{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:47:04Z","timestamp":1740138424017,"version":"3.37.3"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s12031-021-01881-z","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T20:02:30Z","timestamp":1626465750000},"page":"2618-2627","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Overexpression of the PLK4 Gene as a Novel Strategy for the Treatment of Autosomal Recessive Microcephaly by Improving Centrosomal Dysfunction"],"prefix":"10.1007","volume":"71","author":[{"given":"Ya-Song","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Ying","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Fei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Zhen","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1211-211X","authenticated-orcid":false,"given":"Qi-Chang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"issue":"3","key":"1881_CR1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1006\/jsbi.1994.1056","volume":"113","author":"IB Alieva","year":"1994","unstructured":"Alieva IB, Vorobjev IA (1994) Centrosome behavior under the action of a mitochondrial uncoupler and the effect of disruption of cytoskeleton elements on the uncoupler-induced alterations. J Struct Biol 113(3):217\u2013224","journal-title":"J Struct Biol"},{"key":"1881_CR2","doi-asserted-by":"publisher","first-page":"20130468","DOI":"10.1098\/rstb.2013.0468","volume":"369","author":"PL Chavali","year":"2014","unstructured":"Chavali PL, P\u00fctz M, Gergely F (2014) Small organelle, big responsibility: the role of centrosomes in development and disease. Philos Trans R Soc Lond B Biol Sci 369:20130468","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"1","key":"1881_CR3","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.celrep.2015.08.062","volume":"13","author":"E Dzafic","year":"2015","unstructured":"Dzafic E, Strzyz P, Wilsch-Br\u00e4uninger M et al (2015) Centriole Amplification in Zebrafish Affects Proliferation and Survival but Not Differentiation of Neural Progenitor Cells. Cell Rep 13(1):168\u2013182","journal-title":"Cell Rep"},{"key":"1881_CR4","doi-asserted-by":"crossref","unstructured":"Habedanck R, Stierhof YD, Wilkinson CJ et al (2005) The Polo-kinase Plk4 functions in centriole duplication. Nat\u00a0Cell Biol\u00a07:1140\u20131146","DOI":"10.1038\/ncb1320"},{"key":"1881_CR5","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ajo.2019.05.001","volume":"207","author":"S Hull","year":"2019","unstructured":"Hull S, Arno G, Ostergaard P et al (2019) Clinical and molecular characterization of familial exudative vitreoretinopathy associated with microcephaly. Am J Ophthalmol 207:87\u201398","journal-title":"Am J Ophthalmol"},{"issue":"8","key":"1881_CR6","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S0171-9335(99)80020-X","volume":"78","author":"C Jean","year":"1999","unstructured":"Jean C, Tollon Y, Raynaud-Messina B et al (1999) The mammalian interphase centrosome: two independent units maintained together by the dynamics of the microtubule cytoskeleton. Eur J Cell Biol 78(8):549\u2013560","journal-title":"Eur J Cell Biol"},{"issue":"3","key":"1881_CR7","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.pneurobio.2009.11.002","volume":"90","author":"AM Kaindl","year":"2010","unstructured":"Kaindl AM, Passemard S, Kumar P et al (2010) Many roads lead to primary autosomal recessive microcephaly. Prog Neurobiol 90(3):363\u2013383","journal-title":"Prog Neurobiol"},{"key":"1881_CR8","doi-asserted-by":"crossref","unstructured":"Katrien S, Moortgat S, Tim V et al (2018) Biallelic mutations in RTTN are associated with microcephaly, short stature and a wide range of brain malformations. Eur J Med Genet 61(12): 733\u2013737","DOI":"10.1016\/j.ejmg.2018.06.001"},{"issue":"5","key":"1881_CR9","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.celrep.2016.06.069","volume":"16","author":"M Kim","year":"2016","unstructured":"Kim M, O\u2019Rourke B, Soni RK et al (2016) Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis. Cell Rep 16(5):1195\u20131203","journal-title":"Cell Rep"},{"issue":"2","key":"1881_CR10","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.devcel.2007.07.002","volume":"13","author":"J Kleylein-Sohn","year":"2007","unstructured":"Kleylein-Sohn J, Westendorf J, Clech ML et al (2007) Plk4-Induced Centriole Biogenesis in Human Cells. Dev Cell 13(2):190\u2013202","journal-title":"Dev Cell"},{"key":"1881_CR11","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ymeth.2016.08.005","volume":"112","author":"HY Luk","year":"2016","unstructured":"Luk HY, Mcfarlin BK, Vingren JL (2016) Using image-based flow cytometry to monitor satellite cells proliferation and differentiation in vitro. Methods 112:175\u2013181","journal-title":"Methods"},{"key":"1881_CR12","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1038\/ng.3122","volume":"46","author":"CA Martin","year":"2014","unstructured":"Martin CA, Ahmad I, Klingseisen A et al (2014) Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat Genet 46:1283\u20131292","journal-title":"Nat Genet"},{"key":"1881_CR13","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/ncb2746","volume":"15","author":"V Marthiens","year":"2013","unstructured":"Marthiens V, Rujano MA, Pennetier C et al (2013) Centrosome amplification causes microcephaly. Nat Cell Biol 15:731\u2013740","journal-title":"Nat Cell Biol"},{"key":"1881_CR14","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/s41586-020-2710-1","volume":"585","author":"F Meitinger","year":"2020","unstructured":"Meitinger F, Ohta M, Lee KY et al (2020) TRIM37 controls cancer-specific vulnerability to PLK4 inhibition. Nature 585:440\u2013446","journal-title":"Nature"},{"key":"1881_CR15","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.mcp.2015.05.015","volume":"29","author":"DJ Morris-Rosendahl","year":"2015","unstructured":"Morris-Rosendahl DJ, Kaindl AM (2015) What next-generation sequencing (NGS) technology has enabled us to learn about primary autosomal recessive microcephaly (MCPH). Mol Cell Probes 29:271\u2013281","journal-title":"Mol Cell Probes"},{"issue":"11","key":"1881_CR16","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1016\/j.sjbs.2020.09.033","volume":"27","author":"IN Muhammad","year":"2020","unstructured":"Muhammad IN, Angham AA, Mohammed MJ et al (2020) Next generation sequencing reveals novel homozygous frameshift in PUS7 and splice acceptor variants in AASS gene leading to intellectual disability, developmental delay, dysmorphic feature and microcephaly. Saudi J\u00a0Biol Sci 27(11):3125\u20133131","journal-title":"Saudi J\u00a0Biol Sci"},{"issue":"4","key":"1881_CR17","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.ajhg.2015.02.011","volume":"96","author":"S Scheidecker","year":"2015","unstructured":"Scheidecker S, Etard C, Haren L et al (2015) Mutations in TUBGCP4 Alter Microtubule Organization via the \u03b3-Tubulin Ring Complex in Autosomal-Recessive Microcephaly with Chorioretinopathy. Am J Hum Genet 96(4):666\u2013674","journal-title":"Am J Hum Genet"},{"key":"1881_CR18","doi-asserted-by":"crossref","unstructured":"Soden SE, Saunders CJ, Willig LK et al (2014) Effectiveness of exome and genome sequencing guided by acuity of illness for diagnosis of neurodevelopmental disorders.\u00a0Sci Transl Med\u00a06(625):265ra168","DOI":"10.1126\/scitranslmed.3010076"},{"key":"1881_CR19","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1038\/ejhg.2016.119","volume":"24","author":"M Tsutsumi","year":"2016","unstructured":"Tsutsumi M, Yokoi S, Miya F et al (2016) Novel compound heterozygous variants in PLK4 identified in a patient with autosomal recessive microcephaly and chorioretinopathy. Eur J Hum Genet 24:1702\u20131706","journal-title":"Eur J Hum Genet"},{"key":"1881_CR20","doi-asserted-by":"publisher","first-page":"15165","DOI":"10.1038\/srep15165","volume":"5","author":"S Yokoi","year":"2015","unstructured":"Yokoi S, Ishihara N, Miya F et al (2015) TUBA1A mutation can cause a hydranencephaly-like severe form of cortical dysgenesis. Sci Rep 5:15165","journal-title":"Sci Rep"},{"key":"1881_CR21","doi-asserted-by":"crossref","unstructured":"Zhang SD, Yu L, Wang P et al (2019) Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells. Phytomedicine 60:152957","DOI":"10.1016\/j.phymed.2019.152957"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-021-01881-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-021-01881-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-021-01881-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T03:20:39Z","timestamp":1637292039000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-021-01881-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,16]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1881"],"URL":"https:\/\/doi.org\/10.1007\/s12031-021-01881-z","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"type":"print","value":"0895-8696"},{"type":"electronic","value":"1559-1166"}],"subject":[],"published":{"date-parts":[[2021,7,16]]},"assertion":[{"value":"27 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The genetic testing used in this study was approved by the ethical committees of Xiamen Maternal and Child Health Hospital in accordance with the Declaration of Helsinki. All patients provided informed consent, and all protocols were approved by the institutional committee of Xiamen Maternal and Child Health Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Statement"}},{"value":"The work described has not been submitted elsewhere for publication, in whole or in part, and all the authors listed have approved the submission of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"No conflict of interest exits in the submission of this manuscript, and the manuscript is approved by all authors for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest Statement"}}]}}