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This prospective cohort study was conducted in one academic teaching hospital. The study was conducted on 126 patients diagnosed with idiopathic Parkinson\u2019s disease. Blood samples were collected to conduct a genotyping of MAOB, DRD1, DRD2, and DDC genes. Genotype and allele frequencies of MAOB (rs1799836) variants were not associated with the course of PD. Genotype and allele frequencies of DRD2 (rs2283265) variants were associated with risk of dementia (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) and resulted in parts II and III of the UPDRS scale (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Genotype and allele frequencies of DRD2 (rs1076560) variants were associated with risk of dementia (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) and resulted in parts II and III of the UPDRS scale (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Genotype and allele frequencies of DDC (rs921451) variants were not associated with the course of PD.<\/jats:p>","DOI":"10.1007\/s12031-022-01966-3","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T16:03:18Z","timestamp":1642608198000},"page":"812-819","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson\u2019s Disease"],"prefix":"10.1007","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2553-272X","authenticated-orcid":false,"given":"Barbara","family":"Zapa\u0142a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Stefura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Piwowar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylwia","family":"Czekalska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Zawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Hadasik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Solnica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Rudzi\u0144ska-Bar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"1966_CR1","doi-asserted-by":"publisher","unstructured":"Brun L, Ngu LH, Keng WT, Ch'Ng GS, Choy YS, Hwu WL, Lee WT, Willemsen MA, Verbeek MM, Wassenberg T, Regal L (2010)\u00a0Clinical and biochemical features of aromatic L-amino acid decarboxylase deficiency. 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The study was approved by the Bioethics Committee of the Jagiellonian University (122.6120.94.2016).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent was obtained from all the subjects involved in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}