{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T04:31:07Z","timestamp":1787200267616,"version":"build-2736575974"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Innovation and entrepreneurship training program for college students of Harbin Medical University","award":["202210226164"],"award-info":[{"award-number":["202210226164"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81874269"],"award-info":[{"award-number":["81874269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Innovative Science Foundation of Harbin Medical University","award":["31041210066"],"award-info":[{"award-number":["31041210066"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s12031-022-02096-6","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T07:02:42Z","timestamp":1672124562000},"page":"15-27","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Untargeted Metabolomic Analysis Reveals the Metabolic Disturbances and Exacerbation of Oxidative Stress in the Cerebral Cortex of a BTBR Mouse Model of Autism"],"prefix":"10.1007","volume":"73","author":[{"given":"Can","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,27]]},"reference":[{"issue":"-","key":"2096_CR1","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.neuint.2008.01.008","volume":"52","author":"CS Bavaresco","year":"2008","unstructured":"Bavaresco CS, Chiarani F, Kolling J, Netto CA, De Souza Wyse AT (2008) Biochemical effects of pretreatment with vitamins E and C in rats submitted to intrastriatal hypoxanthine administration. Neurochemi Int 52:1276\u20131283. https:\/\/doi.org\/10.1016\/j.neuint.2008.01.008","journal-title":"Neurochemi Int"},{"key":"2096_CR2","doi-asserted-by":"publisher","unstructured":"Beaudet AL (2017) Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias: a hypothesis. BioEssays News Rev Mol Cell Dev Biol 39.\u00a0https:\/\/doi.org\/10.1002\/bies.201700012","DOI":"10.1002\/bies.201700012"},{"key":"2096_CR3","doi-asserted-by":"publisher","unstructured":"Chatterjee S, Balram A, Li W (2021) Convergence: lactosylceramide-centric signaling pathways induce inflammation, oxidative stress, and other phenotypic outcomes. Int J Mol Sci 22.\u00a0https:\/\/doi.org\/10.3390\/ijms22041816","DOI":"10.3390\/ijms22041816"},{"issue":"-","key":"2096_CR4","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1007\/s11064-012-0775-4","volume":"37","author":"A Chauhan","year":"2012","unstructured":"Chauhan A, Audhya T, Chauhan V (2012) Brain region-specific glutathione redox imbalance in autism. Neurochem Res 37:1681\u20131689. https:\/\/doi.org\/10.1007\/s11064-012-0775-4","journal-title":"Neurochem Res"},{"issue":"-","key":"2096_CR5","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1385\/jmn:30:3:297","volume":"30","author":"K Chiasson","year":"2006","unstructured":"Chiasson K, Lahaie-Collins V, Bournival J, Delapierre B, G\u00e9linas S, Martinoli MG (2006) Oxidative stress and 17-alpha- and 17-beta-estradiol modulate neurofilaments differently. J Mol Neurosci\u202f: MN 30:297\u2013310. https:\/\/doi.org\/10.1385\/jmn:30:3:297","journal-title":"J Mol Neurosci : MN"},{"issue":"-","key":"2096_CR6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1146\/annurev.pharmtox.010909.105753","volume":"50","author":"JW Choi","year":"2010","unstructured":"Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (2010) LPA receptors: subtypes and biological actions. Annu Rev Pharmacol Toxicol 50:157\u2013186. https:\/\/doi.org\/10.1146\/annurev.pharmtox.010909.105753","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"-","key":"2096_CR7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/ilar.38.1.41","volume":"38","author":"JD Clark","year":"1997","unstructured":"Clark JD, Gebhart GF, Gonder JC, Keeling ME, Kohn DF (1997) Special report: The 1996 guide for the care and use of laboratory animals. ILAR J 38:41\u201348. https:\/\/doi.org\/10.1093\/ilar.38.1.41","journal-title":"ILAR J"},{"issue":"-","key":"2096_CR8","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1080\/10408360091174231","volume":"37","author":"DE Cole","year":"2000","unstructured":"Cole DE, Evrovski J (2000) The clinical chemistry of inorganic sulfate. Crit Rev Clin Lab Sci 37:299\u2013344. https:\/\/doi.org\/10.1080\/10408360091174231","journal-title":"Crit Rev Clin Lab Sci"},{"key":"2096_CR9","doi-asserted-by":"publisher","first-page":"4660","DOI":"10.1096\/fj.201801424R","volume":"33","author":"U De Marchi","year":"2019","unstructured":"De Marchi U, Galindo AN, Thevenet J, Hermant A, Bermont F, Lassueur S, Domingo JS, Kussmann M, Dayon L, Wiederkehr A (2019) Mitochondrial lysine deacetylation promotes energy metabolism and calcium signaling in insulin-secreting cells. FASEB J Official Publ Fed Am Soc Exp Biol 33:4660\u20134674. https:\/\/doi.org\/10.1096\/fj.201801424R","journal-title":"FASEB J Official Publ Fed Am Soc Exp Biol"},{"key":"2096_CR10","doi-asserted-by":"publisher","unstructured":"El-Ansary AK, Bacha AG, Al-Ayahdi LY (2011) Impaired plasma phospholipids and relative amounts of essential polyunsaturated fatty acids in autistic patients from Saudi Arabia. Lipids Health Dis 10:63.\u00a0https:\/\/doi.org\/10.1186\/1476-511x-10-63","DOI":"10.1186\/1476-511x-10-63"},{"issue":"-","key":"2096_CR11","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1007\/s11011-017-0029-x","volume":"32","author":"A El-Ansary","year":"2017","unstructured":"El-Ansary A, Bj\u00f8rklund G, Chirumbolo S, Alnakhli OM (2017) Predictive value of selected biomarkers related to metabolism and oxidative stress in children with autism spectrum disorder. Metab brain Dis 32:1209\u20131221. https:\/\/doi.org\/10.1007\/s11011-017-0029-x","journal-title":"Metab brain Dis"},{"key":"2096_CR12","doi-asserted-by":"publisher","unstructured":"Fenlon LR, Liu S, Gobius I, Kurniawan ND, Murphy S, Moldrich RX, Richards LJ (2015) Formation of functional areas in the cerebral cortex is disrupted in a mouse model of autism spectrum disorder. Neural Dev 10:10.\u00a0https:\/\/doi.org\/10.1186\/s13064-015-0033-y","DOI":"10.1186\/s13064-015-0033-y"},{"key":"2096_CR13","doi-asserted-by":"publisher","unstructured":"Filice F, Lauber E, V\u00f6rckel KJ, W\u00f6hr M, Schwaller B (2018) 17-\u03b2 estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms. Mol Autism 9:15.https:\/\/doi.org\/10.1186\/s13229-018-0199-3","DOI":"10.1186\/s13229-018-0199-3"},{"issue":"-","key":"2096_CR14","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ntt.2014.10.008","volume":"47","author":"BM Flannery","year":"2015","unstructured":"Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ (2015) Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine. Neurotoxicol Teratol 47:36\u201345. https:\/\/doi.org\/10.1016\/j.ntt.2014.10.008","journal-title":"Neurotoxicol Teratol"},{"issue":"-","key":"2096_CR15","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/dneu.22726","volume":"79","author":"DA Geier","year":"2019","unstructured":"Geier DA, Kern JK, Geier MR (2019) Down syndrome as a genetic model to evaluate the role of oxidative stress and transsulfuration abnormalities in autism spectrum disorder: a 10-year longitudinal cohort study. Dev Neurobiol 79:857\u2013867. https:\/\/doi.org\/10.1002\/dneu.22726","journal-title":"Dev Neurobiol"},{"key":"2096_CR16","doi-asserted-by":"publisher","unstructured":"Gevi F, Zolla L, Gabriele S, Persico AM (2016) Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism. Mol Autism 7:47.\u00a0https:\/\/doi.org\/10.1186\/s13229-016-0109-5","DOI":"10.1186\/s13229-016-0109-5"},{"issue":"-","key":"2096_CR17","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/mco.0000000000000134","volume":"18","author":"F Gu","year":"2015","unstructured":"Gu F, Chauhan V, Chauhan A (2015) Glutathione redox imbalance in brain disorders. Curr Opin Clin Nutr Metab Care 18:89\u201395. https:\/\/doi.org\/10.1097\/mco.0000000000000134","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"-","key":"2096_CR18","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/aur.1665","volume":"10","author":"YP Guo","year":"2017","unstructured":"Guo YP, Commons KG (2017) Serotonin neuron abnormalities in the BTBR mouse model of autism. Autism Res Official J Int Soc Autism Res 10:66\u201377. https:\/\/doi.org\/10.1002\/aur.1665","journal-title":"Autism Res Official J Int Soc Autism Res"},{"issue":"-","key":"2096_CR19","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1002\/jnr.23797","volume":"95","author":"C Gross","year":"2017","unstructured":"Gross C (2017) Defective phosphoinositide metabolism in autism. J Neurosci Res 95:1161\u20131173. https:\/\/doi.org\/10.1002\/jnr.23797","journal-title":"J Neurosci Res"},{"issue":"-","key":"2096_CR20","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/s0378-4347(00)83873-6","volume":"429","author":"RA Harkness","year":"1988","unstructured":"Harkness RA (1988) Hypoxanthine, xanthine and uridine in body fluids, indicators of ATP depletion. J Chromatogr 429:255\u2013278. https:\/\/doi.org\/10.1016\/s0378-4347(00)83873-6","journal-title":"J Chromatogr"},{"issue":"-","key":"2096_CR21","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1073\/pnas.2630225100","volume":"101","author":"Y Hojo","year":"2004","unstructured":"Hojo Y, Hattori TA, Enami T, Furukawa A, Suzuki K, Ishii HT, Mukai H, Morrison JH, Janssen WG, Kominami S, Harada N, Kimoto T, Kawato S (2004) Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons. Proc Natl Acad Sci USA 101:865\u2013870. https:\/\/doi.org\/10.1073\/pnas.2630225100","journal-title":"Proc Natl Acad Sci USA"},{"issue":"-","key":"2096_CR22","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1093\/ajcn\/80.6.1611","volume":"80","author":"SJ James","year":"2004","unstructured":"James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA (2004) Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutri 80:1611\u20131617. https:\/\/doi.org\/10.1093\/ajcn\/80.6.1611","journal-title":"Am J Clin Nutri"},{"key":"2096_CR23","doi-asserted-by":"publisher","unstructured":"Jiang M, Ni J, Cao Y, Xing X, Wu Q, Fan G (2019) Astragaloside IV attenuates myocardial ischemia-reperfusion injury from oxidative stress by regulating succinate, lysophospholipid metabolism, and ROS scavenging system.\u00a0Oxid Med Cell Longev\u00a02019:9137654.\u00a0https:\/\/doi.org\/10.1155\/2019\/9137654","DOI":"10.1155\/2019\/9137654"},{"key":"2096_CR24","doi-asserted-by":"publisher","unstructured":"Joshi L, Plastira I, Bernhart E, Reicher H, Koyani CN, Madl T, Madreiter-Sokolowski C, Koshenov Z, Graier WF, Hallstr\u00f6m S, Sattler W (2021) Lysophosphatidic acid induces aerobic glycolysis, lipogenesis, and increased amino acid uptake in BV-2 microglia. Int J Mol Sci 22.\u00a0https:\/\/doi.org\/10.3390\/ijms22041968","DOI":"10.3390\/ijms22041968"},{"key":"2096_CR25","doi-asserted-by":"publisher","unstructured":"Khan ZUN, Chand P, Majid H, Ahmed S, Khan AH, Jamil A, Ejaz S, Wasim A, Khan KA, Jafri L (2022) Urinary metabolomics using gas chromatography-mass spectrometry: potential biomarkers for autism spectrum disorder. BMC Neurol 22:101.\u00a0https:\/\/doi.org\/10.1186\/s12883-022-02630-4","DOI":"10.1186\/s12883-022-02630-4"},{"issue":"-","key":"2096_CR26","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/emmm.201000079","volume":"2","author":"MJ Kim","year":"2010","unstructured":"Kim MJ, Wainwright HC, Locketz M, Bekker LG, Walther GB, Dittrich C, Visser A, Wang W, Hsu FF, Wiehart U, Tsenova L, Kaplan G, Russell DG (2010) Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism. EMBO Mol Med 2:258\u2013274. https:\/\/doi.org\/10.1002\/emmm.201000079","journal-title":"EMBO Mol Med"},{"issue":"-","key":"2096_CR27","doi-asserted-by":"publisher","first-page":"e520","DOI":"10.1542\/peds.2013-0763","volume":"133","author":"TA Lavelle","year":"2014","unstructured":"Lavelle TA, Weinstein MC, Newhouse JP, Munir K, Kuhlthau KA, Prosser LA (2014) Economic burden of childhood autism spectrum disorders. Pediatrics 133:e520-529. https:\/\/doi.org\/10.1542\/peds.2013-0763","journal-title":"Pediatrics"},{"key":"2096_CR28","doi-asserted-by":"publisher","unstructured":"Li XS, Wang Z, Cajka T, Buffa JA, Nemet I, Hurd AG, Gu X, Skye SM, Roberts AB, Wu Y, Li L, Shahen CJ, Wagner MA, Hartiala JA, Kerby RL, Romano KA, Han Y, Obeid S, L\u00fcscher TF, Allayee H, Rey FE, DiDonato JA, Fiehn O, Tang WHW, Hazen SL (2018) Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk. JCI Insight 3.\u00a0https:\/\/doi.org\/10.1172\/jci.insight.99096","DOI":"10.1172\/jci.insight.99096"},{"issue":"-","key":"2096_CR29","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1002\/1873-3468.13765","volume":"594","author":"Q Lu","year":"2020","unstructured":"Lu Q, Murakami C, Murakami Y, Hoshino F, Asami M, Usuki T, Sakai H, Sakane F (2020) 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain. FEBS Lett 594:1787\u20131796. https:\/\/doi.org\/10.1002\/1873-3468.13765","journal-title":"FEBS Lett"},{"issue":"-","key":"2096_CR30","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.yhbeh.2014.08.011","volume":"66","author":"VN Luine","year":"2014","unstructured":"Luine VN (2014) Estradiol and cognitive function: past, present and future. Horm Behav 66:602\u2013618. https:\/\/doi.org\/10.1016\/j.yhbeh.2014.08.011","journal-title":"Horm Behav"},{"issue":"-","key":"2096_CR31","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.psychres.2018.06.027","volume":"267","author":"QQ Lv","year":"2018","unstructured":"Lv QQ, You C, Zou XB, Deng HZ (2018) Acyl-carnitine, C5DC, and C26 as potential biomarkers for diagnosis of autism spectrum disorder in children. Psychiatry Res 267:277\u2013280. https:\/\/doi.org\/10.1016\/j.psychres.2018.06.027","journal-title":"Psychiatry Res"},{"issue":"-","key":"2096_CR32","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/j.1601-183X.2007.00330.x","volume":"7","author":"HG McFarlane","year":"2008","unstructured":"McFarlane HG, Kusek GK, Yang M, Phoenix JL, Bolivar VJ, Crawley JN (2008) Autism-like behavioral phenotypes in BTBR T+tf\/J mice. Genes Brain Behav 7:152\u2013163. https:\/\/doi.org\/10.1111\/j.1601-183X.2007.00330.x","journal-title":"Genes Brain Behav"},{"key":"2096_CR33","doi-asserted-by":"publisher","unstructured":"McTighe SM, Neal SJ, Lin Q, Hughes ZA, Smith DG (2013) The BTBR mouse model of autism spectrum disorders has learning and attentional impairments and alterations in acetylcholine and kynurenic acid in prefrontal cortex. PloS One 8:e62189.\u00a0https:\/\/doi.org\/10.1371\/journal.pone.0062189","DOI":"10.1371\/journal.pone.0062189"},{"issue":"-","key":"2096_CR34","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.neulet.2011.11.007","volume":"506","author":"F Mercier","year":"2012","unstructured":"Mercier F, Kwon YC, Douet V (2012) Hippocampus\/amygdala alterations, loss of heparan sulfates, fractones and ventricle wall reduction in adult BTBR T+ tf\/J mice, animal model for autism. Neurosci Lett 506:208\u2013213. https:\/\/doi.org\/10.1016\/j.neulet.2011.11.007","journal-title":"Neurosci Lett"},{"issue":"-","key":"2096_CR35","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/npp.2011.181","volume":"37","author":"B Moghaddam","year":"2012","unstructured":"Moghaddam B, Javitt D (2012) From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment. Neuropsychopharmacol Official Publ Am College Neuropsychopharmacol 37:4\u201315. https:\/\/doi.org\/10.1038\/npp.2011.181","journal-title":"Neuropsychopharmacol Official Publ Am College Neuropsychopharmacol"},{"issue":"-","key":"2096_CR36","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.conb.2010.02.001","volume":"20","author":"EA Murray","year":"2010","unstructured":"Murray EA, Wise SP (2010) Interactions between orbital prefrontal cortex and amygdala: advanced cognition, learned responses and instinctive behaviors. Curr Opin Neurobiol 20:212\u2013220. https:\/\/doi.org\/10.1016\/j.conb.2010.02.001","journal-title":"Curr Opin Neurobiol"},{"issue":"-","key":"2096_CR37","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.pnpbp.2018.09.012","volume":"89","author":"A Nadeem","year":"2019","unstructured":"Nadeem A, Ahmad SF, Al-Harbi NO, Attia SM, Alshammari MA, Alzahrani KS, Bakheet SA (2019) Increased oxidative stress in the cerebellum and peripheral immune cells leads to exaggerated autism-like repetitive behavior due to deficiency of antioxidant response in BTBR T + tf\/J mice. Prog Neuro-Psychopharmacol Biol Psychiatry 89:245\u2013253. https:\/\/doi.org\/10.1016\/j.pnpbp.2018.09.012","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"-","key":"2096_CR38","doi-asserted-by":"publisher","first-page":"23264","DOI":"10.1074\/jbc.M113.491431","volume":"288","author":"H Nakamura","year":"2013","unstructured":"Nakamura H, Moriyama Y, Makiyama T, Emori S, Yamashita H, Yamazaki R, Murayama T (2013) Lactosylceramide interacts with and activates cytosolic phospholipase A2\u03b1. J Biol Chem 288:23264\u201323272. https:\/\/doi.org\/10.1074\/jbc.M113.491431","journal-title":"J Biol Chem"},{"issue":"-","key":"2096_CR39","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.biopsych.2020.09.025","volume":"89","author":"BD Needham","year":"2021","unstructured":"Needham BD, Adame MD, Serena G, Rose DR, Preston GM, Conrad MC, Campbell AS, Donabedian DH, Fasano A, Ashwood P, Mazmanian SK (2021) Plasma and fecal metabolite profiles in autism spectrum disorder. Biol Psychiatry 89:451\u2013462. https:\/\/doi.org\/10.1016\/j.biopsych.2020.09.025","journal-title":"Biol Psychiatry"},{"key":"2096_CR40","doi-asserted-by":"publisher","unstructured":"Newell C, Shutt TE, Ahn Y, Hittel DS, Khan A, Rho JM, Shearer J (2016) Tissue specific impacts of a ketogenic diet on mitochondrial dynamics in the BTBR(T+tf\/j) mouse. Front Physiol 7:654.\u00a0https:\/\/doi.org\/10.3389\/fphys.2016.00654","DOI":"10.3389\/fphys.2016.00654"},{"issue":"-","key":"2096_CR41","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/nrd1157","volume":"2","author":"JK Nicholson","year":"2003","unstructured":"Nicholson JK, Wilson ID (2003) Opinion: understanding \u2018global\u2019 systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov 2:668\u2013676. https:\/\/doi.org\/10.1038\/nrd1157","journal-title":"Nat Rev Drug Discov"},{"issue":"-","key":"2096_CR42","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.yfrne.2007.12.005","volume":"29","author":"J Nilsen","year":"2008","unstructured":"Nilsen J (2008) Estradiol and neurodegenerative oxidative stress. Front Neuroendocrinol 29:463\u2013475. https:\/\/doi.org\/10.1016\/j.yfrne.2007.12.005","journal-title":"Front Neuroendocrinol"},{"key":"2096_CR43","doi-asserted-by":"publisher","unstructured":"Nuzzo T, Sekine M, Punzo D, Miroballo M, Katane M, Saitoh Y, Galbusera A, Pasqualetti M, Errico F, Gozzi A, Mothet JP, Homma H, Usiello A (2020) Dysfunctional d-aspartate metabolism in BTBR mouse model of idiopathic autism.\u00a0Biochim Biophys Acta Proteins Proteom\u00a01868:140531.\u00a0https:\/\/doi.org\/10.1016\/j.bbapap.2020.140531","DOI":"10.1016\/j.bbapap.2020.140531"},{"key":"2096_CR44","doi-asserted-by":"publisher","unstructured":"Ojo JO, Algamal M, Leary P, Abdullah L, Mouzon B, Evans JE, Mullan M, Crawford F (2018) Disruption in brain phospholipid content in a humanized tau transgenic model following repetitive mild traumatic brain injury. Front Neurosci 12:893.\u00a0https:\/\/doi.org\/10.3389\/fnins.2018.00893","DOI":"10.3389\/fnins.2018.00893"},{"issue":"-","key":"2096_CR45","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1021\/acschemneuro.5b00073","volume":"6","author":"WY Ong","year":"2015","unstructured":"Ong WY, Farooqui T, Kokotos G, Farooqui AA (2015) Synthetic and natural inhibitors of phospholipases A2: their importance for understanding and treatment of neurological disorders. ACS Chem Neurosci 6:814\u2013831. https:\/\/doi.org\/10.1021\/acschemneuro.5b00073","journal-title":"ACS Chem Neurosci"},{"issue":"-","key":"2096_CR46","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/s0925-4439(99)00113-1","volume":"1500","author":"T Page","year":"2000","unstructured":"Page T, Coleman M (2000) Purine metabolism abnormalities in a hyperuricosuric subclass of autism. Biochim Biophys Acta 1500:291\u2013296. https:\/\/doi.org\/10.1016\/s0925-4439(99)00113-1","journal-title":"Biochim Biophys Acta"},{"issue":"-","key":"2096_CR47","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1159\/000478725","volume":"39","author":"D Pav\u0103l","year":"2017","unstructured":"Pav\u0103l D (2017) A dopamine hypothesis of autism spectrum disorder. Dev Neurosci 39:355\u2013360. https:\/\/doi.org\/10.1159\/000478725","journal-title":"Dev Neurosci"},{"issue":"-","key":"2096_CR48","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jbior.2016.09.004","volume":"63","author":"DM Raben","year":"2017","unstructured":"Raben DM, Barber CN (2017) Phosphatidic acid and neurotransmission. Adv Biol Regul 63:15\u201321. https:\/\/doi.org\/10.1016\/j.jbior.2016.09.004","journal-title":"Adv Biol Regul"},{"issue":"-","key":"2096_CR49","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/mp.2011.165","volume":"17","author":"DA Rossignol","year":"2012","unstructured":"Rossignol DA, Frye RE (2012) A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Mol Psychiatry 17:389\u2013401. https:\/\/doi.org\/10.1038\/mp.2011.165","journal-title":"Mol Psychiatry"},{"key":"2096_CR50","doi-asserted-by":"publisher","unstructured":"Saide A, Lauritano C, Ianora A (2021) A treasure of bioactive compounds from the deep sea. Biomedicines 9.\u00a0https:\/\/doi.org\/10.3390\/biomedicines9111556","DOI":"10.3390\/biomedicines9111556"},{"key":"2096_CR51","doi-asserted-by":"publisher","unstructured":"Savio LEB, Leite-Aguiar R, Alves VS, Coutinho-Silva R, Wyse ATS (2021) Purinergic signaling in the modulation of redox biology. Redox Biol 47:102137.\u00a0https:\/\/doi.org\/10.1016\/j.redox.2021.102137","DOI":"10.1016\/j.redox.2021.102137"},{"issue":"-","key":"2096_CR52","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/bph.14446","volume":"176","author":"JI Sbodio","year":"2019","unstructured":"Sbodio JI, Snyder SH, Paul BD (2019) Regulators of the transsulfuration pathway. Br J Pharmacol 176:583\u2013593. https:\/\/doi.org\/10.1111\/bph.14446","journal-title":"Br J Pharmacol"},{"issue":"-","key":"2096_CR53","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1111\/j.1471-4159.2007.04570.x","volume":"102","author":"T Takenouchi","year":"2007","unstructured":"Takenouchi T, Sato M, Kitani H (2007) Lysophosphatidylcholine potentiates Ca2+ influx, pore formation and p44\/42 MAP kinase phosphorylation mediated by P2X7 receptor activation in mouse microglial cells. J Neurochem 102:1518\u20131532. https:\/\/doi.org\/10.1111\/j.1471-4159.2007.04570.x","journal-title":"J Neurochem"},{"issue":"-","key":"2096_CR54","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.1007\/s10803-020-04685-z","volume":"51","author":"A Thapar","year":"2021","unstructured":"Thapar A, Rutter M (2021) Genetic advances in autism. J Autism Dev Disord 51:4321\u20134332. https:\/\/doi.org\/10.1007\/s10803-020-04685-z","journal-title":"J Autism Dev Disord"},{"issue":"-","key":"2096_CR55","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1007\/s12035-020-01935-0","volume":"57","author":"B Toczylowska","year":"2020","unstructured":"Toczylowska B, Zieminska E, Senator P, Lazarewicz JW (2020) Hippocampal metabolite profiles in two rat models of autism: NMR-based metabolomics studies. Mol Neurobiol 57:3089\u20133105. https:\/\/doi.org\/10.1007\/s12035-020-01935-0","journal-title":"Mol Neurobiol"},{"issue":"-","key":"2096_CR56","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1503\/jpn.140009","volume":"41","author":"H Wang","year":"2016","unstructured":"Wang H, Liang S, Wang M, Gao J, Sun C, Wang J, Xia W, Wu S, Sumner SJ, Zhang F, Sun C, Wu L (2016) Potential serum biomarkers from a metabolomics study of autism. J Psychiatry Neurosci\u202f: JPN 41:27\u201337. https:\/\/doi.org\/10.1503\/jpn.140009","journal-title":"J Psychiatry Neurosci : JPN"},{"key":"2096_CR57","doi-asserted-by":"publisher","unstructured":"Wang L, Peng JL, Qiao FQ, Cheng WM, Lin GW, Zhang Y, Gao TG, Sun YY, Tang WZ, Wang P (2021) Clinical randomized controlled study of acupuncture treatment on children with autism spectrum disorder (ASD): a systematic review and meta-analysis.\u00a0Evid Based Complement Alternat Med eCAM\u00a02021:5549849.\u00a0https:\/\/doi.org\/10.1155\/2021\/5549849","DOI":"10.1155\/2021\/5549849"},{"issue":"-","key":"2096_CR58","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1007\/s11064-016-2035-5","volume":"41","author":"H Wei","year":"2016","unstructured":"Wei H, Ma Y, Ding C, Jin G, Liu J, Chang Q, Hu F, Yu L (2016) Reduced glutamate release in adult BTBR mouse model of autism spectrum disorder. Neurochem Res 41:3129\u20133137. https:\/\/doi.org\/10.1007\/s11064-016-2035-5","journal-title":"Neurochem Res"},{"issue":"-","key":"2096_CR59","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.neuroscience.2015.11.003","volume":"312","author":"H Wei","year":"2016","unstructured":"Wei H, Ma Y, Liu J, Ding C, Hu F, Yu L (2016) Proteomic analysis of cortical brain tissue from the BTBR mouse model of autism: evidence for changes in STOP and myelin-related proteins. Neuroscience 312:26\u201334. https:\/\/doi.org\/10.1016\/j.neuroscience.2015.11.003","journal-title":"Neuroscience"},{"issue":"-","key":"2096_CR60","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1002\/rcm.7241","volume":"29","author":"R Weng","year":"2015","unstructured":"Weng R, Shen S, Yang L, Li M, Tian Y, Bai Y, Liu H (2015) Lipidomic analysis of p-chlorophenylalanine-treated mice using continuous-flow two-dimensional liquid chromatography\/quadrupole time-of-flight mass spectrometry. Rapid Commun Mass Spectrom\u202f: RCM 29:1491\u20131500. https:\/\/doi.org\/10.1002\/rcm.7241","journal-title":"Rapid Commun Mass Spectrom : RCM"},{"issue":"-","key":"2096_CR61","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1111\/jipb.12655","volume":"60","author":"HY Yao","year":"2018","unstructured":"Yao HY, Xue HW (2018) Phosphatidic acid plays key roles regulating plant development and stress responses. J Integr Plant Biol 60:851\u2013863. https:\/\/doi.org\/10.1111\/jipb.12655","journal-title":"J Integr Plant Biol"},{"key":"2096_CR62","doi-asserted-by":"publisher","unstructured":"Yu W, Ying J, Wang X, Liu X, Zhao T, Yoon S, Zheng Q, Fang Y, Yang D, Hua F (2021) The involvement of lactosylceramide in central nervous system inflammation related to neurodegenerative disease. Front Aging Neurosci 13:691230.\u00a0https:\/\/doi.org\/10.3389\/fnagi.2021.691230","DOI":"10.3389\/fnagi.2021.691230"},{"issue":"-","key":"2096_CR63","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/emm.2006.44","volume":"38","author":"DH Yun","year":"2006","unstructured":"Yun DH, Jeon ES, Sung SM, Ryu SH, Kim JH (2006) Lysophosphatidylcholine suppresses apoptosis and induces neurite outgrowth in PC12 cells through activation of phospholipase D2. Exp Mol Med 38:375\u2013384. https:\/\/doi.org\/10.1038\/emm.2006.44","journal-title":"Exp Mol Med"},{"issue":"-","key":"2096_CR64","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.neuron.2015.01.009","volume":"85","author":"YC Yung","year":"2015","unstructured":"Yung YC, Stoddard NC, Mirendil H, Chun J (2015) Lysophosphatidic acid signaling in the nervous system. Neuron 85:669\u2013682. https:\/\/doi.org\/10.1016\/j.neuron.2015.01.009","journal-title":"Neuron"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-022-02096-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-022-02096-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-022-02096-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T07:55:59Z","timestamp":1675324559000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-022-02096-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,27]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["2096"],"URL":"https:\/\/doi.org\/10.1007\/s12031-022-02096-6","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,27]]},"assertion":[{"value":"14 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}