Neurosci 56:540\u2013545","journal-title":"J Mol Neurosci"},{"key":"1467_CR33","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1093\/brain\/awy010","volume":"141","author":"R Wilson","year":"2018","unstructured":"Wilson R, Makuch M, Kienzler AK, Varley J, Taylor J, Woodhall M, Palace J, Leite MI, Waters P, Irani SR (2018) Condition-dependent generation of aquaporin-4 antibodies from circulating B cells in neuromyelitis optica. Brain 141:1063\u20131074","journal-title":"Brain"},{"key":"1467_CR34","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/S1474-4422(07)70216-8","volume":"6","author":"DM Wingerchuk","year":"2007","unstructured":"Wingerchuk DM, Lennon VA, Lucchinetti CF, Pittock SJ, Weinshenker BG (2007) The spectrum of neuromyelitis optica. Lancet Neurol 6:805\u2013815","journal-title":"Lancet Neurol"},{"key":"1467_CR35","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","volume":"85","author":"DM Wingerchuk","year":"2015","unstructured":"Wingerchuk DM, Banwell B, Bennett JL et al (2015) International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology 85:177\u2013189","journal-title":"Neurology"},{"key":"1467_CR36","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1089\/thy.2011.0222","volume":"22","author":"K Yamamoto","year":"2012","unstructured":"Yamamoto K, Itoh M, Okamura T et al (2012) Relative levels of the inflammatory cytokine TNFalpha and the soluble CD40 ligand profile in serum correlate with the thyrotoxic activity of Graves' disease. Thyroid 22:516\u2013521","journal-title":"Thyroid"},{"key":"1467_CR37","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1002\/hep.30105","volume":"68","author":"J Yan","year":"2018","unstructured":"Yan J, Lei J, Chen L, Deng H, Dong D, Jin T, Liu X, Yuan R, Qiu Y, Ge J, Peng X, Shao J (2018) Human leukocyte antigen F locus adjacent transcript 10 overexpression disturbs WISP1 protein and mRNA expression to promote hepatocellular carcinoma progression. Hepatology 68:2268\u20132284","journal-title":"Hepatology"},{"key":"1467_CR38","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00401-015-1501-5","volume":"130","author":"B Zeka","year":"2015","unstructured":"Zeka B, Hastermann M, Hochmeister S, K\u00f6gl N, Kaufmann N, Schanda K, Mader S, Misu T, Rommer P, Fujihara K, Illes Z, Leutmezer F, Sato DK, Nakashima I, Reindl M, Lassmann H, Bradl M (2015) Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS. Acta Neuropathol 130:783\u2013798","journal-title":"Acta Neuropathol"},{"key":"1467_CR39","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s40478-016-0355-y","volume":"4","author":"B Zeka","year":"2016","unstructured":"Zeka B, Hastermann M, Kaufmann N et al (2016) Aquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO\/SD. Acta Neuropathol Commun 4:82","journal-title":"Acta Neuropathol Commun"},{"key":"1467_CR40","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1529-8019.2007.00136.x","volume":"20","author":"J Zwerner","year":"2007","unstructured":"Zwerner J, Fiorentino D (2007) Mycophenolate mofetil. Dermatol Ther 20:229\u2013238","journal-title":"Dermatol Ther"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-019-01467-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12031-019-01467-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-019-01467-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T02:44:44Z","timestamp":1610160284000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12031-019-01467-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,10]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["1467"],"URL":"https:\/\/doi.org\/10.1007\/s12031-019-01467-w","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"type":"print","value":"0895-8696"},{"type":"electronic","value":"1559-1166"}],"subject":[],"published":{"date-parts":[[2020,1,10]]},"assertion":[{"value":"26 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}