{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:24:29Z","timestamp":1790659469243,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Neurosci"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s12031-023-02134-x","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T11:02:22Z","timestamp":1686308542000},"page":"456-468","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["H2S Alleviates Neuropathic Pain in Mice by Nrf2 Signaling Pathway Activation"],"prefix":"10.1007","volume":"73","author":[{"given":"Jun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Dong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"issue":"1","key":"2134_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00296-009-0977-5","volume":"30","author":"J Baranowsky","year":"2009","unstructured":"Baranowsky J, Klose P, Musial F et al (2009) Qualitative systemic review of randomized controlled trials on complementary and alternative medicine treatments in fibromyalgia. Rheumatol Int 30(1):1\u201321","journal-title":"Rheumatol Int"},{"key":"2134_CR2","doi-asserted-by":"crossref","unstructured":"Batall\u00e9 G, Cabarga L, Pol O (2019) The inhibitory effects of slow-releasing hydrogen sulfide donors in the mechanical allodynia, grip strength deficits, and depressive-like behaviors associated with chronic osteoarthritis pain. Antioxidants (Basel) 9(1)","DOI":"10.3390\/antiox9010031"},{"issue":"2 Suppl 1","key":"2134_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0026-0495(00)80077-3","volume":"49","author":"DJ Betteridge","year":"2000","unstructured":"Betteridge DJ (2000) What is oxidative stress? Metabolism 49(2 Suppl 1):3\u20138","journal-title":"Metabolism"},{"issue":"1","key":"2134_CR4","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s11033-018-4465-4","volume":"46","author":"B Caglayan","year":"2019","unstructured":"Caglayan B, Kilic E, Dalay A et al (2019) Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2\/HO-1 and NF-\u03baB pathways in traumatic brain injury in mice. Mol Biol Rep 46(1):241\u2013250","journal-title":"Mol Biol Rep"},{"key":"2134_CR5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3389\/fphys.2018.00095","volume":"9","author":"C Carrasco","year":"2018","unstructured":"Carrasco C, Naziro\u01e7lu M, Rodr\u00edguez AB et al (2018) Neuropathic pain: delving into the oxidative origin and the possible implication of transient receptor potential channels. Front Physiol 9:95","journal-title":"Front Physiol"},{"key":"2134_CR6","doi-asserted-by":"crossref","unstructured":"Cores \u00c1, Abril S, Michalska P et al (2021) Bisavenathramide analogues as Nrf2 inductors and neuroprotectors in in vitro models of oxidative stress and hyperphosphorylation. Antioxidants (Basel) 10(6)","DOI":"10.3390\/antiox10060941"},{"key":"2134_CR7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.neuropharm.2017.04.029","volume":"121","author":"ML Di Cesare","year":"2017","unstructured":"Di Cesare ML, Lucarini E, Micheli L et al (2017) Effects of natural and synthetic isothiocyanate-based H(2)S-releasers against chemotherapy-induced neuropathic pain: role of Kv7 potassium channels. Neuropharmacology 121:49\u201359","journal-title":"Neuropharmacology"},{"key":"2134_CR8","doi-asserted-by":"crossref","unstructured":"Francis N, Rao S, Blanchard C et al (2019) Black sorghum phenolic extract regulates expression of genes associated with oxidative stress and inflammation in human endothelial cells. Molecules 24(18)","DOI":"10.3390\/molecules24183321"},{"issue":"4","key":"2134_CR9","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.mayocp.2015.01.018","volume":"90","author":"I Gilron","year":"2015","unstructured":"Gilron I, Baron R, Jensen T (2015) Neuropathic pain: principles of diagnosis and treatment. Mayo Clin Proc 90(4):532\u2013545","journal-title":"Mayo Clin Proc"},{"key":"2134_CR10","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.neuroscience.2022.06.007","volume":"498","author":"X Guo","year":"2022","unstructured":"Guo X, Kang J, Wang Z et al (2022) Nrf2 Signaling in the oxidative stress response after spinal cord injury. Neuroscience 498:311\u2013324","journal-title":"Neuroscience"},{"issue":"12","key":"2134_CR11","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.tins.2016.10.003","volume":"39","author":"PM Grace","year":"2016","unstructured":"Grace PM, Gaudet AD, Staikopoulos V et al (2016) Nitroxidative signaling mechanisms in pathological pain. Trends Neurosci 39(12):862\u2013879","journal-title":"Trends Neurosci"},{"issue":"1","key":"2134_CR12","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s11011-014-9490-y","volume":"29","author":"P Hao","year":"2014","unstructured":"Hao P, Liang Z, Piao H et al (2014) Conditioned medium of human adipose-derived mesenchymal stem cells mediates protection in neurons following glutamate excitotoxicity by regulating energy metabolism and GAP-43 expression. Metab Brain Dis 29(1):193\u2013205","journal-title":"Metab Brain Dis"},{"issue":"3","key":"2134_CR13","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/nrn.2018.2","volume":"19","author":"K Inoue","year":"2018","unstructured":"Inoue K, Tsuda M (2018) Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci 19(3):138\u2013152","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"2134_CR14","doi-asserted-by":"publisher","first-page":"680","DOI":"10.4049\/jimmunol.181.1.680","volume":"181","author":"NG Innamorato","year":"2008","unstructured":"Innamorato NG, Rojo AI, Garc\u00eda-Yag\u00fce AJ et al (2008) The transcription factor Nrf2 is a therapeutic target against brain inflammation. J Immunol 181(1):680\u2013689","journal-title":"J Immunol"},{"key":"2134_CR15","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.brainres.2011.01.002","volume":"1381","author":"AS Jaggi","year":"2011","unstructured":"Jaggi AS, Singh N (2011) Role of different brain areas in peripheral nerve injury-induced neuropathic pain. Brain Res 1381:187\u2013201","journal-title":"Brain Res"},{"issue":"9","key":"2134_CR16","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/S1474-4422(14)70102-4","volume":"13","author":"TS Jensen","year":"2014","unstructured":"Jensen TS, Finnerup NB (2014) Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms. Lancet Neurol 13(9):924\u2013935","journal-title":"Lancet Neurol"},{"issue":"6312","key":"2134_CR17","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1126\/science.aaf8924","volume":"354","author":"RR Ji","year":"2016","unstructured":"Ji RR, Chamessian A, Zhang YQ (2016) Pain regulation by non-neuronal cells and inflammation. Science 354(6312):572\u2013577","journal-title":"Science"},{"issue":"2","key":"2134_CR18","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","volume":"129","author":"RR Ji","year":"2018","unstructured":"Ji RR, Nackley A, Huh Y et al (2018) Neuroinflammation and central sensitization in chronic and widespread pain. Anesthesiology 129(2):343\u2013366","journal-title":"Anesthesiology"},{"issue":"7","key":"2134_CR19","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nrd4334","volume":"13","author":"RR Ji","year":"2014","unstructured":"Ji RR, Xu ZZ, Gao YJ (2014) Emerging targets in neuroinflammation-driven chronic pain. Nat Rev Drug Discov 13(7):533\u2013548","journal-title":"Nat Rev Drug Discov"},{"key":"2134_CR20","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.niox.2014.11.014","volume":"46","author":"K Kida","year":"2015","unstructured":"Kida K, Marutani E, Nguyen RK et al (2015) Inhaled hydrogen sulfide prevents neuropathic pain after peripheral nerve injury in mice. Nitric Oxide 46:87\u201392","journal-title":"Nitric Oxide"},{"key":"2134_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111777","volume":"185","author":"HJ Kim","year":"2020","unstructured":"Kim HJ, Jang BK, Park JH et al (2020) A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem 185:111777","journal-title":"Eur J Med Chem"},{"key":"2134_CR22","doi-asserted-by":"crossref","unstructured":"Kov\u00e1cs C, Pecze M, Tihanyi \u00c1 et al (2012) The effect of sulphurous water in patients with osteoarthritis of hand. Double-blind, randomized, controlled follow-up study. Clin Rheumatol 31(10):1437\u201342","DOI":"10.1007\/s10067-012-2026-0"},{"key":"2134_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117351","volume":"245","author":"D Li","year":"2020","unstructured":"Li D, Tian H, Li X et al (2020) Zinc promotes functional recovery after spinal cord injury by activating Nrf2\/HO-1 defense pathway and inhibiting inflammation of NLRP3 in nerve cells. Life Sci 245:117351","journal-title":"Life Sci"},{"key":"2134_CR24","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.2147\/JPR.S161882","volume":"11","author":"E Lucarini","year":"2018","unstructured":"Lucarini E, Micheli L, Martelli A et al (2018) Efficacy of isothiocyanate-based compounds on different forms of persistent pain. J Pain Res 11:2905\u20132913","journal-title":"J Pain Res"},{"key":"2134_CR25","doi-asserted-by":"crossref","unstructured":"Michalska P, Le\u00f3n R (2020) When it comes to an end: oxidative stress crosstalk with protein aggregation and neuroinflammation induce neurodegeneration. Antioxidants (Basel) 9(8)","DOI":"10.3390\/antiox9080740"},{"key":"2134_CR26","doi-asserted-by":"crossref","unstructured":"Meacham K, Shepherd A, Mohapatra DP et al (2017) Neuropathic Pain: central vs. peripheral mechanisms. Curr Pain Headache Rep 21(6):28","DOI":"10.1007\/s11916-017-0629-5"},{"key":"2134_CR27","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.bcp.2017.11.019","volume":"149","author":"BD Paul","year":"2018","unstructured":"Paul BD, Snyder SH (2018) Gasotransmitter hydrogen sulfide signaling in neuronal health and disease. Biochem Pharmacol 149:101\u2013109","journal-title":"Biochem Pharmacol"},{"key":"2134_CR28","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/676473","volume":"2015","author":"K Popiolek-Barczyk","year":"2015","unstructured":"Popiolek-Barczyk K, Kolosowska N, Piotrowska A et al (2015) Parthenolide relieves pain and promotes M2 microglia\/macrophage polarization in rat model of neuropathy. Neural Plast 2015:676473","journal-title":"Neural Plast"},{"issue":"1","key":"2134_CR29","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1089\/ars.2012.4612","volume":"17","author":"BL Predmore","year":"2012","unstructured":"Predmore BL, Lefer DJ, Gojon G (2012) Hydrogen sulfide in biochemistry and medicine. Antioxid Redox Signal 17(1):119\u2013140","journal-title":"Antioxid Redox Signal"},{"key":"2134_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110210","volume":"127","author":"B Qabazard","year":"2020","unstructured":"Qabazard B, Masocha W, Khajah M et al (2020) H(2)S donor GYY4137 ameliorates paclitaxel-induced neuropathic pain in mice. Biomed Pharmacother 127:110210","journal-title":"Biomed Pharmacother"},{"key":"2134_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134440","volume":"711","author":"Z Qiang","year":"2019","unstructured":"Qiang Z, Yu W (2019) Chemokine CCL7 regulates spinal phosphorylation of GluA1-containing AMPA receptor via interleukin-18 in remifentanil-induced hyperalgesia in rats. Neurosci Lett 711:134440","journal-title":"Neurosci Lett"},{"issue":"4","key":"2134_CR32","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1159\/000335167","volume":"19","author":"ZF Qin","year":"2012","unstructured":"Qin ZF, Hou DY, Fang YQ et al (2012) Interferon-alpha enhances excitatory transmission in substantia gelatinosa neurons of rat spinal cord. NeuroImmunoModulation 19(4):235\u2013240","journal-title":"NeuroImmunoModulation"},{"issue":"1\u20132","key":"2134_CR33","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jneuroim.2014.09.020","volume":"277","author":"E Rojewska","year":"2014","unstructured":"Rojewska E, Popiolek-Barczyk K, Jurga AM et al (2014) Involvement of pro- and antinociceptive factors in minocycline analgesia in rat neuropathic pain model. J Neuroimmunol 277(1\u20132):57\u201366","journal-title":"J Neuroimmunol"},{"issue":"5","key":"2134_CR34","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1002\/glia.20947","volume":"58","author":"AI Rojo","year":"2010","unstructured":"Rojo AI, Innamorato NG, Mart\u00edn-Moreno AM et al (2010) Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson\u2019s disease. Glia 58(5):588\u2013598","journal-title":"Glia"},{"issue":"6","key":"2134_CR35","doi-asserted-by":"publisher","first-page":"538","DOI":"10.2174\/1568009617666171002144228","volume":"18","author":"S Sajadimajd","year":"2018","unstructured":"Sajadimajd S, Khazaei M (2018) Oxidative stress and cancer: the role of Nrf2. Curr Cancer Drug Targets 18(6):538\u2013557","journal-title":"Curr Cancer Drug Targets"},{"key":"2134_CR36","doi-asserted-by":"publisher","first-page":"174480691984009","DOI":"10.1177\/1744806919840098","volume":"15","author":"HS Shim","year":"2019","unstructured":"Shim HS, Bae C, Wang J et al (2019) Peripheral and central oxidative stress in chemotherapy-induced neuropathic pain. Mol Pain 15:1744806919840098","journal-title":"Mol Pain"},{"key":"2134_CR37","doi-asserted-by":"publisher","first-page":"6175804","DOI":"10.1155\/2019\/6175804","volume":"2019","author":"AV Snezhkina","year":"2019","unstructured":"Snezhkina AV, Kudryavtseva AV, Kardymon OL et al (2019) ROS generation and antioxidant defense systems in normal and malignant cells. Oxid Med Cell Longev 2019:6175804","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"2134_CR38","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/glia.23570","volume":"67","author":"H Tozaki-Saitoh","year":"2019","unstructured":"Tozaki-Saitoh H, Masuda J, Kawada R et al (2019) Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development. Glia 67(4):729\u2013740","journal-title":"Glia"},{"key":"2134_CR39","doi-asserted-by":"crossref","unstructured":"Verhagen AP, Bierma-Zeinstra SM, Boers M et al (2007) Balneotherapy for osteoarthritis. Cochrane Database Syst Rev (4):Cd006864","DOI":"10.1002\/14651858.CD006864"},{"key":"2134_CR40","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.neures.2019.05.003","volume":"154","author":"C Wang","year":"2020","unstructured":"Wang C, Xu R, Wang X et al (2020) Spinal CCL1\/CCR8 regulates phosphorylation of GluA1-containing AMPA receptor in postoperative pain after tibial fracture and orthopedic surgery in mice. Neurosci Res 154:20\u201326","journal-title":"Neurosci Res"},{"issue":"10","key":"2134_CR41","doi-asserted-by":"publisher","first-page":"17123","DOI":"10.1002\/jcb.28972","volume":"120","author":"Z Wang","year":"2019","unstructured":"Wang Z, Zhao W, Shen X et al (2019) The role of P2Y6 receptors in the maintenance of neuropathic pain and its improvement of oxidative stress in rats. J Cell Biochem 120(10):17123\u201317130","journal-title":"J Cell Biochem"},{"key":"2134_CR42","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.neulet.2017.03.015","volume":"647","author":"YW Wang","year":"2017","unstructured":"Wang YW, Zhang X, Chen CL et al (2017) Protective effects of Garcinol against neuropathic pain - evidence from in vivo and in vitro studies. Neurosci Lett 647:85\u201390","journal-title":"Neurosci Lett"},{"issue":"1","key":"2134_CR43","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.brainresbull.2011.10.007","volume":"87","author":"C Xu","year":"2012","unstructured":"Xu C, Xu W, Xu H et al (2012) Role of puerarin in the signalling of neuropathic pain mediated by P2X3 receptor of dorsal root ganglion neurons. Brain Res Bull 87(1):37\u201343","journal-title":"Brain Res Bull"},{"issue":"2","key":"2134_CR44","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jneumeth.2009.06.020","volume":"183","author":"F Xu","year":"2009","unstructured":"Xu F, Li T, Zhang B (2009) An improved method for protecting and fixing the lumbar catheters placed in the spinal subarachnoid space of rats. J Neurosci Methods 183(2):114\u2013118","journal-title":"J Neurosci Methods"},{"key":"2134_CR45","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.neuroscience.2017.02.041","volume":"349","author":"R Yadav","year":"2017","unstructured":"Yadav R, Weng HR (2017) EZH2 regulates spinal neuroinflammation in rats with neuropathic pain. Neuroscience 349:106\u2013117","journal-title":"Neuroscience"},{"issue":"1","key":"2134_CR46","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12974-019-1472-x","volume":"16","author":"B Zhang","year":"2019","unstructured":"Zhang B, Wang G, He J et al (2019) Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner. J Neuroinflammation 16(1):92","journal-title":"J Neuroinflammation"},{"key":"2134_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.898574","volume":"13","author":"H Zhang","year":"2022","unstructured":"Zhang H, Li N, Li Z et al (2022) The involvement of caspases in neuroinflammation and neuronal apoptosis in chronic pain and potential therapeutic targets. Front Pharmacol 13:898574","journal-title":"Front Pharmacol"},{"issue":"5","key":"2134_CR48","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1172\/JCI65364","volume":"123","author":"YK Zhang","year":"2013","unstructured":"Zhang YK, Huang ZJ, Liu S et al (2013) WNT signaling underlies the pathogenesis of neuropathic pain in rodents. J Clin Invest 123(5):2268\u20132286","journal-title":"J Clin Invest"},{"issue":"6","key":"2134_CR49","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1159\/000518879","volume":"146","author":"M Zhou","year":"2021","unstructured":"Zhou M, Yu Y, Luo X et al (2021) Myocardial ischemia-reperfusion injury: therapeutics from a mitochondria-centric perspective. Cardiology 146(6):781\u2013792","journal-title":"Cardiology"},{"issue":"8","key":"2134_CR50","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1038\/s41401-020-0394-6","volume":"41","author":"YQ Zhou","year":"2020","unstructured":"Zhou YQ, Liu DQ, Chen SP et al (2020a) Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain. Acta Pharmacol Sin 41(8):1041\u20131048","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"2134_CR51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41401-019-0261-5","volume":"41","author":"YL Zhou","year":"2020","unstructured":"Zhou YL, Yan YM, Li SY et al (2020b) 6-O-angeloylplenolin exerts neuroprotection against lipopolysaccharide-induced neuroinflammation in vitro and in vivo. Acta Pharmacol Sin 41(1):10\u201321","journal-title":"Acta Pharmacol Sin"}],"container-title":["Journal of Molecular Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-023-02134-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12031-023-02134-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12031-023-02134-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:35:39Z","timestamp":1692232539000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12031-023-02134-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["2134"],"URL":"https:\/\/doi.org\/10.1007\/s12031-023-02134-x","relation":{},"ISSN":["0895-8696","1559-1166"],"issn-type":[{"value":"0895-8696","type":"print"},{"value":"1559-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"17 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental protocols were approved by the Institutional Animal Care and Use Committee of Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all study participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors have approved for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}