{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:42:50Z","timestamp":1775576570394,"version":"3.50.1"},"reference-count":127,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004366","name":"tabriz university of medical sciences","doi-asserted-by":"publisher","award":["64417"],"award-info":[{"award-number":["64417"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s12031-021-01917-4","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T07:12:42Z","timestamp":1633072362000},"page":"642-652","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Possible Engagement of Nicotinic Acetylcholine Receptors in Pathophysiology of Brain Ischemia-Induced Cognitive Impairment"],"prefix":"10.1007","volume":"72","author":[{"given":"Fatemehsadat","family":"Seyedaghamiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javad","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2872-1072","authenticated-orcid":false,"given":"Saeed","family":"Sadigh-Eteghad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Farhoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"issue":"1","key":"1917_CR1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1006\/exnr.2000.7492","volume":"166","author":"CR Almli","year":"2000","unstructured":"Almli CR, Levy TJ, Han BH, Shah AR, Gidday JM, Holtzman DM (2000) BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia. Exp Neurol 166(1):99\u2013114","journal-title":"Exp Neurol"},{"issue":"2","key":"1917_CR2","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00709-019-01439-2","volume":"257","author":"SS Andrabi","year":"2020","unstructured":"Andrabi SS, Parvez S, Tabassum H (2020) Ischemic stroke and mitochondria: mechanisms and targets. Protoplasma 257(2):335\u2013343","journal-title":"Protoplasma"},{"issue":"9","key":"1917_CR3","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/nm747","volume":"8","author":"A Arvidsson","year":"2002","unstructured":"Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O (2002) Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 8(9):963\u2013970","journal-title":"Nat Med"},{"key":"1917_CR4","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.neuropharm.2012.10.004","volume":"67","author":"F Atif","year":"2013","unstructured":"Atif F, Yousuf S, Sayeed I, Ishrat T, Hua F, Stein DG (2013) Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischemic stroke: the role of BDNF\/TrkB\/Erk1\/2 signaling in neuroprotection. Neuropharmacology 67:78\u201387","journal-title":"Neuropharmacology"},{"issue":"1","key":"1917_CR5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.31117\/neuroscirn.v1i1.15","volume":"1","author":"NF Azam","year":"2018","unstructured":"Azam NF, Stanyard RA, Mat NH, Hassan Z (2018) Cholinergic modulation of hippocampal long-term potentiation in chronic cerebral hypoperfused rats. Neurosci Res Notes 1(1):42\u201357","journal-title":"Neurosci Res Notes"},{"issue":"6","key":"1917_CR6","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/aps.2009.37","volume":"30","author":"M Bencherif","year":"2009","unstructured":"Bencherif M (2009) Neuronal nicotinic receptors as novel targets for inflammation and neuroprotection: mechanistic considerations and clinical relevance. Acta Pharmacol Sin 30(6):702\u2013714","journal-title":"Acta Pharmacol Sin"},{"issue":"12","key":"1917_CR7","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1038\/sj.jcbfm.9600153","volume":"25","author":"O Bendel","year":"2005","unstructured":"Bendel O, Bueters T, von Euler M, \u00d6gren SO, Sandin J, von Euler G (2005) Reappearance of hippocampal CA1 neurons after ischemia is associated with recovery of learning and memory. J Cereb Blood Flow Metab 25(12):1586\u20131595","journal-title":"J Cereb Blood Flow Metab"},{"key":"1917_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.bbi.2014.03.005","volume":"40","author":"C Boitard","year":"2014","unstructured":"Boitard C, Cavaroc A, Sauvant J, Aubert A, Castanon N, Lay\u00e9 S et al (2014) Impairment of hippocampal-dependent memory induced by juvenile high-fat diet intake is associated with enhanced hippocampal inflammation in rats. Brain Behav Immun 40:9\u201317","journal-title":"Brain Behav Immun"},{"issue":"1","key":"1917_CR9","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.nlm.2011.09.008","volume":"97","author":"F Cechetti","year":"2012","unstructured":"Cechetti F, Worm PV, Elsner VR, Bertoldi K, Sanches E, Ben J et al (2012) Forced treadmill exercise prevents oxidative stress and memory deficits following chronic cerebral hypoperfusion in the rat. Neurobiol Learn Mem 97(1):90\u201396","journal-title":"Neurobiol Learn Mem"},{"issue":"8","key":"1917_CR10","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S1474-4422(16)00114-9","volume":"15","author":"\u00c1 Chamorro","year":"2016","unstructured":"Chamorro \u00c1, Dirnagl U, Urra X, Planas AM (2016) Neuroprotection in acute stroke: targeting excitotoxicity oxidative and nitrosative stress and inflammation. Lancet Neurol 15(8):869\u2013881","journal-title":"Lancet Neurol"},{"issue":"2","key":"1917_CR11","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3892\/br.2012.48","volume":"1","author":"A Chen","year":"2013","unstructured":"Chen A, Xiong L-J, Tong Y, Mao M (2013) The neuroprotective roles of BDNF in hypoxic ischemic brain injury. Biomed Rep 1(2):167\u2013176","journal-title":"Biomed Rep"},{"issue":"12","key":"1917_CR12","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.4103\/1673-5374.135329","volume":"9","author":"W Chen","year":"2014","unstructured":"Chen W, Sun Y, Liu K, Sun X (2014) Autophagy: a double-edged sword for neuronal survival after cerebral ischemia. Neural Regen Res 9(12):1210\u20131216","journal-title":"Neural Regen Res"},{"issue":"3","key":"1917_CR13","doi-asserted-by":"publisher","first-page":"194","DOI":"10.4103\/2045-9912.215750","volume":"7","author":"Z-q Chen","year":"2017","unstructured":"Chen Z-q, Mou R-t, Feng D-x, Wang Z, Chen G (2017) The role of nitric oxide in stroke. Med Gas Res 7(3):194\u2013203","journal-title":"Med Gas Res"},{"key":"1917_CR14","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.bbr.2013.10.022","volume":"258","author":"CA Cordova","year":"2014","unstructured":"Cordova CA, Jackson D, Langdon KD, Hewlett KA, Corbett D (2014) Impaired executive function following ischemic stroke in the rat medial prefrontal cortex. Behav Brain Res 258:106\u2013111","journal-title":"Behav Brain Res"},{"key":"1917_CR15","doi-asserted-by":"crossref","unstructured":"Cri\u015fan TO, Plantinga TS, van de Veerdonk FL, Farca\u015f MF, Stoffels M, Kullberg B-J et al (2011) Inflammasome-independent modulation of cytokine response by autophagy in human cells. PloS one 6(4):e18666","DOI":"10.1371\/journal.pone.0018666"},{"issue":"6","key":"1917_CR16","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/S1734-1140(09)70163-X","volume":"61","author":"A Czubak","year":"2009","unstructured":"Czubak A, Nowakowska E, Kus K, Burda K, Metelska J, Baer-Dubowska W et al (2009) Influences of chronic venlafaxine, olanzapine and nicotine on the hippocampal and cortical concentrations of brain-derived neurotrophic factor (BDNF). Pharmacol Rep 61(6):1017\u20131023","journal-title":"Pharmacol Rep"},{"issue":"13","key":"1917_CR17","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1016\/S0028-3908(00)00127-1","volume":"39","author":"FA Dajas-Bailador","year":"2000","unstructured":"Dajas-Bailador FA, Lima PA, Wonnacott S (2000) The \u03b17 nicotinic acetylcholine receptor subtype mediates nicotine protection against NMDA excitotoxicity in primary hippocampal cultures through a Ca2+ dependent mechanism. Neuropharmacology 39(13):2799\u20132807","journal-title":"Neuropharmacology"},{"issue":"3","key":"1917_CR18","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.pharep.2019.01.012","volume":"71","author":"T Damodaran","year":"2019","unstructured":"Damodaran T, M\u00fcller CP, Hassan Z (2019) Chronic cerebral hypoperfusion-induced memory impairment and hippocampal long-term potentiation deficits are improved by cholinergic stimulation in rats. Pharmacol Rep 71(3):443\u2013448","journal-title":"Pharmacol Rep"},{"key":"1917_CR19","doi-asserted-by":"crossref","unstructured":"das Nair R, Cogger H, Worthington E, Lincoln NB (2016) Cognitive rehabilitation for memory deficits after stroke. Cochrane Database Syst Rev 9:CD002293","DOI":"10.1002\/14651858.CD002293.pub3"},{"issue":"1","key":"1917_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-019-10723-x","volume":"10","author":"GB Dawe","year":"2019","unstructured":"Dawe GB, Yu H, Gu S, Blackler AN, Matta JA, Siuda ER et al (2019) \u03b17 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins. Nat Comm 10(1):1\u201311","journal-title":"Nat Comm"},{"issue":"7","key":"1917_CR21","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/sj.bjp.0707264","volume":"151","author":"W De Jonge","year":"2007","unstructured":"De Jonge W, Ulloa L (2007) The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation. Br J Pharmacol 151(7):915\u2013929","journal-title":"Br J Pharmacol"},{"issue":"6","key":"1917_CR22","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1097\/ALN.0b013e31828c23f8","volume":"118","author":"V Degos","year":"2013","unstructured":"Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F et al (2013) Bone fracture exacerbates murine ischemic cerebral injury. Anesthesiology 118(6):1362\u20131372","journal-title":"Anesthesiology"},{"key":"1917_CR23","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.2147\/NDT.S183436","volume":"14","author":"X Duan","year":"2018","unstructured":"Duan X, Zhang L, Yu J, Wei W, Liu X, Xu F et al (2018) The effect of different frequencies of electroacupuncture on BDNF and NgF expression in the hippocampal ca3 area of the ischemic hemisphere in cerebral ischemic rats. Neuropsychiatr Dis Treat 14:2689\u20132696","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"4","key":"1917_CR24","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.bcp.2015.07.032","volume":"97","author":"J Egea","year":"2015","unstructured":"Egea J, Buendia I, Parada E, Navarro E, Le\u00f3n R, Lopez MG (2015) Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection. Biochem Pharmacol 97(4):463\u2013472","journal-title":"Biochem Pharmacol"},{"key":"1917_CR25","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.neuint.2018.01.008","volume":"115","author":"W Fan","year":"2018","unstructured":"Fan W, Li X, Huang L, He S, Xie Z, Fu Y et al (2018) S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating \u03b17 nAChR and PI3K\/Akt\/GSK3\u03b2 signal pathway in rats. Neurochem Int 115:50\u201360","journal-title":"Neurochem Int"},{"issue":"3","key":"1917_CR26","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1124\/jpet.102.048173","volume":"305","author":"PA Ferchmin","year":"2003","unstructured":"Ferchmin PA, Perez D, Eterovic VA, de Vellis J (2003) Nicotinic receptors differentially regulate N-methyl-D-aspartate damage in acute hippocampal slices. J Pharmacol Exp Ther 305(3):1071\u20131078","journal-title":"J Pharmacol Exp Ther"},{"issue":"6","key":"1917_CR27","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.tins.2017.04.002","volume":"40","author":"S Forner","year":"2017","unstructured":"Forner S, Baglietto-Vargas D, Martini AC, Trujillo-Estrada L, LaFerla FM (2017) Synaptic impairment in Alzheimer\u2019s disease: a dysregulated symphony. Trends Neurosci 40(6):347\u2013357","journal-title":"Trends Neurosci"},{"issue":"5","key":"1917_CR28","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1523\/JNEUROSCI.13-05-01965.1993","volume":"13","author":"R Freedman","year":"1993","unstructured":"Freedman R, Wetmore C, Stromberg I, Leonard S, Olson L (1993) Alpha-bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression. J Neurosci 13(5):1965\u20131975","journal-title":"J Neurosci"},{"issue":"5","key":"1917_CR29","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1046\/j.1471-4159.2001.00135.x","volume":"76","author":"R Garrido","year":"2001","unstructured":"Garrido R, Mattson MP, Hennig B, Toborek M (2001) Nicotine protects against arachidonic-acid-induced caspase activation cytochrome c release and apoptosis of cultured spinal cord neurons. J Neurochem 76(5):1395\u20131403","journal-title":"J Neurochem"},{"key":"1917_CR30","doi-asserted-by":"crossref","unstructured":"Gergalova G, Lykhmus O, Kalashnyk O, Koval L, Chernyshov V, Kryukova E et al (2012) Mitochondria express \u03b17 nicotinic acetylcholine receptors to regulate Ca 2+ accumulation and cytochrome c release: study on isolated mitochondria. PloS one 7(2):e31361","DOI":"10.1371\/journal.pone.0031361"},{"key":"1917_CR31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.biocel.2014.01.001","volume":"49","author":"G Gergalova","year":"2014","unstructured":"Gergalova G, Lykhmus O, Komisarenko S, Skok M (2014) \u03b17 nicotinic acetylcholine receptors control cytochrome c release from isolated mitochondria through kinase-mediated pathways. Int J Biochem Cell Biol 49:26\u201331","journal-title":"Int J Biochem Cell Biol"},{"key":"1917_CR32","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.nlm.2014.01.009","volume":"109","author":"TJ Gould","year":"2014","unstructured":"Gould TJ, Wilkinson DS, Yildirim E, Poole RL, Leach PT, Simmons SJ (2014) Nicotine shifts the temporal activation of hippocampal protein kinase A and extracellular signal-regulated kinase 1\/2 to enhance long-term but not short-erm, hippocampus-dependent memory. Neurobiol Learn Mem 109:151\u2013159","journal-title":"Neurobiol Learn Mem"},{"issue":"3","key":"1917_CR33","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1007\/s12035-014-8825-3","volume":"51","author":"Y-Z Guan","year":"2015","unstructured":"Guan Y-Z, Jin X-D, Guan L-X, Yan H-C, Wang P, Gong Z et al (2015) Nicotine inhibits microglial proliferation and is neuroprotective in global ischemia rats. Mol Neurobiol 51(3):1480\u20131488","journal-title":"Mol Neurobiol"},{"issue":"7","key":"1917_CR34","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1111\/j.1745-7254.2008.00819.x","volume":"29","author":"Z-z Guan","year":"2008","unstructured":"Guan Z-z (2008) Cross-talk between oxidative stress and modifications of cholinergic and glutaminergic receptors in the pathogenesis of Alzheimer\u2019s disease. Acta Pharmacol Sin 29(7):773\u2013780","journal-title":"Acta Pharmacol Sin"},{"issue":"3","key":"1917_CR35","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0197-0186(03)00009-3","volume":"43","author":"Z-Z Guan","year":"2003","unstructured":"Guan Z-Z, Yu W-F, Nordberg A (2003) Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells. Neurochem Int 43(3):243\u2013249","journal-title":"Neurochem Int"},{"key":"1917_CR36","doi-asserted-by":"publisher","first-page":"559","DOI":"10.3389\/fphys.2017.00559","volume":"8","author":"F Guo","year":"2017","unstructured":"Guo F, Lou J, Han X, Deng Y, Huang X (2017) Repetitive transcranial magnetic stimulation ameliorates cognitive impairment by enhancing neurogenesis and suppressing apoptosis in the hippocampus in rats with ischemic stroke. Front Physiol 8:559","journal-title":"Front Physiol"},{"key":"1917_CR37","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1093\/ntr\/ntz126","volume":"22","author":"T Han","year":"2020","unstructured":"Han T, Wang Q, Lai R, Zhang D, Diao Y, Yin Y (2020) Nicotine induced neurocognitive protection and anti-inflammation effect by activating \u03b14\u03b22 nAChRs in ischemic rats. Nicotine Tob Res 22:919\u2013924","journal-title":"Nicotine Tob Res"},{"issue":"4","key":"1917_CR38","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/jnc.12817","volume":"131","author":"Z Han","year":"2014","unstructured":"Han Z, Li L, Wang L, Degos V, Maze M, Su H (2014a) Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation oxidative stress and brain injury in mice with ischemic stroke and bone fracture. J Neurochem 131(4):498\u2013508","journal-title":"J Neurochem"},{"key":"1917_CR39","doi-asserted-by":"crossref","unstructured":"Han Z, Shen F, He Y, Degos V, Camus M, Maze M et al (2014b) Activation of \u03b1-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress. PloS one 9(8):e105711","DOI":"10.1371\/journal.pone.0105711"},{"issue":"3","key":"1917_CR40","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/S1044-7431(03)00244-6","volume":"24","author":"M Hejmadi","year":"2003","unstructured":"Hejmadi M, Dajas-Bailador F, Barns S, Jones B, Wonnacott S (2003) Neuroprotection by nicotine against hypoxia-induced apoptosis in cortical cultures involves activation of multiple nicotinic acetylcholine receptor subtypes. Mol Cell Neurosci 24(3):779\u2013786","journal-title":"Mol Cell Neurosci"},{"issue":"4","key":"1917_CR41","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1093\/carcin\/19.4.551","volume":"19","author":"WL Heusch","year":"1998","unstructured":"Heusch WL, Maneckjee R (1998) Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis 19(4):551\u2013556","journal-title":"Carcinogenesis"},{"issue":"2","key":"1917_CR42","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1600-0404.2006.00768.x","volume":"115","author":"C Hofgren","year":"2007","unstructured":"Hofgren C, Bj\u00f6rkdahl A, Esbj\u00f6rnsson E, Stibrant-Sunnerhagen K (2007) Recovery after stroke: cognition, ADL function and return to work. Acta Neurol Scand 115(2):73\u201380","journal-title":"Acta Neurol Scand"},{"issue":"4","key":"1917_CR43","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.nlm.2008.01.003","volume":"89","author":"SK Hota","year":"2008","unstructured":"Hota SK, Barhwal K, Ray K, Singh SB, Ilavazhagan G (2008) Ceftriaxone rescues hippocampal neurons from excitotoxicity and enhances memory retrieval in chronic hypobaric hypoxia. Neurobiol Learn Mem 89(4):522\u2013532","journal-title":"Neurobiol Learn Mem"},{"issue":"1","key":"1917_CR44","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s12031-018-1219-7","volume":"67","author":"Y Hu","year":"2019","unstructured":"Hu Y, Chen W, Wu L, Jiang L, Liang N, Tan L et al (2019) TGF-\u03b21 restores hippocampal synaptic plasticity and memory in Alzheimer model via the PI3K\/Akt\/Wnt\/\u03b2-catenin signaling pathway. J Mol Neurosci 67(1):142\u2013149","journal-title":"J Mol Neurosci"},{"issue":"3","key":"1917_CR45","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1007\/s12035-014-8753-2","volume":"51","author":"T-g Huo","year":"2015","unstructured":"Huo T-g, Li W-k, Zhang Y-h, Yuan J, Gao L-y, Yuan Y et al (2015) Excitotoxicity induced by realgar in the rat hippocampus: the involvement of learning memory injury dysfunction of glutamate metabolism and NMDA receptors. Mol Neurobiol 51(3):980\u2013994","journal-title":"Mol Neurobiol"},{"issue":"1","key":"1917_CR46","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0031-9384(97)00143-1","volume":"62","author":"LS Janis","year":"1997","unstructured":"Janis LS, Glasier MM, Stein DG (1997) Effects of a single intraseptal injection of NGF on spatial learning in the water maze. Physiol Behav 62(1):69\u201376","journal-title":"Physiol Behav"},{"issue":"5","key":"1917_CR47","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1152\/jn.2000.83.5.2682","volume":"83","author":"D Ji","year":"2000","unstructured":"Ji D, Dani JA (2000) Inhibition and disinhibition of pyramidal neurons by activation of nicotinic receptors on hippocampal interneurons. J Neurophysiol 83(5):2682\u20132690","journal-title":"J Neurophysiol"},{"key":"1917_CR48","doi-asserted-by":"crossref","unstructured":"Jiang Y, Li L, Liu B, Zhang Y, Chen Q, Li C (2014) Vagus nerve stimulation attenuates cerebral ischemia and reperfusion injury via endogenous cholinergic pathway in rat. PLoS One 9(7):e102342","DOI":"10.1371\/journal.pone.0102342"},{"issue":"4","key":"1917_CR49","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s11883-001-0028-5","volume":"3","author":"RN Kalaria","year":"2001","unstructured":"Kalaria RN, Ballard C (2001) Stroke and cognition. Curr Atheroscler Rep 3(4):334\u2013339","journal-title":"Curr Atheroscler Rep"},{"issue":"12","key":"1917_CR50","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1017\/S1461145714000613","volume":"17","author":"Y Kita","year":"2014","unstructured":"Kita Y, Ago Y, Higashino K, Asada K, Takano E, Takuma K et al (2014) Galantamine promotes adult hippocampal neurogenesis via M1 muscarinic and \u03b1 7 nicotinic receptors in mice. Int J Neuropsychopharmacol 17(12):1957\u20131968","journal-title":"Int J Neuropsychopharmacol"},{"issue":"1","key":"1917_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-6606-7-13","volume":"7","author":"T Kitamura","year":"2014","unstructured":"Kitamura T, Inokuchi K (2014) Role of adult neurogenesis in hippocampal-cortical memory consolidation. Mol Brain 7(1):1\u20138","journal-title":"Mol Brain"},{"issue":"4","key":"1917_CR52","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.pbb.2008.10.009","volume":"91","author":"I-G Ko","year":"2009","unstructured":"Ko I-G, Shin M-S, Kim B-K, Kim S-E, Sung Y-H, Kim T-S et al (2009) Tadalafil improves short-term memory by suppressing ischemia-induced apoptosis of hippocampal neuronal cells in gerbils. Pharmacol Biochem Behav 91(4):629\u2013635","journal-title":"Pharmacol Biochem Behav"},{"issue":"11","key":"1917_CR53","first-page":"1174","volume":"21","author":"C-H Ko","year":"2018","unstructured":"Ko C-H, Huang C-P, Lin Y-W, Hsieh C-L (2018) Paeoniflorin has anti-inflammation and neurogenesis functions through nicotinic acetylcholine receptors in cerebral ischemia-reperfusion injury rats. Iran J Basic Med Sci 21(11):1174","journal-title":"Iran J Basic Med Sci"},{"issue":"1","key":"1917_CR54","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0006-8993(99)02457-9","volume":"861","author":"Y Li","year":"2000","unstructured":"Li Y, King MA, Meyer EM (2000) \u03b17 nicotinic receptor-mediated protection against ethanol-induced oxidative stress and cytotoxicity in PC12 cells. Brain Res 861(1):165\u2013167","journal-title":"Brain Res"},{"issue":"1","key":"1917_CR55","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/jnr.21829","volume":"87","author":"WL Li","year":"2009","unstructured":"Li WL, Cai HH, Wang B, Chen L, Zhou QG, Luo CX et al (2009) Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke. J Neurosci Res 87(1):112\u2013122","journal-title":"J Neurosci Res"},{"issue":"2","key":"1917_CR56","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s12975-015-0441-7","volume":"7","author":"Z Li","year":"2016","unstructured":"Li Z, Wang J, Zhao C, Ren K, Xia Z, Yu H et al (2016) Acute blockage of notch signaling by DAPT induces neuroprotection and neurogenesis in the neonatal rat brain after stroke. Transl Stroke Res 7(2):132\u2013140","journal-title":"Transl Stroke Res"},{"issue":"4","key":"1917_CR57","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/sj.bjp.0705653","volume":"141","author":"Q Liu","year":"2004","unstructured":"Liu Q, Zhao B (2004) Nicotine attenuates \u03b2-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures. Br J Pharmacol 141(4):746\u2013754","journal-title":"Br J Pharmacol"},{"issue":"1","key":"1917_CR58","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1161\/01.STR.0000251791.64910.cd","volume":"38","author":"Z Liu","year":"2007","unstructured":"Liu Z, Fan Y, Won SJ, Neumann M, Hu D, Zhou L et al (2007) Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia. Stroke 38(1):146\u2013152","journal-title":"Stroke"},{"key":"1917_CR59","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.neuropharm.2014.11.028","volume":"91","author":"Y Liu","year":"2015","unstructured":"Liu Y, Zeng X, Hui Y, Zhu C, Wu J, Taylor DH et al (2015a) Activation of \u03b17 nicotinic acetylcholine receptors protects astrocytes against oxidative stress-induced apoptosis: implications for Parkinson\u2019s disease. Neuropharmacology 91:87\u201396","journal-title":"Neuropharmacology"},{"issue":"2","key":"1917_CR60","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1161\/STROKEAHA.114.007482","volume":"46","author":"P Liu","year":"2015","unstructured":"Liu P, Zhao H, Wang R, Wang P, Tao Z, Gao L et al (2015b) MicroRNA-424 protects against focal cerebral ischemia and reperfusion injury in mice by suppressing oxidative stress. Stroke 46(2):513\u2013519","journal-title":"Stroke"},{"issue":"7","key":"1917_CR61","doi-asserted-by":"publisher","first-page":"901","DOI":"10.7150\/ijbs.18404","volume":"13","author":"W-J Liu","year":"2017","unstructured":"Liu W-J, Jiang H-F, Rehman FU, Zhang J-W, Chang Y, Jing L et al (2017) Lycium barbarum polysaccharides decrease hyperglycemia-aggravated ischemic brain injury through maintaining mitochondrial fission and fusion balance. Int J Biol Sci 13(7):901","journal-title":"Int J Biol Sci"},{"issue":"5","key":"1917_CR62","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1139\/bcb-2017-0209","volume":"96","author":"H Liu","year":"2018","unstructured":"Liu H, Zhong L, Zhang Y, Liu X, Li J (2018) Rutin attenuates cerebral ischemia\u2013reperfusion injury in ovariectomized rats via estrogen-receptor-mediated BDNF\u2013TrkB and NGF\u2013TrkA signaling. Biochem Cell Biol 96(5):672\u2013681","journal-title":"Biochem Cell Biol"},{"key":"1917_CR63","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.bbr.2015.07.053","volume":"294","author":"JM Livingston-Thomas","year":"2015","unstructured":"Livingston-Thomas JM, Jeffers MS, Nguemeni C, Shoichet MS, Morshead CM, Corbett D (2015) Assessing cognitive function following medial prefrontal stroke in the rat. Behav Brain Res 294:102\u2013110","journal-title":"Behav Brain Res"},{"issue":"8","key":"1917_CR64","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/nm0809-844","volume":"15","author":"EH Lo","year":"2009","unstructured":"Lo EH (2009) T time in the brain. Nat Med 15(8):844","journal-title":"Nat Med"},{"key":"1917_CR65","doi-asserted-by":"crossref","unstructured":"Lu L, Guo L, Gauba E, Tian J, Wang L, Tandon N et al (2015) Transient cerebral ischemia promotes brain mitochondrial dysfunction and exacerbates cognitive impairments in young 5xFAD mice. PloS one 10(12):e0144068","DOI":"10.1371\/journal.pone.0144068"},{"key":"1917_CR66","first-page":"1","volume":"2017","author":"Y Lu","year":"2017","unstructured":"Lu Y, Jiang L, Li W, Qu M, Song Y, He X et al (2017) Optogenetic inhibition of striatal neuronal activity improves the survival of transplanted neural stem cells and neurological outcomes after ischemic stroke in mice. Stem Cells Int 2017:1\u201311","journal-title":"Stem Cells Int"},{"key":"1917_CR67","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.biocel.2014.05.030","volume":"53","author":"O Lykhmus","year":"2014","unstructured":"Lykhmus O, Gergalova G, Koval L, Zhmak M, Komisarenko S, Skok M (2014) Mitochondria express several nicotinic acetylcholine receptor subtypes to control various pathways of apoptosis induction. Int J Biochem Cell Biol 53:246\u2013252","journal-title":"Int J Biochem Cell Biol"},{"issue":"7","key":"1917_CR68","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1515\/revneuro-2017-0008","volume":"28","author":"A Majdi","year":"2017","unstructured":"Majdi A, Kamari F, Vafaee MS, Sadigh-Eteghad S (2017) Revisiting nicotine\u2019s role in the ageing brain and cognitive impairment. Rev Neurosci 28(7):767\u2013781","journal-title":"Rev Neurosci"},{"key":"1917_CR69","first-page":"1","volume":"12","author":"A Majdi","year":"2018","unstructured":"Majdi A, Kamari F, Sadigh-Eteghad S, Gjedde A (2018) Molecular insights into memory-enhancing metabolites of nicotine in brain: a systematic review. Front Neurosci 12:1\u201311","journal-title":"Front Neurosci"},{"issue":"5435","key":"1917_CR70","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1126\/science.285.5435.1870","volume":"285","author":"RC Malenka","year":"1999","unstructured":"Malenka RC, Nicoll RA (1999) Long-term potentiation\u2014a decade of progress? Science 285(5435):1870\u20131874","journal-title":"Science"},{"issue":"5","key":"1917_CR71","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1177\/1545968312465192","volume":"27","author":"S Marzolini","year":"2013","unstructured":"Marzolini S, Oh P, McIlroy W, Brooks D (2013) The effects of an aerobic and resistance exercise training program on cognition following stroke. Neurorehabil Neural Repair 27(5):392\u2013402","journal-title":"Neurorehabil Neural Repair"},{"key":"1917_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/3674371","volume":"2017","author":"G Mazereeuw","year":"2017","unstructured":"Mazereeuw G, Herrmann N, Andreazza AC, Scola G, Ma DW, Oh PI et al (2017) Baseline oxidative stress is associated with memory changes in omega-3 fatty acid treated coronary artery disease patients. Cardiovasc Psychiatry Neurol 2017:1\u20137","journal-title":"Cardiovasc Psychiatry Neurol"},{"issue":"8","key":"1917_CR73","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.bcp.2007.07.001","volume":"74","author":"BE McKay","year":"2007","unstructured":"McKay BE, Placzek AN, Dani JA (2007) Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors. Biochem Pharmacol 74(8):1120\u20131133","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"1917_CR74","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neulet.2011.12.064","volume":"510","author":"D Min","year":"2012","unstructured":"Min D, Mao X, Wu K, Cao Y, Guo F, Zhu S et al (2012) Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils. Neurosci Lett 510(1):29\u201333","journal-title":"Neurosci Lett"},{"issue":"9","key":"1917_CR75","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.neurobiolaging.2007.12.008","volume":"30","author":"EM Mitsis","year":"2009","unstructured":"Mitsis EM, Cosgrove KP, Staley JK, Bois F, Frohlich EB, Tamagnan GD et al (2009) Age-related decline in nicotinic receptor availability with [123I] 5-IA-85380 SPECT. Neurobiol Aging 30(9):1490\u20131497","journal-title":"Neurobiol Aging"},{"issue":"9","key":"1917_CR76","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1111\/j.1460-9568.2012.08056.x","volume":"35","author":"S Nakauchi","year":"2012","unstructured":"Nakauchi S, Sumikawa K (2012) Endogenously released ACh and exogenous nicotine differentially facilitate long-term potentiation induction in the hippocampal CA1 region of mice. Eur J Neurosci 35(9):1381\u20131395","journal-title":"Eur J Neurosci"},{"issue":"8","key":"1917_CR77","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.bcp.2013.07.028","volume":"86","author":"S Narla","year":"2013","unstructured":"Narla S, Klejbor I, Birkaya B, Lee Y-W, Morys J, Stachowiak EK et al (2013a) \u03b17 nicotinic receptor agonist reactivates neurogenesis in adult brain. Biochem Pharmacol 86(8):1099\u20131104","journal-title":"Biochem Pharmacol"},{"issue":"10","key":"1917_CR78","doi-asserted-by":"publisher","first-page":"776","DOI":"10.5966\/sctm.2012-0103","volume":"2","author":"ST Narla","year":"2013","unstructured":"Narla ST, Klejbor I, Birkaya B, Lee Y-W, Morys J, Stachowiak EK et al (2013b) Activation of developmental nuclear fibroblast growth factor receptor 1 signaling and neurogenesis in adult brain by \u03b17 nicotinic receptor agonist. Stem Cells Transl Med 2(10):776\u2013788","journal-title":"Stem Cells Transl Med"},{"issue":"3","key":"1917_CR79","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s43440-020-00092-4","volume":"72","author":"A Nikiforuk","year":"2020","unstructured":"Nikiforuk A, Litwa E, Krawczyk M, Popik P, Arias H (2020) Desformylflustrabromine a positive allosteric modulator of \u03b14\u03b22-containing nicotinic acetylcholine receptors enhances cognition in rats. Pharmacol Rep 72(3):589","journal-title":"Pharmacol Rep"},{"issue":"4","key":"1917_CR80","doi-asserted-by":"publisher","first-page":"568","DOI":"10.4161\/auto.6.4.11951","volume":"6","author":"J Nishiyama","year":"2010","unstructured":"Nishiyama J, Yuzaki M (2010) Excitotoxicity and autophagy: Lurcher may not be a model of \u201cautophagic cell death.\u201d Autophagy 6(4):568\u2013570","journal-title":"Autophagy"},{"issue":"2","key":"1917_CR81","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1007\/s00429-018-1799-6","volume":"224","author":"SL Otto","year":"2019","unstructured":"Otto SL, Yakel JL (2019) The \u03b17 nicotinic acetylcholine receptors regulate hippocampal adult-neurogenesis in a sexually dimorphic fashion. Brain Struct Funct 224(2):829\u2013846","journal-title":"Brain Struct Funct"},{"issue":"7","key":"1917_CR82","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1038\/nn.3734","volume":"17","author":"P Paez-Gonzalez","year":"2014","unstructured":"Paez-Gonzalez P, Asrican B, Rodriguez E, Kuo CT (2014) Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis. Nat Neurosci 17(7):934\u2013942","journal-title":"Nat Neurosci"},{"key":"1917_CR83","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.brainres.2013.09.033","volume":"1539","author":"G Patki","year":"2013","unstructured":"Patki G, Solanki N, Atrooz F, Allam F, Salim S (2013) Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress. Brain Res 1539:73\u201386","journal-title":"Brain Res"},{"issue":"4","key":"1917_CR84","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/neu.10102","volume":"53","author":"MR Picciotto","year":"2002","unstructured":"Picciotto MR, Zoli M (2002) Nicotinic receptors in aging and dementia. J Neurobiol 53(4):641\u2013655","journal-title":"J Neurobiol"},{"issue":"1","key":"1917_CR85","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1177\/0269881118812097","volume":"33","author":"A Potasiewicz","year":"2019","unstructured":"Potasiewicz A, Golebiowska J, Popik P, Nikiforuk A (2019) Procognitive effects of varenicline in the animal model of schizophrenia depend on \u03b14\u03b22-and \u03b17-nicotinic acetylcholine receptors. J Psychopharmacol 33(1):62\u201373","journal-title":"J Psychopharmacol"},{"issue":"4","key":"1917_CR86","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S1359-6101(97)00018-X","volume":"8","author":"BM Pratt","year":"1997","unstructured":"Pratt BM, McPherson JM (1997) TGF-\u03b2 in the central nervous system: potential roles in ischemic injury and neurodegenerative diseases. Cytokine Growth Factor Rev 8(4):267\u2013292","journal-title":"Cytokine Growth Factor Rev"},{"issue":"3","key":"1917_CR87","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/ana.10853","volume":"55","author":"J Raber","year":"2004","unstructured":"Raber J, Fan Y, Matsumori Y, Liu Z, Weinstein PR, Fike JR et al (2004) Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits. Ann Neurol 55(3):381\u2013389","journal-title":"Ann Neurol"},{"key":"1917_CR88","doi-asserted-by":"crossref","unstructured":"Rama R, Garc\u00eda JC (2016) Excitotoxicity and oxidative stress in acute stroke. Ischemic Stroke-Updates Intech 17\u201342","DOI":"10.5772\/64991"},{"key":"1917_CR89","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.niox.2014.08.009","volume":"43","author":"R Ray","year":"2014","unstructured":"Ray R, Rai S, Katyal A (2014) Cholinergic receptor blockade by scopolamine and mecamylamine exacerbates global cerebral ischemia induced memory dysfunction in C57BL\/6J mice. Nitric Oxide 43:62\u201373","journal-title":"Nitric Oxide"},{"key":"1917_CR90","doi-asserted-by":"crossref","unstructured":"Roberts JP, Stokoe SA, Sathler MF, Nichols RA, Kim S (2021) Selective coactivation of \u03b17-and \u03b14\u03b22-nicotinic acetylcholine receptors reverses beta-amyloid\u2013induced synaptic dysfunction. J Biol Chem 296:100402","DOI":"10.1016\/j.jbc.2021.100402"},{"issue":"2","key":"1917_CR91","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.expneurol.2005.08.004","volume":"196","author":"M Schilling","year":"2005","unstructured":"Schilling M, Besselmann M, M\u00fcller M, Strecker JK, Ringelstein EB, Kiefer R (2005) Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: an investigation using green fluorescent protein transgenic bone marrow chimeric mice. Exp Neurol 196(2):290\u2013297","journal-title":"Exp Neurol"},{"issue":"2","key":"1917_CR92","first-page":"131","volume":"10","author":"A Schurr","year":"2002","unstructured":"Schurr A (2002) Lactate, glucose and energy metabolism in the ischemic brain. Int J Mol Med 10(2):131\u2013136","journal-title":"Int J Mol Med"},{"key":"1917_CR93","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.arcmed.2020.03.014","volume":"51","author":"Z Shabani","year":"2020","unstructured":"Shabani Z, Mahmoudi J, Farajdokht F, Sadigh-Eteghad S (2020) An overview of nicotinic cholinergic system signaling in neurogenesis. Arch Med Res 51:287\u2013296","journal-title":"Arch Med Res"},{"key":"1917_CR94","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3389\/fimmu.2017.00553","volume":"8","author":"B-Z Shao","year":"2017","unstructured":"Shao B-Z, Ke P, Xu Z-Q, Wei W, Cheng M-H, Han B-Z et al (2017) Autophagy plays an important role in anti-inflammatory mechanisms stimulated by alpha7 nicotinic acetylcholine receptor. Front Immunol 8:553","journal-title":"Front Immunol"},{"issue":"1","key":"1917_CR95","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1476-5381.2010.00894.x","volume":"161","author":"H Shen","year":"2010","unstructured":"Shen H, Kihara T, Hongo H, Wu X, Kem W, Shimohama S et al (2010) Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of \u03b17 nicotinic receptors and internalization of NMDA receptors. Br J Pharmacol 161(1):127\u2013139","journal-title":"Br J Pharmacol"},{"issue":"3","key":"1917_CR96","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1101\/lm.76006","volume":"13","author":"K Shimazu","year":"2006","unstructured":"Shimazu K, Zhao M, Sakata K, Akbarian S, Bates B, Jaenisch R et al (2006) NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis. Learn Mem 13(3):307\u2013315","journal-title":"Learn Mem"},{"issue":"1\u20132","key":"1917_CR97","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S0006-8993(97)00194-7","volume":"779","author":"S Shimohama","year":"1998","unstructured":"Shimohama S, Greenwald D, Shafron D, Akaika A, Maeda T, Kaneko S et al (1998) Nicotinic \u03b17 receptors protect against glutamate neurotoxicity and neuronal ischemic damage. Brain Res 779(1\u20132):359\u2013363","journal-title":"Brain Res"},{"key":"1917_CR98","doi-asserted-by":"crossref","unstructured":"Skaper SD (2018) Neurotrophic factors: an overview. Neurotrophic Factors 1\u201317","DOI":"10.1007\/978-1-4939-7571-6_1"},{"key":"1917_CR99","unstructured":"Skok M, Gergalova G, Lykhmus O, Kalashnyk O, Koval L, Uspenska K (2016) Nicotinic acetylcholine receptors in mitochondria: subunit composition function and signaling. Neurotransmitter 3"},{"key":"1917_CR100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2009.04.046","volume":"1278","author":"J-H Son","year":"2009","unstructured":"Son J-H, Winzer-Serhan UH (2009) Chronic neonatal nicotine exposure increases mRNA expression of neurotrophic factors in the postnatal rat hippocampus. Brain Res 1278:1\u201314","journal-title":"Brain Res"},{"issue":"1","key":"1917_CR101","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0006-2952(02)01070-5","volume":"64","author":"R Soto-Otero","year":"2002","unstructured":"Soto-Otero R, M\u00e9ndez-\u00c1lvarez E, Hermida-Ameijeiras \u00c1, L\u00f3pez-Real AM, Labandeira-Garc\u0131\u0301a JL (2002) Effects of (\u2212)-nicotine and (\u2212)-cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: relevance for Parkinson\u2019s disease. Biochem Pharmacol 64(1):125\u2013135","journal-title":"Biochem Pharmacol"},{"issue":"s1","key":"1917_CR102","doi-asserted-by":"publisher","first-page":"S87","DOI":"10.3233\/JAD-170057","volume":"60","author":"HM Stradecki-Cohan","year":"2017","unstructured":"Stradecki-Cohan HM, Cohan CH, Raval AP, Dave KR, Reginensi D, Gittens RA et al (2017) Cognitive deficits after cerebral ischemia and underlying dysfunctional plasticity: potential targets for recovery of cognition. J Alzheimers Dis 60(s1):S87\u2013S105","journal-title":"J Alzheimers Dis"},{"key":"1917_CR103","first-page":"1","volume":"2012","author":"S-Y Su","year":"2012","unstructured":"Su S-Y, Cheng C-Y, Tsai T-H, Hsieh C-L (2012) Paeonol protects memory after ischemic stroke via inhibiting \u03b2-secretase and apoptosis. Evid Based Complement Alternat Med 2012:1\u201311","journal-title":"Evid Based Complement Alternat Med"},{"key":"1917_CR104","doi-asserted-by":"publisher","first-page":"13993","DOI":"10.1038\/srep13993","volume":"5","author":"I Su\u00e1rez-Pereira","year":"2015","unstructured":"Su\u00e1rez-Pereira I, Carri\u00f3n \u00c1M (2015) Updating stored memory requires adult hippocampal neurogenesis. Sci Rep 5:13993","journal-title":"Sci Rep"},{"key":"1917_CR105","doi-asserted-by":"crossref","unstructured":"Tang EY, Amiesimaka O, Harrison SL, Green E, Price C, Robinson L et al (2018) Longitudinal effect of stroke on cognition: a systematic review. J Am Heart Assoc 7(2):e006443","DOI":"10.1161\/JAHA.117.006443"},{"issue":"3","key":"1917_CR106","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1093\/ntr\/nty166","volume":"21","author":"AV Terry Jr","year":"2019","unstructured":"Terry AV Jr, Callahan PM (2019) Nicotinic acetylcholine receptor ligands, cognitive function, and preclinical approaches to drug discovery. Nicotine Tob Res 21(3):383\u2013394","journal-title":"Nicotine Tob Res"},{"issue":"4","key":"1917_CR107","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/BF03033888","volume":"7","author":"Y Tizabi","year":"2005","unstructured":"Tizabi Y, Manaye KF, Taylor RE (2005) Nicotine blocks ethanol-induced apoptosis in primary cultures of rat cerebral cortical and cerebellar granule cells. Neurotox Res 7(4):319","journal-title":"Neurotox Res"},{"issue":"10","key":"1917_CR108","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.tins.2004.07.010","volume":"27","author":"EC Toescu","year":"2004","unstructured":"Toescu EC, Verkhratsky A, Landfield PW (2004) Ca2+ regulation and gene expression in normal brain aging. Trends Neurosci 27(10):614\u2013620","journal-title":"Trends Neurosci"},{"key":"1917_CR109","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.neulet.2016.12.021","volume":"639","author":"M Tortora","year":"2017","unstructured":"Tortora M, Corsini S, Nistri A (2017) Nicotinic receptors modulate the onset of reactive oxygen species production and mitochondrial dysfunction evoked by glutamate uptake block in the rat hypoglossal nucleus. Neurosci Lett 639:43\u201348","journal-title":"Neurosci Lett"},{"issue":"6","key":"1917_CR110","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1152\/jn.00243.2016","volume":"116","author":"M Townsend","year":"2016","unstructured":"Townsend M, Whyment A, Walczak J-S, Jeggo R, van den Top M, Flood DG et al (2016) \u03b17-nAChR agonist enhances neural plasticity in the hippocampus via a GABAergic circuit. J Neurophysiol 116(6):2663\u20132675","journal-title":"J Neurophysiol"},{"issue":"2","key":"1917_CR111","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","volume":"27","author":"G Twig","year":"2008","unstructured":"Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G et al (2008) Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 27(2):433\u2013446","journal-title":"EMBO J"},{"issue":"1","key":"1917_CR112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep25176","volume":"6","author":"R Verma","year":"2016","unstructured":"Verma R, Harris NM, Friedler BD, Crapser J, Patel AR, Venna V et al (2016) Reversal of the detrimental effects of post-stroke social isolation by pair-housing is mediated by activation of BDNF-MAPK\/ERK in aged mice. Sci Rep 6(1):1\u201313","journal-title":"Sci Rep"},{"issue":"1","key":"1917_CR113","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3892\/mmr.2016.5321","volume":"14","author":"Y Wang","year":"2016","unstructured":"Wang Y, Wu C, Han B, Xu F, Mao M, Guo X et al (2016) Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K\/Akt\/Gsk-3\u03b2 signaling disruption, and juvenile cognitive deficits in neonatal rats. Mol Med Rep 14(1):769\u2013775","journal-title":"Mol Med Rep"},{"key":"1917_CR114","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.bbr.2016.09.007","volume":"316","author":"J Wang","year":"2017","unstructured":"Wang J, Fu X, Zhang D, Yu L, Li N, Lu Z et al (2017a) ChAT-positive neurons participate in subventricular zone neurogenesis after middle cerebral artery occlusion in mice. Behav Brain Res 316:145\u2013151","journal-title":"Behav Brain Res"},{"issue":"5","key":"1917_CR115","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s12975-017-0541-7","volume":"8","author":"J Wang","year":"2017","unstructured":"Wang J, Lu Z, Fu X, Zhang D, Yu L, Li N et al (2017b) Alpha-7 nicotinic receptor signaling pathway participates in the neurogenesis induced by ChAT-positive neurons in the subventricular zone. Transl Stroke Res 8(5):484\u2013493","journal-title":"Transl Stroke Res"},{"issue":"2","key":"1917_CR116","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s11064-016-2097-4","volume":"42","author":"J Wang","year":"2017","unstructured":"Wang J, Zhang S, Ma H, Yang S, Liu Z, Wu X et al (2017c) Chronic intermittent hypobaric hypoxia pretreatment ameliorates ischemia-induced cognitive dysfunction through activation of ERK1\/2-CREB-BDNF pathway in anesthetized mice. Neurochem Res 42(2):501\u2013512","journal-title":"Neurochem Res"},{"issue":"5","key":"1917_CR117","doi-asserted-by":"publisher","first-page":"H1402","DOI":"10.1152\/ajpheart.00390.2018","volume":"315","author":"R Ward","year":"2018","unstructured":"Ward R, Valenzuela JP, Li W, Dong G, Fagan SC, Ergul A (2018) Poststroke cognitive impairment and hippocampal neurovascular remodeling: the impact of diabetes and sex. Am J Physiol Heart Circ Physiol 315(5):H1402\u2013H1413","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1917_CR118","doi-asserted-by":"crossref","unstructured":"Xu B, Zhu L, Chu J, Ma Z, Fu Q, Wei W et al (2019) Esculetin improves cognitive impairments induced by transient cerebral ischaemia and reperfusion in mice via regulation of mitochondrial fragmentation and mitophagy. Behav Brain Res 372:112007","DOI":"10.1016\/j.bbr.2019.112007"},{"key":"1917_CR119","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.neuroscience.2013.07.017","volume":"250","author":"Y Yabuki","year":"2013","unstructured":"Yabuki Y, Fukunaga K (2013) Oral administration of glutathione improves memory deficits following transient brain ischemia by reducing brain oxidative stress. Neuroscience 250:394\u2013407","journal-title":"Neuroscience"},{"key":"1917_CR120","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.redox.2018.03.002","volume":"16","author":"J-L Yang","year":"2018","unstructured":"Yang J-L, Mukda S, Chen S-D (2018) Diverse roles of mitochondria in ischemic stroke. Redox Biol 16:263\u2013275","journal-title":"Redox Biol"},{"issue":"4","key":"1917_CR121","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1111\/j.1471-4159.2011.07466.x","volume":"119","author":"W Yu","year":"2011","unstructured":"Yu W, Mechawar N, Krantic S, Quirion R (2011) \u03b17 Nicotinic receptor activation reduces \u03b2-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling. J Neurochem 119(4):848\u2013858","journal-title":"J Neurochem"},{"key":"1917_CR122","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.bbr.2017.07.003","volume":"334","author":"Y Yu","year":"2017","unstructured":"Yu Y, Feng L, Li J, Lan X, Lixiang A, Lv X et al (2017) The alteration of autophagy and apoptosis in the hippocampus of rats with natural aging-dependent cognitive deficits. Behav Brain Res 334:155\u2013162","journal-title":"Behav Brain Res"},{"issue":"10","key":"1917_CR123","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1590\/0004-282x20200081","volume":"78","author":"M Yuan","year":"2020","unstructured":"Yuan M, Zhang X-X, Fu X-C, Bi X (2020) Enriched environment alleviates post-stroke cognitive impairment through enhancing \u03b17-nAChR expression in rats. Arq Neuro-Psiquiatr 78(10):603\u2013610","journal-title":"Arq Neuro-Psiquiatr"},{"issue":"2","key":"1917_CR124","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s12975-013-0298-6","volume":"5","author":"W Zhang","year":"2014","unstructured":"Zhang W, Cheng J, Vagnerova K, Ivashkova Y, Young J, Cornea A et al (2014) Effects of androgens on early post-ischemic neurogenesis in mice. Transl Stroke Res 5(2):301\u2013311","journal-title":"Transl Stroke Res"},{"issue":"1","key":"1917_CR125","first-page":"413","volume":"43","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Yu P, Liu H, Yao H, Yao S, Yuan S et al (2019) Hyperforin improves post-stroke social isolationinduced exaggeration of PSD and PSA via TGF-\u03b2. Int J Mol Med 43(1):413\u2013425","journal-title":"Int J Mol Med"},{"issue":"2","key":"1917_CR126","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/ar.23295","volume":"299","author":"L Zheng","year":"2016","unstructured":"Zheng L, Ding J, Wang J, Zhou C, Zhang W (2016) Effects and mechanism of action of inducible nitric oxide synthase on apoptosis in a rat model of cerebral ischemia-reperfusion injury. Anat Rec 299(2):246\u2013255","journal-title":"Anat Rec"},{"key":"1917_CR127","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.jneuroim.2018.06.018","volume":"323","author":"S Zhou","year":"2018","unstructured":"Zhou S, Qiao B, Chu X, Kong Q (2018) Oxymatrine attenuates cognitive deficits through SIRT1-mediated autophagy in ischemic stroke. J Neuroimmunol 323:136\u2013142","journal-title":"J Neuroimmunol"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-021-01917-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-021-01917-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-021-01917-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T23:09:29Z","timestamp":1666825769000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-021-01917-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,1]]},"references-count":127,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["1917"],"URL":"https:\/\/doi.org\/10.1007\/s12031-021-01917-4","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,1]]},"assertion":[{"value":"30 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Tabriz University of Medical Sciences.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The authors provide consent to publish the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}