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Using a human first trimester prenatal brain multiprotein array (MPA), we demonstrate here that antibodies to the digestive tract bacteria <jats:italic>Helicobacter pylori<\/jats:italic> (\u03b1-<jats:italic>HPy<\/jats:italic>) and <jats:italic>Campylobacter jejuni<\/jats:italic> (\u03b1-<jats:italic>CJe<\/jats:italic>) interact with different synaptic proteins, including the calcium sensor synaptotagmin 5 (Syt5). Interactions of both antisera with Syt5 were confirmed by Western blot with a HEK293-cells overexpression lysate of this protein. Immunofluorescence and Western blotting revealed SiMa cells to express Syt5, which also co-migrated with a band\/spot labeled by either \u03b1-<jats:italic>HPy<\/jats:italic> or \u03b1-<jats:italic>CJe<\/jats:italic>. Functionally, a 12-h pretreatment of SiMa cells with 10\u00a0\u03bcg\/ml of either \u03b1-<jats:italic>HPy<\/jats:italic> or \u03b1-<jats:italic>CJe<\/jats:italic> resulted in a significant reduction of acetylcholine(ACh)-dependent calcium signals as compared to controls. Also ACh-dependent vesicle recycling was significantly reduced in cells pretreated with either \u03b1-<jats:italic>HPy<\/jats:italic> or \u03b1-<jats:italic>CJe<\/jats:italic>. Similar effects were observed upon pretreatment of SiMa cells with Syt5-specific antibodies. In conclusion, the present study supports the view that prenatal maternal antibacterial immune responses towards <jats:italic>HPy<\/jats:italic> and by this to Syt5 are able to cause functional changes, which in the end might contribute also to neurodevelopmental disorders.<\/jats:p>","DOI":"10.1007\/s12031-020-01670-0","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T16:03:59Z","timestamp":1598630639000},"page":"481-505","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interactions of Antibodies to the Gram-Negative Gastric Bacterium Helicobacter pylori with the Synaptic Calcium Sensor Synaptotagmin 5, Correlate to Impaired Vesicle Recycling in SiMa Human Neuroblastoma Cells"],"prefix":"10.1007","volume":"71","author":[{"given":"Aaron David","family":"Kleine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4654-5383","authenticated-orcid":false,"given":"Bernhard","family":"Reuss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"1670_CR1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12031-017-0920-2","volume":"62","author":"A Almamy","year":"2017","unstructured":"Almamy A, Schwerk C, Schroten H, Ishikawa H, Asif AR, Reuss B (2017) Crossreactivity of an antiserum directed to the gram-negative bacterium Neisseria gonorrhoeae with the SNARE-complex protein Snap23 correlates to impaired exocytosis in SH-SY5Y cells. 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