{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:58:21Z","timestamp":1783191501681,"version":"3.54.6"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Natural Science Foundation and Youth Science Fund Project","award":["No. 81703853"],"award-info":[{"award-number":["No. 81703853"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s12031-020-01599-4","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T06:50:33Z","timestamp":1593672633000},"page":"1977-1986","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Silencing RNF13 Alleviates Parkinson\u2019s Disease \u2013 Like Problems in Mouse Models by Regulating the Endoplasmic Reticulum Stress\u2013Mediated IRE1\u03b1-TRAF2-ASK1-JNK Pathway"],"prefix":"10.1007","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3844-9001","authenticated-orcid":false,"given":"Meng","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyin","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"1599_CR1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40478-017-0427-7","volume":"5","author":"DR Amici","year":"2017","unstructured":"Amici DR et al (2017) Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis. Acta Neuropathol Commun 5:24. https:\/\/doi.org\/10.1186\/s40478-017-0427-7","journal-title":"Acta Neuropathol Commun"},{"key":"1599_CR2","doi-asserted-by":"publisher","first-page":"8726","DOI":"10.1074\/jbc.M112.368829","volume":"288","author":"M Arshad","year":"2013","unstructured":"Arshad M, Ye Z, Gu X, Wong CK, Liu Y, Li D, Zhou L, Zhang Y, Bay WP, Yu VC, Li P (2013) RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1alpha)\/c-Jun NH2-terminal kinase pathway. J Biol Chem 288:8726\u20138736. https:\/\/doi.org\/10.1074\/jbc.M112.368829","journal-title":"J Biol Chem"},{"key":"1599_CR3","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3109\/10799893.2013.863920","volume":"34","author":"A Arshad","year":"2014","unstructured":"Arshad A, Gu X, Arshad M (2014) RNF13 protein regulates endoplasmic reticulum stress induced apoptosis in dopaminergic SH-SY5Y cells by enhancing IRE1alpha stability. J Recept Signal Transduct Res 34:119\u2013124. https:\/\/doi.org\/10.3109\/10799893.2013.863920","journal-title":"J Recept Signal Transduct Res"},{"key":"1599_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.neures.2013.09.003","volume":"77","author":"R Asci","year":"2013","unstructured":"Asci R, Vallefuoco F, Andolfo I, Bruno M, De Falco L, Iolascon A (2013) Trasferrin receptor 2 gene regulation by microRNA 221 in SH-SY5Y cells treated with MPP(+) as Parkinson\u2019s disease cellular model. Neurosci Res 77:121\u2013127. https:\/\/doi.org\/10.1016\/j.neures.2013.09.003","journal-title":"Neurosci Res"},{"issue":"199","key":"1599_CR5","first-page":"208","volume":"39","author":"K Bayne","year":"1996","unstructured":"Bayne K (1996) Revised guide for the care and use of laboratory animals available. American Physiological Society Physiologist 39(199):208\u2013111","journal-title":"American Physiological Society Physiologist"},{"key":"1599_CR6","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1172\/JCI11476","volume":"107","author":"A Bertolotti","year":"2001","unstructured":"Bertolotti A et al (2001) Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clin Invest 107:585\u2013593. https:\/\/doi.org\/10.1172\/JCI11476","journal-title":"J Clin Invest"},{"key":"1599_CR7","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1128\/MMBR.00025-06","volume":"70","author":"MA Bogoyevitch","year":"2006","unstructured":"Bogoyevitch MA, Kobe B (2006) Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiol Mol Biol Rev 70:1061\u20131095. https:\/\/doi.org\/10.1128\/MMBR.00025-06","journal-title":"Microbiol Mol Biol Rev"},{"key":"1599_CR8","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/biof.159","volume":"37","author":"T Cali","year":"2011","unstructured":"Cali T, Ottolini D, Brini M (2011) Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson\u2019s disease. Biofactors 37:228\u2013240. https:\/\/doi.org\/10.1002\/biof.159","journal-title":"Biofactors"},{"key":"1599_CR9","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3389\/fncel.2015.00170","volume":"9","author":"D Chen","year":"2015","unstructured":"Chen D, Wang Y, Chin ER (2015) Activation of the endoplasmic reticulum stress response in skeletal muscle of G93A*SOD1 amyotrophic lateral sclerosis mice. Front Cell Neurosci 9:170. https:\/\/doi.org\/10.3389\/fncel.2015.00170","journal-title":"Front Cell Neurosci"},{"key":"1599_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.abb.2010.12.017","volume":"508","author":"SC Daubner","year":"2011","unstructured":"Daubner SC, Le T, Wang S (2011) Tyrosine hydroxylase and regulation of dopamine synthesis. Arch Biochem Biophys 508:1\u201312. https:\/\/doi.org\/10.1016\/j.abb.2010.12.017","journal-title":"Arch Biochem Biophys"},{"key":"1599_CR11","doi-asserted-by":"publisher","first-page":"8188","DOI":"10.3390\/ijms14048188","volume":"14","author":"Y Deng","year":"2013","unstructured":"Deng Y, Srivastava R, Howell SH (2013) Endoplasmic reticulum (ER) stress response and its physiological roles in plants. Int J Mol Sci 14:8188\u20138212. https:\/\/doi.org\/10.3390\/ijms14048188","journal-title":"Int J Mol Sci"},{"key":"1599_CR12","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1111\/j.1582-4934.2011.01374.x","volume":"15","author":"KM Doyle","year":"2011","unstructured":"Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A (2011) Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. J Cell Mol Med 15:2025\u20132039. https:\/\/doi.org\/10.1111\/j.1582-4934.2011.01374.x","journal-title":"J Cell Mol Med"},{"key":"1599_CR13","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/j.1742-4658.2010.07921.x","volume":"278","author":"AH Erickson","year":"2011","unstructured":"Erickson AH (2011) A-TM-RING proteins: a new family of endosomal membrane proteins. FEBS J 278:46. https:\/\/doi.org\/10.1111\/j.1742-4658.2010.07921.x","journal-title":"FEBS J"},{"key":"1599_CR14","doi-asserted-by":"publisher","first-page":"12752","DOI":"10.1128\/JVI.02138-14","volume":"88","author":"TS Fung","year":"2014","unstructured":"Fung TS, Liao Y, Liu DX (2014) The endoplasmic reticulum stress sensor IRE1alpha protects cells from apoptosis induced by the coronavirus infectious bronchitis virus. J Virol 88:12752\u201312764. https:\/\/doi.org\/10.1128\/JVI.02138-14","journal-title":"J Virol"},{"key":"1599_CR15","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1007\/s12031-015-0530-9","volume":"56","author":"W Ge","year":"2015","unstructured":"Ge W, Yin Q, Xian H (2015) Wogonin induced mitochondrial dysfunction and endoplasmic reticulum stress in human malignant neuroblastoma cells via IRE1alpha-dependent pathway. J Mol Neurosci 56:652\u2013662. https:\/\/doi.org\/10.1007\/s12031-015-0530-9","journal-title":"J Mol Neurosci"},{"key":"1599_CR16","doi-asserted-by":"publisher","first-page":"e1000410","DOI":"10.1371\/journal.pbio.1000410","volume":"8","author":"S Gupta","year":"2010","unstructured":"Gupta S, Deepti A, Deegan S, Lisbona F, Hetz C, Samali A (2010) HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction. PLoS Biol 8:e1000410. https:\/\/doi.org\/10.1371\/journal.pbio.1000410","journal-title":"PLoS Biol"},{"key":"1599_CR17","first-page":"55","volume":"15","author":"M Haji Ghasem Kashani","year":"2013","unstructured":"Haji Ghasem Kashani M, Ghorbanian MT, Hosseinpour L (2013) Transplantation of deprenyl-induced tyrosine hydroxylase-positive cells improves 6-OHDA-lesion rat model of Parkinson\u2019s disease: behavioral and immunohistochemical cvaluation. Cell J 15:55\u201364","journal-title":"Cell J"},{"key":"1599_CR18","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/00001756-199412300-00014","volume":"6","author":"P Horellou","year":"1994","unstructured":"Horellou P et al (1994) Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson\u2019s disease. Neuroreport 6:49\u201353. https:\/\/doi.org\/10.1097\/00001756-199412300-00014","journal-title":"Neuroreport"},{"key":"1599_CR19","doi-asserted-by":"publisher","first-page":"565","DOI":"10.2147\/DDDT.S156920","volume":"12","author":"M Hu","year":"2018","unstructured":"Hu M, Li F, Wang W (2018) Vitexin protects dopaminergic neurons in MPTP-induced Parkinson\u2019s disease through PI3K\/Akt signaling pathway. Drug Des Devel Ther 12:565\u2013573. https:\/\/doi.org\/10.2147\/DDDT.S156920","journal-title":"Drug Des Devel Ther"},{"key":"1599_CR20","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1750-1326-5-56","volume":"5","author":"P Jiang","year":"2010","unstructured":"Jiang P, Gan M, Ebrahim AS, Lin WL, Melrose HL, Yen SH (2010) ER stress response plays an important role in aggregation of alpha-synuclein. Mol Neurodegener 5:56. https:\/\/doi.org\/10.1186\/1750-1326-5-56","journal-title":"Mol Neurodegener"},{"key":"1599_CR21","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1074\/jbc.M111.316760","volume":"287","author":"MJ Jurczak","year":"2012","unstructured":"Jurczak MJ, Lee AH, Jornayvaz FR, Lee HY, Birkenfeld AL, Guigni BA, Kahn M, Samuel VT, Glimcher LH, Shulman GI (2012) Dissociation of inositol-requiring enzyme (IRE1alpha)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. J Biol Chem 287:2558\u20132567. https:\/\/doi.org\/10.1074\/jbc.M111.316760","journal-title":"J Biol Chem"},{"key":"1599_CR22","doi-asserted-by":"publisher","first-page":"21256","DOI":"10.1074\/jbc.M510644200","volume":"281","author":"BJ Kim","year":"2006","unstructured":"Kim BJ, Ryu SW, Song BJ (2006) JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J Biol Chem 281:21256\u201321265. https:\/\/doi.org\/10.1074\/jbc.M510644200","journal-title":"J Biol Chem"},{"key":"1599_CR23","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3109\/10715762.2012.760198","volume":"47","author":"CM Liu","year":"2013","unstructured":"Liu CM, Zheng GH, Ming QL, Sun JM, Cheng C (2013) Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1\/JNK and PI3K\/Akt pathway. Free Radic Res 47:192\u2013201. https:\/\/doi.org\/10.3109\/10715762.2012.760198","journal-title":"Free Radic Res"},{"key":"1599_CR24","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1136\/jnnp.2006.097170","volume":"77","author":"G Logroscino","year":"2006","unstructured":"Logroscino G, Sesso HD, Paffenbarger RS Jr, Lee IM (2006) Physical activity and risk of Parkinson\u2019s disease: a prospective cohort study. J Neurol Neurosurg Psychiatry 77:1318\u20131322. https:\/\/doi.org\/10.1136\/jnnp.2006.097170","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1599_CR25","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nrd3430","volume":"10","author":"WG Meissner","year":"2011","unstructured":"Meissner WG et al (2011) Priorities in Parkinson\u2019s disease research. Nat Rev Drug Discov 10:377\u2013393. https:\/\/doi.org\/10.1038\/nrd3430","journal-title":"Nat Rev Drug Discov"},{"key":"1599_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fnagi.2015.00039","volume":"7","author":"G Mercado","year":"2015","unstructured":"Mercado G, Castillo V, Vidal R, Hetz C (2015) ER proteostasis disturbances in Parkinson\u2019s disease: novel insights. Front Aging Neurosci 7:39. https:\/\/doi.org\/10.3389\/fnagi.2015.00039","journal-title":"Front Aging Neurosci"},{"key":"1599_CR27","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1007\/s11064-016-1922-0","volume":"41","author":"B Ning","year":"2016","unstructured":"Ning B, Deng M, Zhang Q, Wang N, Fang Y (2016) Beta-asarone inhibits IRE1\/XBP1 endoplasmic reticulum stress pathway in 6-OHDA-induced Parkinsonian rats. Neurochem Res 41:2097\u20132101. https:\/\/doi.org\/10.1007\/s11064-016-1922-0","journal-title":"Neurochem Res"},{"key":"1599_CR28","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1002\/mnfr.201500750","volume":"60","author":"SH Park","year":"2016","unstructured":"Park SH, Kang MK, Choi YJ, Kim YH, Antika LD, Lim SS, Kang YH (2016) Dietary compound alpha-asarone alleviates ER stress-mediated apoptosis in 7beta-hydroxycholesterol-challenged macrophages. Mol Nutr Food Res 60:1033\u20131047. https:\/\/doi.org\/10.1002\/mnfr.201500750","journal-title":"Mol Nutr Food Res"},{"key":"1599_CR29","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.neuro.2014.07.006","volume":"44","author":"S Sarkar","year":"2014","unstructured":"Sarkar S et al (2014) Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model. Neurotoxicology 44:250\u2013262. https:\/\/doi.org\/10.1016\/j.neuro.2014.07.006","journal-title":"Neurotoxicology"},{"key":"1599_CR30","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40709-017-0059-x","volume":"24","author":"NZ Shaban","year":"2017","unstructured":"Shaban NZ, Ahmed Zahran AM, El-Rashidy FH, Abdo Kodous AS (2017) Protective role of hesperidin against gamma-radiation-induced oxidative stress and apoptosis in rat testis. J Biol Res (Thessalon) 24:5. https:\/\/doi.org\/10.1186\/s40709-017-0059-x","journal-title":"J Biol Res (Thessalon)"},{"key":"1599_CR31","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/sj.embor.7400779","volume":"7","author":"E Szegezdi","year":"2006","unstructured":"Szegezdi E, Logue SE, Gorman AM, Samali A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7:880\u2013885. https:\/\/doi.org\/10.1038\/sj.embor.7400779","journal-title":"EMBO Rep"},{"key":"1599_CR32","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/ncb0311-184","volume":"13","author":"I Tabas","year":"2011","unstructured":"Tabas I, Ron D (2011) Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol 13:184\u2013190. https:\/\/doi.org\/10.1038\/ncb0311-184","journal-title":"Nat Cell Biol"},{"key":"1599_CR33","doi-asserted-by":"publisher","first-page":"3822","DOI":"10.1007\/s12035-015-9309-9","volume":"53","author":"Q Tong","year":"2016","unstructured":"Tong Q, Wu L, Gao Q, Ou Z, Zhu D, Zhang Y (2016) PPARbeta\/delta agonist provides neuroprotection by suppression of IRE1alpha-caspase-12-mediated endoplasmic reticulum stress pathway in the rotenone rat model of Parkinson\u2019s disease. Mol Neurobiol 53:3822\u20133831. https:\/\/doi.org\/10.1007\/s12035-015-9309-9","journal-title":"Mol Neurobiol"},{"key":"1599_CR34","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1590\/s1516-44462009000100010","volume":"31","author":"BA Veiga","year":"2009","unstructured":"Veiga BA, Borges V, Silva SM, Goulart Fde O, Cendoroglo MS, Ferraz HB (2009) Depression in Parkinson's disease: clinical-epidemiological correlates and comparison with a controlled group of non-parkinsonian geriatric patients. Braz J Psychiatry 31:39\u201342. https:\/\/doi.org\/10.1590\/s1516-44462009000100010","journal-title":"Braz J Psychiatry"},{"key":"1599_CR35","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1515\/hsz-2016-0108","volume":"397","author":"ARV Vliet","year":"2016","unstructured":"Vliet ARV, Garg AD, Agostinis P (2016) Coordination of stress, Ca2+, and immunogenic signaling pathways by PERK at the endoplasmic reticulum. Biol Chem 397:649\u2013656","journal-title":"Biol Chem"},{"key":"1599_CR36","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jphs.2018.08.008","volume":"138","author":"Y Wang","year":"2018","unstructured":"Wang Y, Yu X, Zhang P, Ma Y, Wang L, Xu H, Sui D (2018) Neuroprotective effects of pramipexole transdermal patch in the MPTP-induced mouse model of Parkinson\u2019s disease. J Pharmacol Sci 138:31\u201337. https:\/\/doi.org\/10.1016\/j.jphs.2018.08.008","journal-title":"J Pharmacol Sci"},{"key":"1599_CR37","first-page":"4915","volume":"7","author":"H Wu","year":"2014","unstructured":"Wu H, Tang Q, Yang J, Ding J, Ye M, Dong W (2014) Atorvastatin ameliorates myocardial ischemia\/reperfusion injury through attenuation of endoplasmic reticulum stress-induced apoptosis. Int J Clin Exp Med 7:4915\u20134923","journal-title":"Int J Clin Exp Med"},{"key":"1599_CR38","doi-asserted-by":"publisher","first-page":"779","DOI":"10.4103\/1673-5374.206649","volume":"12","author":"LX Xue","year":"2017","unstructured":"Xue LX et al (2017) Neuroprotective effects of Activin A on endoplasmic reticulum stress-mediated apoptotic and autophagic PC12 cell death. Neural Regen Res 12:779\u2013786. https:\/\/doi.org\/10.4103\/1673-5374.206649","journal-title":"Neural Regen Res"},{"key":"1599_CR39","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.neulet.2017.07.019","volume":"657","author":"WL Yin","year":"2017","unstructured":"Yin WL, Yin WG, Huang BS, Wu LX (2017) Neuroprotective effects of lentivirus-mediated cystathionine-beta-synthase overexpression against 6-OHDA-induced Parkinson\u2019s disease rats. Neurosci Lett 657:45\u201352. https:\/\/doi.org\/10.1016\/j.neulet.2017.07.019","journal-title":"Neurosci Lett"},{"key":"1599_CR40","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.freeradbiomed.2013.10.013","volume":"67","author":"XS Zeng","year":"2014","unstructured":"Zeng XS, Jia JJ, Kwon Y, Wang SD, Bai J (2014) The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease. Free Radic Biol Med 67:10\u201318. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2013.10.013","journal-title":"Free Radic Biol Med"},{"key":"1599_CR41","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/cr.2008.285","volume":"19","author":"Q Zhang","year":"2009","unstructured":"Zhang Q, Meng Y, Zhang L, Chen J, Zhu D (2009) RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer. Cell Res 19:348\u2013357. https:\/\/doi.org\/10.1038\/cr.2008.285","journal-title":"Cell Res"},{"key":"1599_CR42","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1111\/j.1742-4658.2009.07498.x","volume":"277","author":"Q Zhang","year":"2010","unstructured":"Zhang Q, Wang K, Zhang Y, Meng J, Yu F, Chen Y, Zhu D (2010) The myostatin-induced E3 ubiquitin ligase RNF13 negatively regulates the proliferation of chicken myoblasts. FEBS J 277:466\u2013476. https:\/\/doi.org\/10.1111\/j.1742-4658.2009.07498.x","journal-title":"FEBS J"},{"key":"1599_CR43","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00018-012-1103-5","volume":"70","author":"Q Zhang","year":"2013","unstructured":"Zhang Q et al (2013) E3 ubiquitin ligase RNF13 involves spatial learning and assembly of the SNARE complex. Cell Mol Life Sci 70:153\u2013165. https:\/\/doi.org\/10.1007\/s00018-012-1103-5","journal-title":"Cell Mol Life Sci"},{"key":"1599_CR44","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s10549-014-2967-x","volume":"145","author":"YZ Zheng","year":"2014","unstructured":"Zheng YZ, Cao ZG, Hu X, Shao ZM (2014) The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancer. Breast Cancer Res Treat 145:349\u2013358. https:\/\/doi.org\/10.1007\/s10549-014-2967-x","journal-title":"Breast Cancer Res Treat"}],"updated-by":[{"DOI":"10.1007\/s12031-020-01746-x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000}}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-020-01599-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-020-01599-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-020-01599-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T23:38:22Z","timestamp":1625182702000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-020-01599-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,2]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1599"],"URL":"https:\/\/doi.org\/10.1007\/s12031-020-01599-4","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s12031-020-01746-x","asserted-by":"object"}]},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,2]]},"assertion":[{"value":"6 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2020","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published: https:\/\/doi.org\/10.1007\/s12031-020-01746-x","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments were conducted with the approval of Ethics Committee of Laboratory Animals in our academy, and all procedures performed in the study conformed with the <i>Guide for the Care and Use of Laboratory Animals<\/i> (NIH) (Bayne ).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}